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Protein

Syntaxin-18

Gene

STX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Molecular functioni

GO - Biological processi

  • endoplasmic reticulum membrane organization Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • positive regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
  • positive regulation of organelle assembly Source: UniProtKB
  • regulation of Golgi organization Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Alternative name(s):
Cell growth-inhibiting gene 9 protein
Gene namesi
Name:STX18
ORF Names:GIG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15942. STX18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 309CytoplasmicSequence analysisAdd BLAST309
Transmembranei310 – 330Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini331 – 335VesicularSequence analysis5

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53407.
OpenTargetsiENSG00000168818.
PharmGKBiPA38061.

Polymorphism and mutation databases

BioMutaiSTX18.
DMDMi17369347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102311 – 335Syntaxin-18Add BLAST335

Proteomic databases

EPDiQ9P2W9.
MaxQBiQ9P2W9.
PaxDbiQ9P2W9.
PeptideAtlasiQ9P2W9.
PRIDEiQ9P2W9.

PTM databases

iPTMnetiQ9P2W9.
PhosphoSitePlusiQ9P2W9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000168818.
CleanExiHS_STX18.
ExpressionAtlasiQ9P2W9. baseline and differential.
GenevisibleiQ9P2W9. HS.

Organism-specific databases

HPAiHPA003019.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119782. 46 interactors.
DIPiDIP-37617N.
IntActiQ9P2W9. 16 interactors.
MINTiMINT-1378736.
STRINGi9606.ENSP00000305810.

Structurei

3D structure databases

ProteinModelPortaliQ9P2W9.
SMRiQ9P2W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 305t-SNARE coiled-coil homologyAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894. Eukaryota.
ENOG410XSGT. LUCA.
GeneTreeiENSGT00390000014853.
HOGENOMiHOG000007595.
HOVERGENiHBG054890.
InParanoidiQ9P2W9.
KOiK08492.
OMAiLQHRKDY.
OrthoDBiEOG091G0FVR.
PhylomeDBiQ9P2W9.
TreeFamiTF105868.

Family and domain databases

InterProiView protein in InterPro
IPR019529. Syntaxin-18_N.
IPR006012. Syntaxin/epimorphin_CS.
PfamiView protein in Pfam
PF10496. Syntaxin-18_N. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT
210 220 230 240 250
EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF
260 270 280 290 300
DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
310 320 330
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS
Length:335
Mass (Da):38,674
Last modified:October 1, 2000 - v1
Checksum:iD89B3B52407D77FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → V in AAV38937 (Ref. 3) Curated1
Sequence conflicti308N → D in AAS47513 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05225032D → Y. Corresponds to variant dbSNP:rs13134070Ensembl.1
Natural variantiVAR_05225151S → G. Corresponds to variant dbSNP:rs36109375Ensembl.1
Natural variantiVAR_052252228S → T. Corresponds to variant dbSNP:rs33952588Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028741 mRNA. Translation: BAA95213.1.
AY453396 mRNA. Translation: AAS47513.1.
BT007150 mRNA. Translation: AAP35814.1.
BT020135 mRNA. Translation: AAV38937.1.
BC014613 mRNA. Translation: AAH14613.1.
CCDSiCCDS3377.1.
RefSeqiNP_001333210.1. NM_001346281.1.
NP_001333211.1. NM_001346282.1.
NP_001333229.1. NM_001346300.1.
NP_058626.1. NM_016930.3.
UniGeneiHs.584913.

Genome annotation databases

EnsembliENST00000306200; ENSP00000305810; ENSG00000168818.
GeneIDi53407.
KEGGihsa:53407.
UCSCiuc003gic.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTX18_HUMAN
AccessioniPrimary (citable) accession number: Q9P2W9
Secondary accession number(s): Q596L3, Q5TZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families