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Protein

Rabankyrin-5

Gene

ANKFY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI3P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1104 – 1164FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol phosphate binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • endosomal vesicle fusion Source: UniProtKB
  • endosome localization Source: UniProtKB
  • Golgi to lysosome transport Source: UniProtKB
  • positive regulation of pinocytosis Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30647-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Rabankyrin-51 Publication
Short name:
Rank-51 Publication
Alternative name(s):
Ankyrin repeat and FYVE domain-containing protein 1
Ankyrin repeats hooked to a zinc finger motif
Gene namesi
Name:ANKFY1
Synonyms:ANKHZN, KIAA1255
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20763. ANKFY1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • macropinosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi421 – 423NPF → APA: Disrupts interaction with EHD1. 1 Publication3
Mutagenesisi424 – 425ED → AA: Decreases interaction with EHD1. 1 Publication2

Organism-specific databases

DisGeNETi51479.
OpenTargetsiENSG00000185722.
PharmGKBiPA134984226.

Polymorphism and mutation databases

BioMutaiANKFY1.
DMDMi33514905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000668902 – 1169Rabankyrin-5Add BLAST1168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P2R3.
MaxQBiQ9P2R3.
PaxDbiQ9P2R3.
PeptideAtlasiQ9P2R3.
PRIDEiQ9P2R3.

PTM databases

iPTMnetiQ9P2R3.
PhosphoSitePlusiQ9P2R3.

Expressioni

Tissue specificityi

High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain.2 Publications

Gene expression databases

BgeeiENSG00000185722.
CleanExiHS_ANKFY1.
ExpressionAtlasiQ9P2R3. baseline and differential.
GenevisibleiQ9P2R3. HS.

Organism-specific databases

HPAiHPA024513.
HPA024522.
HPA065849.

Interactioni

Subunit structurei

Interacts with RAB5A (in GTP-bound form). Interacts with RHOD (independent of GTP-loaded status). Interacts with EHD1. Interacts with VPS26A; the interaction is indepenedent of EHD1 and is indicative for an association with the cargo recognition subcomplex of the retromer complex.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EHD1Q9H4M98EBI-2513908,EBI-490691
EHD3Q9NZN33EBI-2513908,EBI-2870749
GABARAPL2P605202EBI-2513908,EBI-720116

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119564. 33 interactors.
DIPiDIP-46068N.
IntActiQ9P2R3. 20 interactors.
STRINGi9606.ENSP00000459775.

Structurei

3D structure databases

ProteinModelPortaliQ9P2R3.
SMRiQ9P2R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 130BTBPROSITE-ProRule annotationAdd BLAST63
Repeati217 – 247ANK 1Add BLAST31
Repeati255 – 284ANK 2Add BLAST30
Repeati288 – 317ANK 3Add BLAST30
Repeati322 – 362ANK 4Add BLAST41
Repeati366 – 396ANK 5Add BLAST31
Repeati490 – 519ANK 6Add BLAST30
Repeati542 – 572ANK 7Add BLAST31
Repeati588 – 617ANK 8Add BLAST30
Repeati621 – 650ANK 9Add BLAST30
Repeati654 – 683ANK 10Add BLAST30
Repeati687 – 716ANK 11Add BLAST30
Repeati724 – 753ANK 12Add BLAST30
Repeati769 – 798ANK 13Add BLAST30
Repeati802 – 832ANK 14Add BLAST31
Repeati836 – 865ANK 15Add BLAST30
Repeati870 – 899ANK 16Add BLAST30
Repeati905 – 934ANK 17Add BLAST30
Repeati938 – 967ANK 18Add BLAST30
Repeati971 – 1001ANK 19Add BLAST31
Repeati1005 – 1037ANK 20Add BLAST33
Repeati1043 – 1072ANK 21Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni650 – 759Interaction with RHOD and RAB5A1 PublicationAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 423NPF3

Sequence similaritiesi

Contains 21 ANK repeats.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1104 – 1164FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4591. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00850000132305.
HOGENOMiHOG000022583.
HOVERGENiHBG050501.
InParanoidiQ9P2R3.
KOiK20129.
OMAiIHVAISN.
OrthoDBiEOG091G0ITN.
PhylomeDBiQ9P2R3.
TreeFamiTF351263.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 3 hits.
PF00651. BTB. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 21 hits.
SM00225. BTB. 1 hit.
SM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
SSF54695. SSF54695. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 12 hits.
PS50097. BTB. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCALLAAQ ANKESSSESF
60 70 80 90 100
ISRLLAIVAD LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS
110 120 130 140 150
TKELDLSDAN PEVTMTMLRW IYTDELEFRE DDVFLTELMK LANRFQLQLL
160 170 180 190 200
RERCEKGVMS LVNVRNCIRF YQTAEELNAS TLMNYCAEII ASHWDDLRKE
210 220 230 240 250
DFSSMSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE MDSQLPGKLN
260 270 280 290 300
EADHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKSGW SLLHKGIQRG
310 320 330 340 350
DLFAATFLIK NGAFVNAATL GAQETPLHLV ALYSSKKHSA DVMSEMAQIA
360 370 380 390 400
EALLQAGANP NMQDSKGRTP LHVSIMAGNE YVFSQLLQCK QLDLELKDHE
410 420 430 440 450
GSTALWLAVQ HITVSSDQSV NPFEDVPVVN GTSFDENSFA ARLIQRGSHT
460 470 480 490 500
DAPDTATGNC LLQRAAGAGN EAAALFLATN GAHVNHRNKW GETPLHTACR
510 520 530 540 550
HGLANLTAEL LQQGANPNLQ TEEALPLPKE AASLTSLADS VHLQTPLHMA
560 570 580 590 600
IAYNHPDVVS VILEQKANAL HATNNLQIIP DFSLKDSRDQ TVLGLALWTG
610 620 630 640 650
MHTIAAQLLG SGAAINDTMS DGQTLLHMAI QRQDSKSALF LLEHQADINV
660 670 680 690 700
RTQDGETALQ LAIRNQLPLV VDAICTRGAD MSVPDEKGNP PLWLALANNL
710 720 730 740 750
EDIASTLVRH GCDATCWGPG PGGCLQTLLH RAIDENNEPT ACFLIRSGCD
760 770 780 790 800
VNSPRQPGAN GEGEEEARDG QTPLHLAASW GLEETVQCLL EFGANVNAQD
810 820 830 840 850
AEGRTPIHVA ISSQHGVIIQ LLVSHPDIHL NVRDRQGLTP FACAMTFKNN
860 870 880 890 900
KSAEAILKRE SGAAEQVDNK GRNFLHVAVQ NSDIESVLFL ISVHANVNSR
910 920 930 940 950
VQDASKLTPL HLAVQAGSEI IVRNLLLAGA KVNELTKHRQ TALHLAAQQD
960 970 980 990 1000
LPTICSVLLE NGVDFAAVDE NGNNALHLAV MHGRLNNIRV LLTECTVDAE
1010 1020 1030 1040 1050
AFNLRGQSPL HILGQYGKEN AAAIFDLFLE CMPGYPLDKP DADGSTVLLL
1060 1070 1080 1090 1100
AYMKGNANLC RAIVRSGARL GVNNNQGVNI FNYQVATKQL LFRLLDMLSK
1110 1120 1130 1140 1150
EPPWCDGSYC YECTARFGVT TRKHHCRHCG RLLCHKCSTK EIPIIKFDLN
1160
KPVRVCNICF DVLTLGGVS
Length:1,169
Mass (Da):128,399
Last modified:August 4, 2003 - v2
Checksum:i589297CA4ACDDB56
GO
Isoform 2 (identifier: Q9P2R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-650: V → VS

Show »
Length:1,170
Mass (Da):128,486
Checksum:i7972BC32D1D37137
GO
Isoform 4 (identifier: Q9P2R3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MAEE → MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGK

Note: No experimental confirmation available.
Show »
Length:1,211
Mass (Da):132,821
Checksum:i810E7D2D0F90352E
GO

Sequence cautioni

The sequence AAH52308 differs from that shown. Intron retention.Curated
The sequence BAA86569 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48E → K in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti115M → V in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti207A → P in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti235F → S in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti270S → N in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti283 – 291DMVDKSGWS → AWWPRVLE in BAA90300 (PubMed:10940552).Curated9
Sequence conflicti299 – 300RG → E in BAA90300 (PubMed:10940552).Curated2
Sequence conflicti322A → C in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti336 – 337KK → RN in BAA90300 (PubMed:10940552).Curated2
Sequence conflicti379N → D in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti385Q → H in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti645Q → R in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti652 – 654TQD → PQA in BAA90300 (PubMed:10940552).Curated3
Sequence conflicti687K → E in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti713D → G in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti784Missing in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti795N → D in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti798A → P in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti807I → C in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti827 – 829DIH → ISS in BAA90300 (PubMed:10940552).Curated3
Sequence conflicti835R → K in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti849N → D in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti860E → G in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti874F → S in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti889F → S in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti901V → A in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti905S → P in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti913A → V in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti916A → E in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti933N → T in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti940Q → K in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti949Q → E in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti962G → A in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti1120T → A in BAA90300 (PubMed:10940552).Curated1
Sequence conflicti1157N → T in BAA90300 (PubMed:10940552).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0414471 – 4MAEE → MPTPRDCGRLRSRAGRSRAG AACSRGAPRAAREALDCRRC RDAGGK in isoform 4. 1 Publication4
Alternative sequenceiVSP_035607650V → VS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037360 mRNA. Translation: BAA90300.1.
AB033081 mRNA. Translation: BAA86569.2. Different initiation.
AK292930 mRNA. Translation: BAF85619.1.
AC087292 Genomic DNA. No translation available.
AC087742 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90448.1.
BC052308 mRNA. Translation: AAH52308.1. Sequence problems.
CCDSiCCDS42236.1. [Q9P2R3-2]
CCDS58502.1. [Q9P2R3-4]
CCDS82038.1. [Q9P2R3-1]
RefSeqiNP_001244928.1. NM_001257999.2. [Q9P2R3-4]
NP_001316992.1. NM_001330063.1.
NP_057460.3. NM_016376.4. [Q9P2R3-2]
UniGeneiHs.696087.

Genome annotation databases

EnsembliENST00000341657; ENSP00000343362; ENSG00000185722. [Q9P2R3-1]
ENST00000570535; ENSP00000459943; ENSG00000185722. [Q9P2R3-4]
ENST00000574367; ENSP00000459775; ENSG00000185722. [Q9P2R3-2]
GeneIDi51479.
KEGGihsa:51479.
UCSCiuc002fxn.4. human. [Q9P2R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037360 mRNA. Translation: BAA90300.1.
AB033081 mRNA. Translation: BAA86569.2. Different initiation.
AK292930 mRNA. Translation: BAF85619.1.
AC087292 Genomic DNA. No translation available.
AC087742 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90448.1.
BC052308 mRNA. Translation: AAH52308.1. Sequence problems.
CCDSiCCDS42236.1. [Q9P2R3-2]
CCDS58502.1. [Q9P2R3-4]
CCDS82038.1. [Q9P2R3-1]
RefSeqiNP_001244928.1. NM_001257999.2. [Q9P2R3-4]
NP_001316992.1. NM_001330063.1.
NP_057460.3. NM_016376.4. [Q9P2R3-2]
UniGeneiHs.696087.

3D structure databases

ProteinModelPortaliQ9P2R3.
SMRiQ9P2R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119564. 33 interactors.
DIPiDIP-46068N.
IntActiQ9P2R3. 20 interactors.
STRINGi9606.ENSP00000459775.

PTM databases

iPTMnetiQ9P2R3.
PhosphoSitePlusiQ9P2R3.

Polymorphism and mutation databases

BioMutaiANKFY1.
DMDMi33514905.

Proteomic databases

EPDiQ9P2R3.
MaxQBiQ9P2R3.
PaxDbiQ9P2R3.
PeptideAtlasiQ9P2R3.
PRIDEiQ9P2R3.

Protocols and materials databases

DNASUi51479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341657; ENSP00000343362; ENSG00000185722. [Q9P2R3-1]
ENST00000570535; ENSP00000459943; ENSG00000185722. [Q9P2R3-4]
ENST00000574367; ENSP00000459775; ENSG00000185722. [Q9P2R3-2]
GeneIDi51479.
KEGGihsa:51479.
UCSCiuc002fxn.4. human. [Q9P2R3-1]

Organism-specific databases

CTDi51479.
DisGeNETi51479.
GeneCardsiANKFY1.
H-InvDBHIX0013439.
HIX0173682.
HGNCiHGNC:20763. ANKFY1.
HPAiHPA024513.
HPA024522.
HPA065849.
MIMi607927. gene.
neXtProtiNX_Q9P2R3.
OpenTargetsiENSG00000185722.
PharmGKBiPA134984226.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4591. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00850000132305.
HOGENOMiHOG000022583.
HOVERGENiHBG050501.
InParanoidiQ9P2R3.
KOiK20129.
OMAiIHVAISN.
OrthoDBiEOG091G0ITN.
PhylomeDBiQ9P2R3.
TreeFamiTF351263.

Enzyme and pathway databases

BioCyciZFISH:G66-30647-MONOMER.

Miscellaneous databases

ChiTaRSiANKFY1. human.
GeneWikiiANKFY1.
GenomeRNAii51479.
PROiQ9P2R3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185722.
CleanExiHS_ANKFY1.
ExpressionAtlasiQ9P2R3. baseline and differential.
GenevisibleiQ9P2R3. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 3 hits.
PF00651. BTB. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 21 hits.
SM00225. BTB. 1 hit.
SM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
SSF54695. SSF54695. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 12 hits.
PS50097. BTB. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANFY1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2R3
Secondary accession number(s): A8KA65, Q5RKV4, Q9ULG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: August 4, 2003
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.