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Q9P2P6

- STAR9_HUMAN

UniProt

Q9P2P6 - STAR9_HUMAN

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Protein

StAR-related lipid transfer protein 9

Gene

STARD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. lipid binding Source: InterPro
  4. microtubule binding Source: UniProtKB
  5. microtubule motor activity Source: UniProtKB
  6. plus-end-directed microtubule motor activity Source: RefGenome

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. metabolic process Source: UniProtKB
  3. microtubule-based movement Source: RefGenome
  4. spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 9
Alternative name(s):
START domain-containing protein 9
Short name:
StARD9
Gene namesi
Name:STARD9
Synonyms:KIAA1300
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19162. STARD9.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole 1 Publication. Nucleus 1 Publication
Note: Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. Golgi apparatus Source: HPA
  4. kinesin complex Source: RefGenome
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi110 – 1101T → N: Reduced ATPase activity. 1 Publication
Mutagenesisi223 – 2231R → A: Reduced ability to bind microtubules. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 47004700StAR-related lipid transfer protein 9PRO_0000220678Add
BLAST

Proteomic databases

MaxQBiQ9P2P6.
PaxDbiQ9P2P6.
PRIDEiQ9P2P6.

PTM databases

PhosphoSiteiQ9P2P6.

Expressioni

Tissue specificityi

Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung.1 Publication

Gene expression databases

BgeeiQ9P2P6.
CleanExiHS_STARD9.
ExpressionAtlasiQ9P2P6. baseline and differential.
GenevestigatoriQ9P2P6.

Organism-specific databases

HPAiHPA014562.

Interactioni

Subunit structurei

Interacts with ATAD3A.1 Publication

Protein-protein interaction databases

IntActiQ9P2P6. 4 interactions.
MINTiMINT-1432918.
STRINGi9606.ENSP00000290607.

Structurei

3D structure databases

ProteinModelPortaliQ9P2P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 384382Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Domaini498 – 56972FHAAdd
BLAST
Domaini4483 – 4700218STARTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4334 – 438754Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi649 – 71163Gln-richAdd
BLAST
Compositional biasi1917 – 19204Poly-Glu
Compositional biasi2696 – 26994Poly-Ser

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120451.
HOGENOMiHOG000169805.
HOVERGENiHBG108517.
InParanoidiQ9P2P6.
KOiK16491.
OMAiHRAQIQQ.
OrthoDBiEOG7353VX.
PhylomeDBiQ9P2P6.
TreeFamiTF332626.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.530.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2P6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANVQVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DNRPDGFGDS
60 70 80 90 100
REKVMAFGFD YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF
110 120 130 140 150
AYGQTGSGKT YTMLGTPASV GLTPRICEGL FVREKDCASL PSSCRIKVSF
160 170 180 190 200
LEIYNERVRD LLKQSGQKKS YTLRVREHPE MGPYVQGLSQ HVVTNYKQVI
210 220 230 240 250
QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN LPSEMASKIN
260 270 280 290 300
LVDLAGSERA DPSYCKDRIA EGANINKSLV TLGIVISTLA QNSQVFSSCQ
310 320 330 340 350
SLNSSVSNGG DSGILSSPSG TSSGGAPSRR QSYIPYRDSV LTWLLKDSLG
360 370 380 390 400
GNSKTIMVAT VSPAHTSYSE TMSTLRYASS AKNIINKPRV NEDANLKLIR
410 420 430 440 450
ELREEIERLK ALLLSFELRN FSSLSDENLK ELVLQNELKI DQLTKDWTQK
460 470 480 490 500
WNDWQALMEH YSVDINRRRA GVVIDSSLPH LMALEDDVLS TGVVLYHLKE
510 520 530 540 550
GTTKIGRIDS DQEQDIVLQG QWIERDHCTI TSACGVVVLR PARGARCTVN
560 570 580 590 600
GREVTASCRL TQGAVITLGK AQKFRFNHPA EAAVLRQRRQ VGEAAAGRGS
610 620 630 640 650
LEWLDLDGDL AASRLGLSPL LWKERRALEE QCDEDHQTPR DGETSHRAQI
660 670 680 690 700
QQQQSYVEDL RHQILAEEIR AAKELEFDQA WISQQIKENQ QCLLREETWL
710 720 730 740 750
ASLQQQQQED QVAEKELEAS VALDAWLQTD PEIQPSPFVQ SQKRVVHLQL
760 770 780 790 800
LRRHTLRAAE RNVRRKKVSF QLERIIKKQR LLEAQKRLEK LTTLCWLQDD
810 820 830 840 850
STQEPPYQVL SPDATVPRPP CRSKLTSCSS LSPQRLCSKH MPQLHSIFLS
860 870 880 890 900
WDPSTTLPPR PDPTHQTSEK TSSEEHLPQA ASYPARTGCL RKNGLHSSGH
910 920 930 940 950
GQPCTARAAL ARKGASAPDA CLTMSPNSVG IQEMEMGVKQ PHQMVSQGLA
960 970 980 990 1000
SLRKSANKLK PRHEPKIFTS TTQTRGAKGL ADPSHTQAGW RKEGNLGTHK
1010 1020 1030 1040 1050
AAKGASCNSL YPHGPRQTAG HGKAVKTFWT EYKPPSPSRA SKRHQRVLAT
1060 1070 1080 1090 1100
RVRNITKKSS HLPLGSPLKR QQNTRDPDTM VPLTDFSPVM DHSREKDNDL
1110 1120 1130 1140 1150
SDTDSNYSLD SLSCVYAKAL IEPLKPEERK WDFPEPENSE SDDSQLSEDS
1160 1170 1180 1190 1200
LAEKRYQSPK NRLGGNRPTN NRGQPRTRTR ASVRGFTAAS DSDLLAQTHR
1210 1220 1230 1240 1250
SFSLDSLIDA EEELGEDQQE EPFPGSADEI PTETFWHLED SSLPVMDQEA
1260 1270 1280 1290 1300
ICRLGPINYR TAARLDAVLP MSSSFYLDPQ FQPHCELQPH CELQPHCELQ
1310 1320 1330 1340 1350
PHCEQAESQV EPSYSEQADS LQGMQLSRES PLMSMDSWFS CDSKINPSSP
1360 1370 1380 1390 1400
PGIVGSLCPS PDMQEFHSCK GERPGYWPNT EELKPSDAET VLPYSSKLHQ
1410 1420 1430 1440 1450
GSTELLCSAR DEHTASAADT SRLSLWGIQR LIQPGADGTF QGRCIPDMTQ
1460 1470 1480 1490 1500
QGSSEASHNS SVSNVLAASA TTLTHVGSTH ERDWSALQQK YLLELSCPVL
1510 1520 1530 1540 1550
EAIGAPKPAY PYLEEDSGSL AQASSKGGDT LLPVGPRVSS NLNLNNFPVH
1560 1570 1580 1590 1600
LSRIRRLRAE KEQDSLNAKL EGVSDFFSTS EKEASYDETY SADLESLSAS
1610 1620 1630 1640 1650
RSTNAQVFAT ENAIPDSMTE ACEVKQNNLE ECLQSCRKPG LMTSSDEDFF
1660 1670 1680 1690 1700
QKNACHSNVT TATKADHWSQ GWAPLRKNSA VQPGQLSPDS HYPLEEEKTD
1710 1720 1730 1740 1750
CQESSKEAVR RHINVSFALP SGPELYLHSA PWNPLSSSLQ PPLLETFYVT
1760 1770 1780 1790 1800
KSRDALTETA LEIPACREVR VPSPPPREAW GFGHNHQALQ GAYLKNNLPV
1810 1820 1830 1840 1850
LLQNQNSKIA SSQQVTAEIP VDLNTREVIR ESGKCPGNIT EESHDSVYSS
1860 1870 1880 1890 1900
VTQNRHFLPS TSTKVCEFEN QVVILNKKHS FPALEGGEVT AQSCCGASSD
1910 1920 1930 1940 1950
STESGKSLLF RESEAREEEE LDQNTVLRQT INVSLEKDMP GESAVSLKSR
1960 1970 1980 1990 2000
SVDRRVSSPV MVAQGGGPTP KWEGKNETGL LEKGLRPKDS SEEFKLPGTK
2010 2020 2030 2040 2050
PAYERFQLVA CPQERNPSEC KSQEMLNPNR EPSGKKQNKR VNNTDEMARL
2060 2070 2080 2090 2100
IRSVMQLENG ILEIESKQNK QVHASHTPGT DKELVFQDQK EQEKTDHAFR
2110 2120 2130 2140 2150
PDSSGNPLPS KDQPSSPRQT DDTVFRDSEA GAMEVNSIGN HPQVQKITPN
2160 2170 2180 2190 2200
PFRSREGVRE SEPVREHTHP AGSDRPARDI CDSLGKHTTC REFTNTSLHP
2210 2220 2230 2240 2250
QRMKALARAL PLQPRLERSS KNNGQFVKAS ASLKGQPWGL GSLEELETVK
2260 2270 2280 2290 2300
GFQESQVAEH VSSSNQEEPK AQGKVEEMPM QRGGSLQEEN KVTQKFPSLS
2310 2320 2330 2340 2350
QLCRDTFFRQ ETVSPLLSRT EFCTAPLHQD LSNTLPLNSP RWPRRCLHVP
2360 2370 2380 2390 2400
VALGISSLDC VLDLTMLKIH NSPLVTGVEH QDQSTETRSH SPEGNVRGRS
2410 2420 2430 2440 2450
SEAHTAWCGS VRSMAMGSHS QSGVPESIPL GTEDRISAST SPQDHGKDLR
2460 2470 2480 2490 2500
ITLLGFSTSE DFASEAEVAV QKEIRVSSLN KVSSQPEKRV SFSLEEDSDQ
2510 2520 2530 2540 2550
ASKPRQKAEK ETEDVGLTSG VSLAPVSLPR VPSPEPRLLE PSDHASMCLA
2560 2570 2580 2590 2600
ILEEIRQAKA QRKQLHDFVA RGTVLSYCET LLEPECSSRV AGRPQCKQID
2610 2620 2630 2640 2650
QSSSDQTRNE GEAPGFHVAS LSAEAGQIDL LPDERKVQAT SLSADSFESL
2660 2670 2680 2690 2700
PNTETDREPW DPVQAFSHAA PAQDRKRRTG ELRQFAGASE PFICHSSSSE
2710 2720 2730 2740 2750
IIEKKKDATR TPSSADPLAP DSPRSSAPVE EVRRVVSKKV VAALPSQAPY
2760 2770 2780 2790 2800
DDPRVTLHEL SQSVPQETAE GIPPGSQDSS PEHQEPRTLD TTYGEVSDNL
2810 2820 2830 2840 2850
LVTAQGEKTA HFESQSVTCD VQNSTSASGP KQDHVQCPEA STGFEEGRAS
2860 2870 2880 2890 2900
PKQDTILPGA LTRVALEAPT QQCVQCKESV GSGLTEVCRA GSKHSRPIPL
2910 2920 2930 2940 2950
PDQRPSANPG GIGEEAPCRH PREALDGPVF SRNPEGSRTL SPSRGKESRT
2960 2970 2980 2990 3000
LPCRQPCSSQ PVATHAYSSH SSTLLCFRDG DLGKEPFKAA PHTIHPPCVV
3010 3020 3030 3040 3050
PSRAYEMDET GEISRGPDVH LTHGLEPKDV NREFRLTESS TCEPSTVAAV
3060 3070 3080 3090 3100
LSRAQGCRSP SAPDVRTGSF SHSATDGSVG LIGVPEKKVA EKQASTELEA
3110 3120 3130 3140 3150
ASFPAGMYSE PLRQFRDSSV GDQNAQVCQT NPEPPATTQG PHTLDLSEGS
3160 3170 3180 3190 3200
AESKLVVEPQ HECLENTTRC FLEKPQFSTE LRDHNRLDSQ AKFVARLKHT
3210 3220 3230 3240 3250
CSPQEDSPWQ EEEQHRDQAS GGGEGFAQGV NPLPDEDGLD GCQILDAGRE
3260 3270 3280 3290 3300
EVAVAKPPVS KILSQGFKDP ATVSLRQNET PQPAAQRSGH LYTGREQPAP
3310 3320 3330 3340 3350
NHRGSLPVTT IFSGPKHSRS SPTPQFSVVG SSRSLQELNL SVEPPSPTDE
3360 3370 3380 3390 3400
DTQGPNRLWN PHLRGYSSGK SVARTSLQAE DSNQKASSRL DDGTTDHRHL
3410 3420 3430 3440 3450
KPATPPYPMP STLSHMPTPD FTTSWMSGTL EQAQQGKREK LGVQVRPENW
3460 3470 3480 3490 3500
CSQMDKGMLH FGSSDISPYA LPWRPEEPAR ISWKQYMSGS AVDVSCSQKP
3510 3520 3530 3540 3550
QGLTLSNVAR CSSMDNGLED QNSPFHSHLS TYANICDLST THSSTENAQG
3560 3570 3580 3590 3600
SNEAWEVFRG SSSIALGDPH IPTSPEGVAP TSGHDRRPQF RGPSGEADCL
3610 3620 3630 3640 3650
RSKPPLAKGS AAGPVDEIML LYPSEAGCPV GQTRTNTFEQ GTQTLGSRRH
3660 3670 3680 3690 3700
WSSTDISFAQ PEASAVSAFD LASWTSMHNL SLHLSQLLHS TSELLGSLSQ
3710 3720 3730 3740 3750
PDVARREQNT KRDIPDKAPQ ALMMDGSTQT TVDEGSQTDL TLPTLCLQTS
3760 3770 3780 3790 3800
EAEPQGANVI LEGLGSDTST VSQEEGDVPG VPQKREAEET AQKMAQLLYL
3810 3820 3830 3840 3850
QEESTPYKPQ SPSIPSSHLR FQKAPVGQHL PSVSPSVSDA FLPPSSQPEE
3860 3870 3880 3890 3900
SYCLVVSSPS PSSPHSPGLF PSTSEYPGDS RVQKKLGPTS ALFVDRASSP
3910 3920 3930 3940 3950
ILTLSASTQE PGLSPGSLTL SAPSTHPVEG HQKLDSSPDP VDAPRTPMDN
3960 3970 3980 3990 4000
YSQTTDELGG SQRGRSSLQR SNGRSFLELH SPHSPQQSPK LQFSFLGQHP
4010 4020 4030 4040 4050
QQLQPRTTIG VQSRLLPPPL RHRSQRLGNS FVPEKVASPE HCPLSGREPS
4060 4070 4080 4090 4100
QWQSRTENGG ESSASPGEPQ RTLDRPSSWG GLQHLSPCPV SELTDTAGLR
4110 4120 4130 4140 4150
GSALGLPQAC QPEELLCFSC QMCMAPEHQH HSLRDLPVHN KFSNWCGVQK
4160 4170 4180 4190 4200
GSPGGLDMTE EELGASGDLS SEKQEQSPPQ PPNDHSQDSE WSKREQIPLQ
4210 4220 4230 4240 4250
VGAQNLSLSV ELTEAKLHHG FGEADALLQV LQSGTGEALA ADEPVTSTWK
4260 4270 4280 4290 4300
ELYARQKKAI ETLRRERAER LGNFCRTRSL SPQKQLSLLP NKDLFIWDLD
4310 4320 4330 4340 4350
LPSRRREYLQ QLRKDVVETT RSPESVSRSA HTPSDIELML QDYQQAHEEA
4360 4370 4380 4390 4400
KVEIARARDQ LRERTEQEKL RIHQKIISQL LKEEDKLHTL ANSSSLCTSS
4410 4420 4430 4440 4450
NGSLSSGMTS GYNSSPALSG QLQFPENMGH TNLPDSRDVW IGDERGGHSA
4460 4470 4480 4490 4500
VRKNSAYSHR ASLGSCCCSP SSLSSLGTCF SSSYQDLAKH VVDTSMADVM
4510 4520 4530 4540 4550
AACSDNLHNL FSCQATAGWN YQGEEQAVQL YYKVFSPTRH GFLGAGVVSQ
4560 4570 4580 4590 4600
PLSRVWAAVS DPTVWPLYYK PIQTARLHQR VTNSISLVYL VCNTTLCALK
4610 4620 4630 4640 4650
QPRDFCCVCV EAKEGHLSVM AAQSVYDTSM PRPSRKMVRG EILPSAWILQ
4660 4670 4680 4690 4700
PITVEGKEVT RVIYLAQVEL GAPGFPPQLL SSFIKRQPLV IARLASFLGR
Length:4,700
Mass (Da):516,343
Last modified:February 22, 2012 - v3
Checksum:iD422BEE9E5612036
GO
Isoform 2 (identifier: Q9P2P6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-292: AQN → GIF
     293-4700: Missing.

Note: No experimental confirmation available.

Show »
Length:292
Mass (Da):32,326
Checksum:i8BDCDCAEEF042674
GO
Isoform 3 (identifier: Q9P2P6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     360-435: TVSPAHTSYS...DENLKELVLQ → SEWDARAGPV...SISEKGPWPQ
     436-4700: Missing.

Note: No experimental confirmation available.

Show »
Length:323
Mass (Da):35,159
Checksum:i2981E165492842F6
GO

Sequence cautioni

The sequence CAH18258.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH18258.1 differs from that shown. Reason: Erroneous termination at position 2903. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2602 – 26021S → L in CAH18258. (PubMed:17974005)Curated
Sequence conflicti2818 – 28181T → I in CAH18258. (PubMed:17974005)Curated
Sequence conflicti3633 – 36331T → A in CAH18258. (PubMed:17974005)Curated
Sequence conflicti4433 – 44386LPDSRD → IPGIRQ in CAB63725. (PubMed:17974005)Curated
Sequence conflicti4639 – 46391R → H in BAA92538. (PubMed:10718198)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti835 – 8351R → C.
Corresponds to variant rs12594837 [ dbSNP | Ensembl ].
VAR_059811
Natural varianti1172 – 11721R → C.
Corresponds to variant rs12594837 [ dbSNP | Ensembl ].
VAR_037257
Natural varianti1720 – 17201P → L.
Corresponds to variant rs7161810 [ dbSNP | Ensembl ].
VAR_037258
Natural varianti2205 – 22051A → V.
Corresponds to variant rs16957055 [ dbSNP | Ensembl ].
VAR_037259
Natural varianti2677 – 26771R → H.
Corresponds to variant rs8030587 [ dbSNP | Ensembl ].
VAR_037260
Natural varianti2855 – 28551T → I.
Corresponds to variant rs8031218 [ dbSNP | Ensembl ].
VAR_037261
Natural varianti2869 – 28691P → S.
Corresponds to variant rs11857283 [ dbSNP | Ensembl ].
VAR_037262
Natural varianti3015 – 30151R → G.
Corresponds to variant rs3742995 [ dbSNP | Ensembl ].
VAR_037263
Natural varianti3383 – 33831N → D.1 Publication
Corresponds to variant rs3742993 [ dbSNP | Ensembl ].
VAR_037264
Natural varianti3469 – 34691Y → C.
Corresponds to variant rs16957061 [ dbSNP | Ensembl ].
VAR_037266

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 3. 1 PublicationVSP_029573Add
BLAST
Alternative sequencei290 – 2923AQN → GIF in isoform 2. 1 PublicationVSP_029574
Alternative sequencei293 – 47004408Missing in isoform 2. 1 PublicationVSP_029575Add
BLAST
Alternative sequencei360 – 43576TVSPA…ELVLQ → SEWDARAGPVLGLVLYLRER AMAPVSGMPELDLCWDWYSI SEKGPWPQ in isoform 3. 1 PublicationVSP_029576Add
BLAST
Alternative sequencei436 – 47004265Missing in isoform 3. 1 PublicationVSP_029577Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122666 mRNA. Translation: BAC85502.1.
AL133579 mRNA. Translation: CAB63725.1.
CR627426 mRNA. Translation: CAH10513.1.
CR749416 mRNA. Translation: CAH18258.1. Sequence problems.
AC018362 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AB037721 mRNA. Translation: BAA92538.1.
CCDSiCCDS53935.1. [Q9P2P6-1]
PIRiT43486.
RefSeqiNP_065810.2. NM_020759.2. [Q9P2P6-1]
UniGeneiHs.122061.

Genome annotation databases

EnsembliENST00000290607; ENSP00000290607; ENSG00000159433. [Q9P2P6-1]
GeneIDi57519.
KEGGihsa:57519.
UCSCiuc010udj.2. human. [Q9P2P6-1]

Polymorphism databases

DMDMi378405232.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122666 mRNA. Translation: BAC85502.1 .
AL133579 mRNA. Translation: CAB63725.1 .
CR627426 mRNA. Translation: CAH10513.1 .
CR749416 mRNA. Translation: CAH18258.1 . Sequence problems.
AC018362 Genomic DNA. No translation available.
AC090510 Genomic DNA. No translation available.
AB037721 mRNA. Translation: BAA92538.1 .
CCDSi CCDS53935.1. [Q9P2P6-1 ]
PIRi T43486.
RefSeqi NP_065810.2. NM_020759.2. [Q9P2P6-1 ]
UniGenei Hs.122061.

3D structure databases

ProteinModelPortali Q9P2P6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9P2P6. 4 interactions.
MINTi MINT-1432918.
STRINGi 9606.ENSP00000290607.

PTM databases

PhosphoSitei Q9P2P6.

Polymorphism databases

DMDMi 378405232.

Proteomic databases

MaxQBi Q9P2P6.
PaxDbi Q9P2P6.
PRIDEi Q9P2P6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290607 ; ENSP00000290607 ; ENSG00000159433 . [Q9P2P6-1 ]
GeneIDi 57519.
KEGGi hsa:57519.
UCSCi uc010udj.2. human. [Q9P2P6-1 ]

Organism-specific databases

CTDi 57519.
GeneCardsi GC15P042867.
HGNCi HGNC:19162. STARD9.
HPAi HPA014562.
MIMi 614642. gene.
neXtProti NX_Q9P2P6.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120451.
HOGENOMi HOG000169805.
HOVERGENi HBG108517.
InParanoidi Q9P2P6.
KOi K16491.
OMAi HRAQIQQ.
OrthoDBi EOG7353VX.
PhylomeDBi Q9P2P6.
TreeFami TF332626.

Miscellaneous databases

ChiTaRSi STARD9. human.
GenomeRNAii 57519.
NextBioi 63889.
PROi Q9P2P6.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2P6.
CleanExi HS_STARD9.
ExpressionAtlasi Q9P2P6. baseline and differential.
Genevestigatori Q9P2P6.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
3.30.530.20. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF01852. START. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50848. START. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1975-4700 (ISOFORM 1).
    Tissue: Cervix, Fetal kidney and Testis.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2881-4700 (ISOFORM 1), VARIANT ASP-3383.
    Tissue: Brain.
  5. "Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods."
    Halama N., Grauling-Halama S.A., Jager D.
    Int. J. Mol. Med. 18:653-656(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  6. "The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly."
    Torres J.Z., Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y.C., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., Jackson P.K.
    Cell 147:1309-1323(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-110 AND ARG-223.
  7. Cited for: INTERACTION WITH ATAD3A.

Entry informationi

Entry nameiSTAR9_HUMAN
AccessioniPrimary (citable) accession number: Q9P2P6
Secondary accession number(s): Q68DG2
, Q6AI01, Q6ZWK0, Q9UF70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: February 22, 2012
Last modified: November 26, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3