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Q9P6M1 (GST3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione S-transferase 3
EC=2.5.1.18
Alternative name(s):
GST-III
Gene names
Name:gst3
ORF Names:SPAC688.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in the detoxification of various heavy metals. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Interacts with sad1. Ref.3

Subcellular location

Cytoplasm Ref.3.

Induction

By heavy metals such as cadmium and mercury. Ref.1

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence caution

The sequence AAK58430.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processremoval of superoxide radicals

Inferred by curator. Source: GeneDB_Spombe

response to drug

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Cellular componentendoplasmic reticulum

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionglutathione peroxidase activity

Inferred from direct assay. Source: GeneDB_Spombe

glutathione transferase activity

Inferred from direct assay. Source: GeneDB_Spombe

protein homodimerization activity

Inferred from physical interaction. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Glutathione S-transferase 3
PRO_0000185986

Regions

Domain1 – 6262GST N-terminal
Domain68 – 217150GST C-terminal

Amino acid modifications

Modified residue2111Phosphoserine Ref.4
Modified residue2151Phosphothreonine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9P6M1 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: BCE7163982EB58F1

FASTA22526,041
        10         20         30         40         50         60 
MLEELKVPYE IKVYDRVDGR APPAYTKLSP LGKSPIVVDD GVTYIESAAI LEHLVRKYGP 

        70         80         90        100        110        120 
SFKPSEEDVA ELEKYELWMH FSEASLMPFI WASHVLDLSV NMTPIFFRYI VRQFVNGIKS 

       130        140        150        160        170        180 
KYLSKETFLN LDYIDNHLAS NEYFAGEQFT AADPQMCFPI FAAQRDYLSQ KPYKNIKRWM 

       190        200        210        220 
RVVSDRPACR IAAEKVEDNT LTLFSDVERY SHPPTPPPEQ VRSDE

« Hide

References

« Hide 'large scale' references
[1]"Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast."
Shin Y.H., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1577:164-170(2002) [PubMed: 12151111] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast."
Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.
Mol. Genet. Genomics 270:449-461(2004) [PubMed: 14655046] [Abstract]
Cited for: INTERACTION WITH SAD1, SUBCELLULAR LOCATION.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND THR-215, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB90771.2.
AY034792 Genomic DNA. Translation: AAK58430.1. Different initiation.
RefSeqNP_594063.2. NM_001019487.2.

3D structure databases

ProteinModelPortalQ9P6M1.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9P6M1. 1 interaction.
STRINGQ9P6M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2543479.
GenomeReviewsGene locus gst3 in contig CU329670_GR.
KEGGspo:SPAC688.04c.
NMPDRfig|4896.1.peg.4033.

Organism-specific databases

GeneDB_SpombeSPAC688.04c.

Phylogenomic databases

eggNOGfuNOG10594.
GeneTreeEFGT00050000001378.
OMAARIHARP.
OrthoDBEOG4GMZ6F.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001688-MONOMER.

Gene expression databases

ArrayExpressQ9P6M1.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. GST_C_like. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST3_SCHPO
AccessionPrimary (citable) accession number: Q9P6M1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: September 22, 2009
Last modified: December 14, 2011
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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