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Protein

Testicular haploid expressed gene protein

Gene

THEG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved (but not essential) in spermatogenesis.By similarity

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • chaperone-mediated protein complex assembly Source: ProtInc
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testicular haploid expressed gene protein
Alternative name(s):
Cancer/testis antigen 56
Short name:
CT56
Gene namesi
Name:THEG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13706. THEG.

Subcellular locationi

  • Nucleus By similarity

  • Note: Localized predominantly in the nucleus of haploid round spermatid.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953737.

Polymorphism and mutation databases

BioMutaiTHEG.
DMDMi74734914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Testicular haploid expressed gene proteinPRO_0000306267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei295 – 2951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P2T0.
PeptideAtlasiQ9P2T0.
PRIDEiQ9P2T0.

PTM databases

iPTMnetiQ9P2T0.
PhosphoSiteiQ9P2T0.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ9P2T0.
CleanExiHS_THEG.
ExpressionAtlasiQ9P2T0. baseline and differential.
GenevisibleiQ9P2T0. HS.

Organism-specific databases

HPAiHPA042578.

Interactioni

Subunit structurei

Interacts with CCT5.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-751020,EBI-724076

Protein-protein interaction databases

BioGridi119449. 3 interactions.
IntActiQ9P2T0. 1 interaction.
MINTiMINT-1465908.
STRINGi9606.ENSP00000340088.

Structurei

3D structure databases

ProteinModelPortaliQ9P2T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati118 – 13720THEG 1Add
BLAST
Repeati184 – 20320THEG 2Add
BLAST
Repeati222 – 24120THEG 3Add
BLAST
Repeati258 – 27720THEG 4Add
BLAST
Repeati290 – 30920THEG 5Add
BLAST
Repeati326 – 34520THEG 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1278Poly-Arg

Sequence similaritiesi

Contains 6 THEG repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYC3. Eukaryota.
ENOG4111S9N. LUCA.
GeneTreeiENSGT00420000029836.
HOGENOMiHOG000154568.
InParanoidiQ9P2T0.
OMAiKRFYSEY.
OrthoDBiEOG7S21ZS.
PhylomeDBiQ9P2T0.
TreeFamiTF329290.

Family and domain databases

InterProiIPR006623. THEG.
[Graphical view]
PfamiPF14912. THEG. 4 hits.
[Graphical view]
SMARTiSM00705. THEG. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2T0-1) [UniParc]FASTAAdd to basket

Also known as: THEG major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDSRRRSLG NQPSSEAAGR SEREQDGDPR GLQSSVYESR RVTDPERQDL
60 70 80 90 100
DNAELGPEDP EEELPPEEVA GEEFPETLDP KEALSELERV LDKDLEEDIP
110 120 130 140 150
EISRLSISQK LPSTTMTKAR KRRRRRRLME LAEPKINWQV LKDRKGRCGK
160 170 180 190 200
GYAWISPCKM SLHFCLCWPS VYWTERFLED TTLTITVPAV SRRVEELSRP
210 220 230 240 250
KRFYLEYYNN NRTTPVWPIP RSSLEYRASS RLKELAAPKI RDNFWSMPMS
260 270 280 290 300
EVSQVSRAAQ MAVPSSRILQ LSKPKAPATL LEEWDPVPKP KPHVSDHNRL
310 320 330 340 350
LHLARPKAQS DKCVPDRDPR WEVLDVTKKV VASPRIISLA KPKVRKGLNE
360 370
GYDRRPLASM SLPPPKASPE KCDQPRPGL
Length:379
Mass (Da):43,444
Last modified:October 1, 2000 - v1
Checksum:iDE1B6397A4FAA875
GO
Isoform 2 (identifier: Q9P2T0-2) [UniParc]FASTAAdd to basket

Also known as: THEG minor

The sequence of this isoform differs from the canonical sequence as follows:
     145-168: Missing.

Show »
Length:355
Mass (Da):40,686
Checksum:i5FE0A8FDB02BCD04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021R → I.
Corresponds to variant rs2303810 [ dbSNP | Ensembl ].
VAR_035286
Natural varianti267 – 2671R → Q.
Corresponds to variant rs2278287 [ dbSNP | Ensembl ].
VAR_035287
Natural varianti297 – 2971H → Y.
Corresponds to variant rs10422863 [ dbSNP | Ensembl ].
VAR_035288
Natural varianti353 – 3531D → N.
Corresponds to variant rs3764656 [ dbSNP | Ensembl ].
VAR_035289

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 16824Missing in isoform 2. 1 PublicationVSP_028446Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268610 mRNA. Translation: AAG17663.1.
AB033129 mRNA. Translation: BAA93718.1.
AC016588 Genomic DNA. No translation available.
CH471242 Genomic DNA. Translation: EAW61204.1.
BC028574 mRNA. Translation: AAH28574.1.
CCDSiCCDS12025.1. [Q9P2T0-1]
CCDS12026.1. [Q9P2T0-2]
RefSeqiNP_057669.1. NM_016585.4. [Q9P2T0-1]
NP_954672.1. NM_199202.2. [Q9P2T0-2]
UniGeneiHs.250002.

Genome annotation databases

EnsembliENST00000342640; ENSP00000340088; ENSG00000105549. [Q9P2T0-1]
ENST00000346878; ENSP00000264820; ENSG00000105549. [Q9P2T0-2]
GeneIDi51298.
KEGGihsa:51298.
UCSCiuc002lol.3. human. [Q9P2T0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268610 mRNA. Translation: AAG17663.1.
AB033129 mRNA. Translation: BAA93718.1.
AC016588 Genomic DNA. No translation available.
CH471242 Genomic DNA. Translation: EAW61204.1.
BC028574 mRNA. Translation: AAH28574.1.
CCDSiCCDS12025.1. [Q9P2T0-1]
CCDS12026.1. [Q9P2T0-2]
RefSeqiNP_057669.1. NM_016585.4. [Q9P2T0-1]
NP_954672.1. NM_199202.2. [Q9P2T0-2]
UniGeneiHs.250002.

3D structure databases

ProteinModelPortaliQ9P2T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119449. 3 interactions.
IntActiQ9P2T0. 1 interaction.
MINTiMINT-1465908.
STRINGi9606.ENSP00000340088.

PTM databases

iPTMnetiQ9P2T0.
PhosphoSiteiQ9P2T0.

Polymorphism and mutation databases

BioMutaiTHEG.
DMDMi74734914.

Proteomic databases

PaxDbiQ9P2T0.
PeptideAtlasiQ9P2T0.
PRIDEiQ9P2T0.

Protocols and materials databases

DNASUi51298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342640; ENSP00000340088; ENSG00000105549. [Q9P2T0-1]
ENST00000346878; ENSP00000264820; ENSG00000105549. [Q9P2T0-2]
GeneIDi51298.
KEGGihsa:51298.
UCSCiuc002lol.3. human. [Q9P2T0-1]

Organism-specific databases

CTDi51298.
GeneCardsiTHEG.
HGNCiHGNC:13706. THEG.
HPAiHPA042578.
MIMi609503. gene.
neXtProtiNX_Q9P2T0.
PharmGKBiPA134953737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYC3. Eukaryota.
ENOG4111S9N. LUCA.
GeneTreeiENSGT00420000029836.
HOGENOMiHOG000154568.
InParanoidiQ9P2T0.
OMAiKRFYSEY.
OrthoDBiEOG7S21ZS.
PhylomeDBiQ9P2T0.
TreeFamiTF329290.

Miscellaneous databases

GenomeRNAii51298.
PROiQ9P2T0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2T0.
CleanExiHS_THEG.
ExpressionAtlasiQ9P2T0. baseline and differential.
GenevisibleiQ9P2T0. HS.

Family and domain databases

InterProiIPR006623. THEG.
[Graphical view]
PfamiPF14912. THEG. 4 hits.
[Graphical view]
SMARTiSM00705. THEG. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG)."
    Mannan A., Lucke K., Dixkens C., Neesen J., Kamper M., Engel W., Burfeind P.
    Cytogenet. Cell Genet. 91:171-179(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  2. "Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis."
    Yanaka N., Kobayashi K., Wakimoto K., Yamada E., Imahie H., Imai Y., Mori C.
    J. Biol. Chem. 275:14791-14794(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTHEG_HUMAN
AccessioniPrimary (citable) accession number: Q9P2T0
Secondary accession number(s): A6NMJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.