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Protein

Neurexin-2

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi335CalciumBy similarity1
Metal bindingi352Calcium; via carbonyl oxygenBy similarity1
Metal bindingi420Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: BHF-UCL
  • chemical synaptic transmission Source: BHF-UCL
  • gephyrin clustering involved in postsynaptic density assembly Source: BHF-UCL
  • neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCL
  • neuron cell-cell adhesion Source: BHF-UCL
  • neurotransmitter secretion Source: BHF-UCL
  • postsynaptic density protein 95 clustering Source: BHF-UCL
  • postsynaptic membrane assembly Source: BHF-UCL
  • signal transduction Source: BHF-UCL
  • social behavior Source: BHF-UCL
  • synapse assembly Source: BHF-UCL
  • vocalization behavior Source: BHF-UCL
  • vocal learning Source: BHF-UCL

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha
Gene namesi
Name:NRXN2
Synonyms:KIAA0921
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110076.18
HGNCiHGNC:8009 NRXN2
MIMi600566 gene
neXtProtiNX_Q9P2S2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1636ExtracellularSequence analysisAdd BLAST1608
Transmembranei1637 – 1657HelicalSequence analysisAdd BLAST21
Topological domaini1658 – 1712CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9379
OpenTargetsiENSG00000110076
PharmGKBiPA31787

Polymorphism and mutation databases

BioMutaiFAM221B
DMDMi17369343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001949529 – 1712Neurexin-2Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 219By similarity
Disulfide bondi213 ↔ 229By similarity
Disulfide bondi231 ↔ 241By similarity
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 486By similarity
Disulfide bondi657 ↔ 686By similarity
Disulfide bondi694 ↔ 705By similarity
Disulfide bondi699 ↔ 714By similarity
Disulfide bondi716 ↔ 726By similarity
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1065 ↔ 1093By similarity
Disulfide bondi1100 ↔ 1111By similarity
Disulfide bondi1105 ↔ 1120By similarity
Disulfide bondi1122 ↔ 1132By similarity
Glycosylationi1236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9P2S2
PeptideAtlasiQ9P2S2
PRIDEiQ9P2S2

PTM databases

iPTMnetiQ9P2S2
PhosphoSitePlusiQ9P2S2

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSG00000110076
CleanExiHS_NRXN2
ExpressionAtlasiQ9P2S2 baseline and differential
GenevisibleiQ9P2S2 HS

Organism-specific databases

HPAiHPA051470

Interactioni

Subunit structurei

The laminin G-like domain 1 binds to NXPH1. Interacts with PATJ (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Isoforms alpha 2C bind to alpha-dystroglycan (By similarity). Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114780, 6 interactors
IntActiQ9P2S2, 3 interactors
MINTiQ9P2S2
STRINGi9606.ENSP00000265459

Structurei

3D structure databases

ProteinModelPortaliQ9P2S2
SMRiQ9P2S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 206Laminin G-like 1PROSITE-ProRule annotationAdd BLAST178
Domaini202 – 242EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini289 – 486Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini493 – 686Laminin G-like 3PROSITE-ProRule annotationAdd BLAST194
Domaini690 – 727EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini732 – 904Laminin G-like 4PROSITE-ProRule annotationAdd BLAST173
Domaini918 – 1093Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1096 – 1133EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1137 – 1345Laminin G-like 6PROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1368 – 1371Poly-Thr4
Compositional biasi1374 – 1377Poly-Thr4
Compositional biasi1444 – 1447Poly-Pro4
Compositional biasi1644 – 1647Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230481
HOVERGENiHBG052670
InParanoidiQ9P2S2
KOiK07377
OMAiEESCANQ
OrthoDBiEOG091G00KC
PhylomeDBiQ9P2S2
TreeFamiTF321302

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 7 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.
Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGG GAGSHSSAQR
560 570 580 590 600
ADYFAMELLD GHLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGDSEIL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGVCREGWN RFICDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD NVTVEGQMAG
860 870 880 890 900
AHMRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD
910 920 930 940 950
ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA
960 970 980 990 1000
PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ
1010 1020 1030 1040 1050
WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGLSKNMFS
1060 1070 1080 1090 1100
NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE RGCDGPSTTC
1110 1120 1130 1140 1150
TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI FGKGGALITY
1160 1170 1180 1190 1200
TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV
1210 1220 1230 1240 1250
GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY
1260 1270 1280 1290 1300
PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR
1310 1320 1330 1340 1350
DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA
1360 1370 1380 1390 1400
ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTLRDSTT QNTDDLLVAS
1410 1420 1430 1440 1450
AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY
1460 1470 1480 1490 1500
PFLTGVGATQ DTLPPPAARR PPSGGPCQAE RDDSDCEEPI EASGFASGEV
1510 1520 1530 1540 1550
FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL
1560 1570 1580 1590 1600
FAPSAPAPNL PAGKMNHRDP LQPLLENPPL GPGAPTSFEP RRPPPLRPGV
1610 1620 1630 1640 1650
TSAPGFPHLP TANPTGPGER GPPGAVEVIR ESSSTTGMVV GIVAAAALCI
1660 1670 1680 1690 1700
LILLYAMYKY RNRDEGSYQV DQSRNYISNS AQSNGAVVKE KAPAAPKTPS
1710
KAKKNKDKEY YV
Length:1,712
Mass (Da):184,982
Last modified:October 1, 2000 - v1
Checksum:iE4E8EC404DA1D0B0
GO
Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     260-283: Missing.
     393-399: Missing.
     797-806: DCLRVGCAPS → G
     1253-1282: Missing.

Show »
Length:1,642
Mass (Da):177,293
Checksum:i68040E0B3E151C3A
GO
Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P58401.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:666
Mass (Da):70,927
GO

Sequence cautioni

The sequence BAA76765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05026681L → Q. Corresponds to variant dbSNP:rs12273892EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003505260 – 283Missing in isoform 2a. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_003506393 – 399Missing in isoform 2a. 2 Publications7
Alternative sequenceiVSP_003507797 – 806DCLRVGCAPS → G in isoform 2a. 2 Publications10
Alternative sequenceiVSP_0035081253 – 1282Missing in isoform 2a. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035266 mRNA Translation: BAA94075.1
AB023138 mRNA Translation: BAA76765.2 Different initiation.
AC044790 Genomic DNA Translation: AAK68154.1
BC150275 mRNA Translation: AAI50276.1
CCDSiCCDS31597.1 [Q9P2S2-2]
CCDS8077.1 [Q9P2S2-1]
RefSeqiNP_055895.1, NM_015080.3 [Q9P2S2-1]
NP_620060.1, NM_138732.2 [Q9P2S2-2]
UniGeneiHs.372938

Genome annotation databases

EnsembliENST00000265459; ENSP00000265459; ENSG00000110076 [Q9P2S2-1]
ENST00000377551; ENSP00000366774; ENSG00000110076 [Q9P2S2-1]
ENST00000377559; ENSP00000366782; ENSG00000110076 [Q9P2S2-2]
GeneIDi9379
KEGGihsa:9379
UCSCiuc021qkw.2 human [Q9P2S2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNRX2A_HUMAN
AccessioniPrimary (citable) accession number: Q9P2S2
Secondary accession number(s): A7E2C1, Q9Y2D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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