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Q9P6M1

- GST3_SCHPO

UniProt

Q9P6M1 - GST3_SCHPO

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Protein

Glutathione S-transferase 3

Gene

gst3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a role in the detoxification of various heavy metals.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: PomBase
  2. glutathione transferase activity Source: PomBase

GO - Biological processi

  1. oxidation-reduction process Source: GOC
  2. removal of superoxide radicals Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
GST-III
Gene namesi
Name:gst3
ORF Names:SPAC688.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC688.04c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. endoplasmic reticulum Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Glutathione S-transferase 3PRO_0000185986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei228 – 2281Phosphoserine1 Publication
Modified residuei232 – 2321Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P6M1.

Expressioni

Inductioni

By heavy metals such as cadmium and mercury.1 Publication

Interactioni

Subunit structurei

Interacts with sad1.1 Publication

Protein-protein interaction databases

BioGridi279899. 7 interactions.
IntActiQ9P6M1. 1 interaction.
MINTiMINT-4704315.
STRINGi4896.SPAC688.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P6M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7979GST N-terminalAdd
BLAST
Domaini85 – 234150GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125753.
InParanoidiQ9P6M1.
OrthoDBiEOG7BZW43.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P6M1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLHHLKNS RSTRIVWMLE ELKVPYEIKV YDRVDGRAPP AYTKLSPLGK
60 70 80 90 100
SPIVVDDGVT YIESAAILEH LVRKYGPSFK PSEEDVAELE KYELWMHFSE
110 120 130 140 150
ASLMPFIWAS HVLDLSVNMT PIFFRYIVRQ FVNGIKSKYL SKETFLNLDY
160 170 180 190 200
IDNHLASNEY FAGEQFTAAD PQMCFPIFAA QRDYLSQKPY KNIKRWMRVV
210 220 230 240
SDRPACRIAA EKVEDNTLTL FSDVERYSHP PTPPPEQVRS DE
Length:242
Mass (Da):28,113
Last modified:April 18, 2012 - v3
Checksum:i42324A6B9B672938
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY034792 Genomic DNA. Translation: AAK58430.1.
CU329670 Genomic DNA. Translation: CAB90771.3.
RefSeqiNP_594063.3. NM_001019487.3.

Genome annotation databases

EnsemblFungiiSPAC688.04c.1; SPAC688.04c.1:pep; SPAC688.04c.
GeneIDi2543479.
KEGGispo:SPAC688.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY034792 Genomic DNA. Translation: AAK58430.1 .
CU329670 Genomic DNA. Translation: CAB90771.3 .
RefSeqi NP_594063.3. NM_001019487.3.

3D structure databases

ProteinModelPortali Q9P6M1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279899. 7 interactions.
IntActi Q9P6M1. 1 interaction.
MINTi MINT-4704315.
STRINGi 4896.SPAC688.04c-1.

Proteomic databases

MaxQBi Q9P6M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC688.04c.1 ; SPAC688.04c.1:pep ; SPAC688.04c .
GeneIDi 2543479.
KEGGi spo:SPAC688.04c.

Organism-specific databases

PomBasei SPAC688.04c.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125753.
InParanoidi Q9P6M1.
OrthoDBi EOG7BZW43.

Miscellaneous databases

NextBioi 20804491.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast."
    Shin Y.H., Park E.-H., Fuchs J.A., Lim C.-J.
    Biochim. Biophys. Acta 1577:164-170(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  4. "Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast."
    Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.
    Mol. Genet. Genomics 270:449-461(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SAD1, SUBCELLULAR LOCATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228 AND THR-232, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
    Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
    Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGST3_SCHPO
AccessioniPrimary (citable) accession number: Q9P6M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3