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Protein

Alpha-glucosidase

Gene

mal1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212NucleophileBy similarity1
Active sitei269Proton donorBy similarity1
Sitei346Transition state stabilizerBy similarity1

GO - Molecular functioni

  • alpha-1,4-glucosidase activity Source: UniProtKB-EC
  • dextrin alpha-glucosidase activity Source: PomBase
  • maltose alpha-glucosidase activity Source: PomBase
  • starch alpha-glucosidase activity Source: PomBase
  • sucrose alpha-glucosidase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Maltose metabolism

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:mal1
ORF Names:SPBC1683.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1683.07.
PomBaseiSPBC1683.07. mal1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103191 – 579Alpha-glucosidaseAdd BLAST579

Proteomic databases

MaxQBiQ9P6J3.
PRIDEiQ9P6J3.

Expressioni

Inductioni

Repressed by glucose and inositol.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi276520. 8 interactors.
MINTiMINT-4704100.

Structurei

3D structure databases

ProteinModelPortaliQ9P6J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Phylogenomic databases

HOGENOMiHOG000220641.
InParanoidiQ9P6J3.
KOiK01187.
OMAiPKRDWYW.
OrthoDBiEOG092C12JX.
PhylomeDBiQ9P6J3.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 3 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P6J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVPSEKIK PNWWRETSVY QIYPASFKDS NGDGFGDLEG IISKVDYLKA
60 70 80 90 100
LNVESIWLCP IYPSPLKDMG YDVSDYKQID SRYGTLEDLD RLMKALHERD
110 120 130 140 150
MKLVMDLVLN HTSDQHEWFK ESRSSKTNPK RDWYFWKPAR YNEKGERLPP
160 170 180 190 200
NNWRSYFDTS AWEWDEATQE YYLHLWSVGQ PDLNWETPKV REAVHDILRF
210 220 230 240 250
WLDRGVDGFR LDAINMISKD QRFLDAPITD DRYEYQLAYQ YYANGPRIHE
260 270 280 290 300
YLNGIGNILT EYDAFSVGEM PYVLDTNEIL HVVGADRREL TMIFQFDFVD
310 320 330 340 350
LDLDPNQHKY IEGSWELSDL KKSLKKWQSA LLSGGGWNAS FIENHDQTRT
360 370 380 390 400
VSRYLSDSPK YRAYSSKLMA LFIIFQSGTP FVFQGQELAL ANIPRDWPID
410 420 430 440 450
EYLDVETQNF WKLFMSGNPS QEEIEKTMDI VNKRARDNGR TPMHWDSSPN
460 470 480 490 500
GGFTKAGVKP WMRVTNDYKE WNAANQVNDP ESPYTFWSKA LELRKELKDA
510 520 530 540 550
VVYGSFELIS EEDPSIVAFV RESSTYKLII LLNFTGNKVS YDCPLNLTSY
560 570
EILLDNYKDF ICMTSPVTLN PYQAVLLKL
Length:579
Mass (Da):67,752
Last modified:October 1, 2000 - v1
Checksum:i7B79064326E445AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381F → L in AAY57566 (PubMed:16967902).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ019991 Genomic DNA. Translation: AAY57566.1.
CU329671 Genomic DNA. Translation: CAB91169.1.
RefSeqiNP_595063.1. NM_001020969.2.

Genome annotation databases

EnsemblFungiiSPBC1683.07.1; SPBC1683.07.1:pep; SPBC1683.07.
GeneIDi2539976.
KEGGispo:SPBC1683.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ019991 Genomic DNA. Translation: AAY57566.1.
CU329671 Genomic DNA. Translation: CAB91169.1.
RefSeqiNP_595063.1. NM_001020969.2.

3D structure databases

ProteinModelPortaliQ9P6J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276520. 8 interactors.
MINTiMINT-4704100.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Proteomic databases

MaxQBiQ9P6J3.
PRIDEiQ9P6J3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1683.07.1; SPBC1683.07.1:pep; SPBC1683.07.
GeneIDi2539976.
KEGGispo:SPBC1683.07.

Organism-specific databases

EuPathDBiFungiDB:SPBC1683.07.
PomBaseiSPBC1683.07. mal1.

Phylogenomic databases

HOGENOMiHOG000220641.
InParanoidiQ9P6J3.
KOiK01187.
OMAiPKRDWYW.
OrthoDBiEOG092C12JX.
PhylomeDBiQ9P6J3.

Miscellaneous databases

PROiQ9P6J3.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 3 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_SCHPO
AccessioniPrimary (citable) accession number: Q9P6J3
Secondary accession number(s): Q4U125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.