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Q9P327

- PLB4_SCHPO

UniProt

Q9P327 - PLB4_SCHPO

Protein

Putative lysophospholipase C977.09c/C1348.10c

Gene

SPAC977.09c

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC
    2. phospholipase activity Source: PomBase

    GO - Biological processi

    1. glycerophospholipid catabolic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative lysophospholipase C977.09c/C1348.10c (EC:3.1.1.5)
    Alternative name(s):
    Phospholipase B
    Gene namesi
    ORF Names:SPAC977.09c
    AND
    ORF Names:SPBC1348.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I, UP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPAC977.09c.
    SPBC1348.10c.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. endoplasmic reticulum Source: PomBase
    3. external side of plasma membrane Source: PomBase
    4. extracellular region Source: PomBase
    5. fungal-type cell wall Source: PomBase
    6. nucleus Source: PomBase

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 673654Putative lysophospholipase C977.09c/C1348.10cPRO_0000024642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9P327.
    PaxDbiQ9P327.

    Interactioni

    Protein-protein interaction databases

    BioGridi857870. 42 interactions.
    MINTiMINT-4703485.
    STRINGi4896.SPBC1348.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 615542PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG271081.
    HOGENOMiHOG000189547.
    KOiK13333.
    OMAiLQSATYM.
    OrthoDBiEOG7N37NC.
    PhylomeDBiQ9P327.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P327-1 [UniParc]FASTAAdd to Basket

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    MYVNYIGLFA FVQISLTLAY PPGRVEISEI YDFEESSSYK GQDIDTSVLY    50
    TLSKRKPALV KRSTDASYAP FNVTCSNDNL LRPASEGLNE GEQSYINKRI 100
    SKVNSELRSF ISKTGLNVDL DKVVNSSDGP RLGIAFSGGG LRAMVNGGGA 150
    FNAFDSRFES DSPLSGLLQS AMYISGLSGG SWLVGSVAIN NFTNITYLRD 200
    NVWNLEHSVF APHGDNVIEN LNYYNDLRKE IDQKKHAGFD CSLTDLWGRA 250
    LSRKLVDAER GGPGITYSSM RNQSWFQNAD YPYPIIVADS RLEEETAIPA 300
    NTSIFEFTAY EFGTWDNGIK AFIPMEYVGT HLLDGVPPDK SCIHNYDNAG 350
    FVMGTSATLF NSFLLDWNEN VKKNDTYYDI LHAILEDLSK HQDDIAPYPN 400
    PYQNYTTSNT SVVNAFEPYD TIDLVDGGED RENIPLWPLL HPQRFVDVVF 450
    AIDSTYNDPY GWPLGSSIVA TYERVVTFNA NKSVDVRGFP YIPDENTIIS 500
    LGLNTRPTFF GCDGKNTTAG NHDVDNNTPP LLVYFPNYPW TYYSNISTFT 550
    MSMDDKMANG ILENAFMSTT QNNNESFAVC LACAIIQRSL ERKKLSTPTQ 600
    CSSCFQEYCW DGTLATSTAS VYDPTVMSAA TTSRAPSGTT SGTASSTTSS 650
    SVASATPTHK HWWDSIFEAK ENP 673
    Length:673
    Mass (Da):74,596
    Last modified:October 1, 2000 - v1
    Checksum:iB39A773E76CD694B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB94277.1.
    CU329670 Genomic DNA. Translation: CAB69631.1.
    D89183 mRNA. Translation: BAA13845.1.
    PIRiT50281.
    RefSeqiNP_592772.1. NM_001020935.2.
    NP_592781.1. NM_001018181.2.

    Genome annotation databases

    EnsemblFungiiSPAC977.09c.1; SPAC977.09c.1:pep; SPAC977.09c.
    SPBC1348.10c.1; SPBC1348.10c.1:pep; SPBC1348.10c.
    GeneIDi2541836.
    5802732.
    KEGGispo:SPAC977.09c.
    spo:SPBC1348.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB94277.1 .
    CU329670 Genomic DNA. Translation: CAB69631.1 .
    D89183 mRNA. Translation: BAA13845.1 .
    PIRi T50281.
    RefSeqi NP_592772.1. NM_001020935.2.
    NP_592781.1. NM_001018181.2.

    3D structure databases

    ProteinModelPortali Q9P327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 857870. 42 interactions.
    MINTi MINT-4703485.
    STRINGi 4896.SPBC1348.10c-1.

    Proteomic databases

    MaxQBi Q9P327.
    PaxDbi Q9P327.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC977.09c.1 ; SPAC977.09c.1:pep ; SPAC977.09c .
    SPBC1348.10c.1 ; SPBC1348.10c.1:pep ; SPBC1348.10c .
    GeneIDi 2541836.
    5802732.
    KEGGi spo:SPAC977.09c.
    spo:SPBC1348.10c.

    Organism-specific databases

    PomBasei SPAC977.09c.
    SPBC1348.10c.

    Phylogenomic databases

    eggNOGi NOG271081.
    HOGENOMi HOG000189547.
    KOi K13333.
    OMAi LQSATYM.
    OrthoDBi EOG7N37NC.
    PhylomeDBi Q9P327.

    Miscellaneous databases

    NextBioi 20802924.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 427-673.
      Strain: PR745.

    Entry informationi

    Entry nameiPLB4_SCHPO
    AccessioniPrimary (citable) accession number: Q9P327
    Secondary accession number(s): P78834
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3