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Q9P6I3

- YHG7_SCHPO

UniProt

Q9P6I3 - YHG7_SCHPO

Protein

Putative mannan endo-1,6-alpha-mannosidase C1198.07c

Gene

SPBC1198.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans.

    GO - Molecular functioni

    1. mannan endo-1,6-alpha-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular oligosaccharide catabolic process Source: PomBase
    2. extracellular polysaccharide metabolic process Source: PomBase
    3. fungal-type cell wall biogenesis Source: PomBase

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH76. Glycoside Hydrolase Family 76.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative mannan endo-1,6-alpha-mannosidase C1198.07c (EC:3.2.1.101)
    Alternative name(s):
    Endo-alpha-1->6-D-mannanase C1198.07c
    Gene namesi
    ORF Names:SPBC1198.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1198.07c.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: PomBase
    2. endoplasmic reticulum Source: PomBase
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 442423Putative mannan endo-1,6-alpha-mannosidase C1198.07cPRO_0000012130Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9P6I3.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4704014.
    STRINGi4896.SPBC1198.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P6I3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 421402LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 76 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74795.
    HOGENOMiHOG000178818.
    OrthoDBiEOG72RN80.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR005198. Glyco_hydro_76.
    IPR014480. Mannan-1_6-alpha_mannosidase.
    [Graphical view]
    PfamiPF03663. Glyco_hydro_76. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016302. Man_a_manosd. 1 hit.
    SUPFAMiSSF48208. SSF48208. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P6I3-1 [UniParc]FASTAAdd to Basket

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    MRYLSFFFEF FFLFSFAFAF DFDVTSDDSI NSALTTVTDG MLNYYQSTSH    50
    TFTAYWWMTG AGLNSMTDTY AATGNTTHLD MLISALVANK GDNNDYAPNS 100
    EKFDLGNDDQ GIWGLSAMSA AEVNMTTGDS SASFTELAQA VFNEIMSRWD 150
    TSSCGGGVRW QIYSFNNGYS YKNSISNGIL FQLAARLARY TNNDTYVDLA 200
    QKVWDWSTTV GFVDLDDYTV YDGASVTSNC SSITNEQWSY NVGVYLAGTA 250
    FLYNYTNGSS VWQTHMEGLM NKALDYYFTS DKIIYEPSCE PTESCNSDQT 300
    AFKGMLARFL GYTMQLAPYT VETILPYIQS SAEAAALACS GGSDGVTCGY 350
    MWYWNNGTWD DHYGLGEQIS AVETFQALLA QQSATILTLD TGASSESNPD 400
    AGTDDGDTVT ITPATKSDKG WAGFLTFAFS FVFLLFSIWL YF 442
    Length:442
    Mass (Da):48,877
    Last modified:July 11, 2012 - v2
    Checksum:iE5D2F9EEAFCF749A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB91182.2.
    RefSeqiNP_595076.2. NM_001020982.2.

    Genome annotation databases

    EnsemblFungiiSPBC1198.07c.1; SPBC1198.07c.1:pep; SPBC1198.07c.
    GeneIDi2539836.
    KEGGispo:SPBC1198.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB91182.2 .
    RefSeqi NP_595076.2. NM_001020982.2.

    3D structure databases

    ProteinModelPortali Q9P6I3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4704014.
    STRINGi 4896.SPBC1198.07c-1.

    Protein family/group databases

    CAZyi GH76. Glycoside Hydrolase Family 76.

    Proteomic databases

    MaxQBi Q9P6I3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1198.07c.1 ; SPBC1198.07c.1:pep ; SPBC1198.07c .
    GeneIDi 2539836.
    KEGGi spo:SPBC1198.07c.

    Organism-specific databases

    PomBasei SPBC1198.07c.

    Phylogenomic databases

    eggNOGi NOG74795.
    HOGENOMi HOG000178818.
    OrthoDBi EOG72RN80.

    Miscellaneous databases

    NextBioi 20800984.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR005198. Glyco_hydro_76.
    IPR014480. Mannan-1_6-alpha_mannosidase.
    [Graphical view ]
    Pfami PF03663. Glyco_hydro_76. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016302. Man_a_manosd. 1 hit.
    SUPFAMi SSF48208. SSF48208. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYHG7_SCHPO
    AccessioniPrimary (citable) accession number: Q9P6I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3