Q9P430 (XYL1_CANSH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-dependent D-xylose reductase
Short name=XR
EC=1.1.1.-

Gene names

Name:

XYL1

Organism

Candida shehatae (Yeast)

Taxonomic identifier

45589 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces D-xylose into xylitol.
Pathway	Carbohydrate metabolism; D-xylose degradation.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	NAD(P)H-dependent D-xylose reductase		PRO_0000124660
Regions
	Nucleotide binding	219 – 285	67	NAD or NADP By similarity
Sites
	Active site	53	1	Proton donor By similarity
	Binding site	115	1	Substrate By similarity
	Site	82	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9P430 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E5AB1A3141FF27E3	FASTA	323	36,594
	10 20 30 40 50 60 MSPSPIPAFK LNNGLEMPSI GFGCWKLDKS TAADQVYNAI KAGYRLFDGA EDYGNEQEVG 70 80 90 100 110 120 EGVKRAIDEG IVTREEIFLT SKLWNNYHDP KNVETALNKT LKDLKVDYVD LFLIHFPIAF 130 140 150 160 170 180 KFVPIEEKYP PGFYCGDGDN FVYEDVPILE TWKALEKLVK AGKIRSIGVS NFPGALLLDL 190 200 210 220 230 240 FRGATIKPAV LQVEHHPYLQ QPKLIEYAQK VGITVTAYSS FGPQSFVEMN QGRALNTPTL 250 260 270 280 290 300 FEHDVIKAIA AKHNKVPAEV LLRWSAQRGI AVIPKSNLPE RLVQNRSFND FELTKEDFEE 310 320 ISKLDINLRF NDPWDWDNIP IFV

References

[1]	"Isolation and expression of the Candida shehatae xylose reductase gene (XYL1) in Saccharomyces cerevisiae." Govinden R., Pillay B., Pillay D. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CS051.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF278715 Genomic DNA. Translation: AAF86345.1.
3D structure databases
ProteinModelPortal	Q9P430.
SMR	Q9P430. Positions 6-323.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYL1_CANSH

Accession

Primary (citable) accession number: Q9P430

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 1, 2000
Last modified:	June 28, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program