Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and MYND domain-containing protein 1

Gene

ANKMY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri880 – 92041MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and MYND domain-containing protein 1
Alternative name(s):
Testis-specific ankyrin-like protein 1
Zinc finger MYND domain-containing protein 13
Gene namesi
Name:ANKMY1
Synonyms:TSAL1, ZMYND13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20987. ANKMY1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134925670.

Polymorphism and mutation databases

BioMutaiANKMY1.
DMDMi30912747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Ankyrin repeat and MYND domain-containing protein 1PRO_0000066894Add
BLAST

Proteomic databases

PaxDbiQ9P2S6.
PRIDEiQ9P2S6.

PTM databases

iPTMnetiQ9P2S6.
PhosphoSiteiQ9P2S6.

Expressioni

Gene expression databases

BgeeiQ9P2S6.
CleanExiHS_ANKMY1.
ExpressionAtlasiQ9P2S6. baseline and differential.
GenevisibleiQ9P2S6. HS.

Organism-specific databases

HPAiHPA026620.

Interactioni

Protein-protein interaction databases

MINTiMINT-4716008.
STRINGi9606.ENSP00000272972.

Structurei

3D structure databases

ProteinModelPortaliQ9P2S6.
SMRiQ9P2S6. Positions 284-333, 550-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 2423MORN 1Add
BLAST
Repeati25 – 4723MORN 2Add
BLAST
Repeati70 – 9223MORN 3Add
BLAST
Repeati292 – 32130ANK 1Add
BLAST
Repeati513 – 54230ANK 2Add
BLAST
Repeati545 – 57430ANK 3Add
BLAST
Repeati581 – 61333ANK 4Add
BLAST
Repeati657 – 69135ANK 5Add
BLAST
Repeati694 – 72330ANK 6Add
BLAST
Repeati737 – 76630ANK 7Add
BLAST

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 3 MORN repeats.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri880 – 92041MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ14. Eukaryota.
ENOG410ZI92. LUCA.
GeneTreeiENSGT00460000041630.
HOGENOMiHOG000033946.
HOVERGENiHBG064941.
InParanoidiQ9P2S6.
PhylomeDBiQ9P2S6.
TreeFamiTF328860.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003409. MORN.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF02493. MORN. 3 hits.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00698. MORN. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 4 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2S6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQGEFGLNM KLGYGKFSWP TGESYHGQFY RDHCHGLGTY MWPDGSSFTG
60 70 80 90 100
TFYLSHREGY GTMYMKTRLF QGLYKADQRF GPGVETYPDG SQDVGLWFRE
110 120 130 140 150
QLIKLCTQIP SGFSLLRYPE FSSFITHSPA RISLSEEEKT EWGLQEGQDP
160 170 180 190 200
FFYDYKRFLL NDNLTLPPEM YVYSTNSDHL PMTSSFRKEL DARIFLNEIP
210 220 230 240 250
PFVEDGEPWF IINETPLLVK IQKQTYKFRN KPAHTSWNMG AILEGKRSGF
260 270 280 290 300
APCGPKEQLS MEMILKAEEG NHEWICRILK DNFASADVAD AKGYTVLAAA
310 320 330 340 350
ATHCHNDIVN LLLDCGADVN KCSDEGLTAL SMCFLLHYPA QSFKPNVAER
360 370 380 390 400
TIPEPQEPPK FPVVPILSSS FMDTNLESLY YEVNVPSQGS YELRPPPAPL
410 420 430 440 450
LLPRVSGSHE GGHFQDTGQC GGSIDHRSSS LKGDSPLVKG SLGHVESGLE
460 470 480 490 500
DVLGNTDRGS LCSAETKFES NVCVCDFSIE LSQAMLERSA QSHSLLKMAS
510 520 530 540 550
PSPCTSSFDK GTMRRMALSM IERRKRWRTI KLLLRRGADP NLCCVPMQVL
560 570 580 590 600
FLAVKAGDVD GVRLLLEHGA RTDICFPPQL STLTPLHIAA ALPGEEGVQI
610 620 630 640 650
VELLLHAITD VDAKASDEDD TYKPGKLDLL PSSLKLSNEP GPPQAYYSTD
660 670 680 690 700
TALPEEGGRT ALHMACERED DNKCARDIVR LLLSHGANPN LLWSGHSPLS
710 720 730 740 750
LSIASGNELV VKELLTQGAD PNLPLTKGLG SALCVACDLT YEHQRNMDSK
760 770 780 790 800
LALIDRLISH GADILKPVML RQGEKEAVGT AVDYGYFRFF QDRRIARCPF
810 820 830 840 850
HTLMPAERET FLARKRLLEY MGLQLRQAVF AKESQWDPTW LYLCKRAELI
860 870 880 890 900
PSHRMKKKGP SLPRGLDVKE QGQIPFFKFC YQCGRSIGVR LLPCPRCYGI
910 920 930 940
LTCSKYCKTK AWTEFHKKDC GDLVAIVTQL EQVSRRREEF Q
Length:941
Mass (Da):105,516
Last modified:May 16, 2003 - v2
Checksum:iE6FCEE5C22EBD30A
GO
Isoform 2 (identifier: Q9P2S6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-301: MYQGEFGLNM...KGYTVLAAAA → MEGAHASLSL...TMYMKTRLFQ
     627-709: Missing.

Show »
Length:717
Mass (Da):79,878
Checksum:iF4CBCCEA5CDC79D4
GO
Isoform 3 (identifier: Q9P2S6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-301: MYQGEFGLNM...KGYTVLAAAA → MEGAHASLSL...TMYMKTRLFQ
     580-580: L → C
     581-941: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,326
Checksum:i8D1069B175FD63FD
GO
Isoform 4 (identifier: Q9P2S6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-301: Missing.

Show »
Length:711
Mass (Da):79,259
Checksum:i4A64601EDD4DA741
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti455 – 4551N → D in CAB66553 (PubMed:11230166).Curated
Sequence conflicti531 – 5311K → E in BAA91213 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891D → N.
Corresponds to variant rs35278753 [ dbSNP | Ensembl ].
VAR_048264
Natural varianti424 – 4241I → M.1 Publication
Corresponds to variant rs35996697 [ dbSNP | Ensembl ].
VAR_048265
Natural varianti451 – 4511D → V.
Corresponds to variant rs3796118 [ dbSNP | Ensembl ].
VAR_048266
Natural varianti472 – 4721V → L.2 Publications
Corresponds to variant rs3821348 [ dbSNP | Ensembl ].
VAR_048267
Natural varianti649 – 6491T → M.
Corresponds to variant rs35044862 [ dbSNP | Ensembl ].
VAR_048268

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 301301MYQGE…LAAAA → MEGAHASLSLEDEVSGAGSR QRPLEGKGGETPAAEEPGSL KNYAVFATRDVSAAPEKEEE EAEGPLRAQDLRESYIQLVQ GVQEWQDGCMYQGEFGLNMK LGYGKFSWPTGESYHGQFYR DHCHGLGTYMWPDGSSFTGT FYLSHREGYGTMYMKTRLFQ in isoform 2 and isoform 3. 2 PublicationsVSP_007442Add
BLAST
Alternative sequencei72 – 301230Missing in isoform 4. 1 PublicationVSP_039104Add
BLAST
Alternative sequencei580 – 5801L → C in isoform 3. 1 PublicationVSP_007443
Alternative sequencei581 – 941361Missing in isoform 3. 1 PublicationVSP_007444Add
BLAST
Alternative sequencei627 – 70983Missing in isoform 2. 1 PublicationVSP_007445Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034636 mRNA. Translation: BAA92844.1.
AK000506 mRNA. Translation: BAA91213.1.
AK314534 mRNA. Translation: BAG37125.1.
AC124862 Genomic DNA. Translation: AAX88942.1.
CH471063 Genomic DNA. Translation: EAW71190.1.
BC033495 mRNA. Translation: AAH33495.1.
AL136618 mRNA. Translation: CAB66553.1.
AL833866 mRNA. Translation: CAD38724.1.
CCDSiCCDS2535.1. [Q9P2S6-2]
CCDS2536.1. [Q9P2S6-1]
RefSeqiNP_001269700.1. NM_001282771.1.
NP_001269709.1. NM_001282780.1.
NP_001269710.1. NM_001282781.1.
NP_001295304.1. NM_001308375.1.
NP_057636.2. NM_016552.3. [Q9P2S6-1]
NP_060314.2. NM_017844.3. [Q9P2S6-2]
UniGeneiHs.656615.

Genome annotation databases

EnsembliENST00000272972; ENSP00000272972; ENSG00000144504. [Q9P2S6-1]
ENST00000361678; ENSP00000355097; ENSG00000144504. [Q9P2S6-2]
ENST00000405523; ENSP00000385635; ENSG00000144504. [Q9P2S6-3]
GeneIDi51281.
KEGGihsa:51281.
UCSCiuc002vyz.3. human. [Q9P2S6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034636 mRNA. Translation: BAA92844.1.
AK000506 mRNA. Translation: BAA91213.1.
AK314534 mRNA. Translation: BAG37125.1.
AC124862 Genomic DNA. Translation: AAX88942.1.
CH471063 Genomic DNA. Translation: EAW71190.1.
BC033495 mRNA. Translation: AAH33495.1.
AL136618 mRNA. Translation: CAB66553.1.
AL833866 mRNA. Translation: CAD38724.1.
CCDSiCCDS2535.1. [Q9P2S6-2]
CCDS2536.1. [Q9P2S6-1]
RefSeqiNP_001269700.1. NM_001282771.1.
NP_001269709.1. NM_001282780.1.
NP_001269710.1. NM_001282781.1.
NP_001295304.1. NM_001308375.1.
NP_057636.2. NM_016552.3. [Q9P2S6-1]
NP_060314.2. NM_017844.3. [Q9P2S6-2]
UniGeneiHs.656615.

3D structure databases

ProteinModelPortaliQ9P2S6.
SMRiQ9P2S6. Positions 284-333, 550-743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4716008.
STRINGi9606.ENSP00000272972.

PTM databases

iPTMnetiQ9P2S6.
PhosphoSiteiQ9P2S6.

Polymorphism and mutation databases

BioMutaiANKMY1.
DMDMi30912747.

Proteomic databases

PaxDbiQ9P2S6.
PRIDEiQ9P2S6.

Protocols and materials databases

DNASUi51281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272972; ENSP00000272972; ENSG00000144504. [Q9P2S6-1]
ENST00000361678; ENSP00000355097; ENSG00000144504. [Q9P2S6-2]
ENST00000405523; ENSP00000385635; ENSG00000144504. [Q9P2S6-3]
GeneIDi51281.
KEGGihsa:51281.
UCSCiuc002vyz.3. human. [Q9P2S6-1]

Organism-specific databases

CTDi51281.
GeneCardsiANKMY1.
HGNCiHGNC:20987. ANKMY1.
HPAiHPA026620.
neXtProtiNX_Q9P2S6.
PharmGKBiPA134925670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ14. Eukaryota.
ENOG410ZI92. LUCA.
GeneTreeiENSGT00460000041630.
HOGENOMiHOG000033946.
HOVERGENiHBG064941.
InParanoidiQ9P2S6.
PhylomeDBiQ9P2S6.
TreeFamiTF328860.

Miscellaneous databases

ChiTaRSiANKMY1. human.
GenomeRNAii51281.
PROiQ9P2S6.

Gene expression databases

BgeeiQ9P2S6.
CleanExiHS_ANKMY1.
ExpressionAtlasiQ9P2S6. baseline and differential.
GenevisibleiQ9P2S6. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003409. MORN.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF02493. MORN. 3 hits.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00698. MORN. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 4 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Testis specific ankyrin like protein."
    Kato M., Miki Y.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-424.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-472.
    Tissue: Trachea.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-522 (ISOFORM 4), VARIANT LEU-472.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 221-941 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiANKY1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2S6
Secondary accession number(s): B2RB78
, Q4ZFV3, Q8IYX5, Q8NDK5, Q9H0V8, Q9NX10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: June 8, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.