Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 1

Gene

adh-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi157Zinc 1; catalyticBy similarity1
Binding sitei205NADBy similarity1
Binding sitei210NADBy similarity1
Binding sitei346NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 187NADBy similarity7
Nucleotide bindingi274 – 276NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 3627.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:adh-1
ORF Names:B17C10.210, NCU01754
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU01754.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607261 – 353Alcohol dehydrogenase 1Add BLAST353

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9P6C8.
SMRiQ9P6C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiQ9P6C8.
KOiK13953.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P6C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQFEIPEQQ WAQVVEKKGG PVVFKQIPVQ KPGPDEVLIN VKYSGVCHTD
60 70 80 90 100
LHAMKGDWPL ATKMPLVGGH EGAGVVVAKG ELVTEVEVGD HAGIKWLNGS
110 120 130 140 150
CLACSFCMQA DEPLCPHALL SGYTVDGSFQ QYAIAKAAHV AKIPKGCDLE
160 170 180 190 200
TTAPVLCAGI TVYKGLKESG VRPGQCVAIV GAGGGLGSMA IQYANAMGLH
210 220 230 240 250
AIAIDGGEEK GKNCRELGAQ AYVDFTTTKD LVADVKAATP DGLGPHAVIL
260 270 280 290 300
LAVSEKPFHQ AVDYVRSRGT IICIGLPAGA KFQAPVFDTV IRMITIKGSY
310 320 330 340 350
VGNRQDTQEA LDFFARGLIK VPIKTVGLSK LQEVYDLMEE GKIVGRYVVD

TSK
Length:353
Mass (Da):37,443
Last modified:October 1, 2000 - v1
Checksum:i66B71D891324C854
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355926 Genomic DNA. Translation: CAB91241.1.
CM002237 Genomic DNA. Translation: ESA43622.1.
PIRiT49440.
RefSeqiXP_011393501.1. XM_011395199.1.

Genome annotation databases

EnsemblFungiiESA43622; ESA43622; NCU01754.
GeneIDi3873329.
KEGGincr:NCU01754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355926 Genomic DNA. Translation: CAB91241.1.
CM002237 Genomic DNA. Translation: ESA43622.1.
PIRiT49440.
RefSeqiXP_011393501.1. XM_011395199.1.

3D structure databases

ProteinModelPortaliQ9P6C8.
SMRiQ9P6C8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiESA43622; ESA43622; NCU01754.
GeneIDi3873329.
KEGGincr:NCU01754.

Organism-specific databases

EuPathDBiFungiDB:NCU01754.

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiQ9P6C8.
KOiK13953.
OrthoDBiEOG092C2Q8E.

Enzyme and pathway databases

BRENDAi1.1.1.1. 3627.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_NEUCR
AccessioniPrimary (citable) accession number: Q9P6C8
Secondary accession number(s): Q7RV68, V5INI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.