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Protein

ATP-binding cassette transporter abc3

Gene

abc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Iron-regulated vacuolar ABC-type transporter which may be responsible for mobilizing stored iron from the vacuole to the cytosol in response to iron deficiency.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi614 – 621ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1260 – 1267ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-2142850. Hyaluronan biosynthesis and export.
R-SPO-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.28. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette transporter abc3
Gene namesi
Name:abc3
ORF Names:SPBC359.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC359.05.
PomBaseiSPBC359.05. abc3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularSequence analysis8
Transmembranei9 – 29HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini30 – 42CytoplasmicSequence analysisAdd BLAST13
Transmembranei43 – 63HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini64 – 69ExtracellularSequence analysis6
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini91 – 97CytoplasmicSequence analysis7
Transmembranei98 – 118HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini119 – 129ExtracellularSequence analysisAdd BLAST11
Transmembranei130 – 150HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini151 – 235CytoplasmicSequence analysisAdd BLAST85
Transmembranei236 – 256HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini257 – 291ExtracellularSequence analysisAdd BLAST35
Transmembranei292 – 312HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini313 – 362CytoplasmicSequence analysisAdd BLAST50
Transmembranei363 – 383HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini384 – 394ExtracellularSequence analysisAdd BLAST11
Transmembranei395 – 415HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini416 – 480CytoplasmicSequence analysisAdd BLAST65
Transmembranei481 – 501HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini502 – 511ExtracellularSequence analysis10
Transmembranei512 – 532HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini533 – 899CytoplasmicSequence analysisAdd BLAST367
Transmembranei900 – 920HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini921 – 939ExtracellularSequence analysisAdd BLAST19
Transmembranei940 – 960HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini961 – 1033CytoplasmicSequence analysisAdd BLAST73
Transmembranei1034 – 1054HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1055 – 1465ExtracellularSequence analysisAdd BLAST411

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • vacuolar membrane Source: UniProtKB-SubCell
  • vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934711 – 1465ATP-binding cassette transporter abc3Add BLAST1465

Proteomic databases

MaxQBiQ9P5N0.
PRIDEiQ9P5N0.

Expressioni

Inductioni

Induced under conditions of iron deficiency and negatively regulated by iron through fep1.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi277453. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9P5N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 539ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini575 – 804ABC transporter 1PROSITE-ProRule annotationAdd BLAST230
Domaini903 – 1189ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST287
Domaini1226 – 1460ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9P5N0.
OMAiEGNIREN.
OrthoDBiEOG092C0VET.
PhylomeDBiQ9P5N0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P5N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITANKGLSL VLLIPNLFAL VSGGLQYVFD VRRRIFRPHF SQFWTIWMKF
60 70 80 90 100
FSIALVIITQ IYVGYKTKNI GWNFFSVVTY CFVLFLQFAE QSTLRVPMAS
110 120 130 140 150
LLIFWLLKVV TSLLILLFSP YIAITSMARL LTLITLFCSL VCFISEVYVP
160 170 180 190 200
PCNRVWYSDD TNEVEEKGIR PSEVRYANIF SKLSFSWISS FIKFGYTNYL
210 220 230 240 250
KESDVWLLPP DERSGNLIIG FEDWWIYHSK NKRRSLFLWK LLFFNHWKLV
260 270 280 290 300
ALITITKLIQ DVLAFVQPTL IQKTILFISS YTSPNPESPS RGFIIAILVL
310 320 330 340 350
VANFLQTLLL QQYNQLIMLL GMRWKTELLA SIYRKSLLLS SSARQNRSIG
360 370 380 390 400
DIINYMAVDT QKISDLPIYL FIIVSGPFQI ALALSNLYHL MGYSAFTGVA
410 420 430 440 450
ASVILFPCNI IVANVYKKFQ SILMKNKDSR SKLMTEIINN IRSIKLYAWE
460 470 480 490 500
TPFLQKLLHI RNTKELSMLK KIGFITAIGD FAWIFTTIIV TTVAFGAFII
510 520 530 540 550
FHGKTQALTA DIVFPAVSLF NLLQFPLAML PTVISSLLEA SVSVSRIYEF
560 570 580 590 600
LIAQELDYNG VQRFPATEIP HEICLEIKSG TFSWSKKTLK QQVTPTLRQI
610 620 630 640 650
NFVAKNGELT CIFGKVGAGK SSLLEACMGN MYKNSGSVFQ CGSLAYAAQQ
660 670 680 690 700
PWIFDATIRE NILFGSEFDP ELYEKTIHAC CLKRDFEIFT EGDQTEVGQK
710 720 730 740 750
GASLSGGQKS RISLARAIYS QADIYLLDDV LSSVDQHVSR DLIKNLFGPE
760 770 780 790 800
GFLRTHCVVL TTNSLNVLKE ADSIYILSNG KIVEKGNYEH LFVSTNSELK
810 820 830 840 850
QQLSEFNDEK DTQPLPEHTT SYPSTQISLA PSIHVEGLET YSSSERKDSS
860 870 880 890 900
NKYKSRKRNP IRQKVTEDDK GKCVAQTDEL VQRGKVKWHV YWMYFKSCSI
910 920 930 940 950
GLILLYFFFI ISGIMMNVAT NVWLKHWSEE NGKSSSELNP SPYFYLGIYL
960 970 980 990 1000
FFGFLSCAFI SSSSLTMTVL CGIRSGRYLH DSMLKTILRA PMGFFETTSS
1010 1020 1030 1040 1050
GRILNRFSND VYKVDEVVSL TFMFFFRNSI QVLFILGVIC YSAPLSLLLI
1060 1070 1080 1090 1100
VPLFFLYLYN RAYYVRTSRE LKRLDNVTRS PLYAHVQESL SGLSTIRAYG
1110 1120 1130 1140 1150
MQETFVEEND LRIDTNHRVW FMFFSSSRWQ AIRVECIGDL IIFCTAFYGI
1160 1170 1180 1190 1200
LSAIKGSPNP GLVGFSLSYA IQITQGLSFI VQQSVDAENN TVSVERILEY
1210 1220 1230 1240 1250
INVKSEAPEI IPENRPPCEW PTDGAVSFNH YSAKYREDLS FALNNINIEI
1260 1270 1280 1290 1300
SPREKIGIVG RTGAGKSTLA MALFRIIEPT EGKIEIDNED ITKFGLYDLR
1310 1320 1330 1340 1350
SRLSIIPQES QIFEGNIREN LDPNHRLTDK KIWEVLEIAS LKNCISQLED
1360 1370 1380 1390 1400
GLYSRVAEGG ANFSSGQRQL ICLARVLLTS TRILLLDEAT ASVHAETDAI
1410 1420 1430 1440 1450
VQQTIRKRFK DRTILTVAHR INTVMDSDRI LVLDHGKVVE FDATKKLLEN
1460
KDSMFYSLAK ESGLI
Length:1,465
Mass (Da):166,613
Last modified:October 1, 2000 - v1
Checksum:iB15F1579B0895332
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207L → V in BAA87125 (PubMed:10759889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB91574.1.
AB027821 Genomic DNA. Translation: BAA87125.1.
RefSeqiNP_595055.1. NM_001020961.2.

Genome annotation databases

EnsemblFungiiSPBC359.05.1; SPBC359.05.1:pep; SPBC359.05.
GeneIDi2540937.
KEGGispo:SPBC359.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB91574.1.
AB027821 Genomic DNA. Translation: BAA87125.1.
RefSeqiNP_595055.1. NM_001020961.2.

3D structure databases

ProteinModelPortaliQ9P5N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277453. 6 interactors.

Protein family/group databases

TCDBi3.A.1.208.28. the atp-binding cassette (abc) superfamily.

Proteomic databases

MaxQBiQ9P5N0.
PRIDEiQ9P5N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC359.05.1; SPBC359.05.1:pep; SPBC359.05.
GeneIDi2540937.
KEGGispo:SPBC359.05.

Organism-specific databases

EuPathDBiFungiDB:SPBC359.05.
PomBaseiSPBC359.05. abc3.

Phylogenomic databases

InParanoidiQ9P5N0.
OMAiEGNIREN.
OrthoDBiEOG092C0VET.
PhylomeDBiQ9P5N0.

Enzyme and pathway databases

ReactomeiR-SPO-2142850. Hyaluronan biosynthesis and export.
R-SPO-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ9P5N0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABC3_SCHPO
AccessioniPrimary (citable) accession number: Q9P5N0
Secondary accession number(s): Q9UU44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.