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Q9P2U7

- VGLU1_HUMAN

UniProt

Q9P2U7 - VGLU1_HUMAN

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Protein
Vesicular glutamate transporter 1
Gene
SLC17A7, BNPI, VGLUT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.1 Publication

GO - Molecular functioni

  1. L-glutamate transmembrane transporter activity Source: Reactome
  2. inorganic phosphate transmembrane transporter activity Source: Ensembl
  3. sodium-dependent phosphate transmembrane transporter activity Source: ProtInc
  4. sodium:inorganic phosphate symporter activity Source: MGI

GO - Biological processi

  1. L-glutamate import Source: Ensembl
  2. glutamate secretion Source: Reactome
  3. ion transport Source: Reactome
  4. long-term memory Source: Ensembl
  5. neurotransmitter secretion Source: Reactome
  6. phosphate ion transmembrane transport Source: GOC
  7. phosphate ion transport Source: ProtInc
  8. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  9. sequestering of neurotransmitter Source: Ensembl
  10. sodium ion transmembrane transport Source: GOC
  11. synaptic transmission Source: Reactome
  12. synaptic transmission, glutamatergic Source: Ensembl
  13. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.1.14.30. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 1
Short name:
VGluT1
Alternative name(s):
Brain-specific Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 7
Gene namesi
Name:SLC17A7
Synonyms:BNPI, VGLUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16704. SLC17A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 11632Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 1403Cytoplasmic Reviewed prediction
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Topological domaini162 – 1698Extracellular Reviewed prediction
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 20818Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 2367Extracellular Reviewed prediction
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Topological domaini258 – 30245Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Topological domaini324 – 34118Extracellular Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 37816Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Topological domaini400 – 4012Extracellular Reviewed prediction
Transmembranei402 – 42221Helical; Reviewed prediction
Add
BLAST
Topological domaini423 – 43513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei436 – 45621Helical; Reviewed prediction
Add
BLAST
Topological domaini457 – 46913Extracellular Reviewed prediction
Add
BLAST
Transmembranei470 – 49021Helical; Reviewed prediction
Add
BLAST
Topological domaini491 – 56070Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. clathrin-sculpted glutamate transport vesicle membrane Source: Reactome
  3. excitatory synapse Source: Ensembl
  4. integral component of membrane Source: MGI
  5. neuron projection Source: UniProtKB-SubCell
  6. plasma membrane Source: Reactome
  7. presynaptic active zone Source: Ensembl
  8. synaptic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Vesicular glutamate transporter 1
PRO_0000331611Add
BLAST

Proteomic databases

PaxDbiQ9P2U7.
PRIDEiQ9P2U7.

PTM databases

PhosphoSiteiQ9P2U7.

Expressioni

Tissue specificityi

Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.1 Publication

Gene expression databases

ArrayExpressiQ9P2U7.
BgeeiQ9P2U7.
CleanExiHS_SLC17A7.
GenevestigatoriQ9P2U7.

Organism-specific databases

HPAiCAB037183.
HPA050458.

Interactioni

Subunit structurei

Interacts with SHANK3 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000221485.

Structurei

3D structure databases

ProteinModelPortaliQ9P2U7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi530 – 55627Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ9P2U7.
KOiK12302.
OMAiMHGHVVI.
OrthoDBiEOG789C9Z.
PhylomeDBiQ9P2U7.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2U7-1 [UniParc]FASTAAdd to Basket

« Hide

MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP    50
VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG 100
HVVVQKAQFS WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA 150
IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP 200
LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL 250
FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT 300
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV 350
MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS 400
KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM 450
VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP 500
EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS YGATHSTFQP 550
PRPPPPVRDY 560
Length:560
Mass (Da):61,613
Last modified:October 1, 2000 - v1
Checksum:iC88DAFB34B6E45B6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti431 – 4311P → R.1 Publication
Corresponds to variant rs17855709 [ dbSNP | Ensembl ].
VAR_042904

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032436 mRNA. Translation: BAA92875.1.
CH471177 Genomic DNA. Translation: EAW52485.1.
BC059379 mRNA. Translation: AAH59379.1.
CCDSiCCDS12764.1.
RefSeqiNP_064705.1. NM_020309.3.
UniGeneiHs.375616.

Genome annotation databases

EnsembliENST00000221485; ENSP00000221485; ENSG00000104888.
GeneIDi57030.
KEGGihsa:57030.
UCSCiuc002pnp.3. human.

Polymorphism databases

DMDMi74725387.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032436 mRNA. Translation: BAA92875.1 .
CH471177 Genomic DNA. Translation: EAW52485.1 .
BC059379 mRNA. Translation: AAH59379.1 .
CCDSi CCDS12764.1.
RefSeqi NP_064705.1. NM_020309.3.
UniGenei Hs.375616.

3D structure databases

ProteinModelPortali Q9P2U7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000221485.

Protein family/group databases

TCDBi 2.A.1.14.30. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q9P2U7.

Polymorphism databases

DMDMi 74725387.

Proteomic databases

PaxDbi Q9P2U7.
PRIDEi Q9P2U7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221485 ; ENSP00000221485 ; ENSG00000104888 .
GeneIDi 57030.
KEGGi hsa:57030.
UCSCi uc002pnp.3. human.

Organism-specific databases

CTDi 57030.
GeneCardsi GC19M049933.
HGNCi HGNC:16704. SLC17A7.
HPAi CAB037183.
HPA050458.
MIMi 605208. gene.
neXtProti NX_Q9P2U7.
PharmGKBi PA423.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000230812.
HOVERGENi HBG008834.
InParanoidi Q9P2U7.
KOi K12302.
OMAi MHGHVVI.
OrthoDBi EOG789C9Z.
PhylomeDBi Q9P2U7.
TreeFami TF313535.

Enzyme and pathway databases

Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19372. Organic anion transporters.

Miscellaneous databases

GeneWikii Vesicular_glutamate_transporter_1.
GenomeRNAii 57030.
NextBioi 62781.
PROi Q9P2U7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P2U7.
Bgeei Q9P2U7.
CleanExi HS_SLC17A7.
Genevestigatori Q9P2U7.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
    Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
    J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-431.
    Tissue: Brain.

Entry informationi

Entry nameiVGLU1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U7
Secondary accession number(s): Q6PCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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