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Protein

Vesicular glutamate transporter 2

Gene

SLC17A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 2
Short name:
VGluT2
Alternative name(s):
Differentiation-associated BNPI
Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6
Gene namesi
Name:SLC17A6
Synonyms:DNPI, VGLUT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:16703. SLC17A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Topological domaini93 – 12533VesicularSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Topological domaini147 – 1482CytoplasmicSequence Analysis
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Topological domaini170 – 1778VesicularSequence Analysis
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 21618CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Topological domaini238 – 2447VesicularSequence Analysis
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST
Topological domaini266 – 31045CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Topological domaini332 – 34918VesicularSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Topological domaini371 – 38616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Topological domaini408 – 4092VesicularSequence Analysis
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST
Topological domaini465 – 47713VesicularSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Topological domaini499 – 58284CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA424.

Polymorphism and mutation databases

BioMutaiSLC17A6.
DMDMi74734915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Vesicular glutamate transporter 2PRO_0000318169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P2U8.
PRIDEiQ9P2U8.

PTM databases

PhosphoSiteiQ9P2U8.

Expressioni

Tissue specificityi

Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiQ9P2U8.
CleanExiHS_SLC17A6.
GenevisibleiQ9P2U8. HS.

Organism-specific databases

HPAiCAB037130.
HPA039226.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263160.

Structurei

3D structure databases

ProteinModelPortaliQ9P2U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U8.
KOiK12302.
OMAiMHGHVVI.
OrthoDBiEOG789C9Z.
PhylomeDBiQ9P2U8.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL
60 70 80 90 100
EVPERKAPLC DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN
110 120 130 140 150
NSTIHRGGKV IKEKAKFNWD PETVGMIHGS FFWGYIITQI PGGYIASRLA
160 170 180 190 200
ANRVFGAAIL LTSTLNMLIP SAARVHYGCV IFVRILQGLV EGVTYPACHG
210 220 230 240 250
IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT GWSSVFYVYG
260 270 280 290 300
SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK
310 320 330 340 350
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM
360 370 380 390 400
LSAVPHLVMT IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL
410 420 430 440 450
LVVGYSHTRG VAISFLVLAV GFSGFAISGF NVNHLDIAPR YASILMGISN
460 470 480 490 500
GVGTLSGMVC PIIVGAMTKN KSREEWQYVF LIAALVHYGG VIFYAIFASG
510 520 530 540 550
EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT TKSYGATTQA
560 570 580
NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS
Length:582
Mass (Da):64,392
Last modified:October 1, 2000 - v1
Checksum:iCE761E56FA18C6AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401T → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_038710
Natural varianti551 – 5511N → S.
Corresponds to variant rs7117340 [ dbSNP | Ensembl ].
VAR_038711

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032435 mRNA. Translation: BAA92874.1.
AC040936 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68324.1.
BC069629 mRNA. Translation: AAH69629.1.
BC069640 mRNA. Translation: AAH69640.1.
BC069646 mRNA. Translation: AAH69646.1.
CCDSiCCDS7856.1.
RefSeqiNP_065079.1. NM_020346.2.
UniGeneiHs.242821.

Genome annotation databases

EnsembliENST00000263160; ENSP00000263160; ENSG00000091664.
GeneIDi57084.
KEGGihsa:57084.
UCSCiuc001mqk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032435 mRNA. Translation: BAA92874.1.
AC040936 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68324.1.
BC069629 mRNA. Translation: AAH69629.1.
BC069640 mRNA. Translation: AAH69640.1.
BC069646 mRNA. Translation: AAH69646.1.
CCDSiCCDS7856.1.
RefSeqiNP_065079.1. NM_020346.2.
UniGeneiHs.242821.

3D structure databases

ProteinModelPortaliQ9P2U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263160.

Protein family/group databases

TCDBi2.A.1.14.31. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ9P2U8.

Polymorphism and mutation databases

BioMutaiSLC17A6.
DMDMi74734915.

Proteomic databases

PaxDbiQ9P2U8.
PRIDEiQ9P2U8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263160; ENSP00000263160; ENSG00000091664.
GeneIDi57084.
KEGGihsa:57084.
UCSCiuc001mqk.3. human.

Organism-specific databases

CTDi57084.
GeneCardsiGC11P022359.
HGNCiHGNC:16703. SLC17A6.
HPAiCAB037130.
HPA039226.
MIMi607563. gene.
neXtProtiNX_Q9P2U8.
PharmGKBiPA424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U8.
KOiK12302.
OMAiMHGHVVI.
OrthoDBiEOG789C9Z.
PhylomeDBiQ9P2U8.
TreeFamiTF313535.

Enzyme and pathway databases

ReactomeiREACT_19372. Organic anion transporters.

Miscellaneous databases

GenomeRNAii57084.
NextBioi62871.
PROiQ9P2U8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2U8.
CleanExiHS_SLC17A6.
GenevisibleiQ9P2U8. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
    Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
    J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Thalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)."
    Takamori S., Rhee J.S., Rosenmund C., Jahn R.
    J. Neurosci. 21:RC182-RC182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-40.

Entry informationi

Entry nameiVGLU2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U8
Secondary accession number(s): A6NKS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.