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Q9P2Y4

- ZN219_HUMAN

UniProt

Q9P2Y4 - ZN219_HUMAN

Protein

Zinc finger protein 219

Gene

ZNF219

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri85 – 10723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri163 – 18624C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri274 – 29623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. histamine receptor activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of neurotransmitter levels Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 219
    Gene namesi
    Name:ZNF219
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:13011. ZNF219.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37590.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 722722Zinc finger protein 219PRO_0000047461Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2Y4.
    PaxDbiQ9P2Y4.
    PRIDEiQ9P2Y4.

    PTM databases

    PhosphoSiteiQ9P2Y4.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9P2Y4.
    BgeeiQ9P2Y4.
    CleanExiHS_ZNF219.
    GenevestigatoriQ9P2Y4.

    Organism-specific databases

    HPAiHPA030761.
    HPA056168.

    Interactioni

    Protein-protein interaction databases

    BioGridi119387. 8 interactions.
    IntActiQ9P2Y4. 8 interactions.
    MINTiMINT-8247371.
    STRINGi9606.ENSP00000354206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2Y4.
    SMRiQ9P2Y4. Positions 57-210, 271-327, 468-580, 636-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri85 – 10723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri163 – 18624C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri274 – 29623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327366.
    HOGENOMiHOG000140857.
    HOVERGENiHBG054187.
    InParanoidiQ9P2Y4.
    OMAiDASPPYA.
    OrthoDBiEOG7D59N5.
    PhylomeDBiQ9P2Y4.
    TreeFamiTF332241.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR003980. Histamine_H3_rcpt.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 4 hits.
    [Graphical view]
    PRINTSiPR01471. HISTAMINEH3R.
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P2Y4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES    50
    RAGERRFPCP VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL 100
    RSHLRTHQPE RPRSPAARLL LELEERALLR EARLGRARSS GGMQATPATE 150
    GLARPQAPSS SAFRCPYCKG KFRTSAERER HLHILHRPWK CGLCSFGSSQ 200
    EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP RSVPQPEPEP 250
    EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF 300
    DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG 350
    LLAYEPLGPA LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP 400
    GRSFGGFRPL SSALPARARR HRAEEPEEEE EVVEAEEETW ARGRSLGSLA 450
    SLHPRPGEGP GHSASAAGAQ ARSTATQEEN GLLVGGTRPE GGRGATGKDC 500
    PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS LKYHLQRHHR 550
    EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG 600
    AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF 650
    CPFATGAPEL MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS 700
    QEGEEGSGLS RPGEAGLGGQ ER 722
    Length:722
    Mass (Da):76,877
    Last modified:November 23, 2004 - v2
    Checksum:iAB2B6B37904FC14B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2332Missing in AAH00694. (PubMed:15489334)Curated
    Sequence conflicti436 – 4361E → Q in BAA90526. (PubMed:10819330)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti260 – 2601P → T.2 Publications
    Corresponds to variant rs17853549 [ dbSNP | Ensembl ].
    VAR_067624

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015427 mRNA. Translation: BAA90526.1.
    BT006956 mRNA. Translation: AAP35602.1.
    CH471078 Genomic DNA. Translation: EAW66404.1.
    CH471078 Genomic DNA. Translation: EAW66405.1.
    CH471078 Genomic DNA. Translation: EAW66406.1.
    CH471078 Genomic DNA. Translation: EAW66407.1.
    BC000694 mRNA. Translation: AAH00694.1.
    BC036105 mRNA. Translation: AAH36105.1.
    CCDSiCCDS9568.1.
    RefSeqiNP_001095142.1. NM_001101672.1.
    NP_001095924.1. NM_001102454.1.
    NP_057507.2. NM_016423.2.
    XP_006720226.1. XM_006720163.1.
    XP_006720227.1. XM_006720164.1.
    UniGeneiHs.250493.

    Genome annotation databases

    EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
    ENST00000421093; ENSP00000392401; ENSG00000165804.
    ENST00000451119; ENSP00000388558; ENSG00000165804.
    GeneIDi51222.
    KEGGihsa:51222.
    UCSCiuc001vzr.2. human.

    Polymorphism databases

    DMDMi55977885.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015427 mRNA. Translation: BAA90526.1 .
    BT006956 mRNA. Translation: AAP35602.1 .
    CH471078 Genomic DNA. Translation: EAW66404.1 .
    CH471078 Genomic DNA. Translation: EAW66405.1 .
    CH471078 Genomic DNA. Translation: EAW66406.1 .
    CH471078 Genomic DNA. Translation: EAW66407.1 .
    BC000694 mRNA. Translation: AAH00694.1 .
    BC036105 mRNA. Translation: AAH36105.1 .
    CCDSi CCDS9568.1.
    RefSeqi NP_001095142.1. NM_001101672.1.
    NP_001095924.1. NM_001102454.1.
    NP_057507.2. NM_016423.2.
    XP_006720226.1. XM_006720163.1.
    XP_006720227.1. XM_006720164.1.
    UniGenei Hs.250493.

    3D structure databases

    ProteinModelPortali Q9P2Y4.
    SMRi Q9P2Y4. Positions 57-210, 271-327, 468-580, 636-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119387. 8 interactions.
    IntActi Q9P2Y4. 8 interactions.
    MINTi MINT-8247371.
    STRINGi 9606.ENSP00000354206.

    PTM databases

    PhosphoSitei Q9P2Y4.

    Polymorphism databases

    DMDMi 55977885.

    Proteomic databases

    MaxQBi Q9P2Y4.
    PaxDbi Q9P2Y4.
    PRIDEi Q9P2Y4.

    Protocols and materials databases

    DNASUi 51222.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360947 ; ENSP00000354206 ; ENSG00000165804 .
    ENST00000421093 ; ENSP00000392401 ; ENSG00000165804 .
    ENST00000451119 ; ENSP00000388558 ; ENSG00000165804 .
    GeneIDi 51222.
    KEGGi hsa:51222.
    UCSCi uc001vzr.2. human.

    Organism-specific databases

    CTDi 51222.
    GeneCardsi GC14M021558.
    HGNCi HGNC:13011. ZNF219.
    HPAi HPA030761.
    HPA056168.
    MIMi 605036. gene.
    neXtProti NX_Q9P2Y4.
    PharmGKBi PA37590.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327366.
    HOGENOMi HOG000140857.
    HOVERGENi HBG054187.
    InParanoidi Q9P2Y4.
    OMAi DASPPYA.
    OrthoDBi EOG7D59N5.
    PhylomeDBi Q9P2Y4.
    TreeFami TF332241.

    Miscellaneous databases

    GeneWikii ZNF219.
    GenomeRNAii 51222.
    NextBioi 54298.
    PROi Q9P2Y4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2Y4.
    Bgeei Q9P2Y4.
    CleanExi HS_ZNF219.
    Genevestigatori Q9P2Y4.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR003980. Histamine_H3_rcpt.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 4 hits.
    [Graphical view ]
    PRINTSi PR01471. HISTAMINEH3R.
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region."
      Sakai T., Toyoda A., Hashimoto K., Maeda H.
      DNA Res. 7:137-141(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Testis.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
      Tissue: Brain and Kidney.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN219_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2Y4
    Secondary accession number(s): D3DS16
    , Q53Y57, Q8IYC1, Q9BW28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3