Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette transporter abc3

Gene

abc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Iron-regulated vacuolar ABC-type transporter which may be responsible for mobilizing stored iron from the vacuole to the cytosol in response to iron deficiency.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi614 – 6218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1260 – 12678ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-2142850. Hyaluronan biosynthesis and export.
R-SPO-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.28. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette transporter abc3
Gene namesi
Name:abc3
ORF Names:SPBC359.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC359.05.
PomBaseiSPBC359.05. abc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88ExtracellularSequence analysis
Transmembranei9 – 2921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini30 – 4213CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini64 – 696ExtracellularSequence analysis
Transmembranei70 – 9021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini91 – 977CytoplasmicSequence analysis
Transmembranei98 – 11821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini119 – 12911ExtracellularSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini151 – 23585CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini257 – 29135ExtracellularSequence analysisAdd
BLAST
Transmembranei292 – 31221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini313 – 36250CytoplasmicSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini384 – 39411ExtracellularSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini416 – 48065CytoplasmicSequence analysisAdd
BLAST
Transmembranei481 – 50121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini502 – 51110ExtracellularSequence analysis
Transmembranei512 – 53221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini533 – 899367CytoplasmicSequence analysisAdd
BLAST
Transmembranei900 – 92021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini921 – 93919ExtracellularSequence analysisAdd
BLAST
Transmembranei940 – 96021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini961 – 103373CytoplasmicSequence analysisAdd
BLAST
Transmembranei1034 – 105421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1055 – 1465411ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • vacuolar membrane Source: UniProtKB-SubCell
  • vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14651465ATP-binding cassette transporter abc3PRO_0000093471Add
BLAST

Proteomic databases

MaxQBiQ9P5N0.

Expressioni

Inductioni

Induced under conditions of iron deficiency and negatively regulated by iron through fep1.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi277453. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9P5N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 539290ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini575 – 804230ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini903 – 1189287ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1226 – 1460235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9P5N0.
OMAiEGNIREN.
OrthoDBiEOG75XGV5.
PhylomeDBiQ9P5N0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P5N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITANKGLSL VLLIPNLFAL VSGGLQYVFD VRRRIFRPHF SQFWTIWMKF
60 70 80 90 100
FSIALVIITQ IYVGYKTKNI GWNFFSVVTY CFVLFLQFAE QSTLRVPMAS
110 120 130 140 150
LLIFWLLKVV TSLLILLFSP YIAITSMARL LTLITLFCSL VCFISEVYVP
160 170 180 190 200
PCNRVWYSDD TNEVEEKGIR PSEVRYANIF SKLSFSWISS FIKFGYTNYL
210 220 230 240 250
KESDVWLLPP DERSGNLIIG FEDWWIYHSK NKRRSLFLWK LLFFNHWKLV
260 270 280 290 300
ALITITKLIQ DVLAFVQPTL IQKTILFISS YTSPNPESPS RGFIIAILVL
310 320 330 340 350
VANFLQTLLL QQYNQLIMLL GMRWKTELLA SIYRKSLLLS SSARQNRSIG
360 370 380 390 400
DIINYMAVDT QKISDLPIYL FIIVSGPFQI ALALSNLYHL MGYSAFTGVA
410 420 430 440 450
ASVILFPCNI IVANVYKKFQ SILMKNKDSR SKLMTEIINN IRSIKLYAWE
460 470 480 490 500
TPFLQKLLHI RNTKELSMLK KIGFITAIGD FAWIFTTIIV TTVAFGAFII
510 520 530 540 550
FHGKTQALTA DIVFPAVSLF NLLQFPLAML PTVISSLLEA SVSVSRIYEF
560 570 580 590 600
LIAQELDYNG VQRFPATEIP HEICLEIKSG TFSWSKKTLK QQVTPTLRQI
610 620 630 640 650
NFVAKNGELT CIFGKVGAGK SSLLEACMGN MYKNSGSVFQ CGSLAYAAQQ
660 670 680 690 700
PWIFDATIRE NILFGSEFDP ELYEKTIHAC CLKRDFEIFT EGDQTEVGQK
710 720 730 740 750
GASLSGGQKS RISLARAIYS QADIYLLDDV LSSVDQHVSR DLIKNLFGPE
760 770 780 790 800
GFLRTHCVVL TTNSLNVLKE ADSIYILSNG KIVEKGNYEH LFVSTNSELK
810 820 830 840 850
QQLSEFNDEK DTQPLPEHTT SYPSTQISLA PSIHVEGLET YSSSERKDSS
860 870 880 890 900
NKYKSRKRNP IRQKVTEDDK GKCVAQTDEL VQRGKVKWHV YWMYFKSCSI
910 920 930 940 950
GLILLYFFFI ISGIMMNVAT NVWLKHWSEE NGKSSSELNP SPYFYLGIYL
960 970 980 990 1000
FFGFLSCAFI SSSSLTMTVL CGIRSGRYLH DSMLKTILRA PMGFFETTSS
1010 1020 1030 1040 1050
GRILNRFSND VYKVDEVVSL TFMFFFRNSI QVLFILGVIC YSAPLSLLLI
1060 1070 1080 1090 1100
VPLFFLYLYN RAYYVRTSRE LKRLDNVTRS PLYAHVQESL SGLSTIRAYG
1110 1120 1130 1140 1150
MQETFVEEND LRIDTNHRVW FMFFSSSRWQ AIRVECIGDL IIFCTAFYGI
1160 1170 1180 1190 1200
LSAIKGSPNP GLVGFSLSYA IQITQGLSFI VQQSVDAENN TVSVERILEY
1210 1220 1230 1240 1250
INVKSEAPEI IPENRPPCEW PTDGAVSFNH YSAKYREDLS FALNNINIEI
1260 1270 1280 1290 1300
SPREKIGIVG RTGAGKSTLA MALFRIIEPT EGKIEIDNED ITKFGLYDLR
1310 1320 1330 1340 1350
SRLSIIPQES QIFEGNIREN LDPNHRLTDK KIWEVLEIAS LKNCISQLED
1360 1370 1380 1390 1400
GLYSRVAEGG ANFSSGQRQL ICLARVLLTS TRILLLDEAT ASVHAETDAI
1410 1420 1430 1440 1450
VQQTIRKRFK DRTILTVAHR INTVMDSDRI LVLDHGKVVE FDATKKLLEN
1460
KDSMFYSLAK ESGLI
Length:1,465
Mass (Da):166,613
Last modified:October 1, 2000 - v1
Checksum:iB15F1579B0895332
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071L → V in BAA87125 (PubMed:10759889).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB91574.1.
AB027821 Genomic DNA. Translation: BAA87125.1.
RefSeqiNP_595055.1. NM_001020961.2.

Genome annotation databases

EnsemblFungiiSPBC359.05.1; SPBC359.05.1:pep; SPBC359.05.
GeneIDi2540937.
KEGGispo:SPBC359.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB91574.1.
AB027821 Genomic DNA. Translation: BAA87125.1.
RefSeqiNP_595055.1. NM_001020961.2.

3D structure databases

ProteinModelPortaliQ9P5N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277453. 6 interactions.

Protein family/group databases

TCDBi3.A.1.208.28. the atp-binding cassette (abc) superfamily.

Proteomic databases

MaxQBiQ9P5N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC359.05.1; SPBC359.05.1:pep; SPBC359.05.
GeneIDi2540937.
KEGGispo:SPBC359.05.

Organism-specific databases

EuPathDBiFungiDB:SPBC359.05.
PomBaseiSPBC359.05. abc3.

Phylogenomic databases

InParanoidiQ9P5N0.
OMAiEGNIREN.
OrthoDBiEOG75XGV5.
PhylomeDBiQ9P5N0.

Enzyme and pathway databases

ReactomeiR-SPO-2142850. Hyaluronan biosynthesis and export.
R-SPO-382556. ABC-family proteins mediated transport.

Miscellaneous databases

NextBioi20802052.
PROiQ9P5N0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 207-348, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  3. "A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant."
    Iwaki T., Giga-Hama Y., Takegawa K.
    Microbiology 152:2309-2321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  4. "abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe."
    Pouliot B., Jbel M., Mercier A., Labbe S.
    Eukaryot. Cell 9:59-73(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiABC3_SCHPO
AccessioniPrimary (citable) accession number: Q9P5N0
Secondary accession number(s): Q9UU44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.