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Q9P2U8

- VGLU2_HUMAN

UniProt

Q9P2U8 - VGLU2_HUMAN

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Protein
Vesicular glutamate transporter 2
Gene
SLC17A6, DNPI, VGLUT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

GO - Molecular functioni

  1. L-glutamate transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. neurotransmitter uptake Source: Ensembl
  3. sodium ion transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 2
Short name:
VGluT2
Alternative name(s):
Differentiation-associated BNPI
Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6
Gene namesi
Name:SLC17A6
Synonyms:DNPI, VGLUT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16703. SLC17A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Reviewed prediction
Add
BLAST
Topological domaini93 – 12533Vesicular Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Topological domaini147 – 1482Cytoplasmic Reviewed prediction
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Topological domaini170 – 1778Vesicular Reviewed prediction
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Topological domaini199 – 21618Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 2447Vesicular Reviewed prediction
Transmembranei245 – 26521Helical; Reviewed prediction
Add
BLAST
Topological domaini266 – 31045Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Topological domaini332 – 34918Vesicular Reviewed prediction
Add
BLAST
Transmembranei350 – 37021Helical; Reviewed prediction
Add
BLAST
Topological domaini371 – 38616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST
Topological domaini408 – 4092Vesicular Reviewed prediction
Transmembranei410 – 43021Helical; Reviewed prediction
Add
BLAST
Topological domaini431 – 44313Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei444 – 46421Helical; Reviewed prediction
Add
BLAST
Topological domaini465 – 47713Vesicular Reviewed prediction
Add
BLAST
Transmembranei478 – 49821Helical; Reviewed prediction
Add
BLAST
Topological domaini499 – 58284Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. neuron projection Source: UniProtKB-SubCell
  4. synaptic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Vesicular glutamate transporter 2
PRO_0000318169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P2U8.
PRIDEiQ9P2U8.

PTM databases

PhosphoSiteiQ9P2U8.

Expressioni

Tissue specificityi

Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiQ9P2U8.
CleanExiHS_SLC17A6.
GenevestigatoriQ9P2U8.

Organism-specific databases

HPAiCAB037130.
HPA039226.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263160.

Structurei

3D structure databases

ProteinModelPortaliQ9P2U8.
SMRiQ9P2U8. Positions 315-376.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U8.
KOiK12302.
OMAiKQRILTP.
OrthoDBiEOG789C9Z.
PhylomeDBiQ9P2U8.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2U8-1 [UniParc]FASTAAdd to Basket

« Hide

MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL    50
EVPERKAPLC DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN 100
NSTIHRGGKV IKEKAKFNWD PETVGMIHGS FFWGYIITQI PGGYIASRLA 150
ANRVFGAAIL LTSTLNMLIP SAARVHYGCV IFVRILQGLV EGVTYPACHG 200
IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT GWSSVFYVYG 250
SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM 350
LSAVPHLVMT IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL 400
LVVGYSHTRG VAISFLVLAV GFSGFAISGF NVNHLDIAPR YASILMGISN 450
GVGTLSGMVC PIIVGAMTKN KSREEWQYVF LIAALVHYGG VIFYAIFASG 500
EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT TKSYGATTQA 550
NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS 582
Length:582
Mass (Da):64,392
Last modified:October 1, 2000 - v1
Checksum:iCE761E56FA18C6AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401T → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_038710
Natural varianti551 – 5511N → S.
Corresponds to variant rs7117340 [ dbSNP | Ensembl ].
VAR_038711

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032435 mRNA. Translation: BAA92874.1.
AC040936 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68324.1.
BC069629 mRNA. Translation: AAH69629.1.
BC069640 mRNA. Translation: AAH69640.1.
BC069646 mRNA. Translation: AAH69646.1.
CCDSiCCDS7856.1.
RefSeqiNP_065079.1. NM_020346.2.
UniGeneiHs.242821.

Genome annotation databases

EnsembliENST00000263160; ENSP00000263160; ENSG00000091664.
GeneIDi57084.
KEGGihsa:57084.
UCSCiuc001mqk.3. human.

Polymorphism databases

DMDMi74734915.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032435 mRNA. Translation: BAA92874.1 .
AC040936 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68324.1 .
BC069629 mRNA. Translation: AAH69629.1 .
BC069640 mRNA. Translation: AAH69640.1 .
BC069646 mRNA. Translation: AAH69646.1 .
CCDSi CCDS7856.1.
RefSeqi NP_065079.1. NM_020346.2.
UniGenei Hs.242821.

3D structure databases

ProteinModelPortali Q9P2U8.
SMRi Q9P2U8. Positions 315-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000263160.

Protein family/group databases

TCDBi 2.A.1.14.31. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q9P2U8.

Polymorphism databases

DMDMi 74734915.

Proteomic databases

PaxDbi Q9P2U8.
PRIDEi Q9P2U8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263160 ; ENSP00000263160 ; ENSG00000091664 .
GeneIDi 57084.
KEGGi hsa:57084.
UCSCi uc001mqk.3. human.

Organism-specific databases

CTDi 57084.
GeneCardsi GC11P022316.
HGNCi HGNC:16703. SLC17A6.
HPAi CAB037130.
HPA039226.
MIMi 607563. gene.
neXtProti NX_Q9P2U8.
PharmGKBi PA424.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000230812.
HOVERGENi HBG008834.
InParanoidi Q9P2U8.
KOi K12302.
OMAi KQRILTP.
OrthoDBi EOG789C9Z.
PhylomeDBi Q9P2U8.
TreeFami TF313535.

Enzyme and pathway databases

Reactomei REACT_19372. Organic anion transporters.

Miscellaneous databases

GenomeRNAii 57084.
NextBioi 62871.
PROi Q9P2U8.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2U8.
CleanExi HS_SLC17A6.
Genevestigatori Q9P2U8.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
    Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
    J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Thalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)."
    Takamori S., Rhee J.S., Rosenmund C., Jahn R.
    J. Neurosci. 21:RC182-RC182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-40.

Entry informationi

Entry nameiVGLU2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U8
Secondary accession number(s): A6NKS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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