Reviewed, UniProtKB/Swiss-Prot Q9P6I7 (ADA_SCHPO)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	dea2
Synonyms:	aah1
ORF Names:	SPBC1198.02

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3.
Subcellular location	Cytoplasm. Nucleus. Ref.3
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Ref.1 Inferred from direct assay. Source: GeneDB_SPombe purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro purine salvage Ref.1 Inferred from direct assay. Source: GeneDB_SPombe
Cellular component	cytosol Ref.3 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.3 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	adenine deaminase activity Ref.1 Inferred from direct assay. Source: GeneDB_SPombe adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Adenosine deaminase		PRO_0000256237
Sites
	Active site	209	1	Potential
	Active site	257	1	Potential
	Active site	290	1	Potential
	Active site	291	1	Potential
Experimental info
	Mutagenesis	150	1	R → H in allele dea2-1. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9P6I7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4470A2EF23405B85	FASTA	367	41,199
	10 20 30 40 50 60 MSNLPIYNFI RKLPKCEHHV HLEGCLSPDL VFRLAKKNGI TLPSDDAAYT TPSTLLASYE 70 80 90 100 110 120 HFGCLDDFLR YYYIAVSVLI EASDFEALAY EYFSIAHSQG VHHAEVFFDP QTHTSRGISY 130 140 150 160 170 180 DVVVSGFSAA CERANRDFGM STNLIMCFLR HLPSEAAHET FAEALKRNDF ENGIVAGVGL 190 200 210 220 230 240 DSSEVDFPPE LFQEVYKLAA EKGIRRTGHA GEEGDPSYIR SGLDNLSLQR IDHGIRLVED 250 260 270 280 290 300 KELMKRVAEE NIMLTMCPLS NLKLRCVNSI AELPVREFLE AGVPFSINCD DPAYFGGYTL 310 320 330 340 350 360 ENYFAIQKHF NLTVKEWVFI ANAAINGSWI SGKRKEELLS SVQKCVKEYT AEIQQPKTLE TAVEVQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family." Ribard C., Rochet M., Labedan B., Daignan-Fornier B., Alzari P., Scazzocchio C., Oestreicher N. J. Mol. Biol. 334:1117-1131(2003) [PubMed: 14643670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF ARG-150.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329671 Genomic DNA. Translation: CAB91177.1.
RefSeq	NP_595071.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9P6I7.
Genome annotation databases
GeneID	2540066.
GenomeReviews	Gene locus dea2 in contig CU329671_GR.
KEGG	spo:SPBC1198.02.
NMPDR	fig|4896.1.peg.937.
Organism-specific databases
GeneDB_Spombe	SPBC1198.02.
Phylogenomic databases
OMA	CLLRHLP.
Enzyme and pathway databases
BRENDA	3.5.4.4. 653.
Gene expression databases
ArrayExpress	Q9P6I7.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_SCHPO

Accession

Primary (citable) accession number: Q9P6I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)