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Q9P6M1 (GST3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 3

EC=2.5.1.18
Alternative name(s):
GST-III
Gene names
Name:gst3
ORF Names:SPAC688.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in the detoxification of various heavy metals. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Interacts with sad1. Ref.4

Subcellular location

Cytoplasm Ref.4.

Induction

By heavy metals such as cadmium and mercury. Ref.1

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Glutathione S-transferase 3
PRO_0000185986

Regions

Domain1 – 7979GST N-terminal
Domain85 – 234150GST C-terminal

Amino acid modifications

Modified residue2281Phosphoserine Ref.5
Modified residue2321Phosphothreonine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9P6M1 [UniParc].

Last modified April 18, 2012. Version 3.
Checksum: 42324A6B9B672938

FASTA24228,113
        10         20         30         40         50         60 
MIVLHHLKNS RSTRIVWMLE ELKVPYEIKV YDRVDGRAPP AYTKLSPLGK SPIVVDDGVT 

        70         80         90        100        110        120 
YIESAAILEH LVRKYGPSFK PSEEDVAELE KYELWMHFSE ASLMPFIWAS HVLDLSVNMT 

       130        140        150        160        170        180 
PIFFRYIVRQ FVNGIKSKYL SKETFLNLDY IDNHLASNEY FAGEQFTAAD PQMCFPIFAA 

       190        200        210        220        230        240 
QRDYLSQKPY KNIKRWMRVV SDRPACRIAA EKVEDNTLTL FSDVERYSHP PTPPPEQVRS 


DE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast."
Shin Y.H., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1577:164-170(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Comparative functional genomics of the fission yeasts."
Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K. expand/collapse author list , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVISION OF GENE MODEL.
[4]"Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast."
Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.
Mol. Genet. Genomics 270:449-461(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SAD1, SUBCELLULAR LOCATION.
[5]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228 AND THR-232, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY034792 Genomic DNA. Translation: AAK58430.1.
CU329670 Genomic DNA. Translation: CAB90771.3.
RefSeqNP_594063.3. NM_001019487.3.

3D structure databases

ProteinModelPortalQ9P6M1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279899. 7 interactions.
IntActQ9P6M1. 1 interaction.
MINTMINT-4704315.
STRING4896.SPAC688.04c-1.

Proteomic databases

MaxQBQ9P6M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC688.04c.1; SPAC688.04c.1:pep; SPAC688.04c.
GeneID2543479.
KEGGspo:SPAC688.04c.

Organism-specific databases

PomBaseSPAC688.04c.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125753.
OrthoDBEOG7BZW43.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804491.

Entry information

Entry nameGST3_SCHPO
AccessionPrimary (citable) accession number: Q9P6M1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names