Reviewed, UniProtKB/Swiss-Prot Q9P4E5 (LIP10_CANAL)

Names and origin

Protein names

Recommended name:
    Lipase 10
    EC=3.1.1.3

Gene names

Name:	LIP10
ORF Names:	CaO19.4822, CaO19.12285

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 465	449	Lipase 10		PRO_0000017829
Sites
	Active site	196	1	Charge relay system By similarity
	Active site	344	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	319	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9P4E5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 969A90F0ACC71A6B	FASTA	465	50,469
	10 20 30 40 50 60 MKTLLIFLAF LSSIFASLIG LTPPSKDSFY SPPVGFATAK PGDILKIRNT PSAPSSLYLP 70 80 90 100 110 120 IVVKNAWQLL IRSEDSFGNP NAFVATLIQP LNANPSKLVS YQSWEDASHI DCSPSYGMQF 130 140 150 160 170 180 KSPATTVTTQ IDMTLIVPLL QNGYYVIIPD YEGPKSTFTV GRQSGKATLN SIRAALQTGA 190 200 210 220 230 240 FSGIKKTAKV ALWGYSGGSL ATGWAISLQS KYAPELKENL IGAAVGGFAT NITAVAEAVD 250 260 270 280 290 300 GTVFSGFIPL ALNGLANEYP DFKKRLYGEV KLSARSTMEK GSQNCLAASL VGYPMSQYFT 310 320 330 340 350 360 GQNRAFEKGW GLLQDEVFNK TIEDNLLLKL DKTYLPQVPV LIYHGTIDEI IPIKDANAQY 370 380 390 400 410 420 QIWCDRGIQS LEFAEDLSAG HLAETFTGAP AALSWIDARF SGKPAVNGCQ RTIRSSNVLY 430 440 450 460 PGISITIRIY FEGISKTIFG VNLGSGVNAD KSISNKFFAY IRKYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: SC5314.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191323 Genomic DNA. Translation: AAF79930.1. AACQ01000002 Genomic DNA. Translation: EAL04614.1. AACQ01000001 Genomic DNA. Translation: EAL04810.1.
RefSeq	XP_723318.1. XP_723508.1.
3D structure databases
SMR	Q9P4E5. Positions 20-442.
ModBase	Search...
Genome annotation databases
GeneID	3634889. 3635066.
KEGG	cal:CaO19.12285. cal:CaO19.4822.
Organism-specific databases
CGD	CAL0005332. LIP10.
Phylogenomic databases
OrthoDB	EOG9RJHHR.
Enzyme and pathway databases
BRENDA	3.1.1.3. 1124.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP10_CANAL

Accession

Primary (citable) accession number: Q9P4E5
Secondary accession number(s): Q5APE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)