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Protein

FERM domain-containing protein 4A

Gene

FRMD4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 4A
Gene namesi
Name:FRMD4A
Synonyms:FRMD4, KIAA1294
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:25491. FRMD4A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946784.

Polymorphism and mutation databases

BioMutaiFRMD4A.
DMDMi205371790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10391039FERM domain-containing protein 4APRO_0000219444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei530 – 5301PhosphoserineCombined sources
Modified residuei615 – 6151PhosphoserineBy similarity
Modified residuei681 – 6811PhosphoserineCombined sources
Modified residuei711 – 7111PhosphoserineBy similarity
Modified residuei800 – 8001PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2Q2.
MaxQBiQ9P2Q2.
PaxDbiQ9P2Q2.
PRIDEiQ9P2Q2.

PTM databases

iPTMnetiQ9P2Q2.
PhosphoSiteiQ9P2Q2.

Expressioni

Gene expression databases

BgeeiQ9P2Q2.
CleanExiHS_FRMD4A.
ExpressionAtlasiQ9P2Q2. baseline and differential.
GenevisibleiQ9P2Q2. HS.

Organism-specific databases

HPAiHPA038449.

Interactioni

Protein-protein interaction databases

BioGridi120817. 4 interactions.
IntActiQ9P2Q2. 4 interactions.
STRINGi9606.ENSP00000350032.

Structurei

3D structure databases

ProteinModelPortaliQ9P2Q2.
SMRiQ9P2Q2. Positions 29-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 322303FERMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili382 – 41635Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 756130Ser-richAdd
BLAST
Compositional biasi935 – 100773Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000294161.
HOVERGENiHBG062800.
InParanoidiQ9P2Q2.
OrthoDBiEOG7HF1HH.
PhylomeDBiQ9P2Q2.
TreeFamiTF328984.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR021774. DUF3338.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQLVPDSA LGLLMMTEGR RCQVHLLDDR KLELLVQPKL LAKELLDLVA
60 70 80 90 100
SHFNLKEKEY FGIAFTDETG HLNWLQLDRR VLEHDFPKKS GPVVLYFCVR
110 120 130 140 150
FYIESISYLK DNATIELFFL NAKSCIYKEL IDVDSEVVFE LASYILQEAK
160 170 180 190 200
GDFSSNEVVR SDLKKLPALP TQALKEHPSL AYCEDRVIEH YKKLNGQTRG
210 220 230 240 250
QAIVNYMSIV ESLPTYGVHY YAVKDKQGIP WWLGLSYKGI FQYDYHDKVK
260 270 280 290 300
PRKIFQWRQL ENLYFREKKF SVEVHDPRRA SVTRRTFGHS GIAVHTWYAC
310 320 330 340 350
PALIKSIWAM AISQHQFYLD RKQSKSKIHA ARSLSEIAID LTETGTLKTS
360 370 380 390 400
KLANMGSKGK IISGSSGSLL SSGSQESDSS QSAKKDMLAA LKSRQEALEE
410 420 430 440 450
TLRQRLEELK KLCLREAELT GKLPVEYPLD PGEEPPIVRR RIGTAFKLDE
460 470 480 490 500
QKILPKGEEA ELERLEREFA IQSQITEAAR RLASDPNVSK KLKKQRKTSY
510 520 530 540 550
LNALKKLQEI ENAINENRIK SGKKPTQRAS LIIDDGNIAS EDSSLSDALV
560 570 580 590 600
LEDEDSQVTS TISPLHSPHK GLPPRPPSHN RPPPPQSLEG LRQMHYHRND
610 620 630 640 650
YDKSPIKPKM WSESSLDEPY EKVKKRSSHS HSSSHKRFPS TGSCAEAGGG
660 670 680 690 700
SNSLQNSPIR GLPHWNSQSS MPSTPDLRVR SPHYVHSTRS VDISPTRLHS
710 720 730 740 750
LALHFRHRSS SLESQGKLLG SENDTGSPDF YTPRTRSSNG SDPMDDCSSC
760 770 780 790 800
TSHSSSEHYY PAQMNANYST LAEDSPSKAR QRQRQRQRAA GALGSASSGS
810 820 830 840 850
MPNLAARGGA GGAGGAGGGV YLHSQSQPSS QYRIKEYPLY IEGGATPVVV
860 870 880 890 900
RSLESDQEGH YSVKAQFKTS NSYTAGGLFK ESWRGGGGDE GDTGRLTPSR
910 920 930 940 950
SQILRTPSLG REGAHDKGAG RAAVSDELRQ WYQRSTASHK EHSRLSHTSS
960 970 980 990 1000
TSSDSGSQYS TSSQSTFVAH SRVTRMPQMC KATSAALPQS QRSSTPSSEI
1010 1020 1030
GATPPSSPHH ILTWQTGEAT ENSPILDGSE SPPHQSTDE
Length:1,039
Mass (Da):115,458
Last modified:September 2, 2008 - v3
Checksum:iD895CD6B569A683F
GO

Sequence cautioni

The sequence BAA92532.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti859 – 8591G → C in BAA92532 (PubMed:10718198).Curated
Sequence conflicti859 – 8591G → C in AAI51245 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421Q → H.
Corresponds to variant rs11258565 [ dbSNP | Ensembl ].
VAR_048367

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037715 mRNA. Translation: BAA92532.1. Different initiation.
AK289693 mRNA. Translation: BAF82382.1.
AL157392, AC069025, AL365495 Genomic DNA. Translation: CAI13127.1.
AL365495, AC069025, AL157392 Genomic DNA. Translation: CAI13296.1.
BC151244 mRNA. Translation: AAI51245.1.
CCDSiCCDS7101.1.
RefSeqiNP_001305265.1. NM_001318336.1.
NP_001305266.1. NM_001318337.1.
NP_001305267.1. NM_001318338.1.
NP_060497.3. NM_018027.4.
XP_011517848.1. XM_011519546.1.
UniGeneiHs.330463.
Hs.568818.
Hs.656573.

Genome annotation databases

EnsembliENST00000357447; ENSP00000350032; ENSG00000151474.
GeneIDi55691.
KEGGihsa:55691.
UCSCiuc001ims.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037715 mRNA. Translation: BAA92532.1. Different initiation.
AK289693 mRNA. Translation: BAF82382.1.
AL157392, AC069025, AL365495 Genomic DNA. Translation: CAI13127.1.
AL365495, AC069025, AL157392 Genomic DNA. Translation: CAI13296.1.
BC151244 mRNA. Translation: AAI51245.1.
CCDSiCCDS7101.1.
RefSeqiNP_001305265.1. NM_001318336.1.
NP_001305266.1. NM_001318337.1.
NP_001305267.1. NM_001318338.1.
NP_060497.3. NM_018027.4.
XP_011517848.1. XM_011519546.1.
UniGeneiHs.330463.
Hs.568818.
Hs.656573.

3D structure databases

ProteinModelPortaliQ9P2Q2.
SMRiQ9P2Q2. Positions 29-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120817. 4 interactions.
IntActiQ9P2Q2. 4 interactions.
STRINGi9606.ENSP00000350032.

PTM databases

iPTMnetiQ9P2Q2.
PhosphoSiteiQ9P2Q2.

Polymorphism and mutation databases

BioMutaiFRMD4A.
DMDMi205371790.

Proteomic databases

EPDiQ9P2Q2.
MaxQBiQ9P2Q2.
PaxDbiQ9P2Q2.
PRIDEiQ9P2Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357447; ENSP00000350032; ENSG00000151474.
GeneIDi55691.
KEGGihsa:55691.
UCSCiuc001ims.4. human.

Organism-specific databases

CTDi55691.
GeneCardsiFRMD4A.
H-InvDBHIX0008660.
HGNCiHGNC:25491. FRMD4A.
HPAiHPA038449.
MIMi616305. gene.
neXtProtiNX_Q9P2Q2.
PharmGKBiPA134946784.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
GeneTreeiENSGT00830000128251.
HOGENOMiHOG000294161.
HOVERGENiHBG062800.
InParanoidiQ9P2Q2.
OrthoDBiEOG7HF1HH.
PhylomeDBiQ9P2Q2.
TreeFamiTF328984.

Miscellaneous databases

ChiTaRSiFRMD4A. human.
GenomeRNAii55691.
NextBioi60501.
PROiQ9P2Q2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2Q2.
CleanExiHS_FRMD4A.
ExpressionAtlasiQ9P2Q2. baseline and differential.
GenevisibleiQ9P2Q2. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR021774. DUF3338.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF11819. DUF3338. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530; SER-681 AND SER-800, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFRM4A_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Q2
Secondary accession number(s): A7E2Y3, Q5T377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: September 2, 2008
Last modified: May 11, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.