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Protein

Putative lysophospholipase C977.09c/C1348.10c

Gene

SPAC977.09c

more
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
  2. phospholipase activity Source: PomBase

GO - Biological processi

  1. glycerophospholipid catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lysophospholipase C977.09c/C1348.10c (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
ORF Names:SPAC977.09c
AND
ORF Names:SPBC1348.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componentsi: Chromosome I, Chromosome II

Organism-specific databases

PomBaseiSPAC977.09c.
SPBC1348.10c.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. external side of plasma membrane Source: PomBase
  4. extracellular region Source: PomBase
  5. fungal-type cell wall Source: PomBase
  6. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 673654Putative lysophospholipase C977.09c/C1348.10cPRO_0000024642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9P327.
PaxDbiQ9P327.

Interactioni

Protein-protein interaction databases

BioGridi857870. 42 interactions.
MINTiMINT-4703485.
STRINGi4896.SPBC1348.10c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9P327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 615542PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271081.
HOGENOMiHOG000189547.
InParanoidiQ9P327.
KOiK13333.
OMAiLQSATYM.
OrthoDBiEOG7N37NC.
PhylomeDBiQ9P327.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVNYIGLFA FVQISLTLAY PPGRVEISEI YDFEESSSYK GQDIDTSVLY
60 70 80 90 100
TLSKRKPALV KRSTDASYAP FNVTCSNDNL LRPASEGLNE GEQSYINKRI
110 120 130 140 150
SKVNSELRSF ISKTGLNVDL DKVVNSSDGP RLGIAFSGGG LRAMVNGGGA
160 170 180 190 200
FNAFDSRFES DSPLSGLLQS AMYISGLSGG SWLVGSVAIN NFTNITYLRD
210 220 230 240 250
NVWNLEHSVF APHGDNVIEN LNYYNDLRKE IDQKKHAGFD CSLTDLWGRA
260 270 280 290 300
LSRKLVDAER GGPGITYSSM RNQSWFQNAD YPYPIIVADS RLEEETAIPA
310 320 330 340 350
NTSIFEFTAY EFGTWDNGIK AFIPMEYVGT HLLDGVPPDK SCIHNYDNAG
360 370 380 390 400
FVMGTSATLF NSFLLDWNEN VKKNDTYYDI LHAILEDLSK HQDDIAPYPN
410 420 430 440 450
PYQNYTTSNT SVVNAFEPYD TIDLVDGGED RENIPLWPLL HPQRFVDVVF
460 470 480 490 500
AIDSTYNDPY GWPLGSSIVA TYERVVTFNA NKSVDVRGFP YIPDENTIIS
510 520 530 540 550
LGLNTRPTFF GCDGKNTTAG NHDVDNNTPP LLVYFPNYPW TYYSNISTFT
560 570 580 590 600
MSMDDKMANG ILENAFMSTT QNNNESFAVC LACAIIQRSL ERKKLSTPTQ
610 620 630 640 650
CSSCFQEYCW DGTLATSTAS VYDPTVMSAA TTSRAPSGTT SGTASSTTSS
660 670
SVASATPTHK HWWDSIFEAK ENP
Length:673
Mass (Da):74,596
Last modified:September 30, 2000 - v1
Checksum:iB39A773E76CD694B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB94277.1.
CU329670 Genomic DNA. Translation: CAB69631.1.
D89183 mRNA. Translation: BAA13845.1.
PIRiT50281.
RefSeqiNP_592772.1. NM_001020935.2.
NP_592781.1. NM_001018181.2.

Genome annotation databases

EnsemblFungiiSPAC977.09c.1; SPAC977.09c.1:pep; SPAC977.09c.
SPBC1348.10c.1; SPBC1348.10c.1:pep; SPBC1348.10c.
GeneIDi2541836.
5802732.
KEGGispo:SPAC977.09c.
spo:SPBC1348.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB94277.1.
CU329670 Genomic DNA. Translation: CAB69631.1.
D89183 mRNA. Translation: BAA13845.1.
PIRiT50281.
RefSeqiNP_592772.1. NM_001020935.2.
NP_592781.1. NM_001018181.2.

3D structure databases

ProteinModelPortaliQ9P327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi857870. 42 interactions.
MINTiMINT-4703485.
STRINGi4896.SPBC1348.10c-1.

Proteomic databases

MaxQBiQ9P327.
PaxDbiQ9P327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC977.09c.1; SPAC977.09c.1:pep; SPAC977.09c.
SPBC1348.10c.1; SPBC1348.10c.1:pep; SPBC1348.10c.
GeneIDi2541836.
5802732.
KEGGispo:SPAC977.09c.
spo:SPBC1348.10c.

Organism-specific databases

PomBaseiSPAC977.09c.
SPBC1348.10c.

Phylogenomic databases

eggNOGiNOG271081.
HOGENOMiHOG000189547.
InParanoidiQ9P327.
KOiK13333.
OMAiLQSATYM.
OrthoDBiEOG7N37NC.
PhylomeDBiQ9P327.

Miscellaneous databases

NextBioi20802924.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 427-673.
    Strain: PR745.

Entry informationi

Entry nameiPLB4_SCHPO
AccessioniPrimary (citable) accession number: Q9P327
Secondary accession number(s): P78834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2003
Last sequence update: September 30, 2000
Last modified: January 6, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.