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Q9P6L5

- SLA2_SCHPO

UniProt

Q9P6L5 - SLA2_SCHPO

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Protein

Endocytosis protein end4

Gene

end4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis.2 Publications

GO - Molecular functioni

  1. phosphatidylinositol-4,5-bisphosphate binding Source: PomBase
  2. protein binding, bridging Source: PomBase

GO - Biological processi

  1. actin cytoskeleton organization Source: PomBase
  2. activation of bipolar cell growth Source: PomBase
  3. cellular protein localization Source: PomBase
  4. cellular response to nitrogen starvation Source: PomBase
  5. cortical actin cytoskeleton organization Source: PomBase
  6. endocytosis Source: PomBase
  7. establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  8. fungal-type cell wall organization or biogenesis Source: PomBase
  9. G1 to G0 transition Source: PomBase
  10. plasma membrane raft distribution Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endocytosis protein end4
Alternative name(s):
SLA2 protein homolog
Gene namesi
Name:end4
Synonyms:sla2
ORF Names:SPAC688.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC688.11.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication
Note: Localizes at cell ends during interphase and to the medial ring at cell division.

GO - Cellular componenti

  1. actin cortical patch Source: PomBase
  2. cell cortex of cell tip Source: PomBase
  3. cell division site Source: PomBase
  4. cytoplasm Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11021102Endocytosis protein end4PRO_0000071944Add
BLAST

Proteomic databases

MaxQBiQ9P6L5.
PaxDbiQ9P6L5.

Interactioni

Protein-protein interaction databases

BioGridi279759. 10 interactions.
MINTiMINT-4704247.
STRINGi4896.SPAC688.11-1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 139131ENTHPROSITE-ProRule annotationAdd
BLAST
Domaini858 – 1100243I/LWEQPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili338 – 661324Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SLA2 family.Curated
Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation
Contains 1 I/LWEQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG280957.
HOGENOMiHOG000193921.
InParanoidiQ9P6L5.
OrthoDBiEOG7G1VG0.

Family and domain databases

Gene3Di1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR002558. ILWEQ_dom.
[Graphical view]
PfamiPF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P6L5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSFRLQSDH MQSDASLMTS VRKATSIDET APKRKHVRSC IIFTWDHHTA
60 70 80 90 100
RPFWTAIKVQ PLLANEVQTF KALITIHRVL QEGHKSALVD SQSEKGWLKT
110 120 130 140 150
CERQYDGESS PKGYSDLIRD YVDYLLDKLS FHAQHPEFNG TFEYKEYISL
160 170 180 190 200
RQVDDPNEGY ETVYDMMNLQ DHIDEFQKQL FSNFKRSNKN ECRIAALVPL
210 220 230 240 250
VQESYGIYRF LTSMLRALYS TVDAPETLEP LKHRYKSQHH RLRQFYADCS
260 270 280 290 300
NLRYLTSLIS VPRLPHDPPD LEGDDNIPDL PKRPASIAPQ PTGASTIAPQ
310 320 330 340 350
PTGTSPSPPV EMNFPDTSDI TPAYSEPEPI QDFWSDPTLD QQLAAQQAAQ
360 370 380 390 400
QAAQQQAELA AQQAAAQQAQ LAAQQAAEME RQRMAAQQHQ QALEAIQMAQ
410 420 430 440 450
AEQQRIAQEQ LAQQQFQMQT QGQLAELEQQ LLATRGQLEQ SNVLLNQYDA
460 470 480 490 500
RVRTLENELS QAGVNLQEQI HQNDDLIESL KNQILTWKNK YEALAKLYTQ
510 520 530 540 550
LRQEHLDLLS KYKQIQLKAS SAQEAIDKKE KMEREMKNKN LELADMILER
560 570 580 590 600
DRARHELETM HRSQRDKQES TERELRLLQE KAASLERNKS SEVSNLLSRY
610 620 630 640 650
NTEVAHLEDA LHSKDRELAN LGVELKSTEN RYRQLLQEKE EELEIQKAAV
660 670 680 690 700
DESLLQLSKL QLDRNDIDQA MDTQIDELLK SQLEKLDDIV DSVLATGIQR
710 720 730 740 750
LDTSLYELDS PMHAGNQYAT PEFILSTIEN ASNNATDFST AFNNYFADGP
760 770 780 790 800
NADHSEVING VNLFSTAIYE VANNAKGLSR TTGDDQGSDR FVGLSRDLVN
810 820 830 840 850
MAKRFLSSLF SVNTRKMDVN VKTDLVIGEN IELQRYLQQL TQYSEKFLNK
860 870 880 890 900
ESENTVGLLN APGENIEELV DNQLAETAQA IQQAILRLQN IAAKPKDDSL
910 920 930 940 950
SPSELQVHDS LLSASIAITE AIARLIKAAT ASQAEIVAQG RGSSSRGAFY
960 970 980 990 1000
KKHNRWTEGL ISAAKAVARA TTTLIETADG VVNGTSSFEH LIVACNGVSA
1010 1020 1030 1040 1050
ATAQLVAASR VKANFASKVQ DHLEDAAKAV TEACKALVRQ VESVALKAKE
1060 1070 1080 1090 1100
VQHEDFSSLG VHEYRRKEIE QQVQILKLEN DLVAARRRLF DMRKTSYHVA

EE
Length:1,102
Mass (Da):124,373
Last modified:April 18, 2012 - v2
Checksum:i9101E230871A5DD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90777.2.
D89267 mRNA. Translation: BAA13928.1.
PIRiT43195.
RefSeqiNP_594069.2. NM_001019493.2.

Genome annotation databases

EnsemblFungiiSPAC688.11.1; SPAC688.11.1:pep; SPAC688.11.
GeneIDi2543336.
KEGGispo:SPAC688.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB90777.2 .
D89267 mRNA. Translation: BAA13928.1 .
PIRi T43195.
RefSeqi NP_594069.2. NM_001019493.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279759. 10 interactions.
MINTi MINT-4704247.
STRINGi 4896.SPAC688.11-1.

Proteomic databases

MaxQBi Q9P6L5.
PaxDbi Q9P6L5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC688.11.1 ; SPAC688.11.1:pep ; SPAC688.11 .
GeneIDi 2543336.
KEGGi spo:SPAC688.11.

Organism-specific databases

PomBasei SPAC688.11.

Phylogenomic databases

eggNOGi NOG280957.
HOGENOMi HOG000193921.
InParanoidi Q9P6L5.
OrthoDBi EOG7G1VG0.

Miscellaneous databases

NextBioi 20804352.

Family and domain databases

Gene3Di 1.20.1410.10. 1 hit.
1.25.40.90. 1 hit.
InterProi IPR011417. ANTH_dom.
IPR008942. ENTH_VHS.
IPR013809. Epsin-like_N.
IPR002558. ILWEQ_dom.
[Graphical view ]
Pfami PF07651. ANTH. 1 hit.
PF01608. I_LWEQ. 1 hit.
[Graphical view ]
ProDomi PD011820. ILWEQ. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00273. ENTH. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view ]
SUPFAMi SSF109885. SSF109885. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEi PS50942. ENTH. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 635-1102.
    Strain: PR745.
  4. "Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe."
    Iwaki T., Tanaka N., Takagi H., Giga-Hama Y., Takegawa K.
    Yeast 21:867-881(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe."
    Castagnetti S., Behrens R., Nurse P.
    J. Cell Sci. 118:1843-1850(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
    Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
    Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSLA2_SCHPO
AccessioniPrimary (citable) accession number: Q9P6L5
Secondary accession number(s): P78916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: April 18, 2012
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3