SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9P381

- CDSH_SCHPO

UniProt

Q9P381 - CDSH_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative phosphatidate cytidylyltransferase

Gene
SPBC13A2.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade By similarity.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: PomBase

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
  2. phosphatidylglycerol biosynthetic process Source: PomBase
  3. phosphatidylserine metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_188328. Synthesis of PG.
REACT_188329. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
ORF Names:SPBC13A2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC13A2.03.

Subcellular locationi

Mitochondrion membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7120Helical; Reviewed predictionAdd
BLAST
Transmembranei76 – 9823Helical; Reviewed predictionAdd
BLAST
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Transmembranei180 – 19920Helical; Reviewed predictionAdd
BLAST
Transmembranei245 – 26521Helical; Reviewed predictionAdd
BLAST
Transmembranei321 – 34121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Putative phosphatidate cytidylyltransferasePRO_0000316216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P381.

Interactioni

Protein-protein interaction databases

MINTiMINT-4703599.
STRINGi4896.SPBC13A2.03-1.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000209582.
KOiK00981.
OMAiNFAWTHM.
OrthoDBiEOG7XDBQH.
PhylomeDBiQ9P381.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P381-1 [UniParc]FASTAAdd to Basket

« Hide

MARKRTNKRN NSDKENGNVG VVQNKDSASS KTTEPARLTK HKSLARKPSQ    50
NFITRTIWTF LLLGIFFTAL AMGHFWVVLL VTIVQIGVYK EVIAIASVPS 100
REKDLPWTRF INWYFLMTTL YYAYGESIYA YFHHLFIMDS FMLPLVLHHR 150
FISFMLYIIG FVLFVASLKK GNYKFQFSQF CWTHMTLLLV VGQSHFMINN 200
LFEGLFWFFV PVCYVVCNDV FAYLCGKMFG KHPLIQVSPK KTVEGFLGGW 250
ICTVVIGSLI SYVLMHFKYF ICPTRDLSTS AFSGLNCTPN SVFLPHTYTI 300
PAVFVDTFRL PETITLAPIY FHLAIFATFS SLIAPFGGFF ASGLKRAFKI 350
KDFGASIPGH GGLTDRMDCQ FLNGVFVYMY FQSFIAEKST SVADLLDTAV 400
YSLTTTQQVQ LVEDLQNYLI SHGKTSVQAI CSKLLQNSK 439
Length:439
Mass (Da):49,937
Last modified:October 1, 2000 - v1
Checksum:i8285DA1826049BB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB99396.1.
RefSeqiNP_596416.1. NM_001022335.2.

Genome annotation databases

EnsemblFungiiSPBC13A2.03.1; SPBC13A2.03.1:pep; SPBC13A2.03.
GeneIDi2540017.
KEGGispo:SPBC13A2.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB99396.1 .
RefSeqi NP_596416.1. NM_001022335.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4703599.
STRINGi 4896.SPBC13A2.03-1.

Proteomic databases

MaxQBi Q9P381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC13A2.03.1 ; SPBC13A2.03.1:pep ; SPBC13A2.03 .
GeneIDi 2540017.
KEGGi spo:SPBC13A2.03.

Organism-specific databases

PomBasei SPBC13A2.03.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000209582.
KOi K00981.
OMAi NFAWTHM.
OrthoDBi EOG7XDBQH.
PhylomeDBi Q9P381.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
Reactomei REACT_188328. Synthesis of PG.
REACT_188329. Synthesis of PI.

Miscellaneous databases

NextBioi 20801160.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCDSH_SCHPO
AccessioniPrimary (citable) accession number: Q9P381
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi