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Q9P2X7

- DEC1_HUMAN

UniProt

Q9P2X7 - DEC1_HUMAN

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Protein

Deleted in esophageal cancer 1

Gene
DEC1, CTS9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Candidate tumor suppressor.1 Publication

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in esophageal cancer 1
Alternative name(s):
Candidate tumor suppressor CTS9
Gene namesi
Name:DEC1
Synonyms:CTS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23658. DEC1.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134898625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Deleted in esophageal cancer 1PRO_0000240631Add
BLAST

Proteomic databases

PaxDbiQ9P2X7.
PRIDEiQ9P2X7.

Expressioni

Tissue specificityi

Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.1 Publication

Gene expression databases

BgeeiQ9P2X7.
CleanExiHS_DEC1.
GenevestigatoriQ9P2X7.

Interactioni

Protein-protein interaction databases

BioGridi119083. 2 interactions.
STRINGi9606.ENSP00000363128.

Structurei

3D structure databases

ProteinModelPortaliQ9P2X7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70592.
HOGENOMiHOG000112187.
InParanoidiQ9P2X7.
OMAiRERSVKW.
OrthoDBiEOG7H4DXF.
PhylomeDBiQ9P2X7.
TreeFamiTF340655.

Sequencei

Sequence statusi: Complete.

Q9P2X7-1 [UniParc]FASTAAdd to Basket

« Hide

MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN   50
GGKDFAVSLA RPKAAEGIAD 70
Length:70
Mass (Da):7,542
Last modified:October 1, 2000 - v1
Checksum:i91FA5AD3C402EF43
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601A → V.
Corresponds to variant rs2269700 [ dbSNP | Ensembl ].
VAR_050948

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022761 mRNA. Translation: BAA96242.1.
AL714001 Genomic DNA. Translation: CAI16660.1.
CCDSiCCDS6812.1.
RefSeqiNP_059114.1. NM_017418.2.
UniGeneiHs.148841.

Genome annotation databases

EnsembliENST00000374016; ENSP00000363128; ENSG00000173077.
GeneIDi50514.
KEGGihsa:50514.
UCSCiuc004bjk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022761 mRNA. Translation: BAA96242.1 .
AL714001 Genomic DNA. Translation: CAI16660.1 .
CCDSi CCDS6812.1.
RefSeqi NP_059114.1. NM_017418.2.
UniGenei Hs.148841.

3D structure databases

ProteinModelPortali Q9P2X7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119083. 2 interactions.
STRINGi 9606.ENSP00000363128.

Proteomic databases

PaxDbi Q9P2X7.
PRIDEi Q9P2X7.

Protocols and materials databases

DNASUi 50514.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374016 ; ENSP00000363128 ; ENSG00000173077 .
GeneIDi 50514.
KEGGi hsa:50514.
UCSCi uc004bjk.1. human.

Organism-specific databases

CTDi 50514.
GeneCardsi GC09P117904.
HGNCi HGNC:23658. DEC1.
MIMi 604767. gene.
neXtProti NX_Q9P2X7.
PharmGKBi PA134898625.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70592.
HOGENOMi HOG000112187.
InParanoidi Q9P2X7.
OMAi RERSVKW.
OrthoDBi EOG7H4DXF.
PhylomeDBi Q9P2X7.
TreeFami TF340655.

Miscellaneous databases

GeneWikii DEC1.
GenomeRNAii 50514.
NextBioi 53090.
PROi Q9P2X7.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2X7.
CleanExi HS_DEC1.
Genevestigatori Q9P2X7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32."
    Nishiwaki T., Daigo Y., Kawasoe T., Nakamura Y.
    Genes Chromosomes Cancer 27:169-176(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEC1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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