Vesicular glutamate transporter 2 - Homo sapiens (Human)

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Q9P2U8 (VGLU2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Vesicular glutamate transporter 2
Short name=VGluT2

Alternative name(s):
Differentiation-associated BNPI
Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6

Gene names

Name:	SLC17A6
Synonyms:	DNPI, VGLUT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Ref.1 Ref.5
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane By similarity. Membrane; Multi-pass membrane protein Potential. Cell junction › synapse › synaptosome By similarity.
Tissue specificity	Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. Ref.1
Developmental stage	Expressed in fetal brain. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Ontologies

Keywords
Biological process	Ion transport Neurotransmitter transport Sodium transport Symport Transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse Synaptosome
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-glutamate transport Inferred from electronic annotation. Source: GOC neurotransmitter uptake Inferred from electronic annotation. Source: Compara sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuron projection Inferred from electronic annotation. Source: UniProtKB-SubCell synaptic vesicle membrane Traceable author statement. Source: Reactome
Molecular_function	L-glutamate transmembrane transporter activity Inferred from electronic annotation. Source: Compara symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 582

582

Vesicular glutamate transporter 2

PRO_0000318169

Regions

Topological domain

1 – 71

Cytoplasmic Potential

Transmembrane

72 – 92

Helical; Potential

Topological domain

93 – 125

Vesicular Potential

Transmembrane

126 – 146

Helical; Potential

Topological domain

147 – 148

Cytoplasmic Potential

Transmembrane

149 – 169

Helical; Potential

Topological domain

170 – 177

Vesicular Potential

Transmembrane

178 – 198

Helical; Potential

Topological domain

199 – 216

Cytoplasmic Potential

Transmembrane

217 – 237

Helical; Potential

Topological domain

238 – 244

Vesicular Potential

Transmembrane

245 – 265

Helical; Potential

Topological domain

266 – 310

Cytoplasmic Potential

Transmembrane

311 – 331

Helical; Potential

Topological domain

332 – 349

Vesicular Potential

Transmembrane

350 – 370

Helical; Potential

Topological domain

371 – 386

Cytoplasmic Potential

Transmembrane

387 – 407

Helical; Potential

Topological domain

408 – 409

Vesicular Potential

Transmembrane

410 – 430

Helical; Potential

Topological domain

431 – 443

Cytoplasmic Potential

Transmembrane

444 – 464

Helical; Potential

Topological domain

465 – 477

Vesicular Potential

Transmembrane

478 – 498

Helical; Potential

Topological domain

499 – 582

Cytoplasmic Potential

Amino acid modifications

Modified residue

195

Phosphotyrosine By similarity

Glycosylation

100

N-linked (GlcNAc...) Potential

Glycosylation

101

N-linked (GlcNAc...) Potential

Glycosylation

470

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

T → S in a breast cancer sample; somatic mutation. Ref.6

VAR_038710

Natural variant

551

N → S.
Corresponds to variant rs7117340 [ dbSNP | Ensembl ].

VAR_038711

Sequences

Sequence

Length

Mass (Da)

Tools

Q9P2U8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CE761E56FA18C6AD
Show »

FASTA

582

64,392

        10         20         30         40         50         60 
MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC 

        70         80         90        100        110        120 
DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 

       130        140        150        160        170        180 
PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 

       190        200        210        220        230        240 
IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 

       250        260        270        280        290        300 
GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 

       310        320        330        340        350        360 
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 

       370        380        390        400        410        420 
IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 

       430        440        450        460        470        480 
GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 

       490        500        510        520        530        540 
LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 

       550        560        570        580 
TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter." Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J. J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Thalamus.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2)." Takamori S., Rhee J.S., Rosenmund C., Jahn R. J. Neurosci. 21:RC182-RC182(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB032435 mRNA. Translation: BAA92874.1. AC040936 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68324.1. BC069629 mRNA. Translation: AAH69629.1. BC069640 mRNA. Translation: AAH69640.1. BC069646 mRNA. Translation: AAH69646.1.
IPI	IPI00477420.
RefSeq	NP_065079.1. NM_020346.2.
UniGene	Hs.242821.
3D structure databases
ProteinModelPortal	Q9P2U8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000263160.
PTM databases
PhosphoSite	Q9P2U8.
Polymorphism databases
DMDM	74734915.
Proteomic databases
PaxDb	Q9P2U8.
PRIDE	Q9P2U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263160; ENSP00000263160; ENSG00000091664.
GeneID	57084.
KEGG	hsa:57084.
UCSC	uc001mqk.3. human.
Organism-specific databases
CTD	57084.
GeneCards	GC11P022316.
HGNC	HGNC:16703. SLC17A6.
HPA	CAB037130.
MIM	607563. gene.
neXtProt	NX_Q9P2U8.
PharmGKB	PA424.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000230812.
HOVERGEN	HBG008834.
InParanoid	Q9P2U8.
KO	K12302.
OMA	GMIWYMF.
OrthoDB	EOG4XWFXC.
PhylomeDB	Q9P2U8.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
Bgee	Q9P2U8.
CleanEx	HS_SLC17A6.
Genevestigator	Q9P2U8.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57084.
NextBio	62871.
SOURCE	Search...

Entry information

Entry name

VGLU2_HUMAN

Accession

Primary (citable) accession number: Q9P2U8
Secondary accession number(s): A6NKS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents