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Protein

Syntaxin-18

Gene

STX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Biological processi

  • endoplasmic reticulum membrane organization Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • membrane fusion Source: GOC
  • positive regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
  • positive regulation of organelle assembly Source: UniProtKB
  • regulation of Golgi organization Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Alternative name(s):
Cell growth-inhibiting gene 9 protein
Gene namesi
Name:STX18
ORF Names:GIG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15942. STX18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 309309CytoplasmicSequence analysisAdd
BLAST
Transmembranei310 – 33021Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini331 – 3355VesicularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38061.

Polymorphism and mutation databases

BioMutaiSTX18.
DMDMi17369347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Syntaxin-18PRO_0000210231Add
BLAST

Proteomic databases

EPDiQ9P2W9.
MaxQBiQ9P2W9.
PaxDbiQ9P2W9.
PRIDEiQ9P2W9.

PTM databases

iPTMnetiQ9P2W9.
PhosphoSiteiQ9P2W9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9P2W9.
CleanExiHS_STX18.
ExpressionAtlasiQ9P2W9. baseline and differential.
GenevisibleiQ9P2W9. HS.

Organism-specific databases

HPAiHPA003019.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC22BO753962EBI-725334,EBI-1058865
USE1Q9NZ437EBI-725334,EBI-742842

Protein-protein interaction databases

BioGridi119782. 43 interactions.
DIPiDIP-37617N.
IntActiQ9P2W9. 12 interactions.
MINTiMINT-1378736.
STRINGi9606.ENSP00000305810.

Structurei

3D structure databases

ProteinModelPortaliQ9P2W9.
SMRiQ9P2W9. Positions 252-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 30563t-SNARE coiled-coil homologyAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894. Eukaryota.
ENOG410XSGT. LUCA.
GeneTreeiENSGT00390000014853.
HOGENOMiHOG000007595.
HOVERGENiHBG054890.
InParanoidiQ9P2W9.
KOiK08492.
OMAiLHSVEQI.
PhylomeDBiQ9P2W9.
TreeFamiTF105868.

Family and domain databases

InterProiIPR019529. Syntaxin-18_N.
IPR006012. Syntaxin/epimorphin_CS.
[Graphical view]
PfamiPF10496. Syntaxin-18_N. 1 hit.
[Graphical view]
PROSITEiPS00914. SYNTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT
210 220 230 240 250
EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF
260 270 280 290 300
DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
310 320 330
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS
Length:335
Mass (Da):38,674
Last modified:October 1, 2000 - v1
Checksum:iD89B3B52407D77FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111A → V in AAV38937 (Ref. 3) Curated
Sequence conflicti308 – 3081N → D in AAS47513 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321D → Y.
Corresponds to variant rs13134070 [ dbSNP | Ensembl ].
VAR_052250
Natural varianti51 – 511S → G.
Corresponds to variant rs36109375 [ dbSNP | Ensembl ].
VAR_052251
Natural varianti228 – 2281S → T.
Corresponds to variant rs33952588 [ dbSNP | Ensembl ].
VAR_052252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028741 mRNA. Translation: BAA95213.1.
AY453396 mRNA. Translation: AAS47513.1.
BT007150 mRNA. Translation: AAP35814.1.
BT020135 mRNA. Translation: AAV38937.1.
BC014613 mRNA. Translation: AAH14613.1.
CCDSiCCDS3377.1.
RefSeqiNP_058626.1. NM_016930.2.
UniGeneiHs.584913.

Genome annotation databases

EnsembliENST00000306200; ENSP00000305810; ENSG00000168818.
GeneIDi53407.
KEGGihsa:53407.
UCSCiuc003gic.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028741 mRNA. Translation: BAA95213.1.
AY453396 mRNA. Translation: AAS47513.1.
BT007150 mRNA. Translation: AAP35814.1.
BT020135 mRNA. Translation: AAV38937.1.
BC014613 mRNA. Translation: AAH14613.1.
CCDSiCCDS3377.1.
RefSeqiNP_058626.1. NM_016930.2.
UniGeneiHs.584913.

3D structure databases

ProteinModelPortaliQ9P2W9.
SMRiQ9P2W9. Positions 252-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119782. 43 interactions.
DIPiDIP-37617N.
IntActiQ9P2W9. 12 interactions.
MINTiMINT-1378736.
STRINGi9606.ENSP00000305810.

PTM databases

iPTMnetiQ9P2W9.
PhosphoSiteiQ9P2W9.

Polymorphism and mutation databases

BioMutaiSTX18.
DMDMi17369347.

Proteomic databases

EPDiQ9P2W9.
MaxQBiQ9P2W9.
PaxDbiQ9P2W9.
PRIDEiQ9P2W9.

Protocols and materials databases

DNASUi53407.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306200; ENSP00000305810; ENSG00000168818.
GeneIDi53407.
KEGGihsa:53407.
UCSCiuc003gic.4. human.

Organism-specific databases

CTDi53407.
GeneCardsiSTX18.
H-InvDBHIX0120162.
HGNCiHGNC:15942. STX18.
HPAiHPA003019.
MIMi606046. gene.
neXtProtiNX_Q9P2W9.
PharmGKBiPA38061.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3894. Eukaryota.
ENOG410XSGT. LUCA.
GeneTreeiENSGT00390000014853.
HOGENOMiHOG000007595.
HOVERGENiHBG054890.
InParanoidiQ9P2W9.
KOiK08492.
OMAiLHSVEQI.
PhylomeDBiQ9P2W9.
TreeFamiTF105868.

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

GenomeRNAii53407.
PROiQ9P2W9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2W9.
CleanExiHS_STX18.
ExpressionAtlasiQ9P2W9. baseline and differential.
GenevisibleiQ9P2W9. HS.

Family and domain databases

InterProiIPR019529. Syntaxin-18_N.
IPR006012. Syntaxin/epimorphin_CS.
[Graphical view]
PfamiPF10496. Syntaxin-18_N. 1 hit.
[Graphical view]
PROSITEiPS00914. SYNTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking."
    Hatsuzawa K., Hirose H., Tani K., Yamamoto A., Scheller R.H., Tagaya M.
    J. Biol. Chem. 275:13713-13720(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Identification of a human growth inhibiting gene."
    Kim J.W.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
    Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
    EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH USE1L; SEC22B; RINT1 AND ZW10.
  6. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
    Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
    EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BNIP1.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSTX18_HUMAN
AccessioniPrimary (citable) accession number: Q9P2W9
Secondary accession number(s): Q596L3, Q5TZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.