Q9P2P6 (STAR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 9

Alternative name(s):
START domain-containing protein 9
Short name=StARD9

Gene names

Name:	STARD9
Synonyms:	KIAA1300

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4700 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM). Ref.6
Subunit structure	Interacts with ATAD3A. Ref.7
Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole. Nucleus. Note: Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis. Ref.6
Tissue specificity	Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung. Ref.5
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 FHA domain. Contains 1 kinesin-motor domain. Contains 1 START domain.
Sequence caution	The sequence CAH18258.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH18258.1 differs from that shown. Reason: Erroneous termination at position 2903. Translated as Gln.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro spindle assembly Inferred from mutant phenotype Ref.6. Source: UniProtKB
Cellular_component	centriole Inferred from direct assay Ref.6. Source: UniProtKB microtubule associated complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule binding Inferred from direct assay Ref.6. Source: UniProtKB microtubule motor activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2P6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2P6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     290-292: AQN → GIF
     293-4700: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9P2P6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     360-435: TVSPAHTSYS...DENLKELVLQ → SEWDARAGPV...SISEKGPWPQ
     436-4700: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4700	4700	StAR-related lipid transfer protein 9		PRO_0000220678
Regions
	Domain	1 – 277	277	Kinesin-motor
	Domain	498 – 569	72	FHA
	Domain	4483 – 4700	218	START
	Nucleotide binding	103 – 110	8	ATP Potential
	Coiled coil	4334 – 4387	54	Potential
	Compositional bias	649 – 711	63	Gln-rich
	Compositional bias	1917 – 1920	4	Poly-Glu
	Compositional bias	2696 – 2699	4	Poly-Ser
Natural variations
	Alternative sequence	1 – 84	84	Missing in isoform 3.		VSP_029573
	Alternative sequence	290 – 292	3	AQN → GIF in isoform 2.		VSP_029574
	Alternative sequence	293 – 4700	4408	Missing in isoform 2.		VSP_029575
	Alternative sequence	360 – 435	76	TVSPA…ELVLQ → SEWDARAGPVLGLVLYLRER AMAPVSGMPELDLCWDWYSI SEKGPWPQ in isoform 3.		VSP_029576
	Alternative sequence	436 – 4700	4265	Missing in isoform 3.		VSP_029577
	Natural variant	835	1	R → C. Corresponds to variant rs12594837 [ dbSNP | Ensembl ].		VAR_059811
	Natural variant	1172	1	R → C. Corresponds to variant rs12594837 [ dbSNP | Ensembl ].		VAR_037257
	Natural variant	1720	1	P → L. Corresponds to variant rs7161810 [ dbSNP | Ensembl ].		VAR_037258
	Natural variant	2205	1	A → V. Corresponds to variant rs16957055 [ dbSNP | Ensembl ].		VAR_037259
	Natural variant	2677	1	R → H. Corresponds to variant rs8030587 [ dbSNP | Ensembl ].		VAR_037260
	Natural variant	2855	1	T → I. Corresponds to variant rs8031218 [ dbSNP | Ensembl ].		VAR_037261
	Natural variant	2869	1	P → S. Corresponds to variant rs11857283 [ dbSNP | Ensembl ].		VAR_037262
	Natural variant	3015	1	R → G. Corresponds to variant rs3742995 [ dbSNP | Ensembl ].		VAR_037263
	Natural variant	3383	1	N → D. Ref.4 Corresponds to variant rs3742993 [ dbSNP | Ensembl ].		VAR_037264
	Natural variant	3469	1	Y → C. Corresponds to variant rs16957061 [ dbSNP | Ensembl ].		VAR_037266
Experimental info
	Mutagenesis	110	1	T → N: Reduced ATPase activity. Ref.6
	Mutagenesis	223	1	R → A: Reduced ability to bind microtubules. Ref.6
	Sequence conflict	2602	1	S → L in CAH18258. Ref.2
	Sequence conflict	2818	1	T → I in CAH18258. Ref.2
	Sequence conflict	3633	1	T → A in CAH18258. Ref.2
	Sequence conflict	4433 – 4438	6	LPDSRD → IPGIRQ in CAB63725. Ref.2
	Sequence conflict	4639	1	R → H in BAA92538. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 22, 2012. Version 3. Checksum: D422BEE9E5612036	FASTA	4,700	516,343
	10 20 30 40 50 60 MANVQVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DNRPDGFGDS REKVMAFGFD 70 80 90 100 110 120 YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF AYGQTGSGKT YTMLGTPASV 130 140 150 160 170 180 GLTPRICEGL FVREKDCASL PSSCRIKVSF LEIYNERVRD LLKQSGQKKS YTLRVREHPE 190 200 210 220 230 240 MGPYVQGLSQ HVVTNYKQVI QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN 250 260 270 280 290 300 LPSEMASKIN LVDLAGSERA DPSYCKDRIA EGANINKSLV TLGIVISTLA QNSQVFSSCQ 310 320 330 340 350 360 SLNSSVSNGG DSGILSSPSG TSSGGAPSRR QSYIPYRDSV LTWLLKDSLG GNSKTIMVAT 370 380 390 400 410 420 VSPAHTSYSE TMSTLRYASS AKNIINKPRV NEDANLKLIR ELREEIERLK ALLLSFELRN 430 440 450 460 470 480 FSSLSDENLK ELVLQNELKI DQLTKDWTQK WNDWQALMEH YSVDINRRRA GVVIDSSLPH 490 500 510 520 530 540 LMALEDDVLS TGVVLYHLKE GTTKIGRIDS DQEQDIVLQG QWIERDHCTI TSACGVVVLR 550 560 570 580 590 600 PARGARCTVN GREVTASCRL TQGAVITLGK AQKFRFNHPA EAAVLRQRRQ VGEAAAGRGS 610 620 630 640 650 660 LEWLDLDGDL AASRLGLSPL LWKERRALEE QCDEDHQTPR DGETSHRAQI QQQQSYVEDL 670 680 690 700 710 720 RHQILAEEIR AAKELEFDQA WISQQIKENQ QCLLREETWL ASLQQQQQED QVAEKELEAS 730 740 750 760 770 780 VALDAWLQTD PEIQPSPFVQ SQKRVVHLQL LRRHTLRAAE RNVRRKKVSF QLERIIKKQR 790 800 810 820 830 840 LLEAQKRLEK LTTLCWLQDD STQEPPYQVL SPDATVPRPP CRSKLTSCSS LSPQRLCSKH 850 860 870 880 890 900 MPQLHSIFLS WDPSTTLPPR PDPTHQTSEK TSSEEHLPQA ASYPARTGCL RKNGLHSSGH 910 920 930 940 950 960 GQPCTARAAL ARKGASAPDA CLTMSPNSVG IQEMEMGVKQ PHQMVSQGLA SLRKSANKLK 970 980 990 1000 1010 1020 PRHEPKIFTS TTQTRGAKGL ADPSHTQAGW RKEGNLGTHK AAKGASCNSL YPHGPRQTAG 1030 1040 1050 1060 1070 1080 HGKAVKTFWT EYKPPSPSRA SKRHQRVLAT RVRNITKKSS HLPLGSPLKR QQNTRDPDTM 1090 1100 1110 1120 1130 1140 VPLTDFSPVM DHSREKDNDL SDTDSNYSLD SLSCVYAKAL IEPLKPEERK WDFPEPENSE 1150 1160 1170 1180 1190 1200 SDDSQLSEDS LAEKRYQSPK NRLGGNRPTN NRGQPRTRTR ASVRGFTAAS DSDLLAQTHR 1210 1220 1230 1240 1250 1260 SFSLDSLIDA EEELGEDQQE EPFPGSADEI PTETFWHLED SSLPVMDQEA ICRLGPINYR 1270 1280 1290 1300 1310 1320 TAARLDAVLP MSSSFYLDPQ FQPHCELQPH CELQPHCELQ PHCEQAESQV EPSYSEQADS 1330 1340 1350 1360 1370 1380 LQGMQLSRES PLMSMDSWFS CDSKINPSSP PGIVGSLCPS PDMQEFHSCK GERPGYWPNT 1390 1400 1410 1420 1430 1440 EELKPSDAET VLPYSSKLHQ GSTELLCSAR DEHTASAADT SRLSLWGIQR LIQPGADGTF 1450 1460 1470 1480 1490 1500 QGRCIPDMTQ QGSSEASHNS SVSNVLAASA TTLTHVGSTH ERDWSALQQK YLLELSCPVL 1510 1520 1530 1540 1550 1560 EAIGAPKPAY PYLEEDSGSL AQASSKGGDT LLPVGPRVSS NLNLNNFPVH LSRIRRLRAE 1570 1580 1590 1600 1610 1620 KEQDSLNAKL EGVSDFFSTS EKEASYDETY SADLESLSAS RSTNAQVFAT ENAIPDSMTE 1630 1640 1650 1660 1670 1680 ACEVKQNNLE ECLQSCRKPG LMTSSDEDFF QKNACHSNVT TATKADHWSQ GWAPLRKNSA 1690 1700 1710 1720 1730 1740 VQPGQLSPDS HYPLEEEKTD CQESSKEAVR RHINVSFALP SGPELYLHSA PWNPLSSSLQ 1750 1760 1770 1780 1790 1800 PPLLETFYVT KSRDALTETA LEIPACREVR VPSPPPREAW GFGHNHQALQ GAYLKNNLPV 1810 1820 1830 1840 1850 1860 LLQNQNSKIA SSQQVTAEIP VDLNTREVIR ESGKCPGNIT EESHDSVYSS VTQNRHFLPS 1870 1880 1890 1900 1910 1920 TSTKVCEFEN QVVILNKKHS FPALEGGEVT AQSCCGASSD STESGKSLLF RESEAREEEE 1930 1940 1950 1960 1970 1980 LDQNTVLRQT INVSLEKDMP GESAVSLKSR SVDRRVSSPV MVAQGGGPTP KWEGKNETGL 1990 2000 2010 2020 2030 2040 LEKGLRPKDS SEEFKLPGTK PAYERFQLVA CPQERNPSEC KSQEMLNPNR EPSGKKQNKR 2050 2060 2070 2080 2090 2100 VNNTDEMARL IRSVMQLENG ILEIESKQNK QVHASHTPGT DKELVFQDQK EQEKTDHAFR 2110 2120 2130 2140 2150 2160 PDSSGNPLPS KDQPSSPRQT DDTVFRDSEA GAMEVNSIGN HPQVQKITPN PFRSREGVRE 2170 2180 2190 2200 2210 2220 SEPVREHTHP AGSDRPARDI CDSLGKHTTC REFTNTSLHP QRMKALARAL PLQPRLERSS 2230 2240 2250 2260 2270 2280 KNNGQFVKAS ASLKGQPWGL GSLEELETVK GFQESQVAEH VSSSNQEEPK AQGKVEEMPM 2290 2300 2310 2320 2330 2340 QRGGSLQEEN KVTQKFPSLS QLCRDTFFRQ ETVSPLLSRT EFCTAPLHQD LSNTLPLNSP 2350 2360 2370 2380 2390 2400 RWPRRCLHVP VALGISSLDC VLDLTMLKIH NSPLVTGVEH QDQSTETRSH SPEGNVRGRS 2410 2420 2430 2440 2450 2460 SEAHTAWCGS VRSMAMGSHS QSGVPESIPL GTEDRISAST SPQDHGKDLR ITLLGFSTSE 2470 2480 2490 2500 2510 2520 DFASEAEVAV QKEIRVSSLN KVSSQPEKRV SFSLEEDSDQ ASKPRQKAEK ETEDVGLTSG 2530 2540 2550 2560 2570 2580 VSLAPVSLPR VPSPEPRLLE PSDHASMCLA ILEEIRQAKA QRKQLHDFVA RGTVLSYCET 2590 2600 2610 2620 2630 2640 LLEPECSSRV AGRPQCKQID QSSSDQTRNE GEAPGFHVAS LSAEAGQIDL LPDERKVQAT 2650 2660 2670 2680 2690 2700 SLSADSFESL PNTETDREPW DPVQAFSHAA PAQDRKRRTG ELRQFAGASE PFICHSSSSE 2710 2720 2730 2740 2750 2760 IIEKKKDATR TPSSADPLAP DSPRSSAPVE EVRRVVSKKV VAALPSQAPY DDPRVTLHEL 2770 2780 2790 2800 2810 2820 SQSVPQETAE GIPPGSQDSS PEHQEPRTLD TTYGEVSDNL LVTAQGEKTA HFESQSVTCD 2830 2840 2850 2860 2870 2880 VQNSTSASGP KQDHVQCPEA STGFEEGRAS PKQDTILPGA LTRVALEAPT QQCVQCKESV 2890 2900 2910 2920 2930 2940 GSGLTEVCRA GSKHSRPIPL PDQRPSANPG GIGEEAPCRH PREALDGPVF SRNPEGSRTL 2950 2960 2970 2980 2990 3000 SPSRGKESRT LPCRQPCSSQ PVATHAYSSH SSTLLCFRDG DLGKEPFKAA PHTIHPPCVV 3010 3020 3030 3040 3050 3060 PSRAYEMDET GEISRGPDVH LTHGLEPKDV NREFRLTESS TCEPSTVAAV LSRAQGCRSP 3070 3080 3090 3100 3110 3120 SAPDVRTGSF SHSATDGSVG LIGVPEKKVA EKQASTELEA ASFPAGMYSE PLRQFRDSSV 3130 3140 3150 3160 3170 3180 GDQNAQVCQT NPEPPATTQG PHTLDLSEGS AESKLVVEPQ HECLENTTRC FLEKPQFSTE 3190 3200 3210 3220 3230 3240 LRDHNRLDSQ AKFVARLKHT CSPQEDSPWQ EEEQHRDQAS GGGEGFAQGV NPLPDEDGLD 3250 3260 3270 3280 3290 3300 GCQILDAGRE EVAVAKPPVS KILSQGFKDP ATVSLRQNET PQPAAQRSGH LYTGREQPAP 3310 3320 3330 3340 3350 3360 NHRGSLPVTT IFSGPKHSRS SPTPQFSVVG SSRSLQELNL SVEPPSPTDE DTQGPNRLWN 3370 3380 3390 3400 3410 3420 PHLRGYSSGK SVARTSLQAE DSNQKASSRL DDGTTDHRHL KPATPPYPMP STLSHMPTPD 3430 3440 3450 3460 3470 3480 FTTSWMSGTL EQAQQGKREK LGVQVRPENW CSQMDKGMLH FGSSDISPYA LPWRPEEPAR 3490 3500 3510 3520 3530 3540 ISWKQYMSGS AVDVSCSQKP QGLTLSNVAR CSSMDNGLED QNSPFHSHLS TYANICDLST 3550 3560 3570 3580 3590 3600 THSSTENAQG SNEAWEVFRG SSSIALGDPH IPTSPEGVAP TSGHDRRPQF RGPSGEADCL 3610 3620 3630 3640 3650 3660 RSKPPLAKGS AAGPVDEIML LYPSEAGCPV GQTRTNTFEQ GTQTLGSRRH WSSTDISFAQ 3670 3680 3690 3700 3710 3720 PEASAVSAFD LASWTSMHNL SLHLSQLLHS TSELLGSLSQ PDVARREQNT KRDIPDKAPQ 3730 3740 3750 3760 3770 3780 ALMMDGSTQT TVDEGSQTDL TLPTLCLQTS EAEPQGANVI LEGLGSDTST VSQEEGDVPG 3790 3800 3810 3820 3830 3840 VPQKREAEET AQKMAQLLYL QEESTPYKPQ SPSIPSSHLR FQKAPVGQHL PSVSPSVSDA 3850 3860 3870 3880 3890 3900 FLPPSSQPEE SYCLVVSSPS PSSPHSPGLF PSTSEYPGDS RVQKKLGPTS ALFVDRASSP 3910 3920 3930 3940 3950 3960 ILTLSASTQE PGLSPGSLTL SAPSTHPVEG HQKLDSSPDP VDAPRTPMDN YSQTTDELGG 3970 3980 3990 4000 4010 4020 SQRGRSSLQR SNGRSFLELH SPHSPQQSPK LQFSFLGQHP QQLQPRTTIG VQSRLLPPPL 4030 4040 4050 4060 4070 4080 RHRSQRLGNS FVPEKVASPE HCPLSGREPS QWQSRTENGG ESSASPGEPQ RTLDRPSSWG 4090 4100 4110 4120 4130 4140 GLQHLSPCPV SELTDTAGLR GSALGLPQAC QPEELLCFSC QMCMAPEHQH HSLRDLPVHN 4150 4160 4170 4180 4190 4200 KFSNWCGVQK GSPGGLDMTE EELGASGDLS SEKQEQSPPQ PPNDHSQDSE WSKREQIPLQ 4210 4220 4230 4240 4250 4260 VGAQNLSLSV ELTEAKLHHG FGEADALLQV LQSGTGEALA ADEPVTSTWK ELYARQKKAI 4270 4280 4290 4300 4310 4320 ETLRRERAER LGNFCRTRSL SPQKQLSLLP NKDLFIWDLD LPSRRREYLQ QLRKDVVETT 4330 4340 4350 4360 4370 4380 RSPESVSRSA HTPSDIELML QDYQQAHEEA KVEIARARDQ LRERTEQEKL RIHQKIISQL 4390 4400 4410 4420 4430 4440 LKEEDKLHTL ANSSSLCTSS NGSLSSGMTS GYNSSPALSG QLQFPENMGH TNLPDSRDVW 4450 4460 4470 4480 4490 4500 IGDERGGHSA VRKNSAYSHR ASLGSCCCSP SSLSSLGTCF SSSYQDLAKH VVDTSMADVM 4510 4520 4530 4540 4550 4560 AACSDNLHNL FSCQATAGWN YQGEEQAVQL YYKVFSPTRH GFLGAGVVSQ PLSRVWAAVS 4570 4580 4590 4600 4610 4620 DPTVWPLYYK PIQTARLHQR VTNSISLVYL VCNTTLCALK QPRDFCCVCV EAKEGHLSVM 4630 4640 4650 4660 4670 4680 AAQSVYDTSM PRPSRKMVRG EILPSAWILQ PITVEGKEVT RVIYLAQVEL GAPGFPPQLL 4690 4700 SSFIKRQPLV IARLASFLGR
	Isoform 2 [UniParc]. Checksum: 8BDCDCAEEF042674	FASTA	292	32,326
	10 20 30 40 50 60 MANVQVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DNRPDGFGDS REKVMAFGFD 70 80 90 100 110 120 YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF AYGQTGSGKT YTMLGTPASV 130 140 150 160 170 180 GLTPRICEGL FVREKDCASL PSSCRIKVSF LEIYNERVRD LLKQSGQKKS YTLRVREHPE 190 200 210 220 230 240 MGPYVQGLSQ HVVTNYKQVI QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN 250 260 270 280 290 LPSEMASKIN LVDLAGSERA DPSYCKDRIA EGANINKSLV TLGIVISTLG IF
	Isoform 3 [UniParc]. Checksum: 2981E165492842F6	FASTA	323	35,159
	10 20 30 40 50 60 MEVLSGVAKG YNICLFAYGQ TGSGKTYTML GTPASVGLTP RICEGLFVRE KDCASLPSSC 70 80 90 100 110 120 RIKVSFLEIY NERVRDLLKQ SGQKKSYTLR VREHPEMGPY VQGLSQHVVT NYKQVIQLLE 130 140 150 160 170 180 EGIANRITAA THVHEASSRS HAIFTIHYTQ AILENNLPSE MASKINLVDL AGSERADPSY 190 200 210 220 230 240 CKDRIAEGAN INKSLVTLGI VISTLAQNSQ VFSSCQSLNS SVSNGGDSGI LSSPSGTSSG 250 260 270 280 290 300 GAPSRRQSYI PYRDSVLTWL LKDSLGGNSK TIMVASEWDA RAGPVLGLVL YLRERAMAPV 310 320 SGMPELDLCW DWYSISEKGP WPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Thymus.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1975-4700 (ISOFORM 1). Tissue: Cervix, Fetal kidney and Testis.
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2881-4700 (ISOFORM 1), VARIANT ASP-3383. Tissue: Brain.
[5]	"Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods." Halama N., Grauling-Halama S.A., Jager D. Int. J. Mol. Med. 18:653-656(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[6]	"The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly." Torres J.Z., Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y.C., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., Jackson P.K. Cell 147:1309-1323(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-110 AND ARG-223.
[7]	"Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis." He J., Cooper H.M., Reyes A., Di Re M., Sembongi H., Litwin T.R., Gao J., Neuman K.C., Fearnley I.M., Spinazzola A., Walker J.E., Holt I.J. Nucleic Acids Res. 40:6109-6121(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ATAD3A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122666 mRNA. Translation: BAC85502.1. AL133579 mRNA. Translation: CAB63725.1. CR627426 mRNA. Translation: CAH10513.1. CR749416 mRNA. Translation: CAH18258.1. Sequence problems. AC018362 Genomic DNA. No translation available. AC090510 Genomic DNA. No translation available. AB037721 mRNA. Translation: BAA92538.1.
IPI	IPI00784448. IPI00871757. IPI00954850.
PIR	T43486.
RefSeq	NP_065810.2. NM_020759.2.
UniGene	Hs.122061.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2P6. 4 interactions.
MINT	MINT-1432918.
STRING	9606.ENSP00000290607.
PTM databases
PhosphoSite	Q9P2P6.
Polymorphism databases
DMDM	160112933.
Proteomic databases
PaxDb	Q9P2P6.
PRIDE	Q9P2P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290607; ENSP00000290607; ENSG00000159433.
GeneID	57519.
KEGG	hsa:57519.
UCSC	uc010udj.2. human.
Organism-specific databases
CTD	57519.
GeneCards	GC15P042867.
HGNC	HGNC:19162. STARD9.
HPA	HPA014562.
MIM	614642. gene.
neXtProt	NX_Q9P2P6.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOGENOM	HOG000169805.
HOVERGEN	HBG108517.
InParanoid	Q9P2P6.
KO	K16491.
OMA	ELYARQK.
OrthoDB	EOG4TQM83.
Gene expression databases
ArrayExpress	Q9P2P6.
Bgee	Q9P2P6.
CleanEx	HS_STARD9.
Genevestigator	Q9P2P6.
Family and domain databases
Gene3D	2.60.200.20. 1 hit. 3.30.530.20. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR000253. FHA_dom. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR008984. SMAD_FHA_domain. IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF00498. FHA. 1 hit. PF00225. Kinesin. 1 hit. PF01852. START. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00240. FHA. 1 hit. SM00129. KISc. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. False negative. PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STARD9. human.
GenomeRNAi	57519.
NextBio	63889.
SOURCE	Search...

Entry information

Entry name

STAR9_HUMAN

Accession

Primary (citable) accession number: Q9P2P6
Secondary accession number(s): Q68DG2 , Q6AI01, Q6ZWK0, Q9UF70

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	February 22, 2012
Last modified:	April 3, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.