Q9P2X7 (DEC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deleted in esophageal cancer 1

Alternative name(s):
Candidate tumor suppressor CTS9

Gene names

Name:	DEC1
Synonyms:	CTS9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Candidate tumor supressor. Ref.1
Tissue specificity	Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas. Ref.1

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Tumor suppressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 70	70	Deleted in esophageal cancer 1		PRO_0000240631
Natural variations
	Natural variant	60	1	A → V. Corresponds to variant rs2269700 [ dbSNP | Ensembl ].		VAR_050948

Sequences

	Sequence		Length	Mass (Da)
	Q9P2X7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 91FA5AD3C402EF43	FASTA	70	7,542
	10 20 30 40 50 60 MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN GGKDFAVSLA 70 RPKAAEGIAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32." Nishiwaki T., Daigo Y., Kawasoe T., Nakamura Y. Genes Chromosomes Cancer 27:169-176(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB022761 mRNA. Translation: BAA96242.1. AL714001 Genomic DNA. Translation: CAI16660.1.
IPI	IPI00178720.
RefSeq	NP_059114.1. NM_017418.2.
UniGene	Hs.148841.
3D structure databases
ProteinModelPortal	Q9P2X7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363128.
Proteomic databases
PaxDb	Q9P2X7.
PRIDE	Q9P2X7.
Protocols and materials databases
DNASU	50514.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374016; ENSP00000363128; ENSG00000173077.
GeneID	50514.
KEGG	hsa:50514.
UCSC	uc004bjk.1. human.
Organism-specific databases
CTD	50514.
GeneCards	GC09P117904.
HGNC	HGNC:23658. DEC1.
MIM	604767. gene.
neXtProt	NX_Q9P2X7.
PharmGKB	PA134898625.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70592.
HOGENOM	HOG000112187.
InParanoid	Q9P2X7.
OMA	AGKWKSI.
OrthoDB	EOG46145P.
PhylomeDB	Q9P2X7.
Enzyme and pathway databases
Pathway_Interaction_DB	circadianpathway. Circadian rhythm pathway.
Gene expression databases
Bgee	Q9P2X7.
CleanEx	HS_DEC1.
Genevestigator	Q9P2X7.
GermOnline	ENSG00000173077. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	50514.
NextBio	53090.
SOURCE	Search...

Entry information

Entry name

DEC1_HUMAN

Accession

Primary (citable) accession number: Q9P2X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.