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Q9P6L5

- SLA2_SCHPO

UniProt

Q9P6L5 - SLA2_SCHPO

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Protein

Endocytosis protein end4

Gene
end4, sla2, SPAC688.11
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis.2 Publications

GO - Molecular functioni

  1. phosphatidylinositol-4,5-bisphosphate binding Source: PomBase
  2. protein binding Source: PomBase
  3. protein binding, bridging Source: PomBase

GO - Biological processi

  1. actin cytoskeleton organization Source: PomBase
  2. activation of bipolar cell growth Source: PomBase
  3. cellular protein localization Source: PomBase
  4. cellular response to nitrogen starvation Source: PomBase
  5. cortical actin cytoskeleton organization Source: PomBase
  6. endocytosis Source: PomBase
  7. establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  8. fungal-type cell wall organization or biogenesis Source: PomBase
  9. G1 to G0 transition Source: PomBase
  10. membrane raft distribution Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endocytosis protein end4
Alternative name(s):
SLA2 protein homolog
Gene namesi
Name:end4
Synonyms:sla2
ORF Names:SPAC688.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC688.11.

Subcellular locationi

Cytoplasmcytoskeleton
Note: Localizes at cell ends during interphase and to the medial ring at cell division.1 Publication

GO - Cellular componenti

  1. actin cortical patch Source: PomBase
  2. cell cortex of cell tip Source: PomBase
  3. cell division site Source: PomBase
  4. cytoplasm Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11021102Endocytosis protein end4PRO_0000071944Add
BLAST

Proteomic databases

MaxQBiQ9P6L5.
PaxDbiQ9P6L5.

Interactioni

Protein-protein interaction databases

BioGridi279759. 9 interactions.
MINTiMINT-4704247.
STRINGi4896.SPAC688.11-1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 139131ENTHAdd
BLAST
Domaini858 – 1100243I/LWEQAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili338 – 661324 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the SLA2 family.
Contains 1 I/LWEQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG280957.
HOGENOMiHOG000193921.
OrthoDBiEOG7G1VG0.

Family and domain databases

Gene3Di1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR002558. ILWEQ_dom.
[Graphical view]
PfamiPF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P6L5-1 [UniParc]FASTAAdd to Basket

« Hide

MSSFRLQSDH MQSDASLMTS VRKATSIDET APKRKHVRSC IIFTWDHHTA     50
RPFWTAIKVQ PLLANEVQTF KALITIHRVL QEGHKSALVD SQSEKGWLKT 100
CERQYDGESS PKGYSDLIRD YVDYLLDKLS FHAQHPEFNG TFEYKEYISL 150
RQVDDPNEGY ETVYDMMNLQ DHIDEFQKQL FSNFKRSNKN ECRIAALVPL 200
VQESYGIYRF LTSMLRALYS TVDAPETLEP LKHRYKSQHH RLRQFYADCS 250
NLRYLTSLIS VPRLPHDPPD LEGDDNIPDL PKRPASIAPQ PTGASTIAPQ 300
PTGTSPSPPV EMNFPDTSDI TPAYSEPEPI QDFWSDPTLD QQLAAQQAAQ 350
QAAQQQAELA AQQAAAQQAQ LAAQQAAEME RQRMAAQQHQ QALEAIQMAQ 400
AEQQRIAQEQ LAQQQFQMQT QGQLAELEQQ LLATRGQLEQ SNVLLNQYDA 450
RVRTLENELS QAGVNLQEQI HQNDDLIESL KNQILTWKNK YEALAKLYTQ 500
LRQEHLDLLS KYKQIQLKAS SAQEAIDKKE KMEREMKNKN LELADMILER 550
DRARHELETM HRSQRDKQES TERELRLLQE KAASLERNKS SEVSNLLSRY 600
NTEVAHLEDA LHSKDRELAN LGVELKSTEN RYRQLLQEKE EELEIQKAAV 650
DESLLQLSKL QLDRNDIDQA MDTQIDELLK SQLEKLDDIV DSVLATGIQR 700
LDTSLYELDS PMHAGNQYAT PEFILSTIEN ASNNATDFST AFNNYFADGP 750
NADHSEVING VNLFSTAIYE VANNAKGLSR TTGDDQGSDR FVGLSRDLVN 800
MAKRFLSSLF SVNTRKMDVN VKTDLVIGEN IELQRYLQQL TQYSEKFLNK 850
ESENTVGLLN APGENIEELV DNQLAETAQA IQQAILRLQN IAAKPKDDSL 900
SPSELQVHDS LLSASIAITE AIARLIKAAT ASQAEIVAQG RGSSSRGAFY 950
KKHNRWTEGL ISAAKAVARA TTTLIETADG VVNGTSSFEH LIVACNGVSA 1000
ATAQLVAASR VKANFASKVQ DHLEDAAKAV TEACKALVRQ VESVALKAKE 1050
VQHEDFSSLG VHEYRRKEIE QQVQILKLEN DLVAARRRLF DMRKTSYHVA 1100
EE 1102
Length:1,102
Mass (Da):124,373
Last modified:April 18, 2012 - v2
Checksum:i9101E230871A5DD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB90777.2.
D89267 mRNA. Translation: BAA13928.1.
PIRiT43195.
RefSeqiNP_594069.2. NM_001019493.2.

Genome annotation databases

EnsemblFungiiSPAC688.11.1; SPAC688.11.1:pep; SPAC688.11.
GeneIDi2543336.
KEGGispo:SPAC688.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB90777.2 .
D89267 mRNA. Translation: BAA13928.1 .
PIRi T43195.
RefSeqi NP_594069.2. NM_001019493.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279759. 9 interactions.
MINTi MINT-4704247.
STRINGi 4896.SPAC688.11-1.

Proteomic databases

MaxQBi Q9P6L5.
PaxDbi Q9P6L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC688.11.1 ; SPAC688.11.1:pep ; SPAC688.11 .
GeneIDi 2543336.
KEGGi spo:SPAC688.11.

Organism-specific databases

PomBasei SPAC688.11.

Phylogenomic databases

eggNOGi NOG280957.
HOGENOMi HOG000193921.
OrthoDBi EOG7G1VG0.

Miscellaneous databases

NextBioi 20804352.

Family and domain databases

Gene3Di 1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProi IPR011417. ANTH_dom.
IPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR002558. ILWEQ_dom.
[Graphical view ]
Pfami PF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view ]
ProDomi PD011820. ILWEQ. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view ]
SUPFAMi SSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEi PS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 635-1102.
    Strain: PR745.
  4. "Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe."
    Iwaki T., Tanaka N., Takagi H., Giga-Hama Y., Takegawa K.
    Yeast 21:867-881(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe."
    Castagnetti S., Behrens R., Nurse P.
    J. Cell Sci. 118:1843-1850(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
    Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
    Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSLA2_SCHPO
AccessioniPrimary (citable) accession number: Q9P6L5
Secondary accession number(s): P78916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi