Q9P2R3 (ANFY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and FYVE domain-containing protein 1

Alternative name(s):
Ankyrin repeats hooked to a zinc finger motif

Gene names

Name:	ANKFY1
Synonyms:	ANKHZN, KIAA1255

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm. Endosome membrane; Peripheral membrane protein. Note: Also associated with endosomal membranes. Ref.1
Tissue specificity	High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain. Ref.1 Ref.2
Sequence similarities	Contains 21 ANK repeats. Contains 1 BTB (POZ) domain. Contains 1 FYVE-type zinc finger.
Sequence caution	The sequence BAA86569.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Endosome Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	endosome membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2R3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2R3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     650-650: V → VS

Isoform 3 (identifier: Q9P2R3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     459-487: NCLLQRAAGAGNEAAALFLATNGAHVNHR → KARASRRGDAGVCRRQEMACKCLHPKFRN
     488-1169: Missing.

Isoform 4 (identifier: Q9P2R3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MAEE → MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.8
	Chain	2 – 1169	1168	Ankyrin repeat and FYVE domain-containing protein 1		PRO_0000066890
Regions
	Domain	68 – 130	63	BTB
	Repeat	217 – 247	31	ANK 1
	Repeat	255 – 284	30	ANK 2
	Repeat	288 – 317	30	ANK 3
	Repeat	322 – 362	41	ANK 4
	Repeat	366 – 396	31	ANK 5
	Repeat	490 – 519	30	ANK 6
	Repeat	542 – 572	31	ANK 7
	Repeat	588 – 617	30	ANK 8
	Repeat	621 – 650	30	ANK 9
	Repeat	654 – 683	30	ANK 10
	Repeat	687 – 716	30	ANK 11
	Repeat	724 – 753	30	ANK 12
	Repeat	769 – 798	30	ANK 13
	Repeat	802 – 832	31	ANK 14
	Repeat	836 – 865	30	ANK 15
	Repeat	870 – 899	30	ANK 16
	Repeat	905 – 934	30	ANK 17
	Repeat	938 – 967	30	ANK 18
	Repeat	971 – 1001	31	ANK 19
	Repeat	1005 – 1037	33	ANK 20
	Repeat	1043 – 1072	30	ANK 21
	Zinc finger	1104 – 1164	61	FYVE-type
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.8
Natural variations
	Alternative sequence	1 – 4	4	MAEE → MPTPRDCGRLRSRAGRSRAG AACSRGAPRAAREALDCRRC RDAGGK in isoform 4.		VSP_041447
	Alternative sequence	459 – 487	29	NCLLQ…HVNHR → KARASRRGDAGVCRRQEMAC KCLHPKFRN in isoform 3.		VSP_041448
	Alternative sequence	488 – 1169	682	Missing in isoform 3.		VSP_041449
	Alternative sequence	650	1	V → VS in isoform 2.		VSP_035607
Experimental info
	Sequence conflict	48	1	E → K in BAA90300. Ref.1
	Sequence conflict	115	1	M → V in BAA90300. Ref.1
	Sequence conflict	207	1	A → P in BAA90300. Ref.1
	Sequence conflict	235	1	F → S in BAA90300. Ref.1
	Sequence conflict	270	1	S → N in BAA90300. Ref.1
	Sequence conflict	283 – 291	9	DMVDKSGWS → AWWPRVLE in BAA90300. Ref.1
	Sequence conflict	299 – 300	2	RG → E in BAA90300. Ref.1
	Sequence conflict	322	1	A → C in BAA90300. Ref.1
	Sequence conflict	336 – 337	2	KK → RN in BAA90300. Ref.1
	Sequence conflict	379	1	N → D in BAA90300. Ref.1
	Sequence conflict	385	1	Q → H in BAA90300. Ref.1
	Sequence conflict	645	1	Q → R in BAA90300. Ref.1
	Sequence conflict	652 – 654	3	TQD → PQA in BAA90300. Ref.1
	Sequence conflict	687	1	K → E in BAA90300. Ref.1
	Sequence conflict	713	1	D → G in BAA90300. Ref.1
	Sequence conflict	784	1	Missing in BAA90300. Ref.1
	Sequence conflict	795	1	N → D in BAA90300. Ref.1
	Sequence conflict	798	1	A → P in BAA90300. Ref.1
	Sequence conflict	807	1	I → C in BAA90300. Ref.1
	Sequence conflict	827 – 829	3	DIH → ISS in BAA90300. Ref.1
	Sequence conflict	835	1	R → K in BAA90300. Ref.1
	Sequence conflict	849	1	N → D in BAA90300. Ref.1
	Sequence conflict	860	1	E → G in BAA90300. Ref.1
	Sequence conflict	874	1	F → S in BAA90300. Ref.1
	Sequence conflict	889	1	F → S in BAA90300. Ref.1
	Sequence conflict	901	1	V → A in BAA90300. Ref.1
	Sequence conflict	905	1	S → P in BAA90300. Ref.1
	Sequence conflict	913	1	A → V in BAA90300. Ref.1
	Sequence conflict	916	1	A → E in BAA90300. Ref.1
	Sequence conflict	933	1	N → T in BAA90300. Ref.1
	Sequence conflict	940	1	Q → K in BAA90300. Ref.1
	Sequence conflict	949	1	Q → E in BAA90300. Ref.1
	Sequence conflict	962	1	G → A in BAA90300. Ref.1
	Sequence conflict	1120	1	T → A in BAA90300. Ref.1
	Sequence conflict	1157	1	N → T in BAA90300. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 4, 2003. Version 2. Checksum: 589297CA4ACDDB56	FASTA	1,169	128,399
	10 20 30 40 50 60 MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCALLAAQ ANKESSSESF ISRLLAIVAD 70 80 90 100 110 120 LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS TKELDLSDAN PEVTMTMLRW 130 140 150 160 170 180 IYTDELEFRE DDVFLTELMK LANRFQLQLL RERCEKGVMS LVNVRNCIRF YQTAEELNAS 190 200 210 220 230 240 TLMNYCAEII ASHWDDLRKE DFSSMSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE 250 260 270 280 290 300 MDSQLPGKLN EADHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKSGW SLLHKGIQRG 310 320 330 340 350 360 DLFAATFLIK NGAFVNAATL GAQETPLHLV ALYSSKKHSA DVMSEMAQIA EALLQAGANP 370 380 390 400 410 420 NMQDSKGRTP LHVSIMAGNE YVFSQLLQCK QLDLELKDHE GSTALWLAVQ HITVSSDQSV 430 440 450 460 470 480 NPFEDVPVVN GTSFDENSFA ARLIQRGSHT DAPDTATGNC LLQRAAGAGN EAAALFLATN 490 500 510 520 530 540 GAHVNHRNKW GETPLHTACR HGLANLTAEL LQQGANPNLQ TEEALPLPKE AASLTSLADS 550 560 570 580 590 600 VHLQTPLHMA IAYNHPDVVS VILEQKANAL HATNNLQIIP DFSLKDSRDQ TVLGLALWTG 610 620 630 640 650 660 MHTIAAQLLG SGAAINDTMS DGQTLLHMAI QRQDSKSALF LLEHQADINV RTQDGETALQ 670 680 690 700 710 720 LAIRNQLPLV VDAICTRGAD MSVPDEKGNP PLWLALANNL EDIASTLVRH GCDATCWGPG 730 740 750 760 770 780 PGGCLQTLLH RAIDENNEPT ACFLIRSGCD VNSPRQPGAN GEGEEEARDG QTPLHLAASW 790 800 810 820 830 840 GLEETVQCLL EFGANVNAQD AEGRTPIHVA ISSQHGVIIQ LLVSHPDIHL NVRDRQGLTP 850 860 870 880 890 900 FACAMTFKNN KSAEAILKRE SGAAEQVDNK GRNFLHVAVQ NSDIESVLFL ISVHANVNSR 910 920 930 940 950 960 VQDASKLTPL HLAVQAGSEI IVRNLLLAGA KVNELTKHRQ TALHLAAQQD LPTICSVLLE 970 980 990 1000 1010 1020 NGVDFAAVDE NGNNALHLAV MHGRLNNIRV LLTECTVDAE AFNLRGQSPL HILGQYGKEN 1030 1040 1050 1060 1070 1080 AAAIFDLFLE CMPGYPLDKP DADGSTVLLL AYMKGNANLC RAIVRSGARL GVNNNQGVNI 1090 1100 1110 1120 1130 1140 FNYQVATKQL LFRLLDMLSK EPPWCDGSYC YECTARFGVT TRKHHCRHCG RLLCHKCSTK 1150 1160 EIPIIKFDLN KPVRVCNICF DVLTLGGVS
	Isoform 2 [UniParc]. Checksum: 7972BC32D1D37137	FASTA	1,170	128,486
	10 20 30 40 50 60 MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCALLAAQ ANKESSSESF ISRLLAIVAD 70 80 90 100 110 120 LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS TKELDLSDAN PEVTMTMLRW 130 140 150 160 170 180 IYTDELEFRE DDVFLTELMK LANRFQLQLL RERCEKGVMS LVNVRNCIRF YQTAEELNAS 190 200 210 220 230 240 TLMNYCAEII ASHWDDLRKE DFSSMSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE 250 260 270 280 290 300 MDSQLPGKLN EADHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKSGW SLLHKGIQRG 310 320 330 340 350 360 DLFAATFLIK NGAFVNAATL GAQETPLHLV ALYSSKKHSA DVMSEMAQIA EALLQAGANP 370 380 390 400 410 420 NMQDSKGRTP LHVSIMAGNE YVFSQLLQCK QLDLELKDHE GSTALWLAVQ HITVSSDQSV 430 440 450 460 470 480 NPFEDVPVVN GTSFDENSFA ARLIQRGSHT DAPDTATGNC LLQRAAGAGN EAAALFLATN 490 500 510 520 530 540 GAHVNHRNKW GETPLHTACR HGLANLTAEL LQQGANPNLQ TEEALPLPKE AASLTSLADS 550 560 570 580 590 600 VHLQTPLHMA IAYNHPDVVS VILEQKANAL HATNNLQIIP DFSLKDSRDQ TVLGLALWTG 610 620 630 640 650 660 MHTIAAQLLG SGAAINDTMS DGQTLLHMAI QRQDSKSALF LLEHQADINV SRTQDGETAL 670 680 690 700 710 720 QLAIRNQLPL VVDAICTRGA DMSVPDEKGN PPLWLALANN LEDIASTLVR HGCDATCWGP 730 740 750 760 770 780 GPGGCLQTLL HRAIDENNEP TACFLIRSGC DVNSPRQPGA NGEGEEEARD GQTPLHLAAS 790 800 810 820 830 840 WGLEETVQCL LEFGANVNAQ DAEGRTPIHV AISSQHGVII QLLVSHPDIH LNVRDRQGLT 850 860 870 880 890 900 PFACAMTFKN NKSAEAILKR ESGAAEQVDN KGRNFLHVAV QNSDIESVLF LISVHANVNS 910 920 930 940 950 960 RVQDASKLTP LHLAVQAGSE IIVRNLLLAG AKVNELTKHR QTALHLAAQQ DLPTICSVLL 970 980 990 1000 1010 1020 ENGVDFAAVD ENGNNALHLA VMHGRLNNIR VLLTECTVDA EAFNLRGQSP LHILGQYGKE 1030 1040 1050 1060 1070 1080 NAAAIFDLFL ECMPGYPLDK PDADGSTVLL LAYMKGNANL CRAIVRSGAR LGVNNNQGVN 1090 1100 1110 1120 1130 1140 IFNYQVATKQ LLFRLLDMLS KEPPWCDGSY CYECTARFGV TTRKHHCRHC GRLLCHKCST 1150 1160 1170 KEIPIIKFDL NKPVRVCNIC FDVLTLGGVS
	Isoform 3 [UniParc]. Checksum: E27261B7EDC53947	FASTA	487	54,778
	10 20 30 40 50 60 MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCALLAAQ ANKESSSESF ISRLLAIVAD 70 80 90 100 110 120 LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS TKELDLSDAN PEVTMTMLRW 130 140 150 160 170 180 IYTDELEFRE DDVFLTELMK LANRFQLQLL RERCEKGVMS LVNVRNCIRF YQTAEELNAS 190 200 210 220 230 240 TLMNYCAEII ASHWDDLRKE DFSSMSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE 250 260 270 280 290 300 MDSQLPGKLN EADHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKSGW SLLHKGIQRG 310 320 330 340 350 360 DLFAATFLIK NGAFVNAATL GAQETPLHLV ALYSSKKHSA DVMSEMAQIA EALLQAGANP 370 380 390 400 410 420 NMQDSKGRTP LHVSIMAGNE YVFSQLLQCK QLDLELKDHE GSTALWLAVQ HITVSSDQSV 430 440 450 460 470 480 NPFEDVPVVN GTSFDENSFA ARLIQRGSHT DAPDTATGKA RASRRGDAGV CRRQEMACKC LHPKFRN
	Isoform 4 [UniParc]. Checksum: 810E7D2D0F90352E	FASTA	1,211	132,821
	10 20 30 40 50 60 MPTPRDCGRL RSRAGRSRAG AACSRGAPRA AREALDCRRC RDAGGKEVAK LEKHLMLLRQ 70 80 90 100 110 120 EYVKLQKKLA ETEKRCALLA AQANKESSSE SFISRLLAIV ADLYEQEQYS DLKIKVGDRH 130 140 150 160 170 180 ISAHKFVLAA RSDSWSLANL SSTKELDLSD ANPEVTMTML RWIYTDELEF REDDVFLTEL 190 200 210 220 230 240 MKLANRFQLQ LLRERCEKGV MSLVNVRNCI RFYQTAEELN ASTLMNYCAE IIASHWDDLR 250 260 270 280 290 300 KEDFSSMSAQ LLYKMIKSKT EYPLHKAIKV EREDVVFLYL IEMDSQLPGK LNEADHNGDL 310 320 330 340 350 360 ALDLALSRRL ESIATTLVSH KADVDMVDKS GWSLLHKGIQ RGDLFAATFL IKNGAFVNAA 370 380 390 400 410 420 TLGAQETPLH LVALYSSKKH SADVMSEMAQ IAEALLQAGA NPNMQDSKGR TPLHVSIMAG 430 440 450 460 470 480 NEYVFSQLLQ CKQLDLELKD HEGSTALWLA VQHITVSSDQ SVNPFEDVPV VNGTSFDENS 490 500 510 520 530 540 FAARLIQRGS HTDAPDTATG NCLLQRAAGA GNEAAALFLA TNGAHVNHRN KWGETPLHTA 550 560 570 580 590 600 CRHGLANLTA ELLQQGANPN LQTEEALPLP KEAASLTSLA DSVHLQTPLH MAIAYNHPDV 610 620 630 640 650 660 VSVILEQKAN ALHATNNLQI IPDFSLKDSR DQTVLGLALW TGMHTIAAQL LGSGAAINDT 670 680 690 700 710 720 MSDGQTLLHM AIQRQDSKSA LFLLEHQADI NVRTQDGETA LQLAIRNQLP LVVDAICTRG 730 740 750 760 770 780 ADMSVPDEKG NPPLWLALAN NLEDIASTLV RHGCDATCWG PGPGGCLQTL LHRAIDENNE 790 800 810 820 830 840 PTACFLIRSG CDVNSPRQPG ANGEGEEEAR DGQTPLHLAA SWGLEETVQC LLEFGANVNA 850 860 870 880 890 900 QDAEGRTPIH VAISSQHGVI IQLLVSHPDI HLNVRDRQGL TPFACAMTFK NNKSAEAILK 910 920 930 940 950 960 RESGAAEQVD NKGRNFLHVA VQNSDIESVL FLISVHANVN SRVQDASKLT PLHLAVQAGS 970 980 990 1000 1010 1020 EIIVRNLLLA GAKVNELTKH RQTALHLAAQ QDLPTICSVL LENGVDFAAV DENGNNALHL 1030 1040 1050 1060 1070 1080 AVMHGRLNNI RVLLTECTVD AEAFNLRGQS PLHILGQYGK ENAAAIFDLF LECMPGYPLD 1090 1100 1110 1120 1130 1140 KPDADGSTVL LLAYMKGNAN LCRAIVRSGA RLGVNNNQGV NIFNYQVATK QLLFRLLDML 1150 1160 1170 1180 1190 1200 SKEPPWCDGS YCYECTARFG VTTRKHHCRH CGRLLCHKCS TKEIPIIKFD LNKPVRVCNI 1210 CFDVLTLGGV S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and chromosomal mapping of a novel human gene, ANKHZN." Kuriyama H., Asakawa S., Minoshima S., Maruyama H., Ishii N., Ito K., Gejyo F., Arakawa M., Shimizu N., Kuwano R. Gene 253:151-160(2000) [PubMed: 10940552] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Mammary gland.
[8]	Bienvenut W.V., Vousden K.H., Lukashchuk N. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-11; 145-151 AND 924-931, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037360 mRNA. Translation: BAA90300.1. AB033081 mRNA. Translation: BAA86569.2. Different initiation. AK292930 mRNA. Translation: BAF85619.1. AC087292 Genomic DNA. No translation available. AC087742 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90448.1. BC052308 mRNA. Translation: AAH52308.1.
IPI	IPI00159899. IPI00375301. IPI00914539. IPI01019010.
RefSeq	NP_057460.3. NM_016376.3. NP_065791.1. NM_020740.2.
UniGene	Hs.696087.
3D structure databases
ProteinModelPortal	Q9P2R3.
SMR	Q9P2R3. Positions 51-193, 215-573, 690-1164.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46068N.
IntAct	Q9P2R3. 13 interactions.
STRING	Q9P2R3.
PTM databases
PhosphoSite	Q9P2R3.
Polymorphism databases
DMDM	33514905.
Proteomic databases
PRIDE	Q9P2R3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341657; ENSP00000343362; ENSG00000185722. ENST00000433651; ENSP00000416005; ENSG00000185722.
GeneID	51479.
KEGG	hsa:51479.
UCSC	uc002fxn.1. human.
Organism-specific databases
CTD	51479.
GeneCards	GC17M004013.
H-InvDB	HIX0013439.
HGNC	HGNC:20763. ANKFY1.
HPA	HPA024513. HPA024522.
MIM	607927. gene.
neXtProt	NX_Q9P2R3.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11792.
GeneTree	ENSGT00560000077224.
HOGENOM	HBG715841.
HOVERGEN	HBG050501.
InParanoid	Q9P2R3.
OMA	SHPDIHL.
OrthoDB	EOG4F7NJ7.
PhylomeDB	Q9P2R3.
Gene expression databases
ArrayExpress	Q9P2R3.
Bgee	Q9P2R3.
CleanEx	HS_ANKFY1.
Genevestigator	Q9P2R3.
GermOnline	ENSG00000185722. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 3 hits. G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF12796. Ank_2. 5 hits. PF00651. BTB. 1 hit. PF01363. FYVE. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 21 hits. SM00225. BTB. 1 hit. SM00064. FYVE. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 3 hits. SSF54695. BTB/POZ_fold. 1 hit. SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 12 hits. PS50097. BTB. 1 hit. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ANFY1_HUMAN

Accession

Primary (citable) accession number: Q9P2R3
Secondary accession number(s): A8KA65, Q5RKV4, Q9ULG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	August 4, 2003
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.