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Q9P6J3

- MALT_SCHPO

UniProt

Q9P6J3 - MALT_SCHPO

Protein

Alpha-glucosidase

Gene

mal1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei212 – 2121NucleophileBy similarity
    Active sitei269 – 2691Proton donorBy similarity
    Sitei346 – 3461Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. dextrin alpha-glucosidase activity Source: PomBase
    3. maltose alpha-glucosidase activity Source: PomBase
    4. starch alpha-glucosidase activity Source: PomBase
    5. sucrose alpha-glucosidase activity Source: PomBase

    GO - Biological processi

    1. cellular polysaccharide catabolic process Source: PomBase
    2. extracellular polysaccharide metabolic process Source: PomBase
    3. maltose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Maltose metabolism

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-glucosidase (EC:3.2.1.20)
    Alternative name(s):
    Maltase
    Gene namesi
    Name:mal1
    ORF Names:SPBC1683.07
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1683.07.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Alpha-glucosidasePRO_0000310319Add
    BLAST

    Proteomic databases

    MaxQBiQ9P6J3.

    Expressioni

    Inductioni

    Repressed by glucose and inositol.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi276520. 8 interactions.
    MINTiMINT-4704100.
    STRINGi4896.SPBC1683.07-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P6J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Phylogenomic databases

    eggNOGiCOG0366.
    HOGENOMiHOG000220641.
    KOiK01187.
    OMAiVGWNSLY.
    OrthoDBiEOG7M3J7X.
    PhylomeDBiQ9P6J3.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9P6J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVVPSEKIK PNWWRETSVY QIYPASFKDS NGDGFGDLEG IISKVDYLKA    50
    LNVESIWLCP IYPSPLKDMG YDVSDYKQID SRYGTLEDLD RLMKALHERD 100
    MKLVMDLVLN HTSDQHEWFK ESRSSKTNPK RDWYFWKPAR YNEKGERLPP 150
    NNWRSYFDTS AWEWDEATQE YYLHLWSVGQ PDLNWETPKV REAVHDILRF 200
    WLDRGVDGFR LDAINMISKD QRFLDAPITD DRYEYQLAYQ YYANGPRIHE 250
    YLNGIGNILT EYDAFSVGEM PYVLDTNEIL HVVGADRREL TMIFQFDFVD 300
    LDLDPNQHKY IEGSWELSDL KKSLKKWQSA LLSGGGWNAS FIENHDQTRT 350
    VSRYLSDSPK YRAYSSKLMA LFIIFQSGTP FVFQGQELAL ANIPRDWPID 400
    EYLDVETQNF WKLFMSGNPS QEEIEKTMDI VNKRARDNGR TPMHWDSSPN 450
    GGFTKAGVKP WMRVTNDYKE WNAANQVNDP ESPYTFWSKA LELRKELKDA 500
    VVYGSFELIS EEDPSIVAFV RESSTYKLII LLNFTGNKVS YDCPLNLTSY 550
    EILLDNYKDF ICMTSPVTLN PYQAVLLKL 579
    Length:579
    Mass (Da):67,752
    Last modified:October 1, 2000 - v1
    Checksum:i7B79064326E445AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811F → L in AAY57566. (PubMed:16967902)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ019991 Genomic DNA. Translation: AAY57566.1.
    CU329671 Genomic DNA. Translation: CAB91169.1.
    RefSeqiNP_595063.1. NM_001020969.2.

    Genome annotation databases

    EnsemblFungiiSPBC1683.07.1; SPBC1683.07.1:pep; SPBC1683.07.
    GeneIDi2539976.
    KEGGispo:SPBC1683.07.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ019991 Genomic DNA. Translation: AAY57566.1 .
    CU329671 Genomic DNA. Translation: CAB91169.1 .
    RefSeqi NP_595063.1. NM_001020969.2.

    3D structure databases

    ProteinModelPortali Q9P6J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276520. 8 interactions.
    MINTi MINT-4704100.
    STRINGi 4896.SPBC1683.07-1.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    Proteomic databases

    MaxQBi Q9P6J3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1683.07.1 ; SPBC1683.07.1:pep ; SPBC1683.07 .
    GeneIDi 2539976.
    KEGGi spo:SPBC1683.07.

    Organism-specific databases

    PomBasei SPBC1683.07.

    Phylogenomic databases

    eggNOGi COG0366.
    HOGENOMi HOG000220641.
    KOi K01187.
    OMAi VGWNSLY.
    OrthoDBi EOG7M3J7X.
    PhylomeDBi Q9P6J3.

    Miscellaneous databases

    NextBioi 20801119.
    PROi Q9P6J3.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of MAL1+ gene expression encoding maltase in Schizosaccharomyces pombe by added inositol."
      Yao S., Chi Z., He S.
      Indian J. Biochem. Biophys. 43:143-147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], REPRESSION BY GLUCOSE AND INOSITOL.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiMALT_SCHPO
    AccessioniPrimary (citable) accession number: Q9P6J3
    Secondary accession number(s): Q4U125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3