ID   DEC1_HUMAN              Reviewed;          70 AA.
AC   Q9P2X7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 123.
DE   RecName: Full=Deleted in esophageal cancer 1 {ECO:0000305};
DE   AltName: Full=Candidate tumor suppressor CTS9;
GN   Name=DELEC1 {ECO:0000312|HGNC:HGNC:23658}; Synonyms=CTS9, DEC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=10612805;
RX   DOI=10.1002/(sici)1098-2264(200002)27:2<169::aid-gcc8>3.3.co;2-d;
RA   Nishiwaki T., Daigo Y., Kawasoe T., Nakamura Y.;
RT   "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in
RT   esophageal cancer 1), derived from the tumor-suppressor locus on chromosome
RT   9q32.";
RL   Genes Chromosomes Cancer 27:169-176(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- FUNCTION: Candidate tumor suppressor. {ECO:0000269|PubMed:10612805}.
CC   -!- TISSUE SPECIFICITY: Expressed in many tissues, with highest expression
CC       in prostate and testis. Reduced expression in esophageal carcinomas.
CC       {ECO:0000269|PubMed:10612805}.
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DR   EMBL; AB022761; BAA96242.1; -; mRNA.
DR   EMBL; AL714001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_059114.1; NM_017418.2.
DR   AlphaFoldDB; Q9P2X7; -.
DR   BioGRID; 119083; 36.
DR   BioMuta; DEC1; -.
DR   PaxDb; 9606-ENSP00000363128; -.
DR   DNASU; 50514; -.
DR   UCSC; uc004bjk.1; human.
DR   AGR; HGNC:23658; -.
DR   GeneCards; DELEC1; -.
DR   HGNC; HGNC:23658; DELEC1.
DR   MIM; 604767; gene.
DR   neXtProt; NX_Q9P2X7; -.
DR   eggNOG; ENOG502TM3R; Eukaryota.
DR   HOGENOM; CLU_2757121_0_0_1; -.
DR   InParanoid; Q9P2X7; -.
DR   PhylomeDB; Q9P2X7; -.
DR   TreeFam; TF340655; -.
DR   PathwayCommons; Q9P2X7; -.
DR   SignaLink; Q9P2X7; -.
DR   BioGRID-ORCS; 50514; 13 hits in 1077 CRISPR screens.
DR   ChiTaRS; DEC1; human.
DR   GeneWiki; DEC1; -.
DR   GenomeRNAi; 50514; -.
DR   Pharos; Q9P2X7; Tbio.
DR   PRO; PR:Q9P2X7; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9P2X7; Protein.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR   InterPro; IPR031718; DEC1.
DR   Pfam; PF15859; DEC1; 1.
DR   Genevisible; Q9P2X7; HS.
PE   2: Evidence at transcript level;
KW   Reference proteome; Tumor suppressor.
FT   CHAIN           1..70
FT                   /note="Deleted in esophageal cancer 1"
FT                   /id="PRO_0000240631"
FT   VARIANT         60
FT                   /note="A -> V (in dbSNP:rs2269700)"
FT                   /id="VAR_050948"
SQ   SEQUENCE   70 AA;  7542 MW;  91FA5AD3C402EF43 CRC64;
     MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN GGKDFAVSLA
     RPKAAEGIAD
//