Q9P4E6 (LIP9_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 9
EC=3.1.1.3

Gene names

Name:	LIP9
ORF Names:	CaO19.5172, CaO19.12639

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.
Sequence caution	The sequence EAK97944.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence EAK97944.1 differs from that shown. Reason: Frameshift at position 209. The sequence EAK98014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence EAK98014.1 differs from that shown. Reason: Frameshift at position 209.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 14	14	Potential
	Chain	15 – 453	439	Lipase 9		PRO_0000017828
Sites
	Active site	194	1	Charge relay system By similarity
	Active site	339	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	189	1	V → L in AAF79929. Ref.1
	Sequence conflict	245	1	I → T in AAF79929. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9P4E6 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: 68C558D03E171FEE	FASTA	453	49,218
	10 20 30 40 50 60 MLYLILFLIA PIYAGVLLPT KPSIDPFYNA PEGFKNATVG DILQFRKTPK SITGGFVPLN 70 80 90 100 110 120 VQNSWQFLVR SEDSFGNPNV IVTTVIEPVN ADPSKIASYQ VSENAARADC APSYALQFGS 130 140 150 160 170 180 DVSTLATQAE TYLLAPLLDK GYYVVSPDYE GPKSTFTVGK QSGQAVLNSI RASLKSGKIT 190 200 210 220 230 240 NIAEDAKVVM WGYSGGSLAS GWAAALQPDY APELSRNLLG VALGGFITNV TATVEATDDT 250 260 270 280 290 300 IFAGIAANVL GGIANEYPEF KSILQNDTNK SSIFNKINNH CLTDSFIKYV GARFLTGDNK 310 320 330 340 350 360 VFKSGWNIFK NLVVSKIVKD NGLVYQKQLI PTIPVFIYHG SMDQISPILN PKKTYQNWCD 370 380 390 400 410 420 AGISSIEFAE DLTNGHFTES IVGAPAALTW IIDRFSNKPP VDGCQHVVRT TNYEYPNVSS 430 440 450 SILDYFKAAM DVVAQQGLGP NIQKDQLEIK SNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191322 Genomic DNA. Translation: AAF79929.1. AACQ01000061 Genomic DNA. Translation: EAK97944.1. Sequence problems. AACQ01000060 Genomic DNA. Translation: EAK98014.1. Sequence problems.
RefSeq	XP_716927.1. XM_711834.1. XP_716994.1. XM_711901.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641394. 3641444.
KEGG	cal:CaO19.12639. cal:CaO19.5172.
Organism-specific databases
CGD	CAL0076625. LIP9.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP9_CANAL

Accession

Primary (citable) accession number: Q9P4E6
Secondary accession number(s): Q5A5A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 19, 2011
Last modified:	January 25, 2012
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program