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Protein

Testicular haploid expressed gene protein

Gene

THEG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved (but not essential) in spermatogenesis.By similarity

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • chaperone-mediated protein complex assembly Source: ProtInc
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testicular haploid expressed gene protein
Alternative name(s):
Cancer/testis antigen 56
Short name:
CT56
Gene namesi
Name:THEG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105549.10
HGNCiHGNC:13706 THEG
MIMi609503 gene
neXtProtiNX_Q9P2T0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51298
OpenTargetsiENSG00000105549
PharmGKBiPA134953737

Polymorphism and mutation databases

BioMutaiTHEG
DMDMi74734914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062671 – 379Testicular haploid expressed gene proteinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P2T0
PeptideAtlasiQ9P2T0
PRIDEiQ9P2T0

PTM databases

iPTMnetiQ9P2T0
PhosphoSitePlusiQ9P2T0

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000105549
CleanExiHS_THEG
ExpressionAtlasiQ9P2T0 baseline and differential
GenevisibleiQ9P2T0 HS

Interactioni

Subunit structurei

Interacts with CCT5.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-751020,EBI-724076

Protein-protein interaction databases

BioGridi11944911 interactors.
IntActiQ9P2T0 2 interactors.
STRINGi9606.ENSP00000340088

Structurei

3D structure databases

ProteinModelPortaliQ9P2T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati118 – 137THEG 1Add BLAST20
Repeati184 – 203THEG 2Add BLAST20
Repeati222 – 241THEG 3Add BLAST20
Repeati258 – 277THEG 4Add BLAST20
Repeati290 – 309THEG 5Add BLAST20
Repeati326 – 345THEG 6Add BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 127Poly-Arg8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYC3 Eukaryota
ENOG4111S9N LUCA
GeneTreeiENSGT00420000029836
HOGENOMiHOG000154568
InParanoidiQ9P2T0
OMAiDRKGCCG
OrthoDBiEOG091G0EN9
PhylomeDBiQ9P2T0
TreeFamiTF329290

Family and domain databases

InterProiView protein in InterPro
IPR006623 THEG
PfamiView protein in Pfam
PF14912 THEG, 3 hits
SMARTiView protein in SMART
SM00705 THEG, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2T0-1) [UniParc]FASTAAdd to basket
Also known as: THEG major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDSRRRSLG NQPSSEAAGR SEREQDGDPR GLQSSVYESR RVTDPERQDL
60 70 80 90 100
DNAELGPEDP EEELPPEEVA GEEFPETLDP KEALSELERV LDKDLEEDIP
110 120 130 140 150
EISRLSISQK LPSTTMTKAR KRRRRRRLME LAEPKINWQV LKDRKGRCGK
160 170 180 190 200
GYAWISPCKM SLHFCLCWPS VYWTERFLED TTLTITVPAV SRRVEELSRP
210 220 230 240 250
KRFYLEYYNN NRTTPVWPIP RSSLEYRASS RLKELAAPKI RDNFWSMPMS
260 270 280 290 300
EVSQVSRAAQ MAVPSSRILQ LSKPKAPATL LEEWDPVPKP KPHVSDHNRL
310 320 330 340 350
LHLARPKAQS DKCVPDRDPR WEVLDVTKKV VASPRIISLA KPKVRKGLNE
360 370
GYDRRPLASM SLPPPKASPE KCDQPRPGL
Length:379
Mass (Da):43,444
Last modified:October 1, 2000 - v1
Checksum:iDE1B6397A4FAA875
GO
Isoform 2 (identifier: Q9P2T0-2) [UniParc]FASTAAdd to basket
Also known as: THEG minor

The sequence of this isoform differs from the canonical sequence as follows:
     145-168: Missing.

Show »
Length:355
Mass (Da):40,686
Checksum:i5FE0A8FDB02BCD04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035286202R → I. Corresponds to variant dbSNP:rs2303810Ensembl.1
Natural variantiVAR_035287267R → Q. Corresponds to variant dbSNP:rs2278287Ensembl.1
Natural variantiVAR_035288297H → Y. Corresponds to variant dbSNP:rs10422863Ensembl.1
Natural variantiVAR_035289353D → N. Corresponds to variant dbSNP:rs3764656Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028446145 – 168Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268610 mRNA Translation: AAG17663.1
AB033129 mRNA Translation: BAA93718.1
AC016588 Genomic DNA No translation available.
CH471242 Genomic DNA Translation: EAW61204.1
BC028574 mRNA Translation: AAH28574.1
CCDSiCCDS12025.1 [Q9P2T0-1]
CCDS12026.1 [Q9P2T0-2]
RefSeqiNP_057669.1, NM_016585.4 [Q9P2T0-1]
NP_954672.1, NM_199202.2 [Q9P2T0-2]
UniGeneiHs.250002

Genome annotation databases

EnsembliENST00000342640; ENSP00000340088; ENSG00000105549 [Q9P2T0-1]
ENST00000346878; ENSP00000264820; ENSG00000105549 [Q9P2T0-2]
GeneIDi51298
KEGGihsa:51298
UCSCiuc002lol.3 human [Q9P2T0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHEG_HUMAN
AccessioniPrimary (citable) accession number: Q9P2T0
Secondary accession number(s): A6NMJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome