Reviewed,
UniProtKB/Swiss-Prot Q9P2Y5 (UVRAG_HUMAN)
Last modified
June 16, 2009.
Version 57.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UV radiation resistance-associated gene protein Alternative name(s): p63 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 699 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Domain | Coiled coil |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | DNA repair Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 699 | 699 | UV radiation resistance-associated gene protein | PRO_0000065750 | |||||
Regions | |||||||||
| Domain | 44 – 128 | 85 | C2 | ||||||
| Coiled coil | 224 – 305 | 82 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 83 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 498 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 518 | 1 | Phosphothreonine Ref.4 Ref.5 | ||||||
Experimental info | |||||||||
| Sequence conflict | 641 – 699 | 59 | TGFAS…RSSDK → QVSPQVIS Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." Perelman B., Dafni N., Naiman T., Eli D., Yaakov M., Feng T.L.Y., Sinha S., Weber G., Khodaei S., Sancar A., Dotan I., Canaani D. Genomics 41:397-405(1997) [PubMed: 9169138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation." Iida A., Emi M., Matsuoka R., Hiratsuka E., Okui K., Ohashi H., Inazawa J., Fukushima Y., Imai T., Nakamura Y. Hum. Genet. 106:277-287(2000) [PubMed: 10798355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Heart. |
| [3] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, MASS SPECTROMETRY. |
| [4] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498 AND THR-518, MASS SPECTROMETRY. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-518, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X99050 Genomic DNA. Translation: CAA67507.1. AB012958 mRNA. Translation: BAA90829.1. | |
| IPI | IPI00002614. |
| RefSeq | NP_003360.2. |
| UniGene | Hs.714328 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9P2Y5. |
Proteomic databases | |
| PRIDE | Q9P2Y5. |
Genome annotation databases | |
| Ensembl | ENSG00000198382. Homo sapiens. [Contig view] |
| GeneID | 7405. |
| KEGG | hsa:7405. |
Organism-specific databases | |
| GeneCards | GC11P075203. |
| HGNC | HGNC:12640. UVRAG. |
| HPA | HPA016932. |
| MIM | 602493. gene. |
| PharmGKB | PA37264. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9P2Y5. |
| HOVERGEN | Q9P2Y5. |
| OMA | Q9P2Y5. AEEIIGM. |
Gene expression databases | |
| ArrayExpress | Q9P2Y5. |
| Bgee | Q9P2Y5. |
| CleanEx | HS_UVRAG. |
Family and domain databases | |
| InterPro | IPR000008. C2_Ca-dep. [Graphical view] |
| SMART | SM00239. C2. 1 hit. [Graphical view] |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 28992. |
| SOURCE | Search... |
Entry information
| Entry name | UVRAG_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9P2Y5 Secondary accession number(s): O00392 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
