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Q9P6L5

- SLA2_SCHPO

UniProt

Q9P6L5 - SLA2_SCHPO

Protein

Endocytosis protein end4

Gene

end4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis.2 Publications

    GO - Molecular functioni

    1. phosphatidylinositol-4,5-bisphosphate binding Source: PomBase
    2. protein binding Source: PomBase
    3. protein binding, bridging Source: PomBase

    GO - Biological processi

    1. actin cytoskeleton organization Source: PomBase
    2. activation of bipolar cell growth Source: PomBase
    3. cellular protein localization Source: PomBase
    4. cellular response to nitrogen starvation Source: PomBase
    5. cortical actin cytoskeleton organization Source: PomBase
    6. endocytosis Source: PomBase
    7. establishment or maintenance of actin cytoskeleton polarity Source: PomBase
    8. fungal-type cell wall organization or biogenesis Source: PomBase
    9. G1 to G0 transition Source: PomBase
    10. membrane raft distribution Source: PomBase

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endocytosis protein end4
    Alternative name(s):
    SLA2 protein homolog
    Gene namesi
    Name:end4
    Synonyms:sla2
    ORF Names:SPAC688.11
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC688.11.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication
    Note: Localizes at cell ends during interphase and to the medial ring at cell division.

    GO - Cellular componenti

    1. actin cortical patch Source: PomBase
    2. cell cortex of cell tip Source: PomBase
    3. cell division site Source: PomBase
    4. cytoplasm Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11021102Endocytosis protein end4PRO_0000071944Add
    BLAST

    Proteomic databases

    MaxQBiQ9P6L5.
    PaxDbiQ9P6L5.

    Interactioni

    Protein-protein interaction databases

    BioGridi279759. 9 interactions.
    MINTiMINT-4704247.
    STRINGi4896.SPAC688.11-1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 139131ENTHPROSITE-ProRule annotationAdd
    BLAST
    Domaini858 – 1100243I/LWEQPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili338 – 661324Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SLA2 family.Curated
    Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation
    Contains 1 I/LWEQ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG280957.
    HOGENOMiHOG000193921.
    OrthoDBiEOG7G1VG0.

    Family and domain databases

    Gene3Di1.20.1410.10. 1 hit.
    1.25.40.90. 1 hit.
    InterProiIPR011417. ANTH_dom.
    IPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    IPR002558. ILWEQ_dom.
    [Graphical view]
    PfamiPF07651. ANTH. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    [Graphical view]
    ProDomiPD011820. ILWEQ. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00273. ENTH. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF109885. SSF109885. 1 hit.
    SSF48464. SSF48464. 1 hit.
    PROSITEiPS50942. ENTH. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P6L5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFRLQSDH MQSDASLMTS VRKATSIDET APKRKHVRSC IIFTWDHHTA     50
    RPFWTAIKVQ PLLANEVQTF KALITIHRVL QEGHKSALVD SQSEKGWLKT 100
    CERQYDGESS PKGYSDLIRD YVDYLLDKLS FHAQHPEFNG TFEYKEYISL 150
    RQVDDPNEGY ETVYDMMNLQ DHIDEFQKQL FSNFKRSNKN ECRIAALVPL 200
    VQESYGIYRF LTSMLRALYS TVDAPETLEP LKHRYKSQHH RLRQFYADCS 250
    NLRYLTSLIS VPRLPHDPPD LEGDDNIPDL PKRPASIAPQ PTGASTIAPQ 300
    PTGTSPSPPV EMNFPDTSDI TPAYSEPEPI QDFWSDPTLD QQLAAQQAAQ 350
    QAAQQQAELA AQQAAAQQAQ LAAQQAAEME RQRMAAQQHQ QALEAIQMAQ 400
    AEQQRIAQEQ LAQQQFQMQT QGQLAELEQQ LLATRGQLEQ SNVLLNQYDA 450
    RVRTLENELS QAGVNLQEQI HQNDDLIESL KNQILTWKNK YEALAKLYTQ 500
    LRQEHLDLLS KYKQIQLKAS SAQEAIDKKE KMEREMKNKN LELADMILER 550
    DRARHELETM HRSQRDKQES TERELRLLQE KAASLERNKS SEVSNLLSRY 600
    NTEVAHLEDA LHSKDRELAN LGVELKSTEN RYRQLLQEKE EELEIQKAAV 650
    DESLLQLSKL QLDRNDIDQA MDTQIDELLK SQLEKLDDIV DSVLATGIQR 700
    LDTSLYELDS PMHAGNQYAT PEFILSTIEN ASNNATDFST AFNNYFADGP 750
    NADHSEVING VNLFSTAIYE VANNAKGLSR TTGDDQGSDR FVGLSRDLVN 800
    MAKRFLSSLF SVNTRKMDVN VKTDLVIGEN IELQRYLQQL TQYSEKFLNK 850
    ESENTVGLLN APGENIEELV DNQLAETAQA IQQAILRLQN IAAKPKDDSL 900
    SPSELQVHDS LLSASIAITE AIARLIKAAT ASQAEIVAQG RGSSSRGAFY 950
    KKHNRWTEGL ISAAKAVARA TTTLIETADG VVNGTSSFEH LIVACNGVSA 1000
    ATAQLVAASR VKANFASKVQ DHLEDAAKAV TEACKALVRQ VESVALKAKE 1050
    VQHEDFSSLG VHEYRRKEIE QQVQILKLEN DLVAARRRLF DMRKTSYHVA 1100
    EE 1102
    Length:1,102
    Mass (Da):124,373
    Last modified:April 18, 2012 - v2
    Checksum:i9101E230871A5DD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB90777.2.
    D89267 mRNA. Translation: BAA13928.1.
    PIRiT43195.
    RefSeqiNP_594069.2. NM_001019493.2.

    Genome annotation databases

    EnsemblFungiiSPAC688.11.1; SPAC688.11.1:pep; SPAC688.11.
    GeneIDi2543336.
    KEGGispo:SPAC688.11.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB90777.2 .
    D89267 mRNA. Translation: BAA13928.1 .
    PIRi T43195.
    RefSeqi NP_594069.2. NM_001019493.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279759. 9 interactions.
    MINTi MINT-4704247.
    STRINGi 4896.SPAC688.11-1.

    Proteomic databases

    MaxQBi Q9P6L5.
    PaxDbi Q9P6L5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC688.11.1 ; SPAC688.11.1:pep ; SPAC688.11 .
    GeneIDi 2543336.
    KEGGi spo:SPAC688.11.

    Organism-specific databases

    PomBasei SPAC688.11.

    Phylogenomic databases

    eggNOGi NOG280957.
    HOGENOMi HOG000193921.
    OrthoDBi EOG7G1VG0.

    Miscellaneous databases

    NextBioi 20804352.

    Family and domain databases

    Gene3Di 1.20.1410.10. 1 hit.
    1.25.40.90. 1 hit.
    InterProi IPR011417. ANTH_dom.
    IPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    IPR002558. ILWEQ_dom.
    [Graphical view ]
    Pfami PF07651. ANTH. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    [Graphical view ]
    ProDomi PD011820. ILWEQ. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00273. ENTH. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109885. SSF109885. 1 hit.
    SSF48464. SSF48464. 1 hit.
    PROSITEi PS50942. ENTH. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 635-1102.
      Strain: PR745.
    4. "Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe."
      Iwaki T., Tanaka N., Takagi H., Giga-Hama Y., Takegawa K.
      Yeast 21:867-881(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe."
      Castagnetti S., Behrens R., Nurse P.
      J. Cell Sci. 118:1843-1850(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
      Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
      Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSLA2_SCHPO
    AccessioniPrimary (citable) accession number: Q9P6L5
    Secondary accession number(s): P78916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3