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Q9P4T7 (TYSY_AGABI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:tms1
OrganismAgaricus bisporus (White button mushroom)
Taxonomic identifier5341 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000140908

Sites

Active site1711 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9P4T7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8FB8A8989D4A952A

FASTA29633,679
        10         20         30         40         50         60 
MHDEDQYLHL IRRVLDTGDL RPDRTGTGTI SLFAPPNLRF SLRESTVPLL TTKRTFLRGI 

        70         80         90        100        110        120 
VEELLWFTNG LTDSKILSDK GVKIWDGNGS KAFLESRGLG HRREGDLGPV YGFQWRHFGA 

       130        140        150        160        170        180 
EYEDCDADYA GKGVDQLREC IRKIKENPTD RRIILSAWNP KDIPSMALPP CHMLCQFYVH 

       190        200        210        220        230        240 
LPADTAKPEL SCLMFQRSAD LGLGIPFNIA SYALLTHMIA HVTGTTAREL IIQLGDAHVY 

       250        260        270        280        290 
RDHVEALEVQ LQREPRPFPK LRWARDGITD IEDFEYSDFV IEGYNPHPSI AMKMSV 

« Hide

References

[1]"Genomic sequencing of superoxide dismutase in Agaricus bisporus."
Eastwood D.C., Bains N.K., Henderson J., Burton K.S.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Horst U3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ401221 Genomic DNA. Translation: CAB96042.1.

3D structure databases

ProteinModelPortalQ9P4T7.
SMRQ9P4T7. Positions 3-296.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_AGABI
AccessionPrimary (citable) accession number: Q9P4T7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways