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Protein

Protein NYNRIN

Gene

NYNRIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NYNRIN
Alternative name(s):
NYN domain and retroviral integrase catalytic domain-containing protein
Protein cousin of GIN1
Gene namesi
Name:NYNRIN
Synonyms:CGIN1, KIAA1305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20165. NYNRIN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1372 – 139221HelicalSequence analysisAdd
BLAST
Transmembranei1408 – 142821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479228.

Polymorphism and mutation databases

BioMutaiNYNRIN.
DMDMi166218833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18981898Protein NYNRINPRO_0000314174Add
BLAST

Proteomic databases

EPDiQ9P2P1.
MaxQBiQ9P2P1.
PaxDbiQ9P2P1.
PRIDEiQ9P2P1.

PTM databases

iPTMnetiQ9P2P1.
PhosphoSiteiQ9P2P1.

Expressioni

Gene expression databases

BgeeiQ9P2P1.
CleanExiHS_KIAA1305.
GenevisibleiQ9P2P1. HS.

Organism-specific databases

HPAiHPA018945.

Interactioni

Protein-protein interaction databases

BioGridi121584. 6 interactions.
IntActiQ9P2P1. 3 interactions.
MINTiMINT-2875135.
STRINGi9606.ENSP00000371994.

Structurei

3D structure databases

ProteinModelPortaliQ9P2P1.
SMRiQ9P2P1. Positions 792-946, 1535-1766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1609 – 1774166Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 integrase catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0017. Eukaryota.
KOG3740. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000113163.
HOVERGENiHBG108033.
InParanoidiQ9P2P1.
OMAiVHGLQHF.
OrthoDBiEOG7C2R20.
PhylomeDBiQ9P2P1.
TreeFamiTF351195.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021869. RNase_Zc3h12_NYN.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLSGGDPPA QEWFMVQTKS KPRVQRQRLQ VQRIFRVKLN AFQSRPDTPY
60 70 80 90 100
FWLQLEGPRE NMGKAKEYLK GLCSPELWKE VRYPPILHCA FLGAQGLFLD
110 120 130 140 150
CLCWSTLAYL VPGPPGSLMV GGLTESFIMT QNWLEELVGR LRWGPAPLLT
160 170 180 190 200
PRGIWEAEVT RAFGALVWIR GDQHAGDLLQ LPPAVQELLL SLVRDAAGKE
210 220 230 240 250
DIIEWLSRFG ISDSHSDPEV LICPPQQQKE APAMVSVGES PGPFVDMGTL
260 270 280 290 300
QNRGPENSKR LSSLGATGSL ITAQSTPQEA ANQLVRVGSN NQDGMDSAQE
310 320 330 340 350
EGTVQATSSQ DSTNHTQALL KQRQVQKIED KLLFQPPVSA LGVCPPWKAW
360 370 380 390 400
TPGPAFGPLW PGAIAATFWR INELHSLHLA WLLSQACFNF PFWQRPLGPI
410 420 430 440 450
QLKLPGQNPL PLNLEWKQKE LAPLPSAESP AGRPDGGLGG EAALQNCPRP
460 470 480 490 500
EISPKVTSLL VVPGSSDVKD KVSSDLPQIG PPLTSTPQLQ AGGEPGDQGS
510 520 530 540 550
MQLDFKGLEE GPAPVLPTGQ GKPVAQGGLT DQSVPGAQTV PETLKVPMAA
560 570 580 590 600
AVPKAENPSR TQVPSAAPKL PTSRMMLAVH TEPAAPEVPL APTKPTAQLM
610 620 630 640 650
ATAQKTVVNQ PVLVAQVEPT TPKTPQAQKM PVAKTSPAGP KTPKAQAGPA
660 670 680 690 700
ATVSKAPAAS KAPAAPKVPV TPRVSRAPKT PAAQKVPTDA GPTLDVARLL
710 720 730 740 750
SEVQPTSRAS VSLLKGQGQA GRQGPQSSGT LALSSKHQFQ MEGLLGAWEG
760 770 780 790 800
APRQPPRHLQ ANSTVTSFQR YHEALNTPFE LNLSGEPGNQ GLRRVVIDGS
810 820 830 840 850
SVAMVHGLQH FFSCRGIAMA VQFFWNRGHR EVTVFVPTWQ LKKNRRVRES
860 870 880 890 900
HFLTKLHSLK MLSITPSQLE NGKKITTYDY RFMVKLAEET DGIIVTNEQI
910 920 930 940 950
HILMNSSKKL MVKDRLLPFT FAGNLFMVPD DPLGRDGPTL DEFLKKPNRL
960 970 980 990 1000
DTDIGNFLKV WKTLPPSSAS VTELSDDADS GPLESLPNME EVREEKEERQ
1010 1020 1030 1040 1050
DEEQRQGQGT QKAAEEDDLD SSLASVFRVE CPSLSEEILR CLSLHDPPDG
1060 1070 1080 1090 1100
ALDIDLLPGA ASPYLGIPWD GKAPCQQVLA HLAQLTIPSN FTALSFFMGF
1110 1120 1130 1140 1150
MDSHRDAIPD YEALVGPLHS LLKQKPDWQW DQEHEEAFLA LKRALVSALC
1160 1170 1180 1190 1200
LMAPNSQLPF RLEVTVSHVA LTAILHQEHS GRKHPIAYTS KPLLPDEESQ
1210 1220 1230 1240 1250
GPQSGGDSPY AVAWALKHFS RCIGDTPVVL DLSYASRTTA DPEVREGRRV
1260 1270 1280 1290 1300
SKAWLIRWSL LVQDKGKRAL ELALLQGLLG ENRLLTPAAS MPRFFQVLPP
1310 1320 1330 1340 1350
FSDLSTFVCI HMSGYCFYRE DEWCAGFGLY VLSPTSPPVS LSFSCSPYTP
1360 1370 1380 1390 1400
TYAHLAAVAC GLERFGQSPL PVVFLTHCNW IFSLLWELLP LWRARGFLSS
1410 1420 1430 1440 1450
DGAPLPHPSL LSYIISLTSG LSSLPFIYRT SYRGSLFAVT VDTLAKQGAQ
1460 1470 1480 1490 1500
GGGQWWSLPK DVPAPTVSPH AMGKRPNLLA LQLSDSTLAD IIARLQAGQK
1510 1520 1530 1540 1550
LSGSSPFSSA FNSLSLDKES GLLMFKGDKK PRVWVVPTQL RRDLIFSVHD
1560 1570 1580 1590 1600
IPLGAHQRPE ETYKKLRLLG WWPGMQEHVK DYCRSCLFCI PRNLIGSELK
1610 1620 1630 1640 1650
VIESPWPLRS TAPWSNLQIE VVGPVTISEE GHKHVLIVAD PNTRWVEAFP
1660 1670 1680 1690 1700
LKPYTHTAVA QVLLQHVFAR WGVPVRLEAA QGPQFARHVL VSCGLALGAQ
1710 1720 1730 1740 1750
VASLSRDLQF PCLTSSGAYW EFKRALKEFI FLHGKKWAAS LPLLHLAFRA
1760 1770 1780 1790 1800
SSTDATPFKV LTGGESRLTE PLWWEMSSAN IEGLKMDVFL LQLVGELLEL
1810 1820 1830 1840 1850
HWRVADKASE KAENRRFKRE SQEKEWNVGD QVLLLSLPRN GSSAKWVGPF
1860 1870 1880 1890
YIGDRLSLSL YRIWGFPTPE KLGCIYPSSL MKAFAKSGTP LSFKVLEQ
Length:1,898
Mass (Da):208,366
Last modified:January 15, 2008 - v3
Checksum:i081533041B25CA08
GO
Isoform 2 (identifier: Q9P2P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1471: Missing.
     1606-1621: WPLRSTAPWSNLQIEV → ASVLRGQGVCNRSGTR
     1622-1898: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):16,762
Checksum:i9F1B5DE66B3FBADD
GO

Sequence cautioni

The sequence AAH65283.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1475 – 14751R → G in BAB13925 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti457 – 4571T → M.
Corresponds to variant rs12437434 [ dbSNP | Ensembl ].
VAR_037857
Natural varianti659 – 6591A → V.
Corresponds to variant rs8008203 [ dbSNP | Ensembl ].
VAR_037858
Natural varianti978 – 9781A → T.
Corresponds to variant rs8017377 [ dbSNP | Ensembl ].
VAR_037859
Natural varianti997 – 9971E → K.
Corresponds to variant rs3742518 [ dbSNP | Ensembl ].
VAR_037860
Natural varianti1551 – 15511I → V.
Corresponds to variant rs17103672 [ dbSNP | Ensembl ].
VAR_037861

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14711471Missing in isoform 2. 1 PublicationVSP_030237Add
BLAST
Alternative sequencei1606 – 162116WPLRS…LQIEV → ASVLRGQGVCNRSGTR in isoform 2. 1 PublicationVSP_030238Add
BLAST
Alternative sequencei1622 – 1898277Missing in isoform 2. 1 PublicationVSP_030239Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021873 mRNA. Translation: BAB13925.1.
AL132800 Genomic DNA. No translation available.
BC065283 mRNA. Translation: AAH65283.1. Sequence problems.
AB037726 mRNA. Translation: BAA92543.2.
BX248773 mRNA. Translation: CAD66580.1.
CCDSiCCDS45090.1. [Q9P2P1-1]
RefSeqiNP_079357.2. NM_025081.2. [Q9P2P1-1]
UniGeneiHs.288348.

Genome annotation databases

EnsembliENST00000382554; ENSP00000371994; ENSG00000205978. [Q9P2P1-1]
GeneIDi57523.
KEGGihsa:57523.
UCSCiuc001wpf.4. human. [Q9P2P1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021873 mRNA. Translation: BAB13925.1.
AL132800 Genomic DNA. No translation available.
BC065283 mRNA. Translation: AAH65283.1. Sequence problems.
AB037726 mRNA. Translation: BAA92543.2.
BX248773 mRNA. Translation: CAD66580.1.
CCDSiCCDS45090.1. [Q9P2P1-1]
RefSeqiNP_079357.2. NM_025081.2. [Q9P2P1-1]
UniGeneiHs.288348.

3D structure databases

ProteinModelPortaliQ9P2P1.
SMRiQ9P2P1. Positions 792-946, 1535-1766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121584. 6 interactions.
IntActiQ9P2P1. 3 interactions.
MINTiMINT-2875135.
STRINGi9606.ENSP00000371994.

PTM databases

iPTMnetiQ9P2P1.
PhosphoSiteiQ9P2P1.

Polymorphism and mutation databases

BioMutaiNYNRIN.
DMDMi166218833.

Proteomic databases

EPDiQ9P2P1.
MaxQBiQ9P2P1.
PaxDbiQ9P2P1.
PRIDEiQ9P2P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382554; ENSP00000371994; ENSG00000205978. [Q9P2P1-1]
GeneIDi57523.
KEGGihsa:57523.
UCSCiuc001wpf.4. human. [Q9P2P1-1]

Organism-specific databases

CTDi57523.
GeneCardsiNYNRIN.
H-InvDBHIX0202042.
HGNCiHGNC:20165. NYNRIN.
HPAiHPA018945.
neXtProtiNX_Q9P2P1.
PharmGKBiPA165479228.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0017. Eukaryota.
KOG3740. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000113163.
HOVERGENiHBG108033.
InParanoidiQ9P2P1.
OMAiVHGLQHF.
OrthoDBiEOG7C2R20.
PhylomeDBiQ9P2P1.
TreeFamiTF351195.

Miscellaneous databases

GenomeRNAii57523.
NextBioi63906.
PROiQ9P2P1.

Gene expression databases

BgeeiQ9P2P1.
CleanExiHS_KIAA1305.
GenevisibleiQ9P2P1. HS.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021869. RNase_Zc3h12_NYN.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-487 (ISOFORM 1).
    Tissue: Eye.
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-1898 (ISOFORM 1).
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 226-731 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiNYNRI_HUMAN
AccessioniPrimary (citable) accession number: Q9P2P1
Secondary accession number(s): Q6P153, Q86TR3, Q9HAC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.