Q9P3X9 (PPID_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
41 kDa peptidyl-prolyl cis-trans isomerase
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Cyclophilin-41
Short name=CyP41
Rotamase

Gene names

Name:	cyp-41
ORF Names:	NCU03853

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Interacts with CyPBP37. Ref.1
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. PPIase D subfamily. Contains 1 PPIase cyclophilin-type domain. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat TPR repeat
Ligand	Cyclosporin
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC protein refolding Inferred from electronic annotation. Source: EnsemblFungi
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptide binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	41 kDa peptidyl-prolyl cis-trans isomerase		PRO_0000064156
Regions
	Domain	15 – 178	164	PPIase cyclophilin-type
	Repeat	222 – 255	34	TPR 1
	Repeat	274 – 307	34	TPR 2
	Repeat	312 – 345	34	TPR 3

Sequences

	Sequence		Length	Mass (Da)
	Q9P3X9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F5A1B3C078800994	FASTA	375	40,571
	10 20 30 40 50 60 MSSTDDVKQA RSRVFFDITI GGKAAGRIVF ELYNDIVPKT AENFRALCTG EKGVGKLGKP 70 80 90 100 110 120 LHYKGSTFHR VIKQFMIQGG DFTAGNGTGG ESIYGAKFED ENFQLKHDRP FLLSMANAGP 130 140 150 160 170 180 GTNGSQFFVT TVPTPHLDGK HVVFGEVLSG KSVVRQIENL KTQGDKPTKD AVIADCGELS 190 200 210 220 230 240 GDAAVSADTK TADAYGDEYE DFPEDEATDG QPLSASKILK IATDCKDFGN KAFKAGDLPV 250 260 270 280 290 300 ALDKYQKGLR YLNEDPELDN EPADTKQKLD ALRVSLNSNA ALMNMKLSAW DECIRSADGA 310 320 330 340 350 360 LAVATISDKD RAKALYRRGY AQVRIKDEDS ALTSLEEAKK LAPEDGAIVN ELAAVKKAAA 370 ARMAKEKAAY KKFFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel binding protein for a member of CyP40-type Cyclophilins: N.crassa CyPBP37, a growth and thiamine regulated protein homolog to yeast Thi4p." Faou P., Tropschug M. J. Mol. Biol. 333:831-844(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CYPBP37. Strain: 74A.
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ292563 mRNA. Translation: CAC00484.1. AABX02000012 Genomic DNA. Translation: EAA26627.1.
RefSeq	XP_955863.1. XM_950770.1.
UniGene	Ncr.15757.
3D structure databases
ProteinModelPortal	Q9P3X9.
SMR	Q9P3X9. Positions 7-370.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU03853.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000003630; EFNCRP00000003630; EFNCRG00000003626.
GeneID	3872010.
KEGG	ncr:NCU03853.
Phylogenomic databases
eggNOG	COG0457.
HOGENOM	HOG000065980.
KO	K05864.
OMA	CKLKLSD.
OrthoDB	EOG4J9R7J.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. PS50005. TPR. 2 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPID_NEUCR

Accession

Primary (citable) accession number: Q9P3X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program