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Protein

Neurexin-2

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351CalciumBy similarity
Metal bindingi352 – 3521Calcium; via carbonyl oxygenBy similarity
Metal bindingi420 – 4201Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: BHF-UCL
  • gephyrin clustering involved in postsynaptic density assembly Source: BHF-UCL
  • neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCL
  • neuron cell-cell adhesion Source: BHF-UCL
  • neurotransmitter secretion Source: BHF-UCL
  • postsynaptic density protein 95 clustering Source: BHF-UCL
  • postsynaptic membrane assembly Source: BHF-UCL
  • signal transduction Source: BHF-UCL
  • social behavior Source: BHF-UCL
  • synapse assembly Source: BHF-UCL
  • synaptic transmission Source: BHF-UCL
  • vocalization behavior Source: BHF-UCL
  • vocal learning Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha
Gene namesi
Name:NRXN2
Synonyms:KIAA0921
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8009. NRXN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 16361608ExtracellularSequence analysisAdd
BLAST
Transmembranei1637 – 165721HelicalSequence analysisAdd
BLAST
Topological domaini1658 – 171255CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31787.

Polymorphism and mutation databases

BioMutaiFAM221B.
DMDMi17369343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 17121684Neurexin-2PRO_0000019495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi206 ↔ 219By similarity
Disulfide bondi213 ↔ 229By similarity
Disulfide bondi231 ↔ 241By similarity
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi450 ↔ 486By similarity
Disulfide bondi657 ↔ 686By similarity
Disulfide bondi694 ↔ 705By similarity
Disulfide bondi699 ↔ 714By similarity
Disulfide bondi716 ↔ 726By similarity
Glycosylationi841 – 8411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1065 ↔ 1093By similarity
Disulfide bondi1100 ↔ 1111By similarity
Disulfide bondi1105 ↔ 1120By similarity
Disulfide bondi1122 ↔ 1132By similarity
Glycosylationi1236 – 12361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9P2S2.
PaxDbiQ9P2S2.
PeptideAtlasiQ9P2S2.
PRIDEiQ9P2S2.

PTM databases

iPTMnetiQ9P2S2.
PhosphoSiteiQ9P2S2.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiQ9P2S2.
CleanExiHS_NRXN2.
ExpressionAtlasiQ9P2S2. baseline and differential.
GenevisibleiQ9P2S2. HS.

Interactioni

Subunit structurei

The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114780. 6 interactions.
IntActiQ9P2S2. 3 interactions.
MINTiMINT-1381393.
STRINGi9606.ENSP00000265459.

Structurei

3D structure databases

ProteinModelPortaliQ9P2S2.
SMRiQ9P2S2. Positions 285-480, 730-912, 917-1341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 206178Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini202 – 24241EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 486198Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini493 – 686194Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini690 – 72738EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini732 – 904173Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini918 – 1093176Laminin G-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1096 – 113338EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1137 – 1345209Laminin G-like 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1368 – 13714Poly-Thr
Compositional biasi1374 – 13774Poly-Thr
Compositional biasi1444 – 14474Poly-Pro
Compositional biasi1644 – 16474Poly-Ala

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ9P2S2.
KOiK07377.
OMAiIAYEFGN.
PhylomeDBiQ9P2S2.
TreeFamiTF321302.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 3 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.

Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGG GAGSHSSAQR
560 570 580 590 600
ADYFAMELLD GHLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGDSEIL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGVCREGWN RFICDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD NVTVEGQMAG
860 870 880 890 900
AHMRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD
910 920 930 940 950
ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA
960 970 980 990 1000
PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ
1010 1020 1030 1040 1050
WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGLSKNMFS
1060 1070 1080 1090 1100
NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE RGCDGPSTTC
1110 1120 1130 1140 1150
TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI FGKGGALITY
1160 1170 1180 1190 1200
TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV
1210 1220 1230 1240 1250
GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY
1260 1270 1280 1290 1300
PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR
1310 1320 1330 1340 1350
DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA
1360 1370 1380 1390 1400
ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTLRDSTT QNTDDLLVAS
1410 1420 1430 1440 1450
AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY
1460 1470 1480 1490 1500
PFLTGVGATQ DTLPPPAARR PPSGGPCQAE RDDSDCEEPI EASGFASGEV
1510 1520 1530 1540 1550
FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL
1560 1570 1580 1590 1600
FAPSAPAPNL PAGKMNHRDP LQPLLENPPL GPGAPTSFEP RRPPPLRPGV
1610 1620 1630 1640 1650
TSAPGFPHLP TANPTGPGER GPPGAVEVIR ESSSTTGMVV GIVAAAALCI
1660 1670 1680 1690 1700
LILLYAMYKY RNRDEGSYQV DQSRNYISNS AQSNGAVVKE KAPAAPKTPS
1710
KAKKNKDKEY YV
Length:1,712
Mass (Da):184,982
Last modified:October 1, 2000 - v1
Checksum:iE4E8EC404DA1D0B0
GO
Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to basket

Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     260-283: Missing.
     393-399: Missing.
     797-806: DCLRVGCAPS → G
     1253-1282: Missing.

Show »
Length:1,642
Mass (Da):177,293
Checksum:i68040E0B3E151C3A
GO
Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P58401.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:666
Mass (Da):70,927
GO

Sequence cautioni

The sequence BAA76765.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811L → Q.
Corresponds to variant rs12273892 [ dbSNP | Ensembl ].
VAR_050266

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei260 – 28324Missing in isoform 2a. 2 PublicationsVSP_003505Add
BLAST
Alternative sequencei393 – 3997Missing in isoform 2a. 2 PublicationsVSP_003506
Alternative sequencei797 – 80610DCLRVGCAPS → G in isoform 2a. 2 PublicationsVSP_003507
Alternative sequencei1253 – 128230Missing in isoform 2a. 2 PublicationsVSP_003508Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035266 mRNA. Translation: BAA94075.1.
AB023138 mRNA. Translation: BAA76765.2. Different initiation.
AC044790 Genomic DNA. Translation: AAK68154.1.
BC150275 mRNA. Translation: AAI50276.1.
CCDSiCCDS31597.1. [Q9P2S2-2]
CCDS8077.1. [Q9P2S2-1]
RefSeqiNP_055895.1. NM_015080.3. [Q9P2S2-1]
NP_620060.1. NM_138732.2. [Q9P2S2-2]
UniGeneiHs.372938.

Genome annotation databases

EnsembliENST00000265459; ENSP00000265459; ENSG00000110076. [Q9P2S2-1]
ENST00000377551; ENSP00000366774; ENSG00000110076. [Q9P2S2-1]
ENST00000377559; ENSP00000366782; ENSG00000110076. [Q9P2S2-2]
GeneIDi9379.
KEGGihsa:9379.
UCSCiuc021qkw.2. human. [Q9P2S2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035266 mRNA. Translation: BAA94075.1.
AB023138 mRNA. Translation: BAA76765.2. Different initiation.
AC044790 Genomic DNA. Translation: AAK68154.1.
BC150275 mRNA. Translation: AAI50276.1.
CCDSiCCDS31597.1. [Q9P2S2-2]
CCDS8077.1. [Q9P2S2-1]
RefSeqiNP_055895.1. NM_015080.3. [Q9P2S2-1]
NP_620060.1. NM_138732.2. [Q9P2S2-2]
UniGeneiHs.372938.

3D structure databases

ProteinModelPortaliQ9P2S2.
SMRiQ9P2S2. Positions 285-480, 730-912, 917-1341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114780. 6 interactions.
IntActiQ9P2S2. 3 interactions.
MINTiMINT-1381393.
STRINGi9606.ENSP00000265459.

PTM databases

iPTMnetiQ9P2S2.
PhosphoSiteiQ9P2S2.

Polymorphism and mutation databases

BioMutaiFAM221B.
DMDMi17369343.

Proteomic databases

EPDiQ9P2S2.
PaxDbiQ9P2S2.
PeptideAtlasiQ9P2S2.
PRIDEiQ9P2S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265459; ENSP00000265459; ENSG00000110076. [Q9P2S2-1]
ENST00000377551; ENSP00000366774; ENSG00000110076. [Q9P2S2-1]
ENST00000377559; ENSP00000366782; ENSG00000110076. [Q9P2S2-2]
GeneIDi9379.
KEGGihsa:9379.
UCSCiuc021qkw.2. human. [Q9P2S2-1]

Organism-specific databases

CTDi9379.
GeneCardsiNRXN2.
HGNCiHGNC:8009. NRXN2.
MIMi600566. gene.
neXtProtiNX_Q9P2S2.
PharmGKBiPA31787.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ9P2S2.
KOiK07377.
OMAiIAYEFGN.
PhylomeDBiQ9P2S2.
TreeFamiTF321302.

Miscellaneous databases

ChiTaRSiNRXN2. human.
GenomeRNAii9379.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2S2.
CleanExiHS_NRXN2.
ExpressionAtlasiQ9P2S2. baseline and differential.
GenevisibleiQ9P2S2. HS.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 3 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human neurexin II."
    Seki N., Yoshikawa T., Azuma T., Muramatsu M., Saito T.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
    Tissue: Fetal brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A).

Entry informationi

Entry nameiNRX2A_HUMAN
AccessioniPrimary (citable) accession number: Q9P2S2
Secondary accession number(s): A7E2C1, Q9Y2D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.