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Protein

E3 ubiquitin-protein ligase dbl4

Gene

dbl4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.By similarity

Catalytic activityi

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei304By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 178RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri198 – 264IBR-typeSequence analysisAdd BLAST67
Zinc fingeri291 – 320RING-type 2PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase dbl4By similarityCurated (EC:2.3.2.31By similarity)
Alternative name(s):
DNA-break-localizing protein 41 Publication
Histone E3 ligase 1By similarity
RING-type E3 ubiquitin transferase dbl4Curated
Gene namesi
Name:dbl41 Publication
ORF Names:SPAC328.02Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC328.02
PomBaseiSPAC328.02 dbl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104881 – 504E3 ubiquitin-protein ligase dbl4Add BLAST504

Proteomic databases

MaxQBiQ9P3U4
PaxDbiQ9P3U4
PRIDEiQ9P3U4

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279580, 1 interactor
STRINGi4896.SPAC328.02.1

Structurei

3D structure databases

ProteinModelPortaliQ9P3U4
SMRiQ9P3U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

Sequence similaritiesi

Belongs to the RBR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 178RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST48
Zinc fingeri198 – 264IBR-typeSequence analysisAdd BLAST67
Zinc fingeri291 – 320RING-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000216612
InParanoidiQ9P3U4
KOiK11968
OMAiLARYLHY
OrthoDBiEOG092C2999
PhylomeDBiQ9P3U4

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR11685 PTHR11685, 1 hit
PfamiView protein in Pfam
PF01485 IBR, 2 hits
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00647 IBR, 2 hits
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P3U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLLDDEFY EEEFENDLLD ASEFEDEFDE DAEIDDDGFT VERKRRRAHS
60 70 80 90 100
VSYRVVSVRD LRASLNEKIN QLTSIIDLTR EQVLGLYRYF KWNRERLLER
110 120 130 140 150
YIDAPEESLQ KAGVGLSGSK QREVVHHEGT CEICYDEGCL PFFSAECDHE
160 170 180 190 200
FCLACYRQYL DSRISEGESV IQCPEESCTQ IVSIQSITKV LDEKSLDRYH
210 220 230 240 250
RLLDRSFVDD NDHLRWCPAP DCEFAIECHV TQASLSSVVP TVTCNCGKQF
260 270 280 290 300
CFGCGHDNHQ PTICPLVKIW LQKCQDDSET ANWIHANTKE CPKCSTTIEK
310 320 330 340 350
NGGCNHMTCK KCKYEFCWVC LGPWTEHGNN WYTCNRYEEK SSTSARDSQS
360 370 380 390 400
KSRASLERYL HYYNRFANHE QSAKLDHELY EHTHKRMTQM QVDSNLSWVE
410 420 430 440 450
VQFLKNAVDI LFQCRQTLKW TYAFAYYLAR NNQTEIFEDN QRDLELAVEN
460 470 480 490 500
LSELCERPCQ DCSLSVFKQR VLDKTVYVRS RRDVLLDDTA RGLAEGRWEY

VVDV
Length:504
Mass (Da):58,939
Last modified:October 1, 2000 - v1
Checksum:iAA71065239F401CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB95997.1
RefSeqiNP_594204.1, NM_001019627.2

Genome annotation databases

EnsemblFungiiSPAC328.02.1; SPAC328.02.1:pep; SPAC328.02
GeneIDi2543148
KEGGispo:SPAC328.02

Similar proteinsi

Entry informationi

Entry nameiHEL1_SCHPO
AccessioniPrimary (citable) accession number: Q9P3U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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