Q9P2Z0 (THA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THAP domain-containing protein 10

Gene names

Name:

THAP10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 THAP-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	THAP domain-containing protein 10		PRO_0000068651
Regions
	Zinc finger	1 – 90	90	THAP-type

Sequences

	Sequence		Length	Mass (Da)
	Q9P2Z0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 912602126537AD41	FASTA	257	28,351
	10 20 30 40 50 60 MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR SVICSDHFAP 70 80 90 100 110 120 ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG EEGDQAGRLD TRGELQAARH 130 140 150 160 170 180 SEAAPGPVSC TRPRAGKQAA ASQITCENEL VQTQPHADNP SNTVTSVPTH CEEGPVHKST 190 200 210 220 230 240 QISLKRPRHR SVGIQAKVKA FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS 250 EQSDLSYMAV QVKEETC

References

[1]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Substantia nigra.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL360202 mRNA. Translation: CAB96109.1. AK313472 mRNA. Translation: BAG36257.1. CH471082 Genomic DNA. Translation: EAW77863.1. BC027857 mRNA. Translation: AAH27857.1. BC072414 mRNA. Translation: AAH72414.1.
IPI	IPI00024542.
RefSeq	NP_064532.1. NM_020147.3.
UniGene	Hs.591123.
3D structure databases
ProteinModelPortal	Q9P2Z0.
SMR	Q9P2Z0. Positions 1-94.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2Z0. 2 interactions.
MINT	MINT-1473877.
STRING	9606.ENSP00000249861.
PTM databases
PhosphoSite	Q9P2Z0.
Polymorphism databases
DMDM	41018369.
Proteomic databases
PaxDb	Q9P2Z0.
PRIDE	Q9P2Z0.
Protocols and materials databases
DNASU	56906.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249861; ENSP00000249861; ENSG00000129028.
GeneID	56906.
KEGG	hsa:56906.
UCSC	uc002asv.3. human.
Organism-specific databases
CTD	56906.
GeneCards	GC15M071173.
HGNC	HGNC:23193. THAP10.
HPA	HPA041416.
MIM	612538. gene.
neXtProt	NX_Q9P2Z0.
PharmGKB	PA134988462.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG67707.
HOGENOM	HOG000059577.
HOVERGEN	HBG079250.
InParanoid	Q9P2Z0.
OMA	HRSVGIQ.
OrthoDB	EOG48PMKV.
PhylomeDB	Q9P2Z0.
Gene expression databases
Bgee	Q9P2Z0.
CleanEx	HS_THAP10.
Genevestigator	Q9P2Z0.
GermOnline	ENSG00000129028. Homo sapiens.
Family and domain databases
InterPro	IPR006612. Znf_C2CH. [Graphical view]
Pfam	PF05485. THAP. 1 hit. [Graphical view]
SMART	SM00692. DM3. 1 hit. SM00980. THAP. 1 hit. [Graphical view]
PROSITE	PS50950. ZF_THAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56906.
NextBio	62375.
SOURCE	Search...

Entry information

Entry name

THA10_HUMAN

Accession

Primary (citable) accession number: Q9P2Z0
Secondary accession number(s): B2R8R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.