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Q9P2X7 (DEC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deleted in esophageal cancer 1
Alternative name(s):
Candidate tumor suppressor CTS9
Gene names
Name:DEC1
Synonyms:CTS9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Candidate tumor suppressor. Ref.1

Tissue specificity

Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas. Ref.1

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DiseaseTumor suppressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of cell proliferation

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7070Deleted in esophageal cancer 1
PRO_0000240631

Natural variations

Natural variant601A → V.
Corresponds to variant rs2269700 [ dbSNP | Ensembl ].
VAR_050948

Sequences

Sequence LengthMass (Da)Tools
Q9P2X7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 91FA5AD3C402EF43

FASTA707,542
        10         20         30         40         50         60 
MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN GGKDFAVSLA 

        70 
RPKAAEGIAD 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32."
Nishiwaki T., Daigo Y., Kawasoe T., Nakamura Y.
Genes Chromosomes Cancer 27:169-176(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB022761 mRNA. Translation: BAA96242.1.
AL714001 Genomic DNA. Translation: CAI16660.1.
CCDSCCDS6812.1.
RefSeqNP_059114.1. NM_017418.2.
UniGeneHs.148841.

3D structure databases

ProteinModelPortalQ9P2X7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119083. 2 interactions.
STRING9606.ENSP00000363128.

Proteomic databases

PaxDbQ9P2X7.
PRIDEQ9P2X7.

Protocols and materials databases

DNASU50514.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374016; ENSP00000363128; ENSG00000173077.
GeneID50514.
KEGGhsa:50514.
UCSCuc004bjk.1. human.

Organism-specific databases

CTD50514.
GeneCardsGC09P117904.
HGNCHGNC:23658. DEC1.
MIM604767. gene.
neXtProtNX_Q9P2X7.
PharmGKBPA134898625.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70592.
HOGENOMHOG000112187.
InParanoidQ9P2X7.
OMARERSVKW.
OrthoDBEOG7H4DXF.
PhylomeDBQ9P2X7.
TreeFamTF340655.

Gene expression databases

BgeeQ9P2X7.
CleanExHS_DEC1.
GenevestigatorQ9P2X7.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiDEC1.
GenomeRNAi50514.
NextBio53090.
PROQ9P2X7.
SOURCESearch...

Entry information

Entry nameDEC1_HUMAN
AccessionPrimary (citable) accession number: Q9P2X7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM