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Q9P6J3

- MALT_SCHPO

UniProt

Q9P6J3 - MALT_SCHPO

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Protein
Alpha-glucosidase
Gene
mal1, SPBC1683.07
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei212 – 2121Nucleophile By similarity
Active sitei269 – 2691Proton donor By similarity
Sitei346 – 3461Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. dextrin alpha-glucosidase activity Source: PomBase
  3. maltose alpha-glucosidase activity Source: PomBase
  4. starch alpha-glucosidase activity Source: PomBase
  5. sucrose alpha-glucosidase activity Source: PomBase

GO - Biological processi

  1. cellular polysaccharide catabolic process Source: PomBase
  2. extracellular polysaccharide metabolic process Source: PomBase
  3. maltose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Maltose metabolism

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:mal1
ORF Names:SPBC1683.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1683.07.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Alpha-glucosidase
PRO_0000310319Add
BLAST

Proteomic databases

MaxQBiQ9P6J3.

Expressioni

Inductioni

Repressed by glucose and inositol.

Interactioni

Protein-protein interaction databases

BioGridi276520. 8 interactions.
MINTiMINT-4704100.
STRINGi4896.SPBC1683.07-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P6J3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000220641.
KOiK01187.
OMAiVGWNSLY.
OrthoDBiEOG7M3J7X.
PhylomeDBiQ9P6J3.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P6J3-1 [UniParc]FASTAAdd to Basket

« Hide

MKVVPSEKIK PNWWRETSVY QIYPASFKDS NGDGFGDLEG IISKVDYLKA    50
LNVESIWLCP IYPSPLKDMG YDVSDYKQID SRYGTLEDLD RLMKALHERD 100
MKLVMDLVLN HTSDQHEWFK ESRSSKTNPK RDWYFWKPAR YNEKGERLPP 150
NNWRSYFDTS AWEWDEATQE YYLHLWSVGQ PDLNWETPKV REAVHDILRF 200
WLDRGVDGFR LDAINMISKD QRFLDAPITD DRYEYQLAYQ YYANGPRIHE 250
YLNGIGNILT EYDAFSVGEM PYVLDTNEIL HVVGADRREL TMIFQFDFVD 300
LDLDPNQHKY IEGSWELSDL KKSLKKWQSA LLSGGGWNAS FIENHDQTRT 350
VSRYLSDSPK YRAYSSKLMA LFIIFQSGTP FVFQGQELAL ANIPRDWPID 400
EYLDVETQNF WKLFMSGNPS QEEIEKTMDI VNKRARDNGR TPMHWDSSPN 450
GGFTKAGVKP WMRVTNDYKE WNAANQVNDP ESPYTFWSKA LELRKELKDA 500
VVYGSFELIS EEDPSIVAFV RESSTYKLII LLNFTGNKVS YDCPLNLTSY 550
EILLDNYKDF ICMTSPVTLN PYQAVLLKL 579
Length:579
Mass (Da):67,752
Last modified:October 1, 2000 - v1
Checksum:i7B79064326E445AA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811F → L in AAY57566. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ019991 Genomic DNA. Translation: AAY57566.1.
CU329671 Genomic DNA. Translation: CAB91169.1.
RefSeqiNP_595063.1. NM_001020969.2.

Genome annotation databases

EnsemblFungiiSPBC1683.07.1; SPBC1683.07.1:pep; SPBC1683.07.
GeneIDi2539976.
KEGGispo:SPBC1683.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ019991 Genomic DNA. Translation: AAY57566.1 .
CU329671 Genomic DNA. Translation: CAB91169.1 .
RefSeqi NP_595063.1. NM_001020969.2.

3D structure databases

ProteinModelPortali Q9P6J3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276520. 8 interactions.
MINTi MINT-4704100.
STRINGi 4896.SPBC1683.07-1.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Proteomic databases

MaxQBi Q9P6J3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1683.07.1 ; SPBC1683.07.1:pep ; SPBC1683.07 .
GeneIDi 2539976.
KEGGi spo:SPBC1683.07.

Organism-specific databases

PomBasei SPBC1683.07.

Phylogenomic databases

eggNOGi COG0366.
HOGENOMi HOG000220641.
KOi K01187.
OMAi VGWNSLY.
OrthoDBi EOG7M3J7X.
PhylomeDBi Q9P6J3.

Miscellaneous databases

NextBioi 20801119.
PROi Q9P6J3.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of MAL1+ gene expression encoding maltase in Schizosaccharomyces pombe by added inositol."
    Yao S., Chi Z., He S.
    Indian J. Biochem. Biophys. 43:143-147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], REPRESSION BY GLUCOSE AND INOSITOL.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiMALT_SCHPO
AccessioniPrimary (citable) accession number: Q9P6J3
Secondary accession number(s): Q4U125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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