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Reviewed, UniProtKB/Swiss-Prot Q9P4E7 (LIP7_CANAL)

Last modified November 3, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lipase 7
    EC=3.1.1.3
Gene names
Name: LIP7
ORF Names: CaO19.7320
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

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Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted. Ref.1

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

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Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 426411Lipase 7
PRO_0000017826

Sites

Active site1901Charge relay system By similarity
Active site3211Charge relay system By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9P4E7-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2DBBABC4CBCC6A85

FASTA42647,854
        10         20         30         40         50         60 
MFVFLALITL TTCLQIPLNP TIDDFYNPPK DLETSQLGDV LKWRKMPFPV TSMFVNLPIS 

        70         80         90        100        110        120 
NAWQISVRSQ DTLNNSLAIV ATILEPPNGD KNKLISHQAF ENSPLLSCSP SYSMQVPSFE 

       130        140        150        160        170        180 
TFQIQADLIF ISGLLSQGWY VVVPDYEGPN SVFPVGRQSA YSVLDSIRGT IKFFNSTGNS 

       190        200        210        220        230        240 
TVKTALLGYS YGAVASLWAS IVQPNYAPEL ELVGAAVGCT IPNITAFIEK VDEGPYSGLI 

       250        260        270        280        290        300 
VNIFNGLANE YRHFRDRLIH FGALQPLGCL FPICRKFFFQ KMIGGVYDAQ VLTDETIKET 

       310        320        330        340        350        360 
IEINNLLSTR AVPQIPVFLF HSKFNEMSPF LEILKLEKLW CSQLGVNLEI AEDMSYNHMV 

       370        380        390        400        410        420 
EAFSGMPAAI TWIEKRWNNS TLGGCKHVHR LSNFEYPGIA PFLSQYFRSS LQMVLNNNRY 


FNNTTR

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References

« Hide 'large scale' references
[1]"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members."
Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.
Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
Strain: SC5314.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

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Cross-references

Sequence databases

AF191320 Genomic DNA. Translation: AAF79928.1.
AACQ01000069 Genomic DNA. Translation: EAK97459.1.
RefSeqXP_716454.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3641917.
KEGGcal:CaO19.7320.

Organism-specific databases

CGDCAL0004572. LIP7.

Phylogenomic databases

OMANITAFIE.

Enzyme and pathway databases

BRENDA3.1.1.3. 1124.

Family and domain databases

InterProIPR005152. Lipase_secreted.
[Graphical view]
PfamPF03583. LIP. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLIP7_CANAL
AccessionPrimary (citable) accession number: Q9P4E7
Secondary accession number(s): Q5A3Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2000
Last modified: November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents