Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TOM1-like

Gene

B11B22.010

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4043 – 40431Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

mRNA transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TOM1-like (EC:6.3.2.-)
Gene namesi
ORF Names:B11B22.010, NCU08501
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU08501.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 40764076E3 ubiquitin-protein ligase TOM1-likePRO_0000120346Add
BLAST

Proteomic databases

PRIDEiQ9P4Z1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3740 – 4076337HECTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2851 – 292979Sequence analysisAdd
BLAST
Coiled coili3341 – 337535Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi960 – 9645Poly-Ser
Compositional biasi2362 – 2630269Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the UPL family. TOM1/PTR1 subfamily.Curated
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000190931.
InParanoidiQ9P4Z1.
KOiK10592.
OrthoDBiEOG092C016J.

Family and domain databases

InterProiIPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P4Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITKTMQQ KHRDTLSPWL KEFVDTASSA PLPLILQRLD EFPRRWMFPR
60 70 80 90 100
GDLYHWIPLL NRFDNILESI CATYELSKGP QTRDFGRDVL LNNGGPSLEY
110 120 130 140 150
RDEPWTVERL AEAGYKEDGD CQLLVAILKF TRMLLEHCGN RSIYASSHHI
160 170 180 190 200
DRLLNSPYLE VQAAALEVGL ELAQRYNASV KRMPSPPRSV NPTLLANHYN
210 220 230 240 250
IDLEKVQLLA RPFVRTPIVK SLEASSAAPA VSAGSTAKAK DKEKEKEKAT
260 270 280 290 300
GPKNVASMYA NDLKALASSR PDEEDLWKSW GDLKMSYYPD TTNGEPSARD
310 320 330 340 350
SKDAQPVEPR TTSSPAAPTP LRRSSTMNVS QSSRTQRVGS SEEGSPLKPS
360 370 380 390 400
GAATDDRDGP KVVEIPRSVI ESKRIYDLYD MCPSDMPATM KFEFTSRLRT
410 420 430 440 450
CKALLGTHRE RQLALAVRLL AITNLAYILP EAVFVDKVLK YDKDEPRTFQ
460 470 480 490 500
LVYQLAELIA PSPDGNPSEV PKWLQSITLA LLEAISHQQE KHSDVLAALN
510 520 530 540 550
VNVNHGILLY VIRIAVAEMK EDAPVDDQDE LDADNWRGNL FGLTLQIAMA
560 570 580 590 600
TRIGQEMMTA GLMDCLVEIL NLRTAVASRH YSMVLAFLDS LTYAYQTAFS
610 620 630 640 650
QLNSAGGLDA ITNLIVHTVG ESKTLTEAGL GTKPELHASL VDYSIPFYHQ
660 670 680 690 700
QTLKWLLKFI HHVMANTYSF DGTNTERLLR NLVDNSSLLG SLCTIARQNR
710 720 730 740 750
FFGTVVWSNA TTLLSDFINN DPTSFAAISE SGWIQAFLES VTNRPVSIPA
760 770 780 790 800
EQPSLEPSQS RANDGSEGND ADDDSEDDGS AHDAAPDSDG QAATQPHPPT
810 820 830 840 850
QEMLEAPRDF PPAHGILPSS ESMNIIPTVL NSISLNNRGM KMVLSSGAIQ
860 870 880 890 900
SYMEIFESAT HVQCMAHDPE LASTIGSSLD ELSRHHPALR PAIANAIIDM
910 920 930 940 950
IARVTHLVKT MDATKACGAR LEAPESSASP VAEPAQATEV KGKGKEKATD
960 970 980 990 1000
DTDVEMAEAS SSSSGNNKPA QAPSIPYIQV LSTFLQPIIS NSHLKGALIS
1010 1020 1030 1040 1050
AGVIEILLDL AESPSLPHDF GETPACRMLV AAISQLIESA QIVGLPSLLF
1060 1070 1080 1090 1100
RMENTVKVLQ PRINPTTTEP FFAPFLTLNS SVSPVQDEEP ASEKRTPDVS
1110 1120 1130 1140 1150
SGTETVKALL NIQTMIKILY HCFPFSNRSQ MVSMPAVNVY DYYIRLIQSL
1160 1170 1180 1190 1200
GPLLRGVLKE EAAVNGAVPH HWTLKNKPYQ TNSLGSRTDV QDLLTDSAAQ
1210 1220 1230 1240 1250
DSSANGKKLT PEEQSTAEYK NFQTLRVLLH SFMPSIFPFF QTIGKALLPR
1260 1270 1280 1290 1300
RNNNDPYIRS RHLAIAEASA ETLIQQLQQS KAELTVRDIH NWIIMIHTFG
1310 1320 1330 1340 1350
EMVVDTNHRT ASGGAFLILP VITAFKELGG FEALNVMLKR LADMVSTGAT
1360 1370 1380 1390 1400
EGQEATKAKL SMIGMKKVLD IYCFIISGKN LSDSMAQIAL APKPTERTTR
1410 1420 1430 1440 1450
EFSHQLVVEL RMSILPVVRE IWASNIIEKS TGTVVSKIID IIKTIAAGDL
1460 1470 1480 1490 1500
ESNAQSRSDK ESLPHLFKNR ESVPFKWISR KDAETLATEQ GVDVDLALEA
1510 1520 1530 1540 1550
LYRANGKESD TKEYIKYQKA HLVRNRNPVP AEDAFKEVPS PNLSSSAGMS
1560 1570 1580 1590 1600
LSNLLNTPTF PVSDLLGAEP MALDPVPNQP LGEASGETAL GHATESSEDG
1610 1620 1630 1640 1650
SDEGQPGTSR ETNVGASTTA PQQLPVLPSQ QPATESQSNT PRITREDLVE
1660 1670 1680 1690 1700
ERAKLYDTLI DRSLEVISSH PEAVFEVADL IQNTILKTDN EDRRVEVGEI
1710 1720 1730 1740 1750
LANALMSFAS DDADELKENG SSIAAYAHLL ALLLQQTAFM RTTVDMLRDY
1760 1770 1780 1790 1800
VGDYLGFLKL PPASSNDSLP PWIPYILLIF EIMLFKDAQP PDIKWKQPVK
1810 1820 1830 1840 1850
EDDPIEESVI EVKEPNFLAE HRSSLLTTLL DFLPRIGKEE SLAVSVLRIL
1860 1870 1880 1890 1900
VVLTRDHAVA KIVGEKKNLQ RLFVMAKQLC GAGSTRLKQT HISEHIRQIL
1910 1920 1930 1940 1950
RHIIEDEETL RQIFETDIRH LMTSRQRPSA APGLEPQAYL RTQAHLALRS
1960 1970 1980 1990 2000
PKTFVEVSTE LLKLNRAVSH LGDGTLRSTP FLVLKERPAD ASVSPKESSV
2010 2020 2030 2040 2050
EPAVQATEDL TISDVKPSTE VTDKDMHDAP KNPAQDLKRP ILEHPDGVVH
2060 2070 2080 2090 2100
FLLTELLNYK DVDERENVPA PPAAASKPES DATAANEATP SPSGDEQNSE
2110 2120 2130 2140 2150
SKEKEKKLAK SPFKAEDHPI FIYRCFLLDC LAELLQSYNR AKVEFINFKR
2160 2170 2180 2190 2200
SAPVQANAPV KPRSSVLNYI LNDLLCFSPA SGVPESIAMK KKAATAVPAR
2210 2220 2230 2240 2250
AVLVALVSKT GEKPQNRTHE PFEYDDEPDL LFIRRFVLDT ILRAYKDASV
2260 2270 2280 2290 2300
SGEPADIRYG KMNALAELMA QMIGEGDKDS RPNNPRGTDP SIGRSQAQLK
2310 2320 2330 2340 2350
RLMYEKGYLT SLTASIADID LTFPHNRAPL KPILAVIKTL SKTAVSMSQL
2360 2370 2380 2390 2400
GLIPASGTAG TDQAEDEFLS DGSSVSEDLT DDREETPDLY RNSTLGMLEP
2410 2420 2430 2440 2450
GRDDEFSDED EDDDEDMYDD EQYDDELDYG DDMSQDNEDN PSDEEDDLGE
2460 2470 2480 2490 2500
MGEMGGMPGQ PGVVEVLMGE NDDEEDNDDM DDMDEDDEMD EDDEQELSDE
2510 2520 2530 2540 2550
DEDEEVGSED MDDLEDDIHI VDEEGNAIDD DGASWDDGTD EDEEDEEELD
2560 2570 2580 2590 2600
YEAEAQNMQE AQLHNRRTFP EIMRAAMENA GDDLDAEPIR DFDGHYIDDD
2610 2620 2630 2640 2650
EDGEEDDDED EGEDDMDDDM YFDGDGLHDD LLAPNMPSGL GWDIAIEPNH
2660 2670 2680 2690 2700
RHRPSRSPWP NSPFVVGRHR DAIDFQNFFR RPAHLSRHLP PPADVMSGTN
2710 2720 2730 2740 2750
PLLLPQSRRE VPRHAHSQLV RLGITPNMIG GLGMGMGVEP LAFISDLVQH
2760 2770 2780 2790 2800
LPDVRLSAGG GPLALHFTAD GPGGIIRELN AIPIPPPHSR ESRPTEARRD
2810 2820 2830 2840 2850
TYQEPHQAVQ FSPESTHERW QQEVKMIFGF GYQDKAQKLA PLILSKLTPA
2860 2870 2880 2890 2900
AIQAEKEEKA RKAEADRKAE EERKKRQEEE RKKREAKEAE EKAAREKKEA
2910 2920 2930 2940 2950
EERERLERER AEAAAQAAAQ AAADQEANAV SQEAHPMEGV ETQGPGENAE
2960 2970 2980 2990 3000
QQAEDERPRV YYTLRNQQID ITELGIDAEY LEALPEEFRD EVIAQAISTR
3010 3020 3030 3040 3050
RSQAREQVSQ EGENTEVFQE FLEALPEELR NEILHQEQHE QRRRERQNAA
3060 3070 3080 3090 3100
GGQDLGPADM DPASILLTFP PGLRQQVLLD QGEDIMEHLG PELAAEARTL
3110 3120 3130 3140 3150
VARHRQLHAQ QGGQAASRSR DAQRPTEAGA GTVQKIQKRT VVQMLDKQGI
3160 3170 3180 3190 3200
ATLLRLMFVS QQGSIRSSLF SIFANLCENR QNRLDVISSL LQILQDGCAN
3210 3220 3230 3240 3250
MDAVERSFAQ ISHKAKQLKE KDAKTPHPLK RSLTGGTNNN GQFPASSEVS
3260 3270 3280 3290 3300
PLLIVQQCLD LLVELSKLNP HIPSVFLTEH ETVASTLKRS LSRKGKGKDV
3310 3320 3330 3340 3350
NGKAQKFAIN SLLTLLDRSL VMESSAVMQV LADLLNKVTI PLQAIERRRK
3360 3370 3380 3390 3400
EAEEQAKKKK EAEEKAATER EAANAPEEQA STSTEQTPAQ QEATQQPSES
3410 3420 3430 3440 3450
TPAAASGQQP AQQDQENKEL EAPKEKADEK DVQSDEKKIR QLTPPTIPEH
3460 3470 3480 3490 3500
NLKLVINIFV ARECSSKTFQ NTISTIKNLS NIPGAKKVFG DELVRQARVL
3510 3520 3530 3540 3550
SENILSDLDN LLPHILKAES GTQIQGVALA KFSPGASEQN KLLRVLTALD
3560 3570 3580 3590 3600
HLFDSKSKKQ DKPAEGENTK EDLLGSLYWN PTFGKMWDKL SACLSAIRQR
3610 3620 3630 3640 3650
DNMLNVATIL LPLIESLMVV CKNTTLSDAS AVSNANSQKE MLLTSPPPED
3660 3670 3680 3690 3700
RIAGLFFTFT EEHRRILNEL VRHNPKLMSG TFSLLVKNPK VLEFDNKRNY
3710 3720 3730 3740 3750
FNRSVHSKYQ QTRHSFPPLQ LQVRREHVFH DSFRSLYYKK ADELKFGKLN
3760 3770 3780 3790 3800
IRFQGEEGVD AGGVTREWFQ VLSRQMFDPN YVLFVPVSSD RTTFHPNKLS
3810 3820 3830 3840 3850
PINDEHLPFF KFIGRIIGKA LYEGRLLECY FSRAVYKRIL GKPVSVKDME
3860 3870 3880 3890 3900
SFDPDYYKSL VWMLENDITD IITETFSVED DVFGEVKVVD LIENGRNIPV
3910 3920 3930 3940 3950
TEENKHEYVR LIVEHKLITS VKDQMKAFLT GFHEIIPEEL IAIFNEQELE
3960 3970 3980 3990 4000
LLISGLPDID IDDWKANTEY HNYSAGAPQI QWFWRAVRSF DKEELAKLLQ
4010 4020 4030 4040 4050
FVTGTSKVPL NGFKELEGMN GVSRFNIHRD YGSKDRLPSS HTCFNQLDLP
4060 4070
EYENYETLRS QLLKAITAGS DYFGFA
Length:4,076
Mass (Da):453,670
Last modified:March 19, 2014 - v4
Checksum:i0ED7E2C532706D5D
GO

Sequence cautioni

The sequence CAB92704 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356834 Genomic DNA. Translation: CAB92704.2. Sequence problems.
CM002237 Genomic DNA. Translation: EAA34194.3.
PIRiT49799.
RefSeqiXP_963430.3. XM_958337.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000008474; EFNCRP00000008460; EFNCRG00000008460.
GeneIDi3879570.
KEGGincr:NCU08501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356834 Genomic DNA. Translation: CAB92704.2. Sequence problems.
CM002237 Genomic DNA. Translation: EAA34194.3.
PIRiT49799.
RefSeqiXP_963430.3. XM_958337.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9P4Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000008474; EFNCRP00000008460; EFNCRG00000008460.
GeneIDi3879570.
KEGGincr:NCU08501.

Organism-specific databases

EuPathDBiFungiDB:NCU08501.

Phylogenomic databases

HOGENOMiHOG000190931.
InParanoidiQ9P4Z1.
KOiK10592.
OrthoDBiEOG092C016J.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM1_NEUCR
AccessioniPrimary (citable) accession number: Q9P4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 97 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.