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Protein

Vesicular glutamate transporter 1

Gene

SLC17A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104888-MONOMER.
ReactomeiR-HSA-210500. Glutamate Neurotransmitter Release Cycle.
R-HSA-428643. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.30. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 1
Short name:
VGluT1
Alternative name(s):
Brain-specific Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 7
Gene namesi
Name:SLC17A7
Synonyms:BNPI, VGLUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16704. SLC17A7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 116ExtracellularSequence analysisAdd BLAST32
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 140CytoplasmicSequence analysis3
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 169ExtracellularSequence analysis8
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 208CytoplasmicSequence analysisAdd BLAST18
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 236ExtracellularSequence analysis7
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 302CytoplasmicSequence analysisAdd BLAST45
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 341ExtracellularSequence analysisAdd BLAST18
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 378CytoplasmicSequence analysisAdd BLAST16
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 401ExtracellularSequence analysis2
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 435CytoplasmicSequence analysisAdd BLAST13
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21
Topological domaini457 – 469ExtracellularSequence analysisAdd BLAST13
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 560CytoplasmicSequence analysisAdd BLAST70

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57030.
OpenTargetsiENSG00000104888.
PharmGKBiPA423.

Polymorphism and mutation databases

BioMutaiSLC17A7.
DMDMi74725387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316111 – 560Vesicular glutamate transporter 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P2U7.
PeptideAtlasiQ9P2U7.
PRIDEiQ9P2U7.
TopDownProteomicsiQ9P2U7-1. [Q9P2U7-1]

PTM databases

iPTMnetiQ9P2U7.
PhosphoSitePlusiQ9P2U7.

Expressioni

Tissue specificityi

Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.1 Publication

Gene expression databases

BgeeiENSG00000104888.
CleanExiHS_SLC17A7.
ExpressionAtlasiQ9P2U7. baseline and differential.
GenevisibleiQ9P2U7. HS.

Organism-specific databases

HPAiCAB037183.
HPA050458.
HPA063679.

Interactioni

Subunit structurei

Interacts with SHANK3.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000221485.

Structurei

3D structure databases

ProteinModelPortaliQ9P2U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 556Pro-richAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U7.
KOiK12302.
OMAiDKSEEYV.
OrthoDBiEOG091G06DG.
PhylomeDBiQ9P2U7.
TreeFamiTF313535.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP
60 70 80 90 100
VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG
110 120 130 140 150
HVVVQKAQFS WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA
160 170 180 190 200
IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP
210 220 230 240 250
LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL
260 270 280 290 300
FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT
310 320 330 340 350
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV
360 370 380 390 400
MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS
410 420 430 440 450
KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM
460 470 480 490 500
VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP
510 520 530 540 550
EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS YGATHSTFQP
560
PRPPPPVRDY
Length:560
Mass (Da):61,613
Last modified:October 1, 2000 - v1
Checksum:iC88DAFB34B6E45B6
GO
Isoform 2 (identifier: Q9P2U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):53,946
Checksum:i6333DBF37546389F
GO
Isoform 3 (identifier: Q9P2U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEFRQEEFRKLAGRALGKLHR → MGSQLALAG

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):59,887
Checksum:i4FFF0B4E78E6BE69
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042904431P → R.1 PublicationCorresponds to variant rs17855709dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561101 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_0561111 – 21MEFRQ…GKLHR → MGSQLALAG in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032436 mRNA. Translation: BAA92875.1.
AK294226 mRNA. Translation: BAG57530.1.
AK294405 mRNA. Translation: BAG57657.1.
AC010619 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52485.1.
BC059379 mRNA. Translation: AAH59379.1.
CCDSiCCDS12764.1. [Q9P2U7-1]
RefSeqiNP_064705.1. NM_020309.3. [Q9P2U7-1]
UniGeneiHs.375616.

Genome annotation databases

EnsembliENST00000221485; ENSP00000221485; ENSG00000104888. [Q9P2U7-1]
ENST00000600601; ENSP00000470338; ENSG00000104888. [Q9P2U7-2]
GeneIDi57030.
KEGGihsa:57030.
UCSCiuc002pnp.4. human. [Q9P2U7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032436 mRNA. Translation: BAA92875.1.
AK294226 mRNA. Translation: BAG57530.1.
AK294405 mRNA. Translation: BAG57657.1.
AC010619 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52485.1.
BC059379 mRNA. Translation: AAH59379.1.
CCDSiCCDS12764.1. [Q9P2U7-1]
RefSeqiNP_064705.1. NM_020309.3. [Q9P2U7-1]
UniGeneiHs.375616.

3D structure databases

ProteinModelPortaliQ9P2U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000221485.

Protein family/group databases

TCDBi2.A.1.14.30. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9P2U7.
PhosphoSitePlusiQ9P2U7.

Polymorphism and mutation databases

BioMutaiSLC17A7.
DMDMi74725387.

Proteomic databases

PaxDbiQ9P2U7.
PeptideAtlasiQ9P2U7.
PRIDEiQ9P2U7.
TopDownProteomicsiQ9P2U7-1. [Q9P2U7-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221485; ENSP00000221485; ENSG00000104888. [Q9P2U7-1]
ENST00000600601; ENSP00000470338; ENSG00000104888. [Q9P2U7-2]
GeneIDi57030.
KEGGihsa:57030.
UCSCiuc002pnp.4. human. [Q9P2U7-1]

Organism-specific databases

CTDi57030.
DisGeNETi57030.
GeneCardsiSLC17A7.
HGNCiHGNC:16704. SLC17A7.
HPAiCAB037183.
HPA050458.
HPA063679.
MIMi605208. gene.
neXtProtiNX_Q9P2U7.
OpenTargetsiENSG00000104888.
PharmGKBiPA423.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U7.
KOiK12302.
OMAiDKSEEYV.
OrthoDBiEOG091G06DG.
PhylomeDBiQ9P2U7.
TreeFamiTF313535.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104888-MONOMER.
ReactomeiR-HSA-210500. Glutamate Neurotransmitter Release Cycle.
R-HSA-428643. Organic anion transporters.

Miscellaneous databases

ChiTaRSiSLC17A7. human.
GeneWikiiVesicular_glutamate_transporter_1.
GenomeRNAii57030.
PROiQ9P2U7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104888.
CleanExiHS_SLC17A7.
ExpressionAtlasiQ9P2U7. baseline and differential.
GenevisibleiQ9P2U7. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLU1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U7
Secondary accession number(s): B4DFR9, B4DG46, Q6PCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.