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Protein

Deleted in esophageal cancer 1

Gene

DEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Candidate tumor suppressor.1 Publication

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in esophageal cancer 1
Alternative name(s):
Candidate tumor suppressor CTS9
Gene namesi
Name:DEC1
Synonyms:CTS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23658. DEC1.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi50514.
MalaCardsiDEC1.
OpenTargetsiENSG00000173077.
PharmGKBiPA134898625.

Polymorphism and mutation databases

BioMutaiDEC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406311 – 70Deleted in esophageal cancer 1Add BLAST70

Proteomic databases

PaxDbiQ9P2X7.
PRIDEiQ9P2X7.

Expressioni

Tissue specificityi

Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000173077.
CleanExiHS_DEC1.
ExpressionAtlasiQ9P2X7. baseline and differential.
GenevisibleiQ9P2X7. HS.

Interactioni

Protein-protein interaction databases

BioGridi119083. 32 interactors.
STRINGi9606.ENSP00000363128.

Structurei

3D structure databases

ProteinModelPortaliQ9P2X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KEC0. Eukaryota.
ENOG4111BDC. LUCA.
GeneTreeiENSGT00390000016096.
HOGENOMiHOG000112187.
InParanoidiQ9P2X7.
OMAiWKSIVPA.
PhylomeDBiQ9P2X7.
TreeFamiTF340655.

Family and domain databases

InterProiView protein in InterPro
IPR031718. DEC1.
PfamiView protein in Pfam
PF15859. DEC1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P2X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN
60 70
GGKDFAVSLA RPKAAEGIAD
Length:70
Mass (Da):7,542
Last modified:October 1, 2000 - v1
Checksum:i91FA5AD3C402EF43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05094860A → V. Corresponds to variant dbSNP:rs2269700Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022761 mRNA. Translation: BAA96242.1.
AL714001 Genomic DNA. No translation available.
CCDSiCCDS6812.1.
RefSeqiNP_059114.1. NM_017418.2.
UniGeneiHs.148841.

Genome annotation databases

EnsembliENST00000374016; ENSP00000363128; ENSG00000173077.
GeneIDi50514.
KEGGihsa:50514.
UCSCiuc004bjk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDEC1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot