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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene

GNG13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkiQ9P2W3

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesi
Name:GNG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000127588.4
HGNCiHGNC:14131 GNG13
MIMi607298 gene
neXtProtiNX_Q9P2W3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127588
PharmGKBiPA28783

Polymorphism and mutation databases

BioMutaiGNG13
DMDMi20138402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126711 – 64Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13Add BLAST64
PropeptideiPRO_000001267265 – 67Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Cysteine methyl esterBy similarity1
Lipidationi64S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9P2W3
PeptideAtlasiQ9P2W3
PRIDEiQ9P2W3
ProteomicsDBi83903

PTM databases

iPTMnetiQ9P2W3
PhosphoSitePlusiQ9P2W3

Expressioni

Gene expression databases

BgeeiENSG00000127588
CleanExiHS_GNG13
GenevisibleiQ9P2W3 HS

Organism-specific databases

HPAiHPA046272

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
RPRMQ9NS644EBI-11427343,EBI-1052363

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119721, 5 interactors
IntActiQ9P2W3, 24 interactors
STRINGi9606.ENSP00000248150

Structurei

3D structure databases

ProteinModelPortaliQ9P2W3
SMRiQ9P2W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000064157
HOGENOMiHOG000231034
HOVERGENiHBG098057
InParanoidiQ9P2W3
KOiK04547
OMAiTDPLIHA
OrthoDBiEOG091G17J0
PhylomeDBiQ9P2W3
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP
60
DLMKNNPWVE KGKCTIL
Length:67
Mass (Da):7,949
Last modified:October 1, 2000 - v1
Checksum:i080E0C34A8F70327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029486 mRNA Translation: AAK40269.1
AB030207 mRNA Translation: BAA92768.1
AF493880 mRNA Translation: AAM12594.1
AK312139 mRNA Translation: BAG35075.1
AE006465 Genomic DNA Translation: AAK61257.1
AL031033 Genomic DNA No translation available.
BC093760 mRNA Translation: AAH93760.1
BC095525 mRNA Translation: AAH95525.1
CCDSiCCDS10427.1
RefSeqiNP_057625.1, NM_016541.2
UniGeneiHs.247888

Genome annotation databases

EnsembliENST00000248150; ENSP00000248150; ENSG00000127588
GeneIDi51764
KEGGihsa:51764
UCSCiuc002ckh.4 human

Similar proteinsi

Entry informationi

Entry nameiGBG13_HUMAN
AccessioniPrimary (citable) accession number: Q9P2W3
Secondary accession number(s): B2R5C8, Q52LX0, Q9UJJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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