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Protein

Zinc finger protein 219

Gene

ZNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri85 – 10723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18624C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. histamine receptor activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  3. regulation of neurotransmitter levels Source: InterPro
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 219
Gene namesi
Name:ZNF219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:13011. ZNF219.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Zinc finger protein 219PRO_0000047461Add
BLAST

Proteomic databases

MaxQBiQ9P2Y4.
PaxDbiQ9P2Y4.
PRIDEiQ9P2Y4.

PTM databases

PhosphoSiteiQ9P2Y4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9P2Y4.
CleanExiHS_ZNF219.
ExpressionAtlasiQ9P2Y4. baseline and differential.
GenevestigatoriQ9P2Y4.

Organism-specific databases

HPAiHPA030761.
HPA056168.

Interactioni

Protein-protein interaction databases

BioGridi119387. 40 interactions.
IntActiQ9P2Y4. 8 interactions.
MINTiMINT-8247371.
STRINGi9606.ENSP00000354206.

Structurei

3D structure databases

ProteinModelPortaliQ9P2Y4.
SMRiQ9P2Y4. Positions 57-210, 268-332, 395-428, 468-549, 636-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri85 – 10723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18624C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG327366.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000140857.
HOVERGENiHBG054187.
InParanoidiQ9P2Y4.
OMAiDASPPYA.
OrthoDBiEOG7D59N5.
PhylomeDBiQ9P2Y4.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
PRINTSiPR01471. HISTAMINEH3R.
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2Y4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES
60 70 80 90 100
RAGERRFPCP VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL
110 120 130 140 150
RSHLRTHQPE RPRSPAARLL LELEERALLR EARLGRARSS GGMQATPATE
160 170 180 190 200
GLARPQAPSS SAFRCPYCKG KFRTSAERER HLHILHRPWK CGLCSFGSSQ
210 220 230 240 250
EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP RSVPQPEPEP
260 270 280 290 300
EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF
310 320 330 340 350
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG
360 370 380 390 400
LLAYEPLGPA LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP
410 420 430 440 450
GRSFGGFRPL SSALPARARR HRAEEPEEEE EVVEAEEETW ARGRSLGSLA
460 470 480 490 500
SLHPRPGEGP GHSASAAGAQ ARSTATQEEN GLLVGGTRPE GGRGATGKDC
510 520 530 540 550
PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS LKYHLQRHHR
560 570 580 590 600
EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG
610 620 630 640 650
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF
660 670 680 690 700
CPFATGAPEL MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS
710 720
QEGEEGSGLS RPGEAGLGGQ ER
Length:722
Mass (Da):76,877
Last modified:November 23, 2004 - v2
Checksum:iAB2B6B37904FC14B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2332Missing in AAH00694. (PubMed:15489334)Curated
Sequence conflicti436 – 4361E → Q in BAA90526. (PubMed:10819330)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601P → T.2 Publications
Corresponds to variant rs17853549 [ dbSNP | Ensembl ].
VAR_067624

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSiCCDS9568.1.
RefSeqiNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.1.
XP_006720227.1. XM_006720164.1.
UniGeneiHs.250493.

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneIDi51222.
KEGGihsa:51222.
UCSCiuc001vzr.2. human.

Polymorphism databases

DMDMi55977885.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSiCCDS9568.1.
RefSeqiNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.1.
XP_006720227.1. XM_006720164.1.
UniGeneiHs.250493.

3D structure databases

ProteinModelPortaliQ9P2Y4.
SMRiQ9P2Y4. Positions 57-210, 268-332, 395-428, 468-549, 636-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119387. 40 interactions.
IntActiQ9P2Y4. 8 interactions.
MINTiMINT-8247371.
STRINGi9606.ENSP00000354206.

PTM databases

PhosphoSiteiQ9P2Y4.

Polymorphism databases

DMDMi55977885.

Proteomic databases

MaxQBiQ9P2Y4.
PaxDbiQ9P2Y4.
PRIDEiQ9P2Y4.

Protocols and materials databases

DNASUi51222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneIDi51222.
KEGGihsa:51222.
UCSCiuc001vzr.2. human.

Organism-specific databases

CTDi51222.
GeneCardsiGC14M021558.
HGNCiHGNC:13011. ZNF219.
HPAiHPA030761.
HPA056168.
MIMi605036. gene.
neXtProtiNX_Q9P2Y4.
PharmGKBiPA37590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327366.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000140857.
HOVERGENiHBG054187.
InParanoidiQ9P2Y4.
OMAiDASPPYA.
OrthoDBiEOG7D59N5.
PhylomeDBiQ9P2Y4.
TreeFamiTF332241.

Miscellaneous databases

ChiTaRSiZNF219. human.
GeneWikiiZNF219.
GenomeRNAii51222.
NextBioi54298.
PROiQ9P2Y4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2Y4.
CleanExiHS_ZNF219.
ExpressionAtlasiQ9P2Y4. baseline and differential.
GenevestigatoriQ9P2Y4.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
PRINTSiPR01471. HISTAMINEH3R.
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region."
    Sakai T., Toyoda A., Hashimoto K., Maeda H.
    DNA Res. 7:137-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-260.
    Tissue: Brain and Kidney.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN219_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Y4
Secondary accession number(s): D3DS16
, Q53Y57, Q8IYC1, Q9BW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.