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Protein

Putative phosphatidate cytidylyltransferase

Gene

SPBC13A2.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase, mitochondrial (tam41), Putative phosphatidate cytidylyltransferase (SPBC13A2.03)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-SPO-1483148. Synthesis of PG.
R-SPO-1483226. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
ORF Names:SPBC13A2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC13A2.03.
PomBaseiSPBC13A2.03.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 71HelicalSequence analysisAdd BLAST20
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei180 – 199HelicalSequence analysisAdd BLAST20
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003162161 – 439Putative phosphatidate cytidylyltransferaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P381.
PRIDEiQ9P381.

PTM databases

iPTMnetiQ9P381.

Interactioni

Protein-protein interaction databases

MINTiMINT-4703599.

Structurei

3D structure databases

ProteinModelPortaliQ9P381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000209582.
InParanoidiQ9P381.
KOiK00981.
OMAiITRSIWT.
OrthoDBiEOG092C3NVX.
PhylomeDBiQ9P381.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKRTNKRN NSDKENGNVG VVQNKDSASS KTTEPARLTK HKSLARKPSQ
60 70 80 90 100
NFITRTIWTF LLLGIFFTAL AMGHFWVVLL VTIVQIGVYK EVIAIASVPS
110 120 130 140 150
REKDLPWTRF INWYFLMTTL YYAYGESIYA YFHHLFIMDS FMLPLVLHHR
160 170 180 190 200
FISFMLYIIG FVLFVASLKK GNYKFQFSQF CWTHMTLLLV VGQSHFMINN
210 220 230 240 250
LFEGLFWFFV PVCYVVCNDV FAYLCGKMFG KHPLIQVSPK KTVEGFLGGW
260 270 280 290 300
ICTVVIGSLI SYVLMHFKYF ICPTRDLSTS AFSGLNCTPN SVFLPHTYTI
310 320 330 340 350
PAVFVDTFRL PETITLAPIY FHLAIFATFS SLIAPFGGFF ASGLKRAFKI
360 370 380 390 400
KDFGASIPGH GGLTDRMDCQ FLNGVFVYMY FQSFIAEKST SVADLLDTAV
410 420 430
YSLTTTQQVQ LVEDLQNYLI SHGKTSVQAI CSKLLQNSK
Length:439
Mass (Da):49,937
Last modified:October 1, 2000 - v1
Checksum:i8285DA1826049BB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB99396.1.
RefSeqiNP_596416.1. NM_001022335.2.

Genome annotation databases

EnsemblFungiiSPBC13A2.03.1; SPBC13A2.03.1:pep; SPBC13A2.03.
GeneIDi2540017.
KEGGispo:SPBC13A2.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB99396.1.
RefSeqiNP_596416.1. NM_001022335.2.

3D structure databases

ProteinModelPortaliQ9P381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4703599.

PTM databases

iPTMnetiQ9P381.

Proteomic databases

MaxQBiQ9P381.
PRIDEiQ9P381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC13A2.03.1; SPBC13A2.03.1:pep; SPBC13A2.03.
GeneIDi2540017.
KEGGispo:SPBC13A2.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC13A2.03.
PomBaseiSPBC13A2.03.

Phylogenomic databases

HOGENOMiHOG000209582.
InParanoidiQ9P381.
KOiK00981.
OMAiITRSIWT.
OrthoDBiEOG092C3NVX.
PhylomeDBiQ9P381.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
ReactomeiR-SPO-1483148. Synthesis of PG.
R-SPO-1483226. Synthesis of PI.

Miscellaneous databases

PROiQ9P381.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDSH_SCHPO
AccessioniPrimary (citable) accession number: Q9P381
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.