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Protein

KAT8 regulatory NSL complex subunit 3

Gene

KANSL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.1 Publication

GO - Biological processi

  • histone H4-K16 acetylation Source: UniProtKB
  • histone H4-K5 acetylation Source: UniProtKB
  • histone H4-K8 acetylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Protein family/group databases

ESTHERihuman-KANSL3. NLS3-Tex30.

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 3
Alternative name(s):
NSL complex protein NSL3
Non-specific lethal 3 homolog
Serum inhibited-related protein
Testis development protein PRTD
Gene namesi
Name:KANSL3
Synonyms:KIAA1310, NSL3, PRTD, SI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25473. KANSL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55683.
OpenTargetsiENSG00000114982.
PharmGKBiPA162393058.

Polymorphism and mutation databases

BioMutaiKANSL3.
DMDMi147646907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162421 – 904KAT8 regulatory NSL complex subunit 3Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei523PhosphoserineCombined sources1
Modified residuei536PhosphoserineBy similarity1
Modified residuei540PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2N6.
MaxQBiQ9P2N6.
PaxDbiQ9P2N6.
PeptideAtlasiQ9P2N6.
PRIDEiQ9P2N6.

PTM databases

iPTMnetiQ9P2N6.
PhosphoSitePlusiQ9P2N6.

Expressioni

Gene expression databases

BgeeiENSG00000114982.
CleanExiHS_KIAA1310.
ExpressionAtlasiQ9P2N6. baseline and differential.
GenevisibleiQ9P2N6. HS.

Organism-specific databases

HPAiHPA035017.
HPA035018.
HPA041280.

Interactioni

Subunit structurei

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.2 Publications

Protein-protein interaction databases

BioGridi120811. 9 interactors.
IntActiQ9P2N6. 12 interactors.
MINTiMINT-1421538.
STRINGi9606.ENSP00000396749.

Structurei

3D structure databases

ProteinModelPortaliQ9P2N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi700 – 766Ser-richAdd BLAST67

Phylogenomic databases

eggNOGiKOG3253. Eukaryota.
ENOG410XSH5. LUCA.
GeneTreeiENSGT00390000007636.
HOVERGENiHBG062095.
InParanoidiQ9P2N6.
KOiK16719.
OMAiSVNWDTK.
OrthoDBiEOG091G0D4M.
PhylomeDBiQ9P2N6.
TreeFamiTF323466.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR026555. NSL3/Tex30.
[Graphical view]
PANTHERiPTHR13136. PTHR13136. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2N6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD
60 70 80 90 100
ASSARPTRML FVTPRRQHES TIESDVPIDV ETVTSTPMPL YDNQKARSVM
110 120 130 140 150
NECERHVIFA RTDADAPPPP EDWEEHVNRT GWTMAQNKLF NKILKALQSD
160 170 180 190 200
RLARLANEGA CNEPVLRRVA VDKCARRVRQ ALASVSWDTK LIQWLHTTLV
210 220 230 240 250
ETLSLPMLAA YLDALQTLKG KIPTLIDRML VSSNTKTGAA GAEALSLLLK
260 270 280 290 300
RPWDPAVGVL SHNKPSKLPG SPLILIASSG PSSSVFPTSR RHRFWQSQLS
310 320 330 340 350
CLGKVIPVAT HLLNNGSGVG VLQCLEHMIG AVRSKVLEIH SHFPHKPIIL
360 370 380 390 400
IGWNTGALVA CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV
410 420 430 440 450
LFVIGQNSLQ CHPEAMEDFR EKIRAENSLV VVGGADDNLR ISKAKKKSEG
460 470 480 490 500
LTQSMVDRCI QDEIVDFLTG VLTRAEGHMG SEPRDQDAEK KKKPRDVARR
510 520 530 540 550
DLAFEVPERG SRPASPAAKL PASPSGSEDL SSVSSSPTSS PKTKVTTVTS
560 570 580 590 600
AQKSSQIGSS QLLKRHVQRT EAVLTHKQAQ AQFAAFLKQN MLVRKALPPG
610 620 630 640 650
TSSCLFVPIS SEPPEEGEKE DLRVQLKRHH PSSPLPGSKT SKRPKIKVSL
660 670 680 690 700
ISQGDTAGGP CAPSQGSAPE AAGGKPITMT LGQASAGAKE LTGLLTTAKS
710 720 730 740 750
SSSEGGVSAS PVPSVVSSST APSALHTLQS RLVATSPGSS LPGATSASSL
760 770 780 790 800
LQGLSFSLQD ISSKTSGLPA NPSPGPAPQA TSVKLPTPMQ SLGAITTGTS
810 820 830 840 850
TIVRTIPVAT TLSSLGATPG GKPTAIHQLL TNGGLAKLAS SLPGLAQISN
860 870 880 890 900
QASGLKVPTT ITLTLRGQPS RITTLSPMGS GAAPSEESSS QVLPSSSQRL

PPAP
Length:904
Mass (Da):95,992
Last modified:May 15, 2007 - v2
Checksum:i698DD46EC443B5DD
GO
Isoform 2 (identifier: Q9P2N6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     781-904: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:780
Mass (Da):83,673
Checksum:iFDE372433A0CDDC7
GO
Isoform 3 (identifier: Q9P2N6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     581-606: Missing.

Show »
Length:878
Mass (Da):93,170
Checksum:i5D9DD9A62F3A20FA
GO
Isoform 4 (identifier: Q9P2N6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.

Show »
Length:791
Mass (Da):83,296
Checksum:iE77BB055740C1F91
GO
Isoform 5 (identifier: Q9P2N6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.
     671-672: Missing.

Note: No experimental confirmation available.
Show »
Length:789
Mass (Da):83,154
Checksum:iA3D9541D40C75FD0
GO
Isoform 6 (identifier: Q9P2N6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-129: DADAPPPPEDWEEHVNR → MTLPHCHRLMLTHHLFW
     581-606: Missing.
     671-672: Missing.

Note: No experimental confirmation available.
Show »
Length:764
Mass (Da):80,362
Checksum:i8BDC155A0AC701FB
GO
Isoform 7 (identifier: Q9P2N6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     222-228: IPTLIDR → VILTFCG
     229-904: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):16,016
Checksum:i0E8A108B46959AF7
GO
Isoform 8 (identifier: Q9P2N6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.
     637-643: GSKTSKR → VYSWFHH
     644-904: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):58,199
Checksum:i018418758112918F
GO

Sequence cautioni

The sequence AAH15469 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI27821 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence BAA92548 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529D → G in BAA91437 (PubMed:14702039).Curated1
Sequence conflicti640T → I in AAG33852 (Ref. 2) Curated1
Sequence conflicti640T → I in BAB14688 (PubMed:14702039).Curated1
Sequence conflicti660P → S in AAG33852 (Ref. 2) Curated1
Sequence conflicti660P → S in BAB14688 (PubMed:14702039).Curated1
Sequence conflicti667S → C in AAG33852 (Ref. 2) Curated1
Sequence conflicti667S → C in BAB14688 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032268707V → I.Corresponds to variant rs34406082dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253241 – 112Missing in isoform 6. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_0253251 – 87Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST87
Alternative sequenceiVSP_025326113 – 129DADAP…EHVNR → MTLPHCHRLMLTHHLFW in isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_025327222 – 228IPTLIDR → VILTFCG in isoform 7. 1 Publication7
Alternative sequenceiVSP_025328229 – 904Missing in isoform 7. 1 PublicationAdd BLAST676
Alternative sequenceiVSP_025329581 – 606Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 4 PublicationsAdd BLAST26
Alternative sequenceiVSP_025330637 – 643GSKTSKR → VYSWFHH in isoform 8. 1 Publication7
Alternative sequenceiVSP_025331644 – 904Missing in isoform 8. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_025332671 – 672Missing in isoform 5 and isoform 6. 2 Publications2
Alternative sequenceiVSP_025333781 – 904Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050169 mRNA. Translation: AAL13159.1.
AF311326 mRNA. Translation: AAG33852.1.
AB037731 mRNA. Translation: BAA92548.1. Different initiation.
AK000943 mRNA. Translation: BAA91437.1.
AK023813 mRNA. Translation: BAB14688.1.
AC079754 Genomic DNA. Translation: AAX88890.1.
CH471207 Genomic DNA. Translation: EAW71349.1.
CH471207 Genomic DNA. Translation: EAW71350.1.
CH471207 Genomic DNA. Translation: EAW71352.1.
CH471207 Genomic DNA. Translation: EAW71357.1.
CH471207 Genomic DNA. Translation: EAW71358.1.
BC015469 mRNA. Translation: AAH15469.1. Sequence problems.
BC032746 mRNA. Translation: AAH32746.1.
BC051763 mRNA. Translation: AAH51763.1.
BC063792 mRNA. Translation: AAH63792.1.
BC127820 mRNA. Translation: AAI27821.1. Sequence problems.
AL136849 mRNA. Translation: CAB66783.2.
CCDSiCCDS46361.1. [Q9P2N6-3]
RefSeqiNP_001108488.1. NM_001115016.2. [Q9P2N6-3]
XP_005264041.1. XM_005263984.1. [Q9P2N6-1]
UniGeneiHs.516341.

Genome annotation databases

EnsembliENST00000420155; ENSP00000414426; ENSG00000114982. [Q9P2N6-2]
ENST00000431828; ENSP00000396749; ENSG00000114982. [Q9P2N6-3]
GeneIDi55683.
KEGGihsa:55683.
UCSCiuc002swn.6. human. [Q9P2N6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050169 mRNA. Translation: AAL13159.1.
AF311326 mRNA. Translation: AAG33852.1.
AB037731 mRNA. Translation: BAA92548.1. Different initiation.
AK000943 mRNA. Translation: BAA91437.1.
AK023813 mRNA. Translation: BAB14688.1.
AC079754 Genomic DNA. Translation: AAX88890.1.
CH471207 Genomic DNA. Translation: EAW71349.1.
CH471207 Genomic DNA. Translation: EAW71350.1.
CH471207 Genomic DNA. Translation: EAW71352.1.
CH471207 Genomic DNA. Translation: EAW71357.1.
CH471207 Genomic DNA. Translation: EAW71358.1.
BC015469 mRNA. Translation: AAH15469.1. Sequence problems.
BC032746 mRNA. Translation: AAH32746.1.
BC051763 mRNA. Translation: AAH51763.1.
BC063792 mRNA. Translation: AAH63792.1.
BC127820 mRNA. Translation: AAI27821.1. Sequence problems.
AL136849 mRNA. Translation: CAB66783.2.
CCDSiCCDS46361.1. [Q9P2N6-3]
RefSeqiNP_001108488.1. NM_001115016.2. [Q9P2N6-3]
XP_005264041.1. XM_005263984.1. [Q9P2N6-1]
UniGeneiHs.516341.

3D structure databases

ProteinModelPortaliQ9P2N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120811. 9 interactors.
IntActiQ9P2N6. 12 interactors.
MINTiMINT-1421538.
STRINGi9606.ENSP00000396749.

Protein family/group databases

ESTHERihuman-KANSL3. NLS3-Tex30.

PTM databases

iPTMnetiQ9P2N6.
PhosphoSitePlusiQ9P2N6.

Polymorphism and mutation databases

BioMutaiKANSL3.
DMDMi147646907.

Proteomic databases

EPDiQ9P2N6.
MaxQBiQ9P2N6.
PaxDbiQ9P2N6.
PeptideAtlasiQ9P2N6.
PRIDEiQ9P2N6.

Protocols and materials databases

DNASUi55683.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420155; ENSP00000414426; ENSG00000114982. [Q9P2N6-2]
ENST00000431828; ENSP00000396749; ENSG00000114982. [Q9P2N6-3]
GeneIDi55683.
KEGGihsa:55683.
UCSCiuc002swn.6. human. [Q9P2N6-1]

Organism-specific databases

CTDi55683.
DisGeNETi55683.
GeneCardsiKANSL3.
HGNCiHGNC:25473. KANSL3.
HPAiHPA035017.
HPA035018.
HPA041280.
neXtProtiNX_Q9P2N6.
OpenTargetsiENSG00000114982.
PharmGKBiPA162393058.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3253. Eukaryota.
ENOG410XSH5. LUCA.
GeneTreeiENSGT00390000007636.
HOVERGENiHBG062095.
InParanoidiQ9P2N6.
KOiK16719.
OMAiSVNWDTK.
OrthoDBiEOG091G0D4M.
PhylomeDBiQ9P2N6.
TreeFamiTF323466.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiKANSL3. human.
GeneWikiiFLJ10081.
GenomeRNAii55683.
PROiQ9P2N6.

Gene expression databases

BgeeiENSG00000114982.
CleanExiHS_KIAA1310.
ExpressionAtlasiQ9P2N6. baseline and differential.
GenevisibleiQ9P2N6. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR026555. NSL3/Tex30.
[Graphical view]
PANTHERiPTHR13136. PTHR13136. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKANL3_HUMAN
AccessioniPrimary (citable) accession number: Q9P2N6
Secondary accession number(s): A1L184
, D3DXH3, D3DXH4, Q05BU4, Q6P3X2, Q6PJH6, Q86T19, Q96L64, Q9H0C9, Q9H8C9, Q9HAP8, Q9NWE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.