Q9P2N7 (KLH13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch-like protein 13

Alternative name(s):
BTB and kelch domain-containing protein 2

Gene names

Name:	KLHL13
Synonyms:	BKLHD2, KIAA1309

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	655 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Ref.7 Ref.8 Ref.9
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB. Ref.7 Ref.8
Sequence similarities	Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.
Sequence caution	The sequence BAA92547.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC41335.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Kelch repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokinesis Inferred from mutant phenotype Ref.8. Source: UniProtKB mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Inferred from direct assay Ref.8. Source: UniProtKB
Cellular_component	Cul3-RING ubiquitin ligase complex Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2N7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2N7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Isoform 3 (identifier: Q9P2N7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYI → MDHLHRGELVAAILRNR

Isoform 4 (identifier: Q9P2N7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYI → MLRFISHLYCCSSKEDCSEDDKCILSR

Isoform 5 (identifier: Q9P2N7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYI → MMRVQTLREKWAYWRRRQLSLKQADFKDIFKKSTSG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 655	655	Kelch-like protein 13		PRO_0000119115
Regions
	Domain	92 – 161	70	BTB
	Domain	196 – 297	102	BACK
	Repeat	341 – 389	49	Kelch 1
	Repeat	390 – 441	52	Kelch 2
	Repeat	442 – 488	47	Kelch 3
	Repeat	490 – 535	46	Kelch 4
	Repeat	537 – 587	51	Kelch 5
	Repeat	588 – 636	49	Kelch 6
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform 2.		VSP_037530
	Alternative sequence	1 – 33	33	MPLKW…SPAYI → MDHLHRGELVAAILRNR in isoform 3.		VSP_037531
	Alternative sequence	1 – 33	33	MPLKW…SPAYI → MLRFISHLYCCSSKEDCSED DKCILSR in isoform 4.		VSP_037532
	Alternative sequence	1 – 33	33	MPLKW…SPAYI → MMRVQTLREKWAYWRRRQLS LKQADFKDIFKKSTSG in isoform 5.		VSP_037533
	Natural variant	223	1	F → I Found in a renal cell carcinoma sample; somatic mutation. Ref.10		VAR_064725
Experimental info
	Sequence conflict	14	1	K → R in BAG54189. Ref.3
	Sequence conflict	20	1	L → P in BAG54189. Ref.3
	Sequence conflict	352	1	Q → R in BAG54189. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: 0916420562F0B093	FASTA	655	73,868
	10 20 30 40 50 60 MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGGS EMGLSSHLQS 70 80 90 100 110 120 SKAGPTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK 130 140 150 160 170 180 AMFTGGMKEQ DLMCIKLHGV SKVGLRKIID FIYTAKLSLN MDNLQDTLEA ASFLQILPVL 190 200 210 220 230 240 DFCKVFLISG VTLDNCVEVG RIANTYNLTE VDKYVNSFVL KNFPALLSTG EFLKLPFERL 250 260 270 280 290 300 AFVLSSNSLK HCTELELFKA TCRWLRLEEP RMDFAAKLMK NIRFPLMTPQ ELINYVQTVD 310 320 330 340 350 360 FMRTDNTCVN LLLEASNYQM MPYMQPVMQS DRTAIRSDTT HLVTLGGVLR QQLVVSKELR 370 380 390 400 410 420 MYDEKAHEWK SLAPMDAPRY QHGIAVIGNF LYVVGGQSNY DTKGKTAVDT VFRFDPRYNK 430 440 450 460 470 480 WMQVASLNEK RTFFHLSALK GYLYAVGGRN AAGELPTVEC YNPRTNEWTY VAKMSEPHYG 490 500 510 520 530 540 HAGTVYGGVM YISGGITHDT FQKELMCFDP DTDKWIQKAP MTTVRGLHCM CTVGERLYVI 550 560 570 580 590 600 GGNHFRGTSD YDDVLSCEYY SPILDQWTPI AAMLRGQSDV GVAVFENKIY VVGGYSWNNR 610 620 630 640 650 CMVEIVQKYD PDKDEWHKVF DLPESLGGIR ACTLTVFPPE ETTPSPSRES PLSAP
	Isoform 2 [UniParc]. Checksum: DBF234A9F50B1556	FASTA	613	69,090
	10 20 30 40 50 60 MKLSLGGSEM GLSSHLQSSK AGPTRIFTSN THSSVVLQGF DQLRLEGLLC DVTLMPGDTD 70 80 90 100 110 120 DAFPVHRVMM ASASDYFKAM FTGGMKEQDL MCIKLHGVSK VGLRKIIDFI YTAKLSLNMD 130 140 150 160 170 180 NLQDTLEAAS FLQILPVLDF CKVFLISGVT LDNCVEVGRI ANTYNLTEVD KYVNSFVLKN 190 200 210 220 230 240 FPALLSTGEF LKLPFERLAF VLSSNSLKHC TELELFKATC RWLRLEEPRM DFAAKLMKNI 250 260 270 280 290 300 RFPLMTPQEL INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDTTHL 310 320 330 340 350 360 VTLGGVLRQQ LVVSKELRMY DEKAHEWKSL APMDAPRYQH GIAVIGNFLY VVGGQSNYDT 370 380 390 400 410 420 KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGY LYAVGGRNAA GELPTVECYN 430 440 450 460 470 480 PRTNEWTYVA KMSEPHYGHA GTVYGGVMYI SGGITHDTFQ KELMCFDPDT DKWIQKAPMT 490 500 510 520 530 540 TVRGLHCMCT VGERLYVIGG NHFRGTSDYD DVLSCEYYSP ILDQWTPIAA MLRGQSDVGV 550 560 570 580 590 600 AVFENKIYVV GGYSWNNRCM VEIVQKYDPD KDEWHKVFDL PESLGGIRAC TLTVFPPEET 610 TPSPSRESPL SAP
	Isoform 3 [UniParc]. Checksum: 6EEA9A2DD4455933	FASTA	639	72,141
	10 20 30 40 50 60 MDHLHRGELV AAILRNRSLV EEEDQHMKLS LGGSEMGLSS HLQSSKAGPT RIFTSNTHSS 70 80 90 100 110 120 VVLQGFDQLR LEGLLCDVTL MPGDTDDAFP VHRVMMASAS DYFKAMFTGG MKEQDLMCIK 130 140 150 160 170 180 LHGVSKVGLR KIIDFIYTAK LSLNMDNLQD TLEAASFLQI LPVLDFCKVF LISGVTLDNC 190 200 210 220 230 240 VEVGRIANTY NLTEVDKYVN SFVLKNFPAL LSTGEFLKLP FERLAFVLSS NSLKHCTELE 250 260 270 280 290 300 LFKATCRWLR LEEPRMDFAA KLMKNIRFPL MTPQELINYV QTVDFMRTDN TCVNLLLEAS 310 320 330 340 350 360 NYQMMPYMQP VMQSDRTAIR SDTTHLVTLG GVLRQQLVVS KELRMYDEKA HEWKSLAPMD 370 380 390 400 410 420 APRYQHGIAV IGNFLYVVGG QSNYDTKGKT AVDTVFRFDP RYNKWMQVAS LNEKRTFFHL 430 440 450 460 470 480 SALKGYLYAV GGRNAAGELP TVECYNPRTN EWTYVAKMSE PHYGHAGTVY GGVMYISGGI 490 500 510 520 530 540 THDTFQKELM CFDPDTDKWI QKAPMTTVRG LHCMCTVGER LYVIGGNHFR GTSDYDDVLS 550 560 570 580 590 600 CEYYSPILDQ WTPIAAMLRG QSDVGVAVFE NKIYVVGGYS WNNRCMVEIV QKYDPDKDEW 610 620 630 HKVFDLPESL GGIRACTLTV FPPEETTPSP SRESPLSAP
	Isoform 4 [UniParc]. Checksum: 78A8F91FDDA79734	FASTA	649	73,322
	10 20 30 40 50 60 MLRFISHLYC CSSKEDCSED DKCILSRSLV EEEDQHMKLS LGGSEMGLSS HLQSSKAGPT 70 80 90 100 110 120 RIFTSNTHSS VVLQGFDQLR LEGLLCDVTL MPGDTDDAFP VHRVMMASAS DYFKAMFTGG 130 140 150 160 170 180 MKEQDLMCIK LHGVSKVGLR KIIDFIYTAK LSLNMDNLQD TLEAASFLQI LPVLDFCKVF 190 200 210 220 230 240 LISGVTLDNC VEVGRIANTY NLTEVDKYVN SFVLKNFPAL LSTGEFLKLP FERLAFVLSS 250 260 270 280 290 300 NSLKHCTELE LFKATCRWLR LEEPRMDFAA KLMKNIRFPL MTPQELINYV QTVDFMRTDN 310 320 330 340 350 360 TCVNLLLEAS NYQMMPYMQP VMQSDRTAIR SDTTHLVTLG GVLRQQLVVS KELRMYDEKA 370 380 390 400 410 420 HEWKSLAPMD APRYQHGIAV IGNFLYVVGG QSNYDTKGKT AVDTVFRFDP RYNKWMQVAS 430 440 450 460 470 480 LNEKRTFFHL SALKGYLYAV GGRNAAGELP TVECYNPRTN EWTYVAKMSE PHYGHAGTVY 490 500 510 520 530 540 GGVMYISGGI THDTFQKELM CFDPDTDKWI QKAPMTTVRG LHCMCTVGER LYVIGGNHFR 550 560 570 580 590 600 GTSDYDDVLS CEYYSPILDQ WTPIAAMLRG QSDVGVAVFE NKIYVVGGYS WNNRCMVEIV 610 620 630 640 QKYDPDKDEW HKVFDLPESL GGIRACTLTV FPPEETTPSP SRESPLSAP
	Isoform 5 [UniParc]. Checksum: F0CA2A42E52E6306	FASTA	658	74,630
	10 20 30 40 50 60 MMRVQTLREK WAYWRRRQLS LKQADFKDIF KKSTSGSLVE EEDQHMKLSL GGSEMGLSSH 70 80 90 100 110 120 LQSSKAGPTR IFTSNTHSSV VLQGFDQLRL EGLLCDVTLM PGDTDDAFPV HRVMMASASD 130 140 150 160 170 180 YFKAMFTGGM KEQDLMCIKL HGVSKVGLRK IIDFIYTAKL SLNMDNLQDT LEAASFLQIL 190 200 210 220 230 240 PVLDFCKVFL ISGVTLDNCV EVGRIANTYN LTEVDKYVNS FVLKNFPALL STGEFLKLPF 250 260 270 280 290 300 ERLAFVLSSN SLKHCTELEL FKATCRWLRL EEPRMDFAAK LMKNIRFPLM TPQELINYVQ 310 320 330 340 350 360 TVDFMRTDNT CVNLLLEASN YQMMPYMQPV MQSDRTAIRS DTTHLVTLGG VLRQQLVVSK 370 380 390 400 410 420 ELRMYDEKAH EWKSLAPMDA PRYQHGIAVI GNFLYVVGGQ SNYDTKGKTA VDTVFRFDPR 430 440 450 460 470 480 YNKWMQVASL NEKRTFFHLS ALKGYLYAVG GRNAAGELPT VECYNPRTNE WTYVAKMSEP 490 500 510 520 530 540 HYGHAGTVYG GVMYISGGIT HDTFQKELMC FDPDTDKWIQ KAPMTTVRGL HCMCTVGERL 550 560 570 580 590 600 YVIGGNHFRG TSDYDDVLSC EYYSPILDQW TPIAAMLRGQ SDVGVAVFEN KIYVVGGYSW 610 620 630 640 650 NNRCMVEIVQ KYDPDKDEWH KVFDLPESLG GIRACTLTVF PPEETTPSPS RESPLSAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	Howell G.R., Huckle E., Ross M.T. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5). Tissue: Brain, Testis and Thalamus.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." Furukawa M., He Y.J., Borchers C., Xiong Y. Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
[8]	"A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells." Sumara I., Quadroni M., Frei C., Olma M.H., Sumara G., Ricci R., Peter M. Dev. Cell 12:887-900(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AURKB; CUL3 AND KLHL9.
[9]	"The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis." Maerki S., Olma M.H., Staubli T., Steigemann P., Gerlich D.W., Quadroni M., Sumara I., Peter M. J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ILE-223.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037730 mRNA. Translation: BAA92547.1. Different initiation. AL591986 mRNA. Translation: CAC41335.1. Different initiation. AK122724 mRNA. Translation: BAG53690.1. AK125356 mRNA. Translation: BAG54189.1. AK296324 mRNA. Translation: BAH12315.1. AK299257 mRNA. Translation: BAH12978.1. AK302713 mRNA. Translation: BAH13788.1. AC006968 Genomic DNA. No translation available. AC006963 Genomic DNA. Translation: AAF03529.1. CH471161 Genomic DNA. Translation: EAW89898.1. CH471161 Genomic DNA. Translation: EAW89900.1. BC064576 mRNA. Translation: AAH64576.2.
IPI	IPI00002398. IPI00644859. IPI00930289. IPI00930469. IPI00930551.
RefSeq	NP_001161771.1. NM_001168299.1. NP_001161772.1. NM_001168300.1. NP_001161773.1. NM_001168301.1. NP_001161774.1. NM_001168302.1. NP_001161775.1. NM_001168303.1. NP_277030.2. NM_033495.3.
UniGene	Hs.348262.
3D structure databases
ProteinModelPortal	Q9P2N7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2N7. 13 interactions.
PTM databases
PhosphoSite	Q9P2N7.
Polymorphism databases
DMDM	239938883.
Proteomic databases
PaxDb	Q9P2N7.
PRIDE	Q9P2N7.
Protocols and materials databases
DNASU	90293.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262820; ENSP00000262820; ENSG00000003096. ENST00000371876; ENSP00000360943; ENSG00000003096. ENST00000371878; ENSP00000360945; ENSG00000003096. ENST00000371882; ENSP00000360949; ENSG00000003096. ENST00000447671; ENSP00000412640; ENSG00000003096. ENST00000469946; ENSP00000419803; ENSG00000003096. ENST00000539496; ENSP00000443191; ENSG00000003096. ENST00000540167; ENSP00000441029; ENSG00000003096. ENST00000541812; ENSP00000444450; ENSG00000003096. ENST00000545703; ENSP00000440707; ENSG00000003096.
GeneID	90293.
KEGG	hsa:90293.
UCSC	uc004eqk.3. human. uc011mto.2. human. uc011mtp.2. human. uc011mtq.2. human.
Organism-specific databases
CTD	90293.
GeneCards	GC0XM117031.
H-InvDB	HIX0056474.
HGNC	HGNC:22931. KLHL13.
HPA	HPA046039.
MIM	300655. gene.
neXtProt	NX_Q9P2N7.
PharmGKB	PA134959204.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293088.
HOVERGEN	HBG106526.
InParanoid	Q9P2N7.
KO	K10447.
OMA	GATRIFT.
OrthoDB	EOG447FSR.
PhylomeDB	Q9P2N7.
Enzyme and pathway databases
Pathway_Interaction_DB	aurora_b_pathway. Aurora B signaling.
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9P2N7.
Bgee	Q9P2N7.
CleanEx	HS_KLHL13.
Genevestigator	Q9P2N7.
GermOnline	ENSG00000003096. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.80. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015916. Gal_Oxidase_b-propeller. IPR017096. Kelch-like_gigaxonin. IPR006652. Kelch_1. [Graphical view]
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 5 hits. [Graphical view]
PIRSF	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 6 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KLHL13. human.
GenomeRNAi	90293.
NextBio	76640.
SOURCE	Search...

Entry information

Entry name

KLH13_HUMAN

Accession

Primary (citable) accession number: Q9P2N7
Secondary accession number(s): B3KV78 , B3KWM7, B7Z3S9, B7Z5P2, B7Z802, D3DWH6, Q6P2E3, Q96QI7, Q9UDN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.