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Q9P2Y4 (ZN219_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 219
Gene names
Name:ZNF219
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length722 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 6 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 722722Zinc finger protein 219
PRO_0000047461

Regions

Zinc finger57 – 7923C2H2-type 1
Zinc finger85 – 10723C2H2-type 2
Zinc finger163 – 18624C2H2-type 3
Zinc finger274 – 29623C2H2-type 4
Zinc finger302 – 32423C2H2-type 5
Zinc finger498 – 52023C2H2-type 6

Natural variations

Natural variant2601P → T. Ref.2 Ref.4
Corresponds to variant rs17853549 [ dbSNP | Ensembl ].
VAR_067624

Experimental info

Sequence conflict232 – 2332Missing in AAH00694. Ref.4
Sequence conflict4361E → Q in BAA90526. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9P2Y4 [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: AB2B6B37904FC14B

FASTA72276,877
        10         20         30         40         50         60 
MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES RAGERRFPCP 

        70         80         90        100        110        120 
VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL RSHLRTHQPE RPRSPAARLL 

       130        140        150        160        170        180 
LELEERALLR EARLGRARSS GGMQATPATE GLARPQAPSS SAFRCPYCKG KFRTSAERER 

       190        200        210        220        230        240 
HLHILHRPWK CGLCSFGSSQ EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP 

       250        260        270        280        290        300 
RSVPQPEPEP EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF 

       310        320        330        340        350        360 
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG LLAYEPLGPA 

       370        380        390        400        410        420 
LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP GRSFGGFRPL SSALPARARR 

       430        440        450        460        470        480 
HRAEEPEEEE EVVEAEEETW ARGRSLGSLA SLHPRPGEGP GHSASAAGAQ ARSTATQEEN 

       490        500        510        520        530        540 
GLLVGGTRPE GGRGATGKDC PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS 

       550        560        570        580        590        600 
LKYHLQRHHR EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG 

       610        620        630        640        650        660 
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF CPFATGAPEL 

       670        680        690        700        710        720 
MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS QEGEEGSGLS RPGEAGLGGQ 


ER 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region."
Sakai T., Toyoda A., Hashimoto K., Maeda H.
DNA Res. 7:137-141(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Testis.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
Tissue: Brain and Kidney.
[5]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSCCDS9568.1.
RefSeqNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.1.
XP_006720227.1. XM_006720164.1.
UniGeneHs.250493.

3D structure databases

ProteinModelPortalQ9P2Y4.
SMRQ9P2Y4. Positions 57-210, 271-327, 468-580, 636-675.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119387. 8 interactions.
IntActQ9P2Y4. 8 interactions.
MINTMINT-8247371.
STRING9606.ENSP00000354206.

PTM databases

PhosphoSiteQ9P2Y4.

Polymorphism databases

DMDM55977885.

Proteomic databases

MaxQBQ9P2Y4.
PaxDbQ9P2Y4.
PRIDEQ9P2Y4.

Protocols and materials databases

DNASU51222.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneID51222.
KEGGhsa:51222.
UCSCuc001vzr.2. human.

Organism-specific databases

CTD51222.
GeneCardsGC14M021558.
HGNCHGNC:13011. ZNF219.
HPAHPA030761.
HPA056168.
MIM605036. gene.
neXtProtNX_Q9P2Y4.
PharmGKBPA37590.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327366.
HOGENOMHOG000140857.
HOVERGENHBG054187.
InParanoidQ9P2Y4.
OMADASPPYA.
OrthoDBEOG7D59N5.
PhylomeDBQ9P2Y4.
TreeFamTF332241.

Gene expression databases

ArrayExpressQ9P2Y4.
BgeeQ9P2Y4.
CleanExHS_ZNF219.
GenevestigatorQ9P2Y4.

Family and domain databases

Gene3D3.30.160.60. 6 hits.
InterProIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 4 hits.
[Graphical view]
PRINTSPR01471. HISTAMINEH3R.
SMARTSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF219.
GenomeRNAi51222.
NextBio54298.
PROQ9P2Y4.
SOURCESearch...

Entry information

Entry nameZN219_HUMAN
AccessionPrimary (citable) accession number: Q9P2Y4
Secondary accession number(s): D3DS16 expand/collapse secondary AC list , Q53Y57, Q8IYC1, Q9BW28
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM