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Protein

WD repeat-containing protein WRAP73

Gene

WRAP73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).2 Publications

GO - Biological processi

  • cell projection organization Source: UniProtKB-KW
  • mitotic spindle assembly Source: UniProtKB
  • positive regulation of nonmotile primary cilium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkiQ9P2S5.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein WRAP73
Alternative name(s):
WD repeat-containing protein 8
WD repeat-containing protein antisense to TP73 gene
Gene namesi
Name:WRAP73
Synonyms:WDR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12759. WRAP73.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB-SubCell
  • centrosome Source: UniProtKB
  • ciliary basal body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37363.

Polymorphism and mutation databases

BioMutaiWRAP73.
DMDMi17380347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460WD repeat-containing protein WRAP73PRO_0000051356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2S5.
MaxQBiQ9P2S5.
PaxDbiQ9P2S5.
PeptideAtlasiQ9P2S5.
PRIDEiQ9P2S5.

PTM databases

iPTMnetiQ9P2S5.
PhosphoSiteiQ9P2S5.

Expressioni

Tissue specificityi

Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barely detectable expression in lung.

Gene expression databases

BgeeiENSG00000116213.
CleanExiHS_WDR8.
ExpressionAtlasiQ9P2S5. baseline and differential.
GenevisibleiQ9P2S5. HS.

Organism-specific databases

HPAiHPA026893.

Interactioni

Subunit structurei

Interacts with SSX2IP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SSX2IPQ9Y2D89EBI-1054904,EBI-2212028
Ssx2ipQ8VC664EBI-1054904,EBI-6654049From a different organism.

Protein-protein interaction databases

BioGridi119068. 75 interactions.
IntActiQ9P2S5. 146 interactions.
MINTiMINT-4777079.
STRINGi9606.ENSP00000270708.

Structurei

3D structure databases

ProteinModelPortaliQ9P2S5.
SMRiQ9P2S5. Positions 10-58, 332-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 8641WD 1Add
BLAST
Repeati89 – 12941WD 2Add
BLAST
Repeati176 – 21035WD 3Add
BLAST
Repeati221 – 26040WD 4Add
BLAST
Repeati328 – 36942WD 5Add
BLAST
Repeati371 – 41040WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4497. Eukaryota.
ENOG410Y2P7. LUCA.
GeneTreeiENSGT00390000003623.
HOVERGENiHBG022803.
InParanoidiQ9P2S5.
OMAiATKNDNM.
OrthoDBiEOG091G0OTT.
PhylomeDBiQ9P2S5.
TreeFamiTF329103.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ
60 70 80 90 100
IQHIEWSADS LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS
110 120 130 140 150
PDGRHILNTT EFHLRITVWS LCTKSVSYIK YPKACLQGIT FTRDGRYMAL
160 170 180 190 200
AERRDCKDYV SIFVCSDWQL LRHFDTDTQD LTGIEWAPNG CVLAVWDTCL
210 220 230 240 250
EYKILLYSLD GRLLSTYSAY EWSLGIKSVA WSPSSQFLAV GSYDGKVRIL
260 270 280 290 300
NHVTWKMITE FGHPAAINDP KIVVYKEAEK SPQLGLGCLS FPPPRAGAGP
310 320 330 340 350
LPSSESKYEI ASVPVSLQTL KPVTDRANPK IGIGMLAFSP DSYFLATRND
360 370 380 390 400
NIPNAVWVWD IQKLRLFAVL EQLSPVRAFQ WDPQQPRLAI CTGGSRLYLW
410 420 430 440 450
SPAGCMSVQV PGEGDFAVLS LCWHLSGDSM ALLSKDHFCL CFLETEAVVG
460
TACRQLGGHT
Length:460
Mass (Da):51,588
Last modified:October 1, 2000 - v1
Checksum:iC2E318B1F06F79BF
GO

Sequence cautioni

The sequence CAI14336 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI19129 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811W → R in BAA91164 (PubMed:14702039).Curated
Sequence conflicti405 – 4051C → R in BAA91164 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti331 – 3311I → M.
Corresponds to variant rs2760320 [ dbSNP | Ensembl ].
VAR_057624
Natural varianti358 – 3581V → I.
Corresponds to variant rs16823940 [ dbSNP | Ensembl ].
VAR_057625

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034912 mRNA. Translation: BAA92312.1.
AK000437 mRNA. Translation: BAA91164.1.
AL136528, AL513320 Genomic DNA. Translation: CAI19128.1.
AL136528, AL513320 Genomic DNA. Translation: CAI19129.1. Sequence problems.
AL513320, AL136528 Genomic DNA. Translation: CAI14335.1.
AL513320, AL136528 Genomic DNA. Translation: CAI14336.1. Sequence problems.
BC086311 mRNA. Translation: AAH86311.1.
CCDSiCCDS48.1.
RefSeqiNP_060288.3. NM_017818.3.
UniGeneiHs.31714.

Genome annotation databases

EnsembliENST00000270708; ENSP00000270708; ENSG00000116213.
GeneIDi49856.
KEGGihsa:49856.
UCSCiuc001ako.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034912 mRNA. Translation: BAA92312.1.
AK000437 mRNA. Translation: BAA91164.1.
AL136528, AL513320 Genomic DNA. Translation: CAI19128.1.
AL136528, AL513320 Genomic DNA. Translation: CAI19129.1. Sequence problems.
AL513320, AL136528 Genomic DNA. Translation: CAI14335.1.
AL513320, AL136528 Genomic DNA. Translation: CAI14336.1. Sequence problems.
BC086311 mRNA. Translation: AAH86311.1.
CCDSiCCDS48.1.
RefSeqiNP_060288.3. NM_017818.3.
UniGeneiHs.31714.

3D structure databases

ProteinModelPortaliQ9P2S5.
SMRiQ9P2S5. Positions 10-58, 332-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119068. 75 interactions.
IntActiQ9P2S5. 146 interactions.
MINTiMINT-4777079.
STRINGi9606.ENSP00000270708.

PTM databases

iPTMnetiQ9P2S5.
PhosphoSiteiQ9P2S5.

Polymorphism and mutation databases

BioMutaiWRAP73.
DMDMi17380347.

Proteomic databases

EPDiQ9P2S5.
MaxQBiQ9P2S5.
PaxDbiQ9P2S5.
PeptideAtlasiQ9P2S5.
PRIDEiQ9P2S5.

Protocols and materials databases

DNASUi49856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270708; ENSP00000270708; ENSG00000116213.
GeneIDi49856.
KEGGihsa:49856.
UCSCiuc001ako.4. human.

Organism-specific databases

CTDi49856.
GeneCardsiWRAP73.
HGNCiHGNC:12759. WRAP73.
HPAiHPA026893.
MIMi606040. gene.
neXtProtiNX_Q9P2S5.
PharmGKBiPA37363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4497. Eukaryota.
ENOG410Y2P7. LUCA.
GeneTreeiENSGT00390000003623.
HOVERGENiHBG022803.
InParanoidiQ9P2S5.
OMAiATKNDNM.
OrthoDBiEOG091G0OTT.
PhylomeDBiQ9P2S5.
TreeFamiTF329103.

Enzyme and pathway databases

SignaLinkiQ9P2S5.

Miscellaneous databases

ChiTaRSiWRAP73. human.
GeneWikiiWDR8.
GenomeRNAii49856.
PROiQ9P2S5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116213.
CleanExiHS_WDR8.
ExpressionAtlasiQ9P2S5. baseline and differential.
GenevisibleiQ9P2S5. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWRP73_HUMAN
AccessioniPrimary (citable) accession number: Q9P2S5
Secondary accession number(s): Q5T0D6
, Q9BUH7, Q9NTK7, Q9NX56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.