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Q9P2U7

- VGLU1_HUMAN

UniProt

Q9P2U7 - VGLU1_HUMAN

Protein

Vesicular glutamate transporter 1

Gene

SLC17A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.1 Publication

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: Ensembl
    2. L-glutamate transmembrane transporter activity Source: Reactome
    3. sodium:inorganic phosphate symporter activity Source: MGI
    4. sodium-dependent phosphate transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. glutamate secretion Source: Reactome
    2. ion transport Source: Reactome
    3. L-glutamate import Source: Ensembl
    4. long-term memory Source: Ensembl
    5. neurotransmitter secretion Source: Reactome
    6. phosphate ion transmembrane transport Source: GOC
    7. phosphate ion transport Source: ProtInc
    8. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    9. sequestering of neurotransmitter Source: Ensembl
    10. sodium ion transmembrane transport Source: GOC
    11. synaptic transmission Source: Reactome
    12. synaptic transmission, glutamatergic Source: Ensembl
    13. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_19372. Organic anion transporters.

    Protein family/group databases

    TCDBi2.A.1.14.30. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicular glutamate transporter 1
    Short name:
    VGluT1
    Alternative name(s):
    Brain-specific Na(+)-dependent inorganic phosphate cotransporter
    Solute carrier family 17 member 7
    Gene namesi
    Name:SLC17A7
    Synonyms:BNPI, VGLUT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16704. SLC17A7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. clathrin-sculpted glutamate transport vesicle membrane Source: Reactome
    3. excitatory synapse Source: Ensembl
    4. integral component of membrane Source: MGI
    5. neuron projection Source: UniProtKB-SubCell
    6. plasma membrane Source: Reactome
    7. presynaptic active zone Source: Ensembl
    8. synaptic vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA423.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Vesicular glutamate transporter 1PRO_0000331611Add
    BLAST

    Proteomic databases

    PaxDbiQ9P2U7.
    PRIDEiQ9P2U7.

    PTM databases

    PhosphoSiteiQ9P2U7.

    Expressioni

    Tissue specificityi

    Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2U7.
    BgeeiQ9P2U7.
    CleanExiHS_SLC17A7.
    GenevestigatoriQ9P2U7.

    Organism-specific databases

    HPAiCAB037183.
    HPA050458.

    Interactioni

    Subunit structurei

    Interacts with SHANK3.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000221485.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 11632ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 1403CytoplasmicSequence Analysis
    Topological domaini162 – 1698ExtracellularSequence Analysis
    Topological domaini191 – 20818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 2367ExtracellularSequence Analysis
    Topological domaini258 – 30245CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 34118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini363 – 37816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 4012ExtracellularSequence Analysis
    Topological domaini423 – 43513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini457 – 46913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini491 – 56070CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi530 – 55627Pro-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000230812.
    HOVERGENiHBG008834.
    InParanoidiQ9P2U7.
    KOiK12302.
    OMAiMHGHVVI.
    OrthoDBiEOG789C9Z.
    PhylomeDBiQ9P2U7.
    TreeFamiTF313535.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2U7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP    50
    VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG 100
    HVVVQKAQFS WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA 150
    IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP 200
    LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL 250
    FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT 300
    SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV 350
    MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS 400
    KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM 450
    VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP 500
    EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS YGATHSTFQP 550
    PRPPPPVRDY 560
    Length:560
    Mass (Da):61,613
    Last modified:October 1, 2000 - v1
    Checksum:iC88DAFB34B6E45B6
    GO
    Isoform 2 (identifier: Q9P2U7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:493
    Mass (Da):53,946
    Checksum:i6333DBF37546389F
    GO
    Isoform 3 (identifier: Q9P2U7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: MEFRQEEFRKLAGRALGKLHR → MGSQLALAG

    Note: No experimental confirmation available.

    Show »
    Length:548
    Mass (Da):59,887
    Checksum:i4FFF0B4E78E6BE69
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti431 – 4311P → R.1 Publication
    Corresponds to variant rs17855709 [ dbSNP | Ensembl ].
    VAR_042904

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767Missing in isoform 2. 1 PublicationVSP_056110Add
    BLAST
    Alternative sequencei1 – 2121MEFRQ…GKLHR → MGSQLALAG in isoform 3. 1 PublicationVSP_056111Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032436 mRNA. Translation: BAA92875.1.
    AK294226 mRNA. Translation: BAG57530.1.
    AK294405 mRNA. Translation: BAG57657.1.
    AC010619 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52485.1.
    BC059379 mRNA. Translation: AAH59379.1.
    CCDSiCCDS12764.1.
    RefSeqiNP_064705.1. NM_020309.3.
    UniGeneiHs.375616.

    Genome annotation databases

    EnsembliENST00000221485; ENSP00000221485; ENSG00000104888.
    ENST00000543531; ENSP00000441767; ENSG00000104888.
    ENST00000600601; ENSP00000470338; ENSG00000104888.
    GeneIDi57030.
    KEGGihsa:57030.
    UCSCiuc002pnp.3. human.

    Polymorphism databases

    DMDMi74725387.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032436 mRNA. Translation: BAA92875.1 .
    AK294226 mRNA. Translation: BAG57530.1 .
    AK294405 mRNA. Translation: BAG57657.1 .
    AC010619 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52485.1 .
    BC059379 mRNA. Translation: AAH59379.1 .
    CCDSi CCDS12764.1.
    RefSeqi NP_064705.1. NM_020309.3.
    UniGenei Hs.375616.

    3D structure databases

    ProteinModelPortali Q9P2U7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000221485.

    Protein family/group databases

    TCDBi 2.A.1.14.30. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9P2U7.

    Polymorphism databases

    DMDMi 74725387.

    Proteomic databases

    PaxDbi Q9P2U7.
    PRIDEi Q9P2U7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221485 ; ENSP00000221485 ; ENSG00000104888 .
    ENST00000543531 ; ENSP00000441767 ; ENSG00000104888 .
    ENST00000600601 ; ENSP00000470338 ; ENSG00000104888 .
    GeneIDi 57030.
    KEGGi hsa:57030.
    UCSCi uc002pnp.3. human.

    Organism-specific databases

    CTDi 57030.
    GeneCardsi GC19M049933.
    HGNCi HGNC:16704. SLC17A7.
    HPAi CAB037183.
    HPA050458.
    MIMi 605208. gene.
    neXtProti NX_Q9P2U7.
    PharmGKBi PA423.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000230812.
    HOVERGENi HBG008834.
    InParanoidi Q9P2U7.
    KOi K12302.
    OMAi MHGHVVI.
    OrthoDBi EOG789C9Z.
    PhylomeDBi Q9P2U7.
    TreeFami TF313535.

    Enzyme and pathway databases

    Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_19372. Organic anion transporters.

    Miscellaneous databases

    GeneWikii Vesicular_glutamate_transporter_1.
    GenomeRNAii 57030.
    NextBioi 62781.
    PROi Q9P2U7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2U7.
    Bgeei Q9P2U7.
    CleanExi HS_SLC17A7.
    Genevestigatori Q9P2U7.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter."
      Aihara Y., Mashima H., Onda H., Hisano S., Kasuya H., Hori T., Yamada S., Tomura H., Yamada Y., Inoue I., Kojima I., Takeda J.
      J. Neurochem. 74:2622-2625(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Amygdala.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-431.
      Tissue: Brain.

    Entry informationi

    Entry nameiVGLU1_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2U7
    Secondary accession number(s): B4DFR9, B4DG46, Q6PCD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3