Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P2X7

- DEC1_HUMAN

UniProt

Q9P2X7 - DEC1_HUMAN

Protein

Deleted in esophageal cancer 1

Gene

DEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Candidate tumor suppressor.1 Publication

    GO - Biological processi

    1. negative regulation of cell proliferation Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deleted in esophageal cancer 1
    Alternative name(s):
    Candidate tumor suppressor CTS9
    Gene namesi
    Name:DEC1
    Synonyms:CTS9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23658. DEC1.

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134898625.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070Deleted in esophageal cancer 1PRO_0000240631Add
    BLAST

    Proteomic databases

    PaxDbiQ9P2X7.
    PRIDEiQ9P2X7.

    Expressioni

    Tissue specificityi

    Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.1 Publication

    Gene expression databases

    BgeeiQ9P2X7.
    CleanExiHS_DEC1.
    GenevestigatoriQ9P2X7.

    Interactioni

    Protein-protein interaction databases

    BioGridi119083. 2 interactions.
    STRINGi9606.ENSP00000363128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2X7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG70592.
    HOGENOMiHOG000112187.
    InParanoidiQ9P2X7.
    OMAiRERSVKW.
    OrthoDBiEOG7H4DXF.
    PhylomeDBiQ9P2X7.
    TreeFamiTF340655.

    Sequencei

    Sequence statusi: Complete.

    Q9P2X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN   50
    GGKDFAVSLA RPKAAEGIAD 70
    Length:70
    Mass (Da):7,542
    Last modified:October 1, 2000 - v1
    Checksum:i91FA5AD3C402EF43
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601A → V.
    Corresponds to variant rs2269700 [ dbSNP | Ensembl ].
    VAR_050948

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022761 mRNA. Translation: BAA96242.1.
    AL714001 Genomic DNA. Translation: CAI16660.1.
    CCDSiCCDS6812.1.
    RefSeqiNP_059114.1. NM_017418.2.
    UniGeneiHs.148841.

    Genome annotation databases

    EnsembliENST00000374016; ENSP00000363128; ENSG00000173077.
    GeneIDi50514.
    KEGGihsa:50514.
    UCSCiuc004bjk.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022761 mRNA. Translation: BAA96242.1 .
    AL714001 Genomic DNA. Translation: CAI16660.1 .
    CCDSi CCDS6812.1.
    RefSeqi NP_059114.1. NM_017418.2.
    UniGenei Hs.148841.

    3D structure databases

    ProteinModelPortali Q9P2X7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119083. 2 interactions.
    STRINGi 9606.ENSP00000363128.

    Proteomic databases

    PaxDbi Q9P2X7.
    PRIDEi Q9P2X7.

    Protocols and materials databases

    DNASUi 50514.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374016 ; ENSP00000363128 ; ENSG00000173077 .
    GeneIDi 50514.
    KEGGi hsa:50514.
    UCSCi uc004bjk.1. human.

    Organism-specific databases

    CTDi 50514.
    GeneCardsi GC09P117904.
    HGNCi HGNC:23658. DEC1.
    MIMi 604767. gene.
    neXtProti NX_Q9P2X7.
    PharmGKBi PA134898625.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70592.
    HOGENOMi HOG000112187.
    InParanoidi Q9P2X7.
    OMAi RERSVKW.
    OrthoDBi EOG7H4DXF.
    PhylomeDBi Q9P2X7.
    TreeFami TF340655.

    Miscellaneous databases

    GeneWikii DEC1.
    GenomeRNAii 50514.
    NextBioi 53090.
    PROi Q9P2X7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P2X7.
    CleanExi HS_DEC1.
    Genevestigatori Q9P2X7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32."
      Nishiwaki T., Daigo Y., Kawasoe T., Nakamura Y.
      Genes Chromosomes Cancer 27:169-176(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDEC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3