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Reviewed, UniProtKB/Swiss-Prot Q9P4C2 (ADH2_KLUMA)

Last modified November 4, 2008. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase II
Gene names
Name: ADH2
OrganismKluyveromyces marxianus (Yeast) (Candida kefyr)
Taxonomic identifier4911 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

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Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 348347Alcohol dehydrogenase 2
PRO_0000160725

Sites

Metal binding441Zinc 1; catalytic By similarity
Metal binding671Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1541Zinc 1; catalytic By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9P4C2-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5083E01524DAFEC1

FASTA34836,968
        10         20         30         40         50         60 
MSIPTTQKGV IFYENGGQLY YKDIPVPKPK SNELLINVKY SGVCHTDLHA WKGDWPLDTK 

        70         80         90        100        110        120 
LPLVGGHEGA GVVVAMGDNV KGWKIGDLAG IKWLNGSCMN CEECELSNES NCPDADLSGY 

       130        140        150        160        170        180 
THDGSFQQYA TADAVQAAHI PAGTDLAQVA PILCAGVTVY KALKTAEMKA GDWVAISGAA 

       190        200        210        220        230        240 
GGLGSLAVQY AKAMGFRVLG IDGGEGKEEL FKSLGGEVFI DFTKSKDIVG EVIKATNGGA 

       250        260        270        280        290        300 
HGVINVSVSE KAIESSIEYC RSNGTVVLVG LPKDAKCKSD VFNQVVKSIH IVGSYVGNRA 

       310        320        330        340 
DTREALDFFC RGLVNAPIKV VGLSTLPEIY EKMEQGKVLG RYVVDTSK

« Hide

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References

[1]"Kluyveromyces marxianus exhibits an ancestral Saccharomyces cerevisiae genome organization downstream of ADH2."
Ladriere J.-M., Georis I., Guerineau M., Vandenhaute J.
Gene 255:83-91(2000) [PubMed: 10974568] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 12424 / NRRL Y-610.

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Cross-references

Sequence databases

AF225206 Genomic DNA. Translation: AAF91235.1.

3D structure databases

HSSPHSSP built from PDB template 1JVB based on UniProtKB P39462.
SMRQ9P4C2. Positions 2-348.
ModBaseSearch...

Family and domain databases

InterProIPR013154. AlcDHase_GroES-like.
IPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR002328. AlcDHase_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameADH2_KLUMA
AccessionPrimary (citable) accession number: Q9P4C2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 4, 2008
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents