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Q9P2Y4

- ZN219_HUMAN

UniProt

Q9P2Y4 - ZN219_HUMAN

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Protein

Zinc finger protein 219

Gene
ZNF219
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1Add
BLAST
Zinc fingeri85 – 10723C2H2-type 2Add
BLAST
Zinc fingeri163 – 18624C2H2-type 3Add
BLAST
Zinc fingeri274 – 29623C2H2-type 4Add
BLAST
Zinc fingeri302 – 32423C2H2-type 5Add
BLAST
Zinc fingeri498 – 52023C2H2-type 6Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. histamine receptor activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of neurotransmitter levels Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 219
Gene namesi
Name:ZNF219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:13011. ZNF219.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Zinc finger protein 219PRO_0000047461Add
BLAST

Proteomic databases

MaxQBiQ9P2Y4.
PaxDbiQ9P2Y4.
PRIDEiQ9P2Y4.

PTM databases

PhosphoSiteiQ9P2Y4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9P2Y4.
BgeeiQ9P2Y4.
CleanExiHS_ZNF219.
GenevestigatoriQ9P2Y4.

Organism-specific databases

HPAiHPA030761.
HPA056168.

Interactioni

Protein-protein interaction databases

BioGridi119387. 8 interactions.
IntActiQ9P2Y4. 8 interactions.
MINTiMINT-8247371.
STRINGi9606.ENSP00000354206.

Structurei

3D structure databases

ProteinModelPortaliQ9P2Y4.
SMRiQ9P2Y4. Positions 57-210, 271-327, 468-580, 636-675.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1Add
BLAST
Zinc fingeri85 – 10723C2H2-type 2Add
BLAST
Zinc fingeri163 – 18624C2H2-type 3Add
BLAST
Zinc fingeri274 – 29623C2H2-type 4Add
BLAST
Zinc fingeri302 – 32423C2H2-type 5Add
BLAST
Zinc fingeri498 – 52023C2H2-type 6Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG327366.
HOGENOMiHOG000140857.
HOVERGENiHBG054187.
InParanoidiQ9P2Y4.
OMAiDASPPYA.
OrthoDBiEOG7D59N5.
PhylomeDBiQ9P2Y4.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
PRINTSiPR01471. HISTAMINEH3R.
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2Y4-1 [UniParc]FASTAAdd to Basket

« Hide

MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES    50
RAGERRFPCP VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL 100
RSHLRTHQPE RPRSPAARLL LELEERALLR EARLGRARSS GGMQATPATE 150
GLARPQAPSS SAFRCPYCKG KFRTSAERER HLHILHRPWK CGLCSFGSSQ 200
EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP RSVPQPEPEP 250
EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF 300
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG 350
LLAYEPLGPA LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP 400
GRSFGGFRPL SSALPARARR HRAEEPEEEE EVVEAEEETW ARGRSLGSLA 450
SLHPRPGEGP GHSASAAGAQ ARSTATQEEN GLLVGGTRPE GGRGATGKDC 500
PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS LKYHLQRHHR 550
EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG 600
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF 650
CPFATGAPEL MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS 700
QEGEEGSGLS RPGEAGLGGQ ER 722
Length:722
Mass (Da):76,877
Last modified:November 23, 2004 - v2
Checksum:iAB2B6B37904FC14B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601P → T.2 Publications
Corresponds to variant rs17853549 [ dbSNP | Ensembl ].
VAR_067624

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2332Missing in AAH00694. 1 Publication
Sequence conflicti436 – 4361E → Q in BAA90526. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSiCCDS9568.1.
RefSeqiNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.1.
XP_006720227.1. XM_006720164.1.
UniGeneiHs.250493.

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneIDi51222.
KEGGihsa:51222.
UCSCiuc001vzr.2. human.

Polymorphism databases

DMDMi55977885.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015427 mRNA. Translation: BAA90526.1 .
BT006956 mRNA. Translation: AAP35602.1 .
CH471078 Genomic DNA. Translation: EAW66404.1 .
CH471078 Genomic DNA. Translation: EAW66405.1 .
CH471078 Genomic DNA. Translation: EAW66406.1 .
CH471078 Genomic DNA. Translation: EAW66407.1 .
BC000694 mRNA. Translation: AAH00694.1 .
BC036105 mRNA. Translation: AAH36105.1 .
CCDSi CCDS9568.1.
RefSeqi NP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.1.
XP_006720227.1. XM_006720164.1.
UniGenei Hs.250493.

3D structure databases

ProteinModelPortali Q9P2Y4.
SMRi Q9P2Y4. Positions 57-210, 271-327, 468-580, 636-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119387. 8 interactions.
IntActi Q9P2Y4. 8 interactions.
MINTi MINT-8247371.
STRINGi 9606.ENSP00000354206.

PTM databases

PhosphoSitei Q9P2Y4.

Polymorphism databases

DMDMi 55977885.

Proteomic databases

MaxQBi Q9P2Y4.
PaxDbi Q9P2Y4.
PRIDEi Q9P2Y4.

Protocols and materials databases

DNASUi 51222.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360947 ; ENSP00000354206 ; ENSG00000165804 .
ENST00000421093 ; ENSP00000392401 ; ENSG00000165804 .
ENST00000451119 ; ENSP00000388558 ; ENSG00000165804 .
GeneIDi 51222.
KEGGi hsa:51222.
UCSCi uc001vzr.2. human.

Organism-specific databases

CTDi 51222.
GeneCardsi GC14M021558.
HGNCi HGNC:13011. ZNF219.
HPAi HPA030761.
HPA056168.
MIMi 605036. gene.
neXtProti NX_Q9P2Y4.
PharmGKBi PA37590.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327366.
HOGENOMi HOG000140857.
HOVERGENi HBG054187.
InParanoidi Q9P2Y4.
OMAi DASPPYA.
OrthoDBi EOG7D59N5.
PhylomeDBi Q9P2Y4.
TreeFami TF332241.

Miscellaneous databases

GeneWikii ZNF219.
GenomeRNAii 51222.
NextBioi 54298.
PROi Q9P2Y4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P2Y4.
Bgeei Q9P2Y4.
CleanExi HS_ZNF219.
Genevestigatori Q9P2Y4.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
[Graphical view ]
PRINTSi PR01471. HISTAMINEH3R.
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region."
    Sakai T., Toyoda A., Hashimoto K., Maeda H.
    DNA Res. 7:137-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
    Tissue: Brain and Kidney.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN219_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Y4
Secondary accession number(s): D3DS16
, Q53Y57, Q8IYC1, Q9BW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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