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Q9P327

- PLB4_SCHPO

UniProt

Q9P327 - PLB4_SCHPO

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Protein
Putative lysophospholipase C977.09c/C1348.10c
Gene
SPAC977.09c
SPBC1348.10c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
  2. phospholipase activity Source: PomBase

GO - Biological processi

  1. glycerophospholipid catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Putative lysophospholipase C977.09c/C1348.10c (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
ORF Names:SPAC977.09c
AND
ORF Names:SPBC1348.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I, UP000002485: Chromosome II
PomBaseiSPAC977.09c.
SPBC1348.10c.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. external side of plasma membrane Source: PomBase
  4. extracellular region Source: PomBase
  5. fungal-type cell wall Source: PomBase
  6. nucleus Source: PomBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 673654Putative lysophospholipase C977.09c/C1348.10c
PRO_0000024642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi404 – 4041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9P327.
PaxDbiQ9P327.

Interactioni

Protein-protein interaction databases

BioGridi857870. 42 interactions.
MINTiMINT-4703485.
STRINGi4896.SPBC1348.10c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P327.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 615542PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271081.
HOGENOMiHOG000189547.
KOiK13333.
OMAiLQSATYM.
OrthoDBiEOG7N37NC.
PhylomeDBiQ9P327.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P327-1 [UniParc]FASTAAdd to Basket

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MYVNYIGLFA FVQISLTLAY PPGRVEISEI YDFEESSSYK GQDIDTSVLY    50
TLSKRKPALV KRSTDASYAP FNVTCSNDNL LRPASEGLNE GEQSYINKRI 100
SKVNSELRSF ISKTGLNVDL DKVVNSSDGP RLGIAFSGGG LRAMVNGGGA 150
FNAFDSRFES DSPLSGLLQS AMYISGLSGG SWLVGSVAIN NFTNITYLRD 200
NVWNLEHSVF APHGDNVIEN LNYYNDLRKE IDQKKHAGFD CSLTDLWGRA 250
LSRKLVDAER GGPGITYSSM RNQSWFQNAD YPYPIIVADS RLEEETAIPA 300
NTSIFEFTAY EFGTWDNGIK AFIPMEYVGT HLLDGVPPDK SCIHNYDNAG 350
FVMGTSATLF NSFLLDWNEN VKKNDTYYDI LHAILEDLSK HQDDIAPYPN 400
PYQNYTTSNT SVVNAFEPYD TIDLVDGGED RENIPLWPLL HPQRFVDVVF 450
AIDSTYNDPY GWPLGSSIVA TYERVVTFNA NKSVDVRGFP YIPDENTIIS 500
LGLNTRPTFF GCDGKNTTAG NHDVDNNTPP LLVYFPNYPW TYYSNISTFT 550
MSMDDKMANG ILENAFMSTT QNNNESFAVC LACAIIQRSL ERKKLSTPTQ 600
CSSCFQEYCW DGTLATSTAS VYDPTVMSAA TTSRAPSGTT SGTASSTTSS 650
SVASATPTHK HWWDSIFEAK ENP 673
Length:673
Mass (Da):74,596
Last modified:October 1, 2000 - v1
Checksum:iB39A773E76CD694B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB94277.1.
CU329670 Genomic DNA. Translation: CAB69631.1.
D89183 mRNA. Translation: BAA13845.1.
PIRiT50281.
RefSeqiNP_592772.1. NM_001020935.2.
NP_592781.1. NM_001018181.2.

Genome annotation databases

EnsemblFungiiSPAC977.09c.1; SPAC977.09c.1:pep; SPAC977.09c.
SPBC1348.10c.1; SPBC1348.10c.1:pep; SPBC1348.10c.
GeneIDi2541836.
5802732.
KEGGispo:SPAC977.09c.
spo:SPBC1348.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB94277.1 .
CU329670 Genomic DNA. Translation: CAB69631.1 .
D89183 mRNA. Translation: BAA13845.1 .
PIRi T50281.
RefSeqi NP_592772.1. NM_001020935.2.
NP_592781.1. NM_001018181.2.

3D structure databases

ProteinModelPortali Q9P327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 857870. 42 interactions.
MINTi MINT-4703485.
STRINGi 4896.SPBC1348.10c-1.

Proteomic databases

MaxQBi Q9P327.
PaxDbi Q9P327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC977.09c.1 ; SPAC977.09c.1:pep ; SPAC977.09c .
SPBC1348.10c.1 ; SPBC1348.10c.1:pep ; SPBC1348.10c .
GeneIDi 2541836.
5802732.
KEGGi spo:SPAC977.09c.
spo:SPBC1348.10c.

Organism-specific databases

PomBasei SPAC977.09c.
SPBC1348.10c.

Phylogenomic databases

eggNOGi NOG271081.
HOGENOMi HOG000189547.
KOi K13333.
OMAi LQSATYM.
OrthoDBi EOG7N37NC.
PhylomeDBi Q9P327.

Miscellaneous databases

NextBioi 20802924.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 427-673.
    Strain: PR745.

Entry informationi

Entry nameiPLB4_SCHPO
AccessioniPrimary (citable) accession number: Q9P327
Secondary accession number(s): P78834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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