Q9P2W3 (GBG13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene names

Name:

GNG13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome
Molecular function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 64	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13		PRO_0000012671
	Propeptide	65 – 67	3	Removed in mature form By similarity		PRO_0000012672
Amino acid modifications
	Modified residue	64	1	Cysteine methyl ester By similarity
	Lipidation	64	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9P2W3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 080E0C34A8F70327	FASTA	67	7,949
	10 20 30 40 50 60 MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP DLMKNNPWVE KGKCTIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium." Huang L., Shanker Y.G., Dubauskaite J., Zheng J.Z., Yan W., Rosenzweig S., Spielman A.I., Max M., Margolskee R.F. Nat. Neurosci. 2:1055-1062(1999) [PubMed: 10570481] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"E.coli toxicity assay: a novel expression screening method for isolation of mammalian genes with membrane-associated domains or ATP binding/ATPase domains." Inoue S., Sano H., Ohta M. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[5]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY029486 mRNA. Translation: AAK40269.1. AB030207 mRNA. Translation: BAA92768.1. AF493880 mRNA. Translation: AAM12594.1. AK312139 mRNA. Translation: BAG35075.1. AE006465 Genomic DNA. Translation: AAK61257.1. AL031033 Genomic DNA. Translation: CAB53059.2. BC093760 mRNA. Translation: AAH93760.1. BC095525 mRNA. Translation: AAH95525.1.
IPI	IPI00009785.
RefSeq	NP_057625.1. NM_016541.2.
UniGene	Hs.247888.
3D structure databases
ProteinModelPortal	Q9P2W3.
SMR	Q9P2W3. Positions 5-62.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9P2W3.
Polymorphism databases
DMDM	20138402.
Proteomic databases
PRIDE	Q9P2W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248150; ENSP00000248150; ENSG00000127588.
GeneID	51764.
KEGG	hsa:51764.
UCSC	uc002ckh.2. human.
Organism-specific databases
CTD	51764.
GeneCards	GC16M000848.
H-InvDB	HIX0202319.
HGNC	HGNC:14131. GNG13.
HPA	HPA046272.
MIM	607298. gene.
neXtProt	NX_Q9P2W3.
PharmGKB	PA28783.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21227.
GeneTree	ENSGT00530000064157.
HOGENOM	HBG379223.
HOVERGEN	HBG098057.
InParanoid	Q9P2W3.
OMA	EKGKCSI.
OrthoDB	EOG4X6CB1.
PhylomeDB	Q9P2W3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9P2W3.
Bgee	Q9P2W3.
CleanEx	HS_GNG13.
Genevestigator	Q9P2W3.
GermOnline	ENSG00000127588. Homo sapiens.
Family and domain databases
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
Gene3D	G3DSA:4.10.260.10. G-protein_gamma_dom. 1 hit.
KO	K04547.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55883.
SOURCE	Search...

Entry information

Entry name

GBG13_HUMAN

Accession

Primary (citable) accession number: Q9P2W3
Secondary accession number(s): B2R5C8, Q52LX0, Q9UJJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.