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Q9P6M1

- GST3_SCHPO

UniProt

Q9P6M1 - GST3_SCHPO

Protein

Glutathione S-transferase 3

Gene

gst3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    May have a role in the detoxification of various heavy metals.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: PomBase
    2. glutathione transferase activity Source: PomBase

    GO - Biological processi

    1. oxidation-reduction process Source: GOC
    2. removal of superoxide radicals Source: PomBase
    3. response to drug Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 3 (EC:2.5.1.18)
    Alternative name(s):
    GST-III
    Gene namesi
    Name:gst3
    ORF Names:SPAC688.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC688.04c.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. endoplasmic reticulum Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Glutathione S-transferase 3PRO_0000185986Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei228 – 2281Phosphoserine1 Publication
    Modified residuei232 – 2321Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P6M1.

    Expressioni

    Inductioni

    By heavy metals such as cadmium and mercury.1 Publication

    Interactioni

    Subunit structurei

    Interacts with sad1.1 Publication

    Protein-protein interaction databases

    BioGridi279899. 7 interactions.
    IntActiQ9P6M1. 1 interaction.
    MINTiMINT-4704315.
    STRINGi4896.SPAC688.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P6M1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7979GST N-terminalAdd
    BLAST
    Domaini85 – 234150GST C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125753.
    OrthoDBiEOG7BZW43.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P6M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVLHHLKNS RSTRIVWMLE ELKVPYEIKV YDRVDGRAPP AYTKLSPLGK    50
    SPIVVDDGVT YIESAAILEH LVRKYGPSFK PSEEDVAELE KYELWMHFSE 100
    ASLMPFIWAS HVLDLSVNMT PIFFRYIVRQ FVNGIKSKYL SKETFLNLDY 150
    IDNHLASNEY FAGEQFTAAD PQMCFPIFAA QRDYLSQKPY KNIKRWMRVV 200
    SDRPACRIAA EKVEDNTLTL FSDVERYSHP PTPPPEQVRS DE 242
    Length:242
    Mass (Da):28,113
    Last modified:April 18, 2012 - v3
    Checksum:i42324A6B9B672938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY034792 Genomic DNA. Translation: AAK58430.1.
    CU329670 Genomic DNA. Translation: CAB90771.3.
    RefSeqiNP_594063.3. NM_001019487.3.

    Genome annotation databases

    EnsemblFungiiSPAC688.04c.1; SPAC688.04c.1:pep; SPAC688.04c.
    GeneIDi2543479.
    KEGGispo:SPAC688.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY034792 Genomic DNA. Translation: AAK58430.1 .
    CU329670 Genomic DNA. Translation: CAB90771.3 .
    RefSeqi NP_594063.3. NM_001019487.3.

    3D structure databases

    ProteinModelPortali Q9P6M1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279899. 7 interactions.
    IntActi Q9P6M1. 1 interaction.
    MINTi MINT-4704315.
    STRINGi 4896.SPAC688.04c-1.

    Proteomic databases

    MaxQBi Q9P6M1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC688.04c.1 ; SPAC688.04c.1:pep ; SPAC688.04c .
    GeneIDi 2543479.
    KEGGi spo:SPAC688.04c.

    Organism-specific databases

    PomBasei SPAC688.04c.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125753.
    OrthoDBi EOG7BZW43.

    Miscellaneous databases

    NextBioi 20804491.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast."
      Shin Y.H., Park E.-H., Fuchs J.A., Lim C.-J.
      Biochim. Biophys. Acta 1577:164-170(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    4. "Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast."
      Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.
      Mol. Genet. Genomics 270:449-461(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SAD1, SUBCELLULAR LOCATION.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228 AND THR-232, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
      Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
      Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiGST3_SCHPO
    AccessioniPrimary (citable) accession number: Q9P6M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3