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Q9P2P6

- STAR9_HUMAN

UniProt

Q9P2P6 - STAR9_HUMAN

Protein

StAR-related lipid transfer protein 9

Gene

STARD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. lipid binding Source: InterPro
    3. microtubule binding Source: UniProtKB
    4. microtubule motor activity Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: UniProtKB
    2. microtubule-based movement Source: InterPro
    3. spindle assembly Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    StAR-related lipid transfer protein 9
    Alternative name(s):
    START domain-containing protein 9
    Short name:
    StARD9
    Gene namesi
    Name:STARD9
    Synonyms:KIAA1300
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:19162. STARD9.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication. Nucleus 1 Publication
    Note: Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. Golgi apparatus Source: HPA
    4. kinesin complex Source: InterPro
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi110 – 1101T → N: Reduced ATPase activity. 1 Publication
    Mutagenesisi223 – 2231R → A: Reduced ability to bind microtubules. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 47004700StAR-related lipid transfer protein 9PRO_0000220678Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2P6.
    PaxDbiQ9P2P6.
    PRIDEiQ9P2P6.

    PTM databases

    PhosphoSiteiQ9P2P6.

    Expressioni

    Tissue specificityi

    Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2P6.
    BgeeiQ9P2P6.
    CleanExiHS_STARD9.
    GenevestigatoriQ9P2P6.

    Organism-specific databases

    HPAiHPA014562.

    Interactioni

    Subunit structurei

    Interacts with ATAD3A.1 Publication

    Protein-protein interaction databases

    IntActiQ9P2P6. 4 interactions.
    MINTiMINT-1432918.
    STRINGi9606.ENSP00000290607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2P6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 384382Kinesin motorPROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 56972FHAAdd
    BLAST
    Domaini4483 – 4700218STARTPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili4334 – 438754Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi649 – 71163Gln-richAdd
    BLAST
    Compositional biasi1917 – 19204Poly-Glu
    Compositional biasi2696 – 26994Poly-Ser

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 FHA domain.Curated
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation
    Contains 1 START domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000169805.
    HOVERGENiHBG108517.
    InParanoidiQ9P2P6.
    KOiK16491.
    OMAiHRAQIQQ.
    OrthoDBiEOG7353VX.
    PhylomeDBiQ9P2P6.
    TreeFamiTF332626.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    3.30.530.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00498. FHA. 1 hit.
    PF00225. Kinesin. 1 hit.
    PF01852. START. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50848. START. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2P6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANVQVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DNRPDGFGDS     50
    REKVMAFGFD YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF 100
    AYGQTGSGKT YTMLGTPASV GLTPRICEGL FVREKDCASL PSSCRIKVSF 150
    LEIYNERVRD LLKQSGQKKS YTLRVREHPE MGPYVQGLSQ HVVTNYKQVI 200
    QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN LPSEMASKIN 250
    LVDLAGSERA DPSYCKDRIA EGANINKSLV TLGIVISTLA QNSQVFSSCQ 300
    SLNSSVSNGG DSGILSSPSG TSSGGAPSRR QSYIPYRDSV LTWLLKDSLG 350
    GNSKTIMVAT VSPAHTSYSE TMSTLRYASS AKNIINKPRV NEDANLKLIR 400
    ELREEIERLK ALLLSFELRN FSSLSDENLK ELVLQNELKI DQLTKDWTQK 450
    WNDWQALMEH YSVDINRRRA GVVIDSSLPH LMALEDDVLS TGVVLYHLKE 500
    GTTKIGRIDS DQEQDIVLQG QWIERDHCTI TSACGVVVLR PARGARCTVN 550
    GREVTASCRL TQGAVITLGK AQKFRFNHPA EAAVLRQRRQ VGEAAAGRGS 600
    LEWLDLDGDL AASRLGLSPL LWKERRALEE QCDEDHQTPR DGETSHRAQI 650
    QQQQSYVEDL RHQILAEEIR AAKELEFDQA WISQQIKENQ QCLLREETWL 700
    ASLQQQQQED QVAEKELEAS VALDAWLQTD PEIQPSPFVQ SQKRVVHLQL 750
    LRRHTLRAAE RNVRRKKVSF QLERIIKKQR LLEAQKRLEK LTTLCWLQDD 800
    STQEPPYQVL SPDATVPRPP CRSKLTSCSS LSPQRLCSKH MPQLHSIFLS 850
    WDPSTTLPPR PDPTHQTSEK TSSEEHLPQA ASYPARTGCL RKNGLHSSGH 900
    GQPCTARAAL ARKGASAPDA CLTMSPNSVG IQEMEMGVKQ PHQMVSQGLA 950
    SLRKSANKLK PRHEPKIFTS TTQTRGAKGL ADPSHTQAGW RKEGNLGTHK 1000
    AAKGASCNSL YPHGPRQTAG HGKAVKTFWT EYKPPSPSRA SKRHQRVLAT 1050
    RVRNITKKSS HLPLGSPLKR QQNTRDPDTM VPLTDFSPVM DHSREKDNDL 1100
    SDTDSNYSLD SLSCVYAKAL IEPLKPEERK WDFPEPENSE SDDSQLSEDS 1150
    LAEKRYQSPK NRLGGNRPTN NRGQPRTRTR ASVRGFTAAS DSDLLAQTHR 1200
    SFSLDSLIDA EEELGEDQQE EPFPGSADEI PTETFWHLED SSLPVMDQEA 1250
    ICRLGPINYR TAARLDAVLP MSSSFYLDPQ FQPHCELQPH CELQPHCELQ 1300
    PHCEQAESQV EPSYSEQADS LQGMQLSRES PLMSMDSWFS CDSKINPSSP 1350
    PGIVGSLCPS PDMQEFHSCK GERPGYWPNT EELKPSDAET VLPYSSKLHQ 1400
    GSTELLCSAR DEHTASAADT SRLSLWGIQR LIQPGADGTF QGRCIPDMTQ 1450
    QGSSEASHNS SVSNVLAASA TTLTHVGSTH ERDWSALQQK YLLELSCPVL 1500
    EAIGAPKPAY PYLEEDSGSL AQASSKGGDT LLPVGPRVSS NLNLNNFPVH 1550
    LSRIRRLRAE KEQDSLNAKL EGVSDFFSTS EKEASYDETY SADLESLSAS 1600
    RSTNAQVFAT ENAIPDSMTE ACEVKQNNLE ECLQSCRKPG LMTSSDEDFF 1650
    QKNACHSNVT TATKADHWSQ GWAPLRKNSA VQPGQLSPDS HYPLEEEKTD 1700
    CQESSKEAVR RHINVSFALP SGPELYLHSA PWNPLSSSLQ PPLLETFYVT 1750
    KSRDALTETA LEIPACREVR VPSPPPREAW GFGHNHQALQ GAYLKNNLPV 1800
    LLQNQNSKIA SSQQVTAEIP VDLNTREVIR ESGKCPGNIT EESHDSVYSS 1850
    VTQNRHFLPS TSTKVCEFEN QVVILNKKHS FPALEGGEVT AQSCCGASSD 1900
    STESGKSLLF RESEAREEEE LDQNTVLRQT INVSLEKDMP GESAVSLKSR 1950
    SVDRRVSSPV MVAQGGGPTP KWEGKNETGL LEKGLRPKDS SEEFKLPGTK 2000
    PAYERFQLVA CPQERNPSEC KSQEMLNPNR EPSGKKQNKR VNNTDEMARL 2050
    IRSVMQLENG ILEIESKQNK QVHASHTPGT DKELVFQDQK EQEKTDHAFR 2100
    PDSSGNPLPS KDQPSSPRQT DDTVFRDSEA GAMEVNSIGN HPQVQKITPN 2150
    PFRSREGVRE SEPVREHTHP AGSDRPARDI CDSLGKHTTC REFTNTSLHP 2200
    QRMKALARAL PLQPRLERSS KNNGQFVKAS ASLKGQPWGL GSLEELETVK 2250
    GFQESQVAEH VSSSNQEEPK AQGKVEEMPM QRGGSLQEEN KVTQKFPSLS 2300
    QLCRDTFFRQ ETVSPLLSRT EFCTAPLHQD LSNTLPLNSP RWPRRCLHVP 2350
    VALGISSLDC VLDLTMLKIH NSPLVTGVEH QDQSTETRSH SPEGNVRGRS 2400
    SEAHTAWCGS VRSMAMGSHS QSGVPESIPL GTEDRISAST SPQDHGKDLR 2450
    ITLLGFSTSE DFASEAEVAV QKEIRVSSLN KVSSQPEKRV SFSLEEDSDQ 2500
    ASKPRQKAEK ETEDVGLTSG VSLAPVSLPR VPSPEPRLLE PSDHASMCLA 2550
    ILEEIRQAKA QRKQLHDFVA RGTVLSYCET LLEPECSSRV AGRPQCKQID 2600
    QSSSDQTRNE GEAPGFHVAS LSAEAGQIDL LPDERKVQAT SLSADSFESL 2650
    PNTETDREPW DPVQAFSHAA PAQDRKRRTG ELRQFAGASE PFICHSSSSE 2700
    IIEKKKDATR TPSSADPLAP DSPRSSAPVE EVRRVVSKKV VAALPSQAPY 2750
    DDPRVTLHEL SQSVPQETAE GIPPGSQDSS PEHQEPRTLD TTYGEVSDNL 2800
    LVTAQGEKTA HFESQSVTCD VQNSTSASGP KQDHVQCPEA STGFEEGRAS 2850
    PKQDTILPGA LTRVALEAPT QQCVQCKESV GSGLTEVCRA GSKHSRPIPL 2900
    PDQRPSANPG GIGEEAPCRH PREALDGPVF SRNPEGSRTL SPSRGKESRT 2950
    LPCRQPCSSQ PVATHAYSSH SSTLLCFRDG DLGKEPFKAA PHTIHPPCVV 3000
    PSRAYEMDET GEISRGPDVH LTHGLEPKDV NREFRLTESS TCEPSTVAAV 3050
    LSRAQGCRSP SAPDVRTGSF SHSATDGSVG LIGVPEKKVA EKQASTELEA 3100
    ASFPAGMYSE PLRQFRDSSV GDQNAQVCQT NPEPPATTQG PHTLDLSEGS 3150
    AESKLVVEPQ HECLENTTRC FLEKPQFSTE LRDHNRLDSQ AKFVARLKHT 3200
    CSPQEDSPWQ EEEQHRDQAS GGGEGFAQGV NPLPDEDGLD GCQILDAGRE 3250
    EVAVAKPPVS KILSQGFKDP ATVSLRQNET PQPAAQRSGH LYTGREQPAP 3300
    NHRGSLPVTT IFSGPKHSRS SPTPQFSVVG SSRSLQELNL SVEPPSPTDE 3350
    DTQGPNRLWN PHLRGYSSGK SVARTSLQAE DSNQKASSRL DDGTTDHRHL 3400
    KPATPPYPMP STLSHMPTPD FTTSWMSGTL EQAQQGKREK LGVQVRPENW 3450
    CSQMDKGMLH FGSSDISPYA LPWRPEEPAR ISWKQYMSGS AVDVSCSQKP 3500
    QGLTLSNVAR CSSMDNGLED QNSPFHSHLS TYANICDLST THSSTENAQG 3550
    SNEAWEVFRG SSSIALGDPH IPTSPEGVAP TSGHDRRPQF RGPSGEADCL 3600
    RSKPPLAKGS AAGPVDEIML LYPSEAGCPV GQTRTNTFEQ GTQTLGSRRH 3650
    WSSTDISFAQ PEASAVSAFD LASWTSMHNL SLHLSQLLHS TSELLGSLSQ 3700
    PDVARREQNT KRDIPDKAPQ ALMMDGSTQT TVDEGSQTDL TLPTLCLQTS 3750
    EAEPQGANVI LEGLGSDTST VSQEEGDVPG VPQKREAEET AQKMAQLLYL 3800
    QEESTPYKPQ SPSIPSSHLR FQKAPVGQHL PSVSPSVSDA FLPPSSQPEE 3850
    SYCLVVSSPS PSSPHSPGLF PSTSEYPGDS RVQKKLGPTS ALFVDRASSP 3900
    ILTLSASTQE PGLSPGSLTL SAPSTHPVEG HQKLDSSPDP VDAPRTPMDN 3950
    YSQTTDELGG SQRGRSSLQR SNGRSFLELH SPHSPQQSPK LQFSFLGQHP 4000
    QQLQPRTTIG VQSRLLPPPL RHRSQRLGNS FVPEKVASPE HCPLSGREPS 4050
    QWQSRTENGG ESSASPGEPQ RTLDRPSSWG GLQHLSPCPV SELTDTAGLR 4100
    GSALGLPQAC QPEELLCFSC QMCMAPEHQH HSLRDLPVHN KFSNWCGVQK 4150
    GSPGGLDMTE EELGASGDLS SEKQEQSPPQ PPNDHSQDSE WSKREQIPLQ 4200
    VGAQNLSLSV ELTEAKLHHG FGEADALLQV LQSGTGEALA ADEPVTSTWK 4250
    ELYARQKKAI ETLRRERAER LGNFCRTRSL SPQKQLSLLP NKDLFIWDLD 4300
    LPSRRREYLQ QLRKDVVETT RSPESVSRSA HTPSDIELML QDYQQAHEEA 4350
    KVEIARARDQ LRERTEQEKL RIHQKIISQL LKEEDKLHTL ANSSSLCTSS 4400
    NGSLSSGMTS GYNSSPALSG QLQFPENMGH TNLPDSRDVW IGDERGGHSA 4450
    VRKNSAYSHR ASLGSCCCSP SSLSSLGTCF SSSYQDLAKH VVDTSMADVM 4500
    AACSDNLHNL FSCQATAGWN YQGEEQAVQL YYKVFSPTRH GFLGAGVVSQ 4550
    PLSRVWAAVS DPTVWPLYYK PIQTARLHQR VTNSISLVYL VCNTTLCALK 4600
    QPRDFCCVCV EAKEGHLSVM AAQSVYDTSM PRPSRKMVRG EILPSAWILQ 4650
    PITVEGKEVT RVIYLAQVEL GAPGFPPQLL SSFIKRQPLV IARLASFLGR 4700
    Length:4,700
    Mass (Da):516,343
    Last modified:February 22, 2012 - v3
    Checksum:iD422BEE9E5612036
    GO
    Isoform 2 (identifier: Q9P2P6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         290-292: AQN → GIF
         293-4700: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:292
    Mass (Da):32,326
    Checksum:i8BDCDCAEEF042674
    GO
    Isoform 3 (identifier: Q9P2P6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.
         360-435: TVSPAHTSYS...DENLKELVLQ → SEWDARAGPV...SISEKGPWPQ
         436-4700: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:323
    Mass (Da):35,159
    Checksum:i2981E165492842F6
    GO

    Sequence cautioni

    The sequence CAH18258.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAH18258.1 differs from that shown. Reason: Erroneous termination at position 2903. Translated as Gln.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2602 – 26021S → L in CAH18258. (PubMed:17974005)Curated
    Sequence conflicti2818 – 28181T → I in CAH18258. (PubMed:17974005)Curated
    Sequence conflicti3633 – 36331T → A in CAH18258. (PubMed:17974005)Curated
    Sequence conflicti4433 – 44386LPDSRD → IPGIRQ in CAB63725. (PubMed:17974005)Curated
    Sequence conflicti4639 – 46391R → H in BAA92538. (PubMed:10718198)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti835 – 8351R → C.
    Corresponds to variant rs12594837 [ dbSNP | Ensembl ].
    VAR_059811
    Natural varianti1172 – 11721R → C.
    Corresponds to variant rs12594837 [ dbSNP | Ensembl ].
    VAR_037257
    Natural varianti1720 – 17201P → L.
    Corresponds to variant rs7161810 [ dbSNP | Ensembl ].
    VAR_037258
    Natural varianti2205 – 22051A → V.
    Corresponds to variant rs16957055 [ dbSNP | Ensembl ].
    VAR_037259
    Natural varianti2677 – 26771R → H.
    Corresponds to variant rs8030587 [ dbSNP | Ensembl ].
    VAR_037260
    Natural varianti2855 – 28551T → I.
    Corresponds to variant rs8031218 [ dbSNP | Ensembl ].
    VAR_037261
    Natural varianti2869 – 28691P → S.
    Corresponds to variant rs11857283 [ dbSNP | Ensembl ].
    VAR_037262
    Natural varianti3015 – 30151R → G.
    Corresponds to variant rs3742995 [ dbSNP | Ensembl ].
    VAR_037263
    Natural varianti3383 – 33831N → D.1 Publication
    Corresponds to variant rs3742993 [ dbSNP | Ensembl ].
    VAR_037264
    Natural varianti3469 – 34691Y → C.
    Corresponds to variant rs16957061 [ dbSNP | Ensembl ].
    VAR_037266

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 3. 1 PublicationVSP_029573Add
    BLAST
    Alternative sequencei290 – 2923AQN → GIF in isoform 2. 1 PublicationVSP_029574
    Alternative sequencei293 – 47004408Missing in isoform 2. 1 PublicationVSP_029575Add
    BLAST
    Alternative sequencei360 – 43576TVSPA…ELVLQ → SEWDARAGPVLGLVLYLRER AMAPVSGMPELDLCWDWYSI SEKGPWPQ in isoform 3. 1 PublicationVSP_029576Add
    BLAST
    Alternative sequencei436 – 47004265Missing in isoform 3. 1 PublicationVSP_029577Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122666 mRNA. Translation: BAC85502.1.
    AL133579 mRNA. Translation: CAB63725.1.
    CR627426 mRNA. Translation: CAH10513.1.
    CR749416 mRNA. Translation: CAH18258.1. Sequence problems.
    AC018362 Genomic DNA. No translation available.
    AC090510 Genomic DNA. No translation available.
    AB037721 mRNA. Translation: BAA92538.1.
    CCDSiCCDS53935.1. [Q9P2P6-1]
    PIRiT43486.
    RefSeqiNP_065810.2. NM_020759.2. [Q9P2P6-1]
    UniGeneiHs.122061.

    Genome annotation databases

    EnsembliENST00000290607; ENSP00000290607; ENSG00000159433. [Q9P2P6-1]
    GeneIDi57519.
    KEGGihsa:57519.
    UCSCiuc010udj.2. human. [Q9P2P6-1]

    Polymorphism databases

    DMDMi378405232.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122666 mRNA. Translation: BAC85502.1 .
    AL133579 mRNA. Translation: CAB63725.1 .
    CR627426 mRNA. Translation: CAH10513.1 .
    CR749416 mRNA. Translation: CAH18258.1 . Sequence problems.
    AC018362 Genomic DNA. No translation available.
    AC090510 Genomic DNA. No translation available.
    AB037721 mRNA. Translation: BAA92538.1 .
    CCDSi CCDS53935.1. [Q9P2P6-1 ]
    PIRi T43486.
    RefSeqi NP_065810.2. NM_020759.2. [Q9P2P6-1 ]
    UniGenei Hs.122061.

    3D structure databases

    ProteinModelPortali Q9P2P6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9P2P6. 4 interactions.
    MINTi MINT-1432918.
    STRINGi 9606.ENSP00000290607.

    PTM databases

    PhosphoSitei Q9P2P6.

    Polymorphism databases

    DMDMi 378405232.

    Proteomic databases

    MaxQBi Q9P2P6.
    PaxDbi Q9P2P6.
    PRIDEi Q9P2P6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290607 ; ENSP00000290607 ; ENSG00000159433 . [Q9P2P6-1 ]
    GeneIDi 57519.
    KEGGi hsa:57519.
    UCSCi uc010udj.2. human. [Q9P2P6-1 ]

    Organism-specific databases

    CTDi 57519.
    GeneCardsi GC15P042867.
    HGNCi HGNC:19162. STARD9.
    HPAi HPA014562.
    MIMi 614642. gene.
    neXtProti NX_Q9P2P6.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000169805.
    HOVERGENi HBG108517.
    InParanoidi Q9P2P6.
    KOi K16491.
    OMAi HRAQIQQ.
    OrthoDBi EOG7353VX.
    PhylomeDBi Q9P2P6.
    TreeFami TF332626.

    Miscellaneous databases

    ChiTaRSi STARD9. human.
    GenomeRNAii 57519.
    NextBioi 63889.
    PROi Q9P2P6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2P6.
    Bgeei Q9P2P6.
    CleanExi HS_STARD9.
    Genevestigatori Q9P2P6.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    3.30.530.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00498. FHA. 1 hit.
    PF00225. Kinesin. 1 hit.
    PF01852. START. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1975-4700 (ISOFORM 1).
      Tissue: Cervix, Fetal kidney and Testis.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2881-4700 (ISOFORM 1), VARIANT ASP-3383.
      Tissue: Brain.
    5. "Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods."
      Halama N., Grauling-Halama S.A., Jager D.
      Int. J. Mol. Med. 18:653-656(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    6. "The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly."
      Torres J.Z., Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y.C., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., Jackson P.K.
      Cell 147:1309-1323(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-110 AND ARG-223.
    7. Cited for: INTERACTION WITH ATAD3A.

    Entry informationi

    Entry nameiSTAR9_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2P6
    Secondary accession number(s): Q68DG2
    , Q6AI01, Q6ZWK0, Q9UF70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3