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Protein

Probable ubiquitin carboxyl-terminal hydrolase 2

Gene

ubp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei623NucleophilePROSITE-ProRule annotation1
Active sitei1076Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.A56

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 2
Ubiquitin thioesterase 2
Ubiquitin-specific-processing protease 2
Gene namesi
Name:ubp2
ORF Names:SPAC328.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC328.06
PomBaseiSPAC328.06 ubp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806031 – 1141Probable ubiquitin carboxyl-terminal hydrolase 2Add BLAST1141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112Phosphothreonine1 Publication1
Modified residuei113Phosphoserine1 Publication1
Modified residuei115Phosphothreonine1 Publication1
Modified residuei721Phosphothreonine1 Publication1
Modified residuei722Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P3U0
PaxDbiQ9P3U0
PRIDEiQ9P3U0

PTM databases

iPTMnetiQ9P3U0

Interactioni

Protein-protein interaction databases

BioGridi278537, 149 interactors
STRINGi4896.SPAC328.06.1

Structurei

3D structure databases

ProteinModelPortaliQ9P3U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini614 – 1124USPAdd BLAST511

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiQ9P3U0
KOiK11849
OMAiFRKYNDE
OrthoDBiEOG092C04TL
PhylomeDBiQ9P3U0

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR025305 UCH_repeat_domain
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF13446 RPT, 4 hits
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P3U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVKNLRIG KSPNRLIQDL DVFDSPSAGW NDPWSPHSSR YHWQLHSNLG
60 70 80 90 100
ESAVFDENDF WCVCQKTRKH LHVKVRRDRG KPLIEEPEEN YGIKDRIPVY
110 120 130 140 150
YEEEELPEPH VTSPTKSEFA TTSTCMKWSS KTTKSEIEVE WRDSYLDANC
160 170 180 190 200
IKEIIDSRRP SFASLLTKKS SSHQGSSHSS QPSLFTTFTS LELFLRNVLV
210 220 230 240 250
HNDQRAISAA PEGTFERHVG KGRQIQSLMK SLLFEYHHEN VNYVPTIADA
260 270 280 290 300
PLTDEQKLNL YLARNELIVL ANHFRDTKED PAIVANPFPV RLARPALINA
310 320 330 340 350
FGVPNYDSVV PMYTTVFRDN SASLPDDPAF IALGITNDYP DSFVRYFYEE
360 370 380 390 400
QKKNDEANVR VYADALAHIY NLRKSSFLRD LIAADRKNGI VSSDVIQAAY
410 420 430 440 450
SSLGLEAEVG PDYRYSQEKI FEAFHSALLR KPEFARAIRN DLETIGYARK
460 470 480 490 500
SSEILNYVLS TEQAFYTVNE AYQWLGIKSN TEDAMVASVA LVKFEDDSDK
510 520 530 540 550
AIEAVKWIAE ERNSSILYDF LASQGRPSNK KPKEVPMDED LAYNTLGVQD
560 570 580 590 600
RALSDDVLIN VYGFAVEDHP EQSDTLRAAL KCIGEVRNSR LITHYLEHGN
610 620 630 640 650
LDIPPEVSSL DTPIGLENTG NLCYLNSLIQ YYFIIKPLRN AILDIDENKD
660 670 680 690 700
LNMIENKEAV KKVGGRIVTR IEFLRALQFT YELRKLFIEL ITSKSSSVHP
710 720 730 740 750
SSVLTYLALI PLTLDQVKSG TSSVMDLSSS RELSNLNERS ITIDPRAEEQ
760 770 780 790 800
AQGLEQEQGQ DEAKSPAEQS SSVNLIDFPM ANTNGESQTQ PHYFEVSEEE
810 820 830 840 850
INSSMDLGRQ QDVLECIDHV LFQLEASLGR ISNSEDRLGS DNDLIRRLFS
860 870 880 890 900
GKLKQTLNDA SQGVRSNYEI FSHLIVDLFE EKQTLYDALD GVFETVNIDM
910 920 930 940 950
GSETAQRSLC ITELPIILQL QIQRVQFDRT TGQPFKSNAF VEFGKELSMD
960 970 980 990 1000
RYVEDTDGKM APLLQRYWDL KREIINLQKR QQLLLTTNSN LMSSVDTLSI
1010 1020 1030 1040 1050
LSKWAAQQQD SRLPINPKLP DILQEEINNV VAEVDMLKKQ EASLKEERTH
1060 1070 1080 1090 1100
LFDNYISHSY DLLAVFVHRG QASFGHYWTY IHDFENNVYR KYNDEYVTVV
1110 1120 1130 1140
DESEIFADTT GNNANPYMLT YIRKEYRHII ECVHREHNLL L
Length:1,141
Mass (Da):130,297
Last modified:October 1, 2000 - v1
Checksum:i1499E32DB6CB26CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB96001.1
RefSeqiNP_594208.1, NM_001019631.2

Genome annotation databases

EnsemblFungiiSPAC328.06.1; SPAC328.06.1:pep; SPAC328.06
GeneIDi2542059
KEGGispo:SPAC328.06

Similar proteinsi

Entry informationi

Entry nameiUBP2_SCHPO
AccessioniPrimary (citable) accession number: Q9P3U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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