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Protein

High-affinity glucose transporter ght1

Gene

ght1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose:proton symporter activity Source: PomBase
  • high-affinity hydrogen:glucose symporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.112. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter ght1
Alternative name(s):
Hexose transporter 1
Gene namesi
Name:ght1
ORF Names:SPCC548.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC548.07c.
PomBaseiSPCC548.07c. ght1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini31 – 5828ExtracellularSequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 878CytoplasmicSequence analysis
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 1124ExtracellularSequence analysis
Transmembranei113 – 13321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini134 – 14411CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini166 – 17914ExtracellularSequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini201 – 26666CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28519Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini286 – 30116ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini323 – 3286CytoplasmicSequence analysis
Transmembranei329 – 34921Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini350 – 36314ExtracellularSequence analysisAdd
BLAST
Transmembranei364 – 38421Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini385 – 40420CytoplasmicSequence analysisAdd
BLAST
Transmembranei405 – 42521Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini426 – 4327ExtracellularSequence analysis
Transmembranei433 – 45321Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini454 – 557104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: PomBase
  • plasma membrane Source: PomBase
  • plasma membrane of cell tip Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557High-affinity glucose transporter ght1PRO_0000050409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Not glycosylated.

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi275316. 6 interactions.
MINTiMINT-4703743.

Structurei

3D structure databases

ProteinModelPortaliQ9P3U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiQ9P3U6.
KOiK08139.
OrthoDBiEOG73JM4H.
PhylomeDBiQ9P3U6.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P3U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTLTITML LFVSMAGWMF GADTGSIGGI TNMRDFQSRF ADRYNPVTDT
60 70 80 90 100
YSYSSARQGL ITGMVNVGSF FGCLISSPTT DRIGKRNSII GFCVIYLIGV
110 120 130 140 150
IIQVTAVPSW VQIMVAKIWT GLGIGALSVL APGYQSEVAP PHIRGTIVVT
160 170 180 190 200
YQLCVTAGIF IAACINMGTH KLYKTAQWRV SIGINLLWGI ITLVGVSFLS
210 220 230 240 250
ESPRYLVSIG KDDEAIQVMC KNAELPPDSD IIQTEYKQIK SDCEAAVEGG
260 270 280 290 300
PCTWPEIFGK EIRYRTFLGM AIMSFNQLTG CNYYFYYGTQ VFKGTGMESP
310 320 330 340 350
YLASLILDAV NFGCTFGGLF VLEYCGRRVP LIIGGVWQSI CFFIYAAVGN
360 370 380 390 400
RALTRKNGTS NHRAGAVMIV FSCLFIFSFA QTWGPAAYVI VGESYPIRYR
410 420 430 440 450
SKCAAVATTS NWLWNFLISF FTPFITNSIG FKYGYIFASC NLCASIVTFL
460 470 480 490 500
FAHESKGLTL EEINELYLSD AKPWMSRPKN LSEMAEAKEV EREETRPKGE
510 520 530 540 550
SARYLEHADS NSDSEDLSSS ANNDVHEPVA RQDPFNENEV EKSRTRPSQE

SYTTSSN
Length:557
Mass (Da):61,639
Last modified:October 1, 2000 - v1
Checksum:i03D3D002640CAB4B
GO

Sequence cautioni

The sequence X91218 differs from that shown. Reason: Frameshift at position 533. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91218 Genomic DNA. No translation available.
CU329672 Genomic DNA. Translation: CAB94949.1.
RefSeqiNP_587747.1. NM_001022741.2.

Genome annotation databases

EnsemblFungiiSPCC548.07c.1; SPCC548.07c.1:pep; SPCC548.07c.
GeneIDi2538732.
KEGGispo:SPCC548.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91218 Genomic DNA. No translation available.
CU329672 Genomic DNA. Translation: CAB94949.1.
RefSeqiNP_587747.1. NM_001022741.2.

3D structure databases

ProteinModelPortaliQ9P3U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275316. 6 interactions.
MINTiMINT-4703743.

Protein family/group databases

TCDBi2.A.1.1.112. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC548.07c.1; SPCC548.07c.1:pep; SPCC548.07c.
GeneIDi2538732.
KEGGispo:SPCC548.07c.

Organism-specific databases

EuPathDBiFungiDB:SPCC548.07c.
PomBaseiSPCC548.07c. ght1.

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiQ9P3U6.
KOiK08139.
OrthoDBiEOG73JM4H.
PhylomeDBiQ9P3U6.

Miscellaneous databases

PROiQ9P3U6.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Properties and heterologous expression of the glucose transporter GHT1 from Schizosaccharomyces pombe."
    Lichternberg-Frate H., Naeschen T., Heiland S., Hoefer M.
    Yeast 13:215-224(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGHT1_SCHPO
AccessioniPrimary (citable) accession number: Q9P3U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.