Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9P2U8 (VGLU2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicular glutamate transporter 2

Short name=VGluT2
Alternative name(s):
Differentiation-associated BNPI
Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6
Gene names
Name:SLC17A6
Synonyms:DNPI, VGLUT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Ref.1 Ref.5

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity. Membrane; Multi-pass membrane protein Potential. Cell junctionsynapsesynaptosome By similarity.

Tissue specificity

Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. Ref.1

Developmental stage

Expressed in fetal brain. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Vesicular glutamate transporter 2
PRO_0000318169

Regions

Topological domain1 – 7171Cytoplasmic Potential
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 12533Vesicular Potential
Transmembrane126 – 14621Helical; Potential
Topological domain147 – 1482Cytoplasmic Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 1778Vesicular Potential
Transmembrane178 – 19821Helical; Potential
Topological domain199 – 21618Cytoplasmic Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 2447Vesicular Potential
Transmembrane245 – 26521Helical; Potential
Topological domain266 – 31045Cytoplasmic Potential
Transmembrane311 – 33121Helical; Potential
Topological domain332 – 34918Vesicular Potential
Transmembrane350 – 37021Helical; Potential
Topological domain371 – 38616Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 4092Vesicular Potential
Transmembrane410 – 43021Helical; Potential
Topological domain431 – 44313Cytoplasmic Potential
Transmembrane444 – 46421Helical; Potential
Topological domain465 – 47713Vesicular Potential
Transmembrane478 – 49821Helical; Potential
Topological domain499 – 58284Cytoplasmic Potential

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential

Natural variations

Natural variant401T → S in a breast cancer sample; somatic mutation. Ref.6
VAR_038710
Natural variant5511N → S.
Corresponds to variant rs7117340 [ dbSNP | Ensembl ].
VAR_038711

Sequences

Sequence LengthMass (Da)Tools
Q9P2U8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CE761E56FA18C6AD

FASTA58264,392
        10         20         30         40         50         60 
MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC 

        70         80         90        100        110        120 
DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 

       130        140        150        160        170        180 
PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 

       190        200        210        220        230        240 
IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 

       250        260        270        280        290        300 
GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 

       310        320        330        340        350        360 
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 

       370        380        390        400        410        420 
IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 

       430        440        450        460        470        480 
GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 

       490        500        510        520        530        540 
LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 

       550        560        570        580 
TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Thalamus.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)."
Takamori S., Rhee J.S., Rosenmund C., Jahn R.
J. Neurosci. 21:RC182-RC182(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-40.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032435 mRNA. Translation: BAA92874.1.
AC040936 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68324.1.
BC069629 mRNA. Translation: AAH69629.1.
BC069640 mRNA. Translation: AAH69640.1.
BC069646 mRNA. Translation: AAH69646.1.
RefSeqNP_065079.1. NM_020346.2.
UniGeneHs.242821.

3D structure databases

ProteinModelPortalQ9P2U8.
SMRQ9P2U8. Positions 180-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000263160.

Protein family/group databases

TCDB2.A.1.14.31. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ9P2U8.

Polymorphism databases

DMDM74734915.

Proteomic databases

PaxDbQ9P2U8.
PRIDEQ9P2U8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263160; ENSP00000263160; ENSG00000091664.
GeneID57084.
KEGGhsa:57084.
UCSCuc001mqk.3. human.

Organism-specific databases

CTD57084.
GeneCardsGC11P022316.
HGNCHGNC:16703. SLC17A6.
HPACAB037130.
HPA039226.
MIM607563. gene.
neXtProtNX_Q9P2U8.
PharmGKBPA424.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000230812.
HOVERGENHBG008834.
InParanoidQ9P2U8.
KOK12302.
OMAKDRDEYS.
OrthoDBEOG789C9Z.
PhylomeDBQ9P2U8.
TreeFamTF313535.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

BgeeQ9P2U8.
CleanExHS_SLC17A6.
GenevestigatorQ9P2U8.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57084.
NextBio62871.
PROQ9P2U8.
SOURCESearch...

Entry information

Entry nameVGLU2_HUMAN
AccessionPrimary (citable) accession number: Q9P2U8
Secondary accession number(s): A6NKS2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM