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Q9P3U0

- UBP2_SCHPO

UniProt

Q9P3U0 - UBP2_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 2

Gene

ubp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei623 – 6231NucleophilePROSITE-ProRule annotation
    Active sitei1076 – 10761Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: PomBase
    2. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 2
    Ubiquitin thioesterase 2
    Ubiquitin-specific-processing protease 2
    Gene namesi
    Name:ubp2
    ORF Names:SPAC328.06
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC328.06.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11411141Probable ubiquitin carboxyl-terminal hydrolase 2PRO_0000080603Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei112 – 1121Phosphothreonine1 Publication
    Modified residuei113 – 1131Phosphoserine1 Publication
    Modified residuei115 – 1151Phosphothreonine1 Publication
    Modified residuei721 – 7211Phosphothreonine1 Publication
    Modified residuei722 – 7221Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P3U0.

    Interactioni

    Protein-protein interaction databases

    BioGridi278537. 142 interactions.
    MINTiMINT-4703705.
    STRINGi4896.SPAC328.06-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P3U0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini614 – 1124511USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG275561.
    KOiK11849.
    OMAiPESHETK.
    OrthoDBiEOG7327X3.
    PhylomeDBiQ9P3U0.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR025305. UCH_repeat_domain.
    [Graphical view]
    PfamiPF13446. RPT. 3 hits.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P3U0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVKNLRIG KSPNRLIQDL DVFDSPSAGW NDPWSPHSSR YHWQLHSNLG     50
    ESAVFDENDF WCVCQKTRKH LHVKVRRDRG KPLIEEPEEN YGIKDRIPVY 100
    YEEEELPEPH VTSPTKSEFA TTSTCMKWSS KTTKSEIEVE WRDSYLDANC 150
    IKEIIDSRRP SFASLLTKKS SSHQGSSHSS QPSLFTTFTS LELFLRNVLV 200
    HNDQRAISAA PEGTFERHVG KGRQIQSLMK SLLFEYHHEN VNYVPTIADA 250
    PLTDEQKLNL YLARNELIVL ANHFRDTKED PAIVANPFPV RLARPALINA 300
    FGVPNYDSVV PMYTTVFRDN SASLPDDPAF IALGITNDYP DSFVRYFYEE 350
    QKKNDEANVR VYADALAHIY NLRKSSFLRD LIAADRKNGI VSSDVIQAAY 400
    SSLGLEAEVG PDYRYSQEKI FEAFHSALLR KPEFARAIRN DLETIGYARK 450
    SSEILNYVLS TEQAFYTVNE AYQWLGIKSN TEDAMVASVA LVKFEDDSDK 500
    AIEAVKWIAE ERNSSILYDF LASQGRPSNK KPKEVPMDED LAYNTLGVQD 550
    RALSDDVLIN VYGFAVEDHP EQSDTLRAAL KCIGEVRNSR LITHYLEHGN 600
    LDIPPEVSSL DTPIGLENTG NLCYLNSLIQ YYFIIKPLRN AILDIDENKD 650
    LNMIENKEAV KKVGGRIVTR IEFLRALQFT YELRKLFIEL ITSKSSSVHP 700
    SSVLTYLALI PLTLDQVKSG TSSVMDLSSS RELSNLNERS ITIDPRAEEQ 750
    AQGLEQEQGQ DEAKSPAEQS SSVNLIDFPM ANTNGESQTQ PHYFEVSEEE 800
    INSSMDLGRQ QDVLECIDHV LFQLEASLGR ISNSEDRLGS DNDLIRRLFS 850
    GKLKQTLNDA SQGVRSNYEI FSHLIVDLFE EKQTLYDALD GVFETVNIDM 900
    GSETAQRSLC ITELPIILQL QIQRVQFDRT TGQPFKSNAF VEFGKELSMD 950
    RYVEDTDGKM APLLQRYWDL KREIINLQKR QQLLLTTNSN LMSSVDTLSI 1000
    LSKWAAQQQD SRLPINPKLP DILQEEINNV VAEVDMLKKQ EASLKEERTH 1050
    LFDNYISHSY DLLAVFVHRG QASFGHYWTY IHDFENNVYR KYNDEYVTVV 1100
    DESEIFADTT GNNANPYMLT YIRKEYRHII ECVHREHNLL L 1141
    Length:1,141
    Mass (Da):130,297
    Last modified:October 1, 2000 - v1
    Checksum:i1499E32DB6CB26CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB96001.1.
    RefSeqiNP_594208.1. NM_001019631.2.

    Genome annotation databases

    EnsemblFungiiSPAC328.06.1; SPAC328.06.1:pep; SPAC328.06.
    GeneIDi2542059.
    KEGGispo:SPAC328.06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB96001.1 .
    RefSeqi NP_594208.1. NM_001019631.2.

    3D structure databases

    ProteinModelPortali Q9P3U0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278537. 142 interactions.
    MINTi MINT-4703705.
    STRINGi 4896.SPAC328.06-1.

    Protein family/group databases

    MEROPSi C19.A56.

    Proteomic databases

    MaxQBi Q9P3U0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC328.06.1 ; SPAC328.06.1:pep ; SPAC328.06 .
    GeneIDi 2542059.
    KEGGi spo:SPAC328.06.

    Organism-specific databases

    PomBasei SPAC328.06.

    Phylogenomic databases

    eggNOGi NOG275561.
    KOi K11849.
    OMAi PESHETK.
    OrthoDBi EOG7327X3.
    PhylomeDBi Q9P3U0.

    Miscellaneous databases

    NextBioi 20803133.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR025305. UCH_repeat_domain.
    [Graphical view ]
    Pfami PF13446. RPT. 3 hits.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-112; SER-113; THR-115; THR-721 AND SER-722, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiUBP2_SCHPO
    AccessioniPrimary (citable) accession number: Q9P3U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3