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Q9P6C8 (ADH1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 1
EC=1.1.1.1
Alternative name(s):
Alcohol dehydrogenase I
Gene names
Name:adh-1
ORF Names:B17C10.210, NCU01754
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Alcohol dehydrogenase 1
PRO_0000160726

Regions

Nucleotide binding181 – 1877NAD By similarity
Nucleotide binding274 – 2763NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding701Zinc 1; catalytic By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1071Zinc 2 By similarity
Metal binding1151Zinc 2 By similarity
Metal binding1571Zinc 1; catalytic By similarity
Binding site2051NAD By similarity
Binding site2101NAD By similarity
Binding site3461NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9P6C8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 66B71D891324C854

FASTA35337,443
        10         20         30         40         50         60 
MPQFEIPEQQ WAQVVEKKGG PVVFKQIPVQ KPGPDEVLIN VKYSGVCHTD LHAMKGDWPL 

        70         80         90        100        110        120 
ATKMPLVGGH EGAGVVVAKG ELVTEVEVGD HAGIKWLNGS CLACSFCMQA DEPLCPHALL 

       130        140        150        160        170        180 
SGYTVDGSFQ QYAIAKAAHV AKIPKGCDLE TTAPVLCAGI TVYKGLKESG VRPGQCVAIV 

       190        200        210        220        230        240 
GAGGGLGSMA IQYANAMGLH AIAIDGGEEK GKNCRELGAQ AYVDFTTTKD LVADVKAATP 

       250        260        270        280        290        300 
DGLGPHAVIL LAVSEKPFHQ AVDYVRSRGT IICIGLPAGA KFQAPVFDTV IRMITIKGSY 

       310        320        330        340        350 
VGNRQDTQEA LDFFARGLIK VPIKTVGLSK LQEVYDLMEE GKIVGRYVVD TSK

« Hide

References

[1]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL355926 Genomic DNA. Translation: CAB91241.1.
AABX02000005 Genomic DNA. Translation: EAA27941.1.
PIRT49440.
RefSeqXP_957177.1. XM_952084.2.
UniGeneNcr.5564.

3D structure databases

ProteinModelPortalQ9P6C8.
SMRQ9P6C8. Positions 5-353.
ModBaseSearch...

Protein-protein interaction databases

STRING5141.NCU01754.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000001711; EFNCRP00000001711; EFNCRG00000001709.
GeneID3873329.
KEGGncr:NCU01754.

Phylogenomic databases

eggNOGCOG1064.
HOGENOMHOG000294685.
KOK13953.
OrthoDBEOG4Q5CZM.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH1_NEUCR
AccessionPrimary (citable) accession number: Q9P6C8
Secondary accession number(s): Q7RV68
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents