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Q9P3U0

- UBP2_SCHPO

UniProt

Q9P3U0 - UBP2_SCHPO

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Protein

Probable ubiquitin carboxyl-terminal hydrolase 2

Gene

ubp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei623 – 6231NucleophilePROSITE-ProRule annotation
Active sitei1076 – 10761Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. protein deubiquitination Source: PomBase
  2. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A56.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 2
Ubiquitin thioesterase 2
Ubiquitin-specific-processing protease 2
Gene namesi
Name:ubp2
ORF Names:SPAC328.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC328.06.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11411141Probable ubiquitin carboxyl-terminal hydrolase 2PRO_0000080603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121Phosphothreonine1 Publication
Modified residuei113 – 1131Phosphoserine1 Publication
Modified residuei115 – 1151Phosphothreonine1 Publication
Modified residuei721 – 7211Phosphothreonine1 Publication
Modified residuei722 – 7221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P3U0.

Interactioni

Protein-protein interaction databases

BioGridi278537. 143 interactions.
MINTiMINT-4703705.
STRINGi4896.SPAC328.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P3U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini614 – 1124511USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG275561.
InParanoidiQ9P3U0.
KOiK11849.
OMAiPESHETK.
OrthoDBiEOG7327X3.
PhylomeDBiQ9P3U0.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR025305. UCH_repeat_domain.
[Graphical view]
PfamiPF13446. RPT. 3 hits.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P3U0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVKNLRIG KSPNRLIQDL DVFDSPSAGW NDPWSPHSSR YHWQLHSNLG
60 70 80 90 100
ESAVFDENDF WCVCQKTRKH LHVKVRRDRG KPLIEEPEEN YGIKDRIPVY
110 120 130 140 150
YEEEELPEPH VTSPTKSEFA TTSTCMKWSS KTTKSEIEVE WRDSYLDANC
160 170 180 190 200
IKEIIDSRRP SFASLLTKKS SSHQGSSHSS QPSLFTTFTS LELFLRNVLV
210 220 230 240 250
HNDQRAISAA PEGTFERHVG KGRQIQSLMK SLLFEYHHEN VNYVPTIADA
260 270 280 290 300
PLTDEQKLNL YLARNELIVL ANHFRDTKED PAIVANPFPV RLARPALINA
310 320 330 340 350
FGVPNYDSVV PMYTTVFRDN SASLPDDPAF IALGITNDYP DSFVRYFYEE
360 370 380 390 400
QKKNDEANVR VYADALAHIY NLRKSSFLRD LIAADRKNGI VSSDVIQAAY
410 420 430 440 450
SSLGLEAEVG PDYRYSQEKI FEAFHSALLR KPEFARAIRN DLETIGYARK
460 470 480 490 500
SSEILNYVLS TEQAFYTVNE AYQWLGIKSN TEDAMVASVA LVKFEDDSDK
510 520 530 540 550
AIEAVKWIAE ERNSSILYDF LASQGRPSNK KPKEVPMDED LAYNTLGVQD
560 570 580 590 600
RALSDDVLIN VYGFAVEDHP EQSDTLRAAL KCIGEVRNSR LITHYLEHGN
610 620 630 640 650
LDIPPEVSSL DTPIGLENTG NLCYLNSLIQ YYFIIKPLRN AILDIDENKD
660 670 680 690 700
LNMIENKEAV KKVGGRIVTR IEFLRALQFT YELRKLFIEL ITSKSSSVHP
710 720 730 740 750
SSVLTYLALI PLTLDQVKSG TSSVMDLSSS RELSNLNERS ITIDPRAEEQ
760 770 780 790 800
AQGLEQEQGQ DEAKSPAEQS SSVNLIDFPM ANTNGESQTQ PHYFEVSEEE
810 820 830 840 850
INSSMDLGRQ QDVLECIDHV LFQLEASLGR ISNSEDRLGS DNDLIRRLFS
860 870 880 890 900
GKLKQTLNDA SQGVRSNYEI FSHLIVDLFE EKQTLYDALD GVFETVNIDM
910 920 930 940 950
GSETAQRSLC ITELPIILQL QIQRVQFDRT TGQPFKSNAF VEFGKELSMD
960 970 980 990 1000
RYVEDTDGKM APLLQRYWDL KREIINLQKR QQLLLTTNSN LMSSVDTLSI
1010 1020 1030 1040 1050
LSKWAAQQQD SRLPINPKLP DILQEEINNV VAEVDMLKKQ EASLKEERTH
1060 1070 1080 1090 1100
LFDNYISHSY DLLAVFVHRG QASFGHYWTY IHDFENNVYR KYNDEYVTVV
1110 1120 1130 1140
DESEIFADTT GNNANPYMLT YIRKEYRHII ECVHREHNLL L
Length:1,141
Mass (Da):130,297
Last modified:October 1, 2000 - v1
Checksum:i1499E32DB6CB26CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB96001.1.
RefSeqiNP_594208.1. NM_001019631.2.

Genome annotation databases

EnsemblFungiiSPAC328.06.1; SPAC328.06.1:pep; SPAC328.06.
GeneIDi2542059.
KEGGispo:SPAC328.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB96001.1 .
RefSeqi NP_594208.1. NM_001019631.2.

3D structure databases

ProteinModelPortali Q9P3U0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278537. 143 interactions.
MINTi MINT-4703705.
STRINGi 4896.SPAC328.06-1.

Protein family/group databases

MEROPSi C19.A56.

Proteomic databases

MaxQBi Q9P3U0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC328.06.1 ; SPAC328.06.1:pep ; SPAC328.06 .
GeneIDi 2542059.
KEGGi spo:SPAC328.06.

Organism-specific databases

PomBasei SPAC328.06.

Phylogenomic databases

eggNOGi NOG275561.
InParanoidi Q9P3U0.
KOi K11849.
OMAi PESHETK.
OrthoDBi EOG7327X3.
PhylomeDBi Q9P3U0.

Miscellaneous databases

NextBioi 20803133.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR025305. UCH_repeat_domain.
[Graphical view ]
Pfami PF13446. RPT. 3 hits.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-112; SER-113; THR-115; THR-721 AND SER-722, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiUBP2_SCHPO
AccessioniPrimary (citable) accession number: Q9P3U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3