Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P2U8

- VGLU2_HUMAN

UniProt

Q9P2U8 - VGLU2_HUMAN

Protein

Vesicular glutamate transporter 2

Gene

SLC17A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

    GO - Molecular functioni

    1. L-glutamate transmembrane transporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: Reactome
    2. neurotransmitter uptake Source: Ensembl
    3. sodium ion transport Source: UniProtKB-KW
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19372. Organic anion transporters.

    Protein family/group databases

    TCDBi2.A.1.14.31. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicular glutamate transporter 2
    Short name:
    VGluT2
    Alternative name(s):
    Differentiation-associated BNPI
    Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
    Solute carrier family 17 member 6
    Gene namesi
    Name:SLC17A6
    Synonyms:DNPI, VGLUT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16703. SLC17A6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. neuron projection Source: UniProtKB-SubCell
    4. synaptic vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA424.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Vesicular glutamate transporter 2PRO_0000318169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9P2U8.
    PRIDEiQ9P2U8.

    PTM databases

    PhosphoSiteiQ9P2U8.

    Expressioni

    Tissue specificityi

    Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.1 Publication

    Developmental stagei

    Expressed in fetal brain.1 Publication

    Gene expression databases

    BgeeiQ9P2U8.
    CleanExiHS_SLC17A6.
    GenevestigatoriQ9P2U8.

    Organism-specific databases

    HPAiCAB037130.
    HPA039226.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000263160.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2U8.
    SMRiQ9P2U8. Positions 315-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7171CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 12533VesicularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 1482CytoplasmicSequence Analysis
    Topological domaini170 – 1778VesicularSequence Analysis
    Topological domaini199 – 21618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 2447VesicularSequence Analysis
    Topological domaini266 – 31045CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini332 – 34918VesicularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 38616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 4092VesicularSequence Analysis
    Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini465 – 47713VesicularSequence AnalysisAdd
    BLAST
    Topological domaini499 – 58284CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000230812.
    HOVERGENiHBG008834.
    InParanoidiQ9P2U8.
    KOiK12302.
    OMAiKQRILTP.
    OrthoDBiEOG789C9Z.
    PhylomeDBiQ9P2U8.
    TreeFamiTF313535.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P2U8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL    50
    EVPERKAPLC DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN 100
    NSTIHRGGKV IKEKAKFNWD PETVGMIHGS FFWGYIITQI PGGYIASRLA 150
    ANRVFGAAIL LTSTLNMLIP SAARVHYGCV IFVRILQGLV EGVTYPACHG 200
    IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT GWSSVFYVYG 250
    SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
    TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM 350
    LSAVPHLVMT IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL 400
    LVVGYSHTRG VAISFLVLAV GFSGFAISGF NVNHLDIAPR YASILMGISN 450
    GVGTLSGMVC PIIVGAMTKN KSREEWQYVF LIAALVHYGG VIFYAIFASG 500
    EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT TKSYGATTQA 550
    NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS 582
    Length:582
    Mass (Da):64,392
    Last modified:October 1, 2000 - v1
    Checksum:iCE761E56FA18C6AD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401T → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_038710
    Natural varianti551 – 5511N → S.
    Corresponds to variant rs7117340 [ dbSNP | Ensembl ].
    VAR_038711

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032435 mRNA. Translation: BAA92874.1.
    AC040936 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68324.1.
    BC069629 mRNA. Translation: AAH69629.1.
    BC069640 mRNA. Translation: AAH69640.1.
    BC069646 mRNA. Translation: AAH69646.1.
    CCDSiCCDS7856.1.
    RefSeqiNP_065079.1. NM_020346.2.
    UniGeneiHs.242821.

    Genome annotation databases

    EnsembliENST00000263160; ENSP00000263160; ENSG00000091664.
    GeneIDi57084.
    KEGGihsa:57084.
    UCSCiuc001mqk.3. human.

    Polymorphism databases

    DMDMi74734915.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032435 mRNA. Translation: BAA92874.1 .
    AC040936 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68324.1 .
    BC069629 mRNA. Translation: AAH69629.1 .
    BC069640 mRNA. Translation: AAH69640.1 .
    BC069646 mRNA. Translation: AAH69646.1 .
    CCDSi CCDS7856.1.
    RefSeqi NP_065079.1. NM_020346.2.
    UniGenei Hs.242821.

    3D structure databases

    ProteinModelPortali Q9P2U8.
    SMRi Q9P2U8. Positions 315-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000263160.

    Protein family/group databases

    TCDBi 2.A.1.14.31. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9P2U8.

    Polymorphism databases

    DMDMi 74734915.

    Proteomic databases

    PaxDbi Q9P2U8.
    PRIDEi Q9P2U8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263160 ; ENSP00000263160 ; ENSG00000091664 .
    GeneIDi 57084.
    KEGGi hsa:57084.
    UCSCi uc001mqk.3. human.

    Organism-specific databases

    CTDi 57084.
    GeneCardsi GC11P022316.
    HGNCi HGNC:16703. SLC17A6.
    HPAi CAB037130.
    HPA039226.
    MIMi 607563. gene.
    neXtProti NX_Q9P2U8.
    PharmGKBi PA424.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000230812.
    HOVERGENi HBG008834.
    InParanoidi Q9P2U8.
    KOi K12302.
    OMAi KQRILTP.
    OrthoDBi EOG789C9Z.
    PhylomeDBi Q9P2U8.
    TreeFami TF313535.

    Enzyme and pathway databases

    Reactomei REACT_19372. Organic anion transporters.

    Miscellaneous databases

    GenomeRNAii 57084.
    NextBioi 62871.
    PROi Q9P2U8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P2U8.
    CleanExi HS_SLC17A6.
    Genevestigatori Q9P2U8.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
      Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
      J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Thalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)."
      Takamori S., Rhee J.S., Rosenmund C., Jahn R.
      J. Neurosci. 21:RC182-RC182(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-40.

    Entry informationi

    Entry nameiVGLU2_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2U8
    Secondary accession number(s): A6NKS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3