Reviewed, UniProtKB/Swiss-Prot Q9P4T7 (TYSY_AGABI)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase
      Short name=TSase
      Short name=TS
    EC=2.1.1.45

Gene names

Name:

tms1

Organism

Agaricus bisporus (Common mushroom)

Taxonomic identifier

5341 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Agaricaceae › Agaricus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Thymidylate synthase		PRO_0000140908
Sites
	Active site	171	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9P4T7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8FB8A8989D4A952A	FASTA	296	33,679
	10 20 30 40 50 60 MHDEDQYLHL IRRVLDTGDL RPDRTGTGTI SLFAPPNLRF SLRESTVPLL TTKRTFLRGI 70 80 90 100 110 120 VEELLWFTNG LTDSKILSDK GVKIWDGNGS KAFLESRGLG HRREGDLGPV YGFQWRHFGA 130 140 150 160 170 180 EYEDCDADYA GKGVDQLREC IRKIKENPTD RRIILSAWNP KDIPSMALPP CHMLCQFYVH 190 200 210 220 230 240 LPADTAKPEL SCLMFQRSAD LGLGIPFNIA SYALLTHMIA HVTGTTAREL IIQLGDAHVY 250 260 270 280 290 RDHVEALEVQ LQREPRPFPK LRWARDGITD IEDFEYSDFV IEGYNPHPSI AMKMSV

References

[1]	"Genomic sequencing of superoxide dismutase in Agaricus bisporus." Eastwood D.C., Bains N.K., Henderson J., Burton K.S. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Horst U3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ401221 Genomic DNA. Translation: CAB96042.1.
3D structure databases
HSSP	HSSP built from PDB template 1HW4 based on UniProtKB P04818.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.45. 984.
Family and domain databases
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
ProDom	PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_AGABI

Accession

Primary (citable) accession number: Q9P4T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)