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Protein

Zinc finger protein 219

Gene

ZNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri274 – 296C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of neurotransmitter levels Source: InterPro
  • regulation of transcription, DNA-templated Source: UniProtKB
  • signal transduction Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165804-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 219
Gene namesi
Name:ZNF219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:13011. ZNF219.

Subcellular locationi

GO - Cellular componenti

  • integral component of membrane Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165804.
PharmGKBiPA37590.

Polymorphism and mutation databases

BioMutaiZNF219.
DMDMi55977885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474611 – 722Zinc finger protein 219Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2Y4.
MaxQBiQ9P2Y4.
PaxDbiQ9P2Y4.
PeptideAtlasiQ9P2Y4.
PRIDEiQ9P2Y4.

PTM databases

iPTMnetiQ9P2Y4.
PhosphoSitePlusiQ9P2Y4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000165804.
CleanExiHS_ZNF219.
ExpressionAtlasiQ9P2Y4. baseline and differential.
GenevisibleiQ9P2Y4. HS.

Organism-specific databases

HPAiHPA030761.
HPA056168.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LMO1P258003EBI-3937106,EBI-8639312
TTC32Q5I0X73EBI-3937106,EBI-8636434

Protein-protein interaction databases

BioGridi119387. 43 interactors.
IntActiQ9P2Y4. 13 interactors.
MINTiMINT-8247371.
STRINGi9606.ENSP00000354206.

Structurei

3D structure databases

ProteinModelPortaliQ9P2Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri274 – 296C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000140857.
HOVERGENiHBG054187.
InParanoidiQ9P2Y4.
OMAiDASPPYA.
OrthoDBiEOG091G05JC.
PhylomeDBiQ9P2Y4.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PRINTSiPR01471. HISTAMINEH3R.
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES
60 70 80 90 100
RAGERRFPCP VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL
110 120 130 140 150
RSHLRTHQPE RPRSPAARLL LELEERALLR EARLGRARSS GGMQATPATE
160 170 180 190 200
GLARPQAPSS SAFRCPYCKG KFRTSAERER HLHILHRPWK CGLCSFGSSQ
210 220 230 240 250
EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP RSVPQPEPEP
260 270 280 290 300
EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF
310 320 330 340 350
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG
360 370 380 390 400
LLAYEPLGPA LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP
410 420 430 440 450
GRSFGGFRPL SSALPARARR HRAEEPEEEE EVVEAEEETW ARGRSLGSLA
460 470 480 490 500
SLHPRPGEGP GHSASAAGAQ ARSTATQEEN GLLVGGTRPE GGRGATGKDC
510 520 530 540 550
PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS LKYHLQRHHR
560 570 580 590 600
EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG
610 620 630 640 650
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF
660 670 680 690 700
CPFATGAPEL MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS
710 720
QEGEEGSGLS RPGEAGLGGQ ER
Length:722
Mass (Da):76,877
Last modified:November 23, 2004 - v2
Checksum:iAB2B6B37904FC14B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232 – 233Missing in AAH00694 (PubMed:15489334).Curated2
Sequence conflicti436E → Q in BAA90526 (PubMed:10819330).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067624260P → T.2 PublicationsCorresponds to variant rs17853549dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSiCCDS9568.1.
RefSeqiNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.2.
XP_006720227.1. XM_006720164.3.
XP_016876843.1. XM_017021354.1.
XP_016876844.1. XM_017021355.1.
UniGeneiHs.250493.

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneIDi51222.
KEGGihsa:51222.
UCSCiuc001vzr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA. Translation: BAA90526.1.
BT006956 mRNA. Translation: AAP35602.1.
CH471078 Genomic DNA. Translation: EAW66404.1.
CH471078 Genomic DNA. Translation: EAW66405.1.
CH471078 Genomic DNA. Translation: EAW66406.1.
CH471078 Genomic DNA. Translation: EAW66407.1.
BC000694 mRNA. Translation: AAH00694.1.
BC036105 mRNA. Translation: AAH36105.1.
CCDSiCCDS9568.1.
RefSeqiNP_001095142.1. NM_001101672.1.
NP_001095924.1. NM_001102454.1.
NP_057507.2. NM_016423.2.
XP_006720226.1. XM_006720163.2.
XP_006720227.1. XM_006720164.3.
XP_016876843.1. XM_017021354.1.
XP_016876844.1. XM_017021355.1.
UniGeneiHs.250493.

3D structure databases

ProteinModelPortaliQ9P2Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119387. 43 interactors.
IntActiQ9P2Y4. 13 interactors.
MINTiMINT-8247371.
STRINGi9606.ENSP00000354206.

PTM databases

iPTMnetiQ9P2Y4.
PhosphoSitePlusiQ9P2Y4.

Polymorphism and mutation databases

BioMutaiZNF219.
DMDMi55977885.

Proteomic databases

EPDiQ9P2Y4.
MaxQBiQ9P2Y4.
PaxDbiQ9P2Y4.
PeptideAtlasiQ9P2Y4.
PRIDEiQ9P2Y4.

Protocols and materials databases

DNASUi51222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804.
ENST00000421093; ENSP00000392401; ENSG00000165804.
ENST00000451119; ENSP00000388558; ENSG00000165804.
GeneIDi51222.
KEGGihsa:51222.
UCSCiuc001vzr.3. human.

Organism-specific databases

CTDi51222.
GeneCardsiZNF219.
HGNCiHGNC:13011. ZNF219.
HPAiHPA030761.
HPA056168.
MIMi605036. gene.
neXtProtiNX_Q9P2Y4.
OpenTargetsiENSG00000165804.
PharmGKBiPA37590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000140857.
HOVERGENiHBG054187.
InParanoidiQ9P2Y4.
OMAiDASPPYA.
OrthoDBiEOG091G05JC.
PhylomeDBiQ9P2Y4.
TreeFamiTF332241.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165804-MONOMER.

Miscellaneous databases

ChiTaRSiZNF219. human.
GeneWikiiZNF219.
GenomeRNAii51222.
PROiQ9P2Y4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165804.
CleanExiHS_ZNF219.
ExpressionAtlasiQ9P2Y4. baseline and differential.
GenevisibleiQ9P2Y4. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR003980. Histamine_H3_rcpt.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PRINTSiPR01471. HISTAMINEH3R.
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN219_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Y4
Secondary accession number(s): D3DS16
, Q53Y57, Q8IYC1, Q9BW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.