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Protein

THAP domain-containing protein 10

Gene

THAP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 9090THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 10
Gene namesi
Name:THAP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:23193. THAP10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988462.

Polymorphism and mutation databases

BioMutaiTHAP10.
DMDMi41018369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257THAP domain-containing protein 10PRO_0000068651Add
BLAST

Proteomic databases

MaxQBiQ9P2Z0.
PaxDbiQ9P2Z0.
PRIDEiQ9P2Z0.

PTM databases

PhosphoSiteiQ9P2Z0.

Expressioni

Gene expression databases

BgeeiQ9P2Z0.
CleanExiHS_THAP10.
ExpressionAtlasiQ9P2Z0. baseline and differential.
GenevisibleiQ9P2Z0. HS.

Organism-specific databases

HPAiHPA041416.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952734EBI-745404,EBI-748961
KRTAP10-5P603703EBI-745404,EBI-10172150
KRTAP10-8P604103EBI-745404,EBI-10171774
KRTAP10-9P604113EBI-745404,EBI-10172052
LZTS2Q9BRK43EBI-745404,EBI-741037
PTSQ033933EBI-745404,EBI-712344

Protein-protein interaction databases

BioGridi121236. 11 interactions.
IntActiQ9P2Z0. 8 interactions.
MINTiMINT-1473877.
STRINGi9606.ENSP00000249861.

Structurei

3D structure databases

ProteinModelPortaliQ9P2Z0.
SMRiQ9P2Z0. Positions 1-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 9090THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG67707.
GeneTreeiENSGT00510000050001.
HOGENOMiHOG000059577.
HOVERGENiHBG079250.
InParanoidiQ9P2Z0.
OMAiHRSVGIQ.
OrthoDBiEOG7TF79Z.
PhylomeDBiQ9P2Z0.
TreeFamiTF330127.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR
60 70 80 90 100
SVICSDHFAP ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG
110 120 130 140 150
EEGDQAGRLD TRGELQAARH SEAAPGPVSC TRPRAGKQAA ASQITCENEL
160 170 180 190 200
VQTQPHADNP SNTVTSVPTH CEEGPVHKST QISLKRPRHR SVGIQAKVKA
210 220 230 240 250
FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS EQSDLSYMAV

QVKEETC
Length:257
Mass (Da):28,351
Last modified:October 1, 2000 - v1
Checksum:i912602126537AD41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360202 mRNA. Translation: CAB96109.1.
AK313472 mRNA. Translation: BAG36257.1.
CH471082 Genomic DNA. Translation: EAW77863.1.
BC027857 mRNA. Translation: AAH27857.1.
BC072414 mRNA. Translation: AAH72414.1.
CCDSiCCDS10237.1.
RefSeqiNP_064532.1. NM_020147.3.
UniGeneiHs.591123.

Genome annotation databases

EnsembliENST00000249861; ENSP00000249861; ENSG00000129028.
GeneIDi56906.
KEGGihsa:56906.
UCSCiuc002asv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360202 mRNA. Translation: CAB96109.1.
AK313472 mRNA. Translation: BAG36257.1.
CH471082 Genomic DNA. Translation: EAW77863.1.
BC027857 mRNA. Translation: AAH27857.1.
BC072414 mRNA. Translation: AAH72414.1.
CCDSiCCDS10237.1.
RefSeqiNP_064532.1. NM_020147.3.
UniGeneiHs.591123.

3D structure databases

ProteinModelPortaliQ9P2Z0.
SMRiQ9P2Z0. Positions 1-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121236. 11 interactions.
IntActiQ9P2Z0. 8 interactions.
MINTiMINT-1473877.
STRINGi9606.ENSP00000249861.

PTM databases

PhosphoSiteiQ9P2Z0.

Polymorphism and mutation databases

BioMutaiTHAP10.
DMDMi41018369.

Proteomic databases

MaxQBiQ9P2Z0.
PaxDbiQ9P2Z0.
PRIDEiQ9P2Z0.

Protocols and materials databases

DNASUi56906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249861; ENSP00000249861; ENSG00000129028.
GeneIDi56906.
KEGGihsa:56906.
UCSCiuc002asv.3. human.

Organism-specific databases

CTDi56906.
GeneCardsiGC15M071173.
HGNCiHGNC:23193. THAP10.
HPAiHPA041416.
MIMi612538. gene.
neXtProtiNX_Q9P2Z0.
PharmGKBiPA134988462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG67707.
GeneTreeiENSGT00510000050001.
HOGENOMiHOG000059577.
HOVERGENiHBG079250.
InParanoidiQ9P2Z0.
OMAiHRSVGIQ.
OrthoDBiEOG7TF79Z.
PhylomeDBiQ9P2Z0.
TreeFamiTF330127.

Miscellaneous databases

GenomeRNAii56906.
NextBioi62375.
PROiQ9P2Z0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2Z0.
CleanExiHS_THAP10.
ExpressionAtlasiQ9P2Z0. baseline and differential.
GenevisibleiQ9P2Z0. HS.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Skin.

Entry informationi

Entry nameiTHA10_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Z0
Secondary accession number(s): B2R8R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.