Q9P4E8 (LIP6_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 6
EC=3.1.1.3

Gene names

Name:	LIP6
ORF Names:	CaO19.4823, CaO19.12286

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 463	447	Lipase 6		PRO_0000017825
Sites
	Active site	196	1	Charge relay system By similarity
	Active site	344	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	422	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P4E8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 21F5E66B04F73DAF	FASTA	463	50,480
	10 20 30 40 50 60 MRDLILFLSL LHTIFASLFS LKPPSQDDFY KAPAGFKAAK PGDILKTRKS PNKPSSLYAP 70 80 90 100 110 120 VDVQNSWQLL VRSEDSFGNP NAFVTTIIQP KNADPSKVVS YQNWEDASNI NCSPSYGSQL 130 140 150 160 170 180 GAPLSTILTQ LDMTFIVPPL KSGYYVVLPD YEGPKSTFGV GRQSGKATLD SIKAVLKTKD 190 200 210 220 230 240 FSGINDDAKV VLWGYSGGSF ASGWAAVLQP EYAPELKDNL IGAALGGFAA NLTGIAESVD 250 260 270 280 290 300 GEVFSGFIPL ALNGIANEYP DFKKRLYEEV KPGAKADLQK GAENCLAASL ISYPMYQYFT 310 320 330 340 350 360 GPRRVFEKGW SLLEDKTIGK TLEDNLLIAL SKEHMPQIPI FVYHGTIDKI IPIKDSIKIY 370 380 390 400 410 420 KNWCDWGIGS FEFSEDKSNG HTTETVVGAP AALTWIDARF AGKPAVEGCS FTTRASNFLY 430 440 450 460 PNISESAASY FKGIYQTILR SKLGSGVTSD DVSVNGLRSL YHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191319 Genomic DNA. Translation: AAF79927.1. AACQ01000002 Genomic DNA. Translation: EAL04615.1. AACQ01000001 Genomic DNA. Translation: EAL04811.1.
RefSeq	XP_723319.1. XM_718226.1. XP_723509.1. XM_718416.1.
3D structure databases
ProteinModelPortal	Q9P4E8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3634890. 3635067.
KEGG	cal:CaO19.12286. cal:CaO19.4823.
Organism-specific databases
CGD	CAL0005333. LIP6.
Phylogenomic databases
OMA	NCANIAP.
PhylomeDB	Q9P4E8.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP6_CANAL

Accession

Primary (citable) accession number: Q9P4E8
Secondary accession number(s): Q5APE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program