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Protein

RNA-binding protein 27

Gene

RBM27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 301C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 27
Alternative name(s):
RNA-binding motif protein 27
Gene namesi
Name:RBM27
Synonyms:KIAA1311
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000091009.7.
HGNCiHGNC:29243. RBM27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54439.
OpenTargetsiENSG00000091009.
PharmGKBiPA134925458.

Polymorphism and mutation databases

BioMutaiRBM27.
DMDMi124021005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730441 – 1060RNA-binding protein 27Add BLAST1060

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei447PhosphothreonineCombined sources1
Modified residuei455Omega-N-methylarginineCombined sources1
Modified residuei927PhosphoserineBy similarity1
Modified residuei1012PhosphoserineCombined sources1
Modified residuei1020PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9P2N5.
MaxQBiQ9P2N5.
PaxDbiQ9P2N5.
PeptideAtlasiQ9P2N5.
PRIDEiQ9P2N5.

PTM databases

iPTMnetiQ9P2N5.
PhosphoSitePlusiQ9P2N5.

Miscellaneous databases

PMAP-CutDBiQ9P2N5.

Expressioni

Gene expression databases

BgeeiENSG00000091009.
CleanExiHS_RBM27.
GenevisibleiQ9P2N5. HS.

Organism-specific databases

HPAiHPA035944.
HPA036422.

Interactioni

Protein-protein interaction databases

BioGridi119955. 44 interactors.
IntActiQ9P2N5. 13 interactors.
MINTiMINT-2820712.
STRINGi9606.ENSP00000265271.

Structurei

3D structure databases

ProteinModelPortaliQ9P2N5.
SMRiQ9P2N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini600 – 674RRMPROSITE-ProRule annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili809 – 886Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 201Arg-richAdd BLAST71
Compositional biasi311 – 417Pro-richAdd BLAST107
Compositional biasi678 – 718Gln-richAdd BLAST41

Domaini

The RRM domain mediates integration into cytospeckles.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 301C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2135. Eukaryota.
ENOG410Y2TW. LUCA.
GeneTreeiENSGT00510000046929.
HOGENOMiHOG000067963.
HOVERGENiHBG057372.
InParanoidiQ9P2N5.
KOiK13193.
OMAiHHGRRNF.
OrthoDBiEOG091G08U0.
PhylomeDBiQ9P2N5.
TreeFamiTF319253.

Family and domain databases

CDDicd12517. RRM_RBM27. 1 hit.
Gene3Di4.10.1000.10. 1 hit.
InterProiView protein in InterPro
IPR002483. PWI_dom.
IPR035979. RBD_domain_sf.
IPR034451. RBM27_RRM.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
IPR036855. Znf_CCCH_sf.
PfamiView protein in Pfam
PF01480. PWI. 1 hit.
PF00642. zf-CCCH. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P2N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIEDVDALK SWLAKLLEPI CDADPSALAN YVVALVKKDK PEKELKAFCA
60 70 80 90 100
DQLDVFLQKE TSGFVDKLFE SLYTKNYLPL LEPVKPEPKP LVQEKEEIKE
110 120 130 140 150
EVFQEPAEEE RDGRKKKYPS PQKTRSESSE RRTREKKRED GKWRDYDRYY
160 170 180 190 200
ERNELYREKY DWRRGRSKSR SKSRGLSRSR SRSRGRSKDR DPNRNVEHRE
210 220 230 240 250
RSKFKSERND LESSYVPVSA PPPNSSEQYS SGAQSIPSTV TVIAPAHHSE
260 270 280 290 300
NTTESWSNYY NNHSSSNSFG RNLPPKRRCR DYDERGFCVL GDLCQFDHGN
310 320 330 340 350
DPLVVDEVAL PSMIPFPPPP PGLPPPPPPG MLMPPMPGPG PGPGPGPGPG
360 370 380 390 400
PGPGPGPGHS MRLPVPQGHG QPPPSVVLPI PRPPITQSSL INSRDQPGTS
410 420 430 440 450
AVPNLASVGT RLPPPLPQNL LYTVSERQPM YSREHGAAAS ERLQLGTPPP
460 470 480 490 500
LLAARLVPPR NLMGSSIGYH TSVSSPTPLV PDTYEPDGYN PEAPSITSSG
510 520 530 540 550
RSQYRQFFSR TQTQRPNLIG LTSGDMDVNP RAANIVIQTE PPVPVSINSN
560 570 580 590 600
ITRVVLEPDS RKRAMSGLEG PLTKKPWLGK QGNNNQNKPG FLRKNQYTNT
610 620 630 640 650
KLEVKKIPQE LNNITKLNEH FSKFGTIVNI QVAFKGDPEA ALIQYLTNEE
660 670 680 690 700
ARKAISSTEA VLNNRFIRVL WHRENNEQPT LQSSAQLLLQ QQQTLSHLSQ
710 720 730 740 750
QHHHLPQHLH QQQVLVAQSA PSTVHGGIQK MMSKPQTSGA YVLNKVPVKH
760 770 780 790 800
RLGHAGGNQS DASHLLNQSG GAGEDCQIFS TPGHPKMIYS SSNLKTPSKL
810 820 830 840 850
CSGSKSHDVQ EVLKKKQEAM KLQQDMRKKR QEVLEKQIEC QKMLISKLEK
860 870 880 890 900
NKNMKPEERA NIMKTLKELG EKISQLKDEL KTSSAVSTPS KVKTKTEAQK
910 920 930 940 950
ELLDTELDLH KRLSSGEDTT ELRKKLSQLQ VEAARLGILP VGRGKTMSSQ
960 970 980 990 1000
GRGRGRGRGG RGRGSLNHMV VDHRPKALTV GGFIEEEKED LLQHFSTANQ
1010 1020 1030 1040 1050
GPKFKDRRLQ ISWHKPKVPS ISTETEEEEV KEEETETSDL FLPDDDDEDE
1060
DEYESRSWRR
Length:1,060
Mass (Da):118,718
Last modified:January 23, 2007 - v2
Checksum:i9DACF8B155187456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091959 Genomic DNA. No translation available.
AB037732 mRNA. Translation: BAA92549.1.
BC033524 mRNA. Translation: AAH33524.1.
CCDSiCCDS43378.1.
RefSeqiNP_061862.1. NM_018989.1.
UniGeneiHs.61441.

Genome annotation databases

EnsembliENST00000265271; ENSP00000265271; ENSG00000091009.
GeneIDi54439.
KEGGihsa:54439.
UCSCiuc003lnz.5. human.

Similar proteinsi

Entry informationi

Entry nameiRBM27_HUMAN
AccessioniPrimary (citable) accession number: Q9P2N5
Secondary accession number(s): Q8IYW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM