Reviewed,
UniProtKB/Swiss-Prot Q9P6C8 (ADH1_NEUCR)
Last modified
January 19, 2010.
Version 68.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase 1 EC=1.1.1.1 Alternative name(s): Alcohol dehydrogenase I | ||||
| Gene names |
| ||||
| Organism | Neurospora crassa [Complete proteome] | ||||
| Taxonomic identifier | 5141 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora |
Protein attributes
| Sequence length | 353 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 353 | 353 | Alcohol dehydrogenase 1 | PRO_0000160726 | |||||
Regions | |||||||||
| Nucleotide binding | 181 – 187 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 274 – 276 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Metal binding | 47 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 70 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 101 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 104 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 107 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 115 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 157 | 1 | Zinc 1; catalytic By similarity | ||||||
| Binding site | 205 | 1 | NAD By similarity | ||||||
| Binding site | 210 | 1 | NAD By similarity | ||||||
| Binding site | 346 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987. |
| [2] | "The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. Birren B.W.Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL355926 Genomic DNA. Translation: CAB91241.1. AABX02000005 Genomic DNA. Translation: EAA27941.1. |
| PIR | T49440. |
| RefSeq | XP_957177.1. |
3D structure databases | |
| SMR | Q9P6C8. Positions 5-353. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9P6C8. |
Genome annotation databases | |
| GeneID | 3873329. |
| KEGG | ncr:NCU01754. |
| NMPDR | fig|5141.1.peg.6126. |
Phylogenomic databases | |
| eggNOG | fuNOG04605. |
| OrthoDB | EOG95HTDV. |
| PhylomeDB | Q9P6C8. |
Enzyme and pathway databases | |
| BioCyc | NCRA-XX3-01:NCRA-XX3-01-005464-MONOMER. |
| BRENDA | 1.1.1.1. 266. |
Family and domain databases | |
| InterPro | IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR11695. ADH_Sf_Zn. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADH1_NEUCR | ||||||||
| Accession | Primary (citable) accession number: Q9P6C8 Secondary accession number(s): Q7RV68 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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