Q9P2N4 (ATS9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 9
Short name=ADAM-TS 9
Short name=ADAM-TS9
Short name=ADAMTS-9
EC=3.4.24.-

Gene names

Name:	ADAMTS9
Synonyms:	KIAA1312

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1935 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cleaves the large aggregating proteoglycans, aggrecan and versican. Ref.2
Catalytic activity	Cleaves aggrecan at the 1838-Glu-|-Ala-1839 site and versican at the 1428-Glu-|-Ala-1429 site.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.
Domain	The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix By similarity. The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 GON domain. Contains 1 peptidase M12B domain. Contains 15 TSP type-1 domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycoprotein catabolic process Traceable author statement Ref.1. Source: ProtInc multicellular organismal development Traceable author statement Ref.1. Source: ProtInc positive regulation of melanocyte differentiation Inferred from electronic annotation. Source: Compara proteolysis Inferred from direct assay Ref.2. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Inferred from direct assay Ref.2. Source: MGI
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from direct assay Ref.2. Source: MGI zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2N4-3)

Also known as: ADAMTS-9B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2N4-1)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     1624-1629: CSVTCG → VPSWEL
     1630-1935: Missing.

Note: May result from the retention of an intron in the cDNA leading to a prematurate stop codon.

Isoform 3 (identifier: Q9P2N4-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1064-1072: CLVTCGKGH → VRWEGCYFP
     1073-1935: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 287	269			PRO_0000029182
	Chain	288 – 1935	1648	A disintegrin and metalloproteinase with thrombospondin motifs 9		PRO_0000029183
Regions
	Domain	293 – 499	207	Peptidase M12B
	Domain	509 – 587	79	Disintegrin
	Domain	588 – 643	56	TSP type-1 1
	Domain	878 – 936	59	TSP type-1 2
	Domain	939 – 997	59	TSP type-1 3
	Domain	998 – 1049	52	TSP type-1 4
	Domain	1052 – 1109	58	TSP type-1 5
	Domain	1110 – 1166	57	TSP type-1 6
	Domain	1182 – 1240	59	TSP type-1 7
	Domain	1241 – 1296	56	TSP type-1 8
	Domain	1328 – 1379	52	TSP type-1 9
	Domain	1382 – 1440	59	TSP type-1 10
	Domain	1441 – 1494	54	TSP type-1 11
	Domain	1497 – 1555	59	TSP type-1 12
	Domain	1556 – 1611	56	TSP type-1 13
	Domain	1612 – 1676	65	TSP type-1 14
	Domain	1677 – 1734	58	TSP type-1 15
	Domain	1735 – 1935	201	GON
	Region	753 – 877	125	Spacer
	Motif	221 – 228	8	Cysteine switch By similarity
	Compositional bias	88 – 96	9	Poly-Ser
	Compositional bias	644 – 752	109	Cys-rich
Sites
	Active site	435	1	By similarity
	Metal binding	223	1	Zinc; in inhibited form By similarity
	Metal binding	434	1	Zinc; catalytic By similarity
	Metal binding	438	1	Zinc; catalytic By similarity
	Metal binding	444	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	135	1	N-linked (GlcNAc...) Potential
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	749	1	N-linked (GlcNAc...) Potential
	Glycosylation	840	1	N-linked (GlcNAc...) Potential
	Glycosylation	1213	1	N-linked (GlcNAc...) Potential
	Glycosylation	1267	1	N-linked (GlcNAc...) Potential
	Glycosylation	1788	1	N-linked (GlcNAc...) Potential
	Glycosylation	1806	1	N-linked (GlcNAc...) Potential
	Disulfide bond	412 ↔ 494		By similarity
	Disulfide bond	450 ↔ 478		By similarity
	Disulfide bond	600 ↔ 637		By similarity
	Disulfide bond	604 ↔ 642		By similarity
	Disulfide bond	615 ↔ 627		By similarity
	Disulfide bond	890 ↔ 931		By similarity
	Disulfide bond	894 ↔ 935		By similarity
	Disulfide bond	904 ↔ 918		By similarity
	Disulfide bond	1250 ↔ 1290		By similarity
	Disulfide bond	1254 ↔ 1295		By similarity
	Disulfide bond	1265 ↔ 1278		By similarity
	Disulfide bond	1624 ↔ 1670		By similarity
	Disulfide bond	1628 ↔ 1675		By similarity
	Disulfide bond	1639 ↔ 1659		By similarity
Natural variations
	Alternative sequence	1064 – 1072	9	CLVTCGKGH → VRWEGCYFP in isoform 3.		VSP_005499
	Alternative sequence	1073 – 1935	863	Missing in isoform 3.		VSP_005500
	Alternative sequence	1624 – 1629	6	CSVTCG → VPSWEL in isoform 2.		VSP_007548
	Alternative sequence	1630 – 1935	306	Missing in isoform 2.		VSP_007549
	Natural variant	96	1	S → P. Ref.2 Corresponds to variant rs36115950 [ dbSNP | Ensembl ].		VAR_047081
	Natural variant	96	1	S → T. Corresponds to variant rs36115950 [ dbSNP | Ensembl ].		VAR_051592
	Natural variant	1579	1	K → E. Corresponds to variant rs17071010 [ dbSNP | Ensembl ].		VAR_047082
	Natural variant	1674	1	D → E. Ref.2 Corresponds to variant rs6787633 [ dbSNP | Ensembl ].		VAR_047083
	Natural variant	1740	1	K → R. Corresponds to variant rs17070967 [ dbSNP | Ensembl ].		VAR_047084
	Natural variant	1791	1	E → Q. Corresponds to variant rs3796381 [ dbSNP | Ensembl ].		VAR_047085
	Natural variant	1921	1	K → E. Corresponds to variant rs17070909 [ dbSNP | Ensembl ].		VAR_051593
	Natural variant	1933	1	R → Q. Corresponds to variant rs17070905 [ dbSNP | Ensembl ].		VAR_047086
Experimental info
	Sequence conflict	46	1	S → G in AAF89106. Ref.1
	Sequence conflict	182	1	D → G in AAO15765. Ref.2
	Sequence conflict	367	1	F → L in AAF89106. Ref.1
	Sequence conflict	1117	1	G → V in AAO15765. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ADAMTS-9B) [UniParc]. Last modified November 4, 2008. Version 4. Checksum: 150B78D4C5CC2CCC	FASTA	1,935	216,491
	10 20 30 40 50 60 MQFVSWATLL TLLVRDLAEM GSPDAAAAVR KDRLHPRQVK LLETLSEYEI VSPIRVNALG 70 80 90 100 110 120 EPFPTNVHFK RTRRSINSAT DPWPAFASSS SSSTSSQAHY RLSAFGQQFL FNLTANAGFI 130 140 150 160 170 180 APLFTVTLLG TPGVNQTKFY SEEEAELKHC FYKGYVNTNS EHTAVISLCS GMLGTFRSHD 190 200 210 220 230 240 GDYFIEPLQS MDEQEDEEEQ NKPHIIYRRS APQREPSTGR HACDTSEHKN RHSKDKKKTR 250 260 270 280 290 300 ARKWGERINL AGDVAALNSG LATEAFSAYG NKTDNTREKR THRRTKRFLS YPRFVEVLVV 310 320 330 340 350 360 ADNRMVSYHG ENLQHYILTL MSIVASIYKD PSIGNLINIV IVNLIVIHNE QDGPSISFNA 370 380 390 400 410 420 QTTLKNFCQW QHSKNSPGGI HHDTAVLLTR QDICRAHDKC DTLGLAELGT ICDPYRSCSI 430 440 450 460 470 480 SEDSGLSTAF TIAHELGHVF NMPHDDNNKC KEEGVKSPQH VMAPTLNFYT NPWMWSKCSR 490 500 510 520 530 540 KYITEFLDTG YGECLLNEPE SRPYPLPVQL PGILYNVNKQ CELIFGPGSQ VCPYMMQCRR 550 560 570 580 590 600 LWCNNVNGVH KGCRTQHTPW ADGTECEPGK HCKYGFCVPK EMDVPVTDGS WGSWSPFGTC 610 620 630 640 650 660 SRTCGGGIKT AIRECNRPEP KNGGKYCVGR RMKFKSCNTE PCLKQKRDFR DEQCAHFDGK 670 680 690 700 710 720 HFNINGLLPN VRWVPKYSGI LMKDRCKLFC RVAGNTAYYQ LRDRVIDGTP CGQDTNDICV 730 740 750 760 770 780 QGLCRQAGCD HVLNSKARRD KCGVCGGDNS SCKTVAGTFN TVHYGYNTVV RIPAGATNID 790 800 810 820 830 840 VRQHSFSGET DDDNYLALSS SKGEFLLNGN FVVTMAKREI RIGNAVVEYS GSETAVERIN 850 860 870 880 890 900 STDRIEQELL LQVLSVGKLY NPDVRYSFNI PIEDKPQQFY WNSHGPWQAC SKPCQGERKR 910 920 930 940 950 960 KLVCTRESDQ LTVSDQRCDR LPQPGHITEP CGTDCDLRWH VASRSECSAQ CGLGYRTLDI 970 980 990 1000 1010 1020 YCAKYSRLDG KTEKVDDGFC SSHPKPSNRE KCSGECNTGG WRYSAWTECS KSCDGGTQRR 1030 1040 1050 1060 1070 1080 RAICVNTRND VLDDSKCTHQ EKVTIQRCSE FPCPQWKSGD WSECLVTCGK GHKHRQVWCQ 1090 1100 1110 1120 1130 1140 FGEDRLNDRM CDPETKPTSM QTCQQPECAS WQAGPWGQCS VTCGQGYQLR AVKCIIGTYM 1150 1160 1170 1180 1190 1200 SVVDDNDCNA ATRPTDTQDC ELPSCHPPPA APETRRSTYS APRTQWRFGS WTPCSATCGK 1210 1220 1230 1240 1250 1260 GTRMRYVSCR DENGSVADES ACATLPRPVA KEECSVTPCG QWKALDWSSC SVTCGQGRAT 1270 1280 1290 1300 1310 1320 RQVMCVNYSD HVIDRSECDQ DYIPETDQDC SMSPCPQRTP DSGLAQHPFQ NEDYRPRSAS 1330 1340 1350 1360 1370 1380 PSRTHVLGGN QWRTGPWGAC SSTCAGGSQR RVVVCQDENG YTANDCVERI KPDEQRACES 1390 1400 1410 1420 1430 1440 GPCPQWAYGN WGECTKLCGG GIRTRLVVCQ RSNGERFPDL SCEILDKPPD REQCNTHACP 1450 1460 1470 1480 1490 1500 HDAAWSTGPW SSCSVSCGRG HKQRNVYCMA KDGSHLESDY CKHLAKPHGH RKCRGGRCPK 1510 1520 1530 1540 1550 1560 WKAGAWSQCS VSCGRGVQQR HVGCQIGTHK IARETECNPY TRPESERDCQ GPRCPLYTWR 1570 1580 1590 1600 1610 1620 AEEWQECTKT CGEGSRYRKV VCVDDNKNEV HGARCDVSKR PVDRESCSLQ PCEYVWITGE 1630 1640 1650 1660 1670 1680 WSECSVTCGK GYKQRLVSCS EIYTGKENYE YSYQTTINCP GTQPPSVHPC YLRDCPVSAT 1690 1700 1710 1720 1730 1740 WRVGNWGSCS VSCGVGVMQR SVQCLTNEDQ PSHLCHTDLK PEERKTCRNV YNCELPQNCK 1750 1760 1770 1780 1790 1800 EVKRLKGASE DGEYFLMIRG KLLKIFCAGM HSDHPKEYVT LVHGDSENFS EVYGHRLHNP 1810 1820 1830 1840 1850 1860 TECPYNGSRR DDCQCRKDYT AAGFSSFQKI RIDLTSMQII TTDLQFARTS EGHPVPFATA 1870 1880 1890 1900 1910 1920 GDCYSAAKCP QGRFSINLYG TGLSLTESAR WISQGNYAVS DIKKSPDGTR VVGKCGGYCG 1930 KCTPSSGTGL EVRVL
	Isoform 2 (Long) [UniParc]. Checksum: E72B933CEED67809	FASTA	1,629	182,680
	10 20 30 40 50 60 MQFVSWATLL TLLVRDLAEM GSPDAAAAVR KDRLHPRQVK LLETLSEYEI VSPIRVNALG 70 80 90 100 110 120 EPFPTNVHFK RTRRSINSAT DPWPAFASSS SSSTSSQAHY RLSAFGQQFL FNLTANAGFI 130 140 150 160 170 180 APLFTVTLLG TPGVNQTKFY SEEEAELKHC FYKGYVNTNS EHTAVISLCS GMLGTFRSHD 190 200 210 220 230 240 GDYFIEPLQS MDEQEDEEEQ NKPHIIYRRS APQREPSTGR HACDTSEHKN RHSKDKKKTR 250 260 270 280 290 300 ARKWGERINL AGDVAALNSG LATEAFSAYG NKTDNTREKR THRRTKRFLS YPRFVEVLVV 310 320 330 340 350 360 ADNRMVSYHG ENLQHYILTL MSIVASIYKD PSIGNLINIV IVNLIVIHNE QDGPSISFNA 370 380 390 400 410 420 QTTLKNFCQW QHSKNSPGGI HHDTAVLLTR QDICRAHDKC DTLGLAELGT ICDPYRSCSI 430 440 450 460 470 480 SEDSGLSTAF TIAHELGHVF NMPHDDNNKC KEEGVKSPQH VMAPTLNFYT NPWMWSKCSR 490 500 510 520 530 540 KYITEFLDTG YGECLLNEPE SRPYPLPVQL PGILYNVNKQ CELIFGPGSQ VCPYMMQCRR 550 560 570 580 590 600 LWCNNVNGVH KGCRTQHTPW ADGTECEPGK HCKYGFCVPK EMDVPVTDGS WGSWSPFGTC 610 620 630 640 650 660 SRTCGGGIKT AIRECNRPEP KNGGKYCVGR RMKFKSCNTE PCLKQKRDFR DEQCAHFDGK 670 680 690 700 710 720 HFNINGLLPN VRWVPKYSGI LMKDRCKLFC RVAGNTAYYQ LRDRVIDGTP CGQDTNDICV 730 740 750 760 770 780 QGLCRQAGCD HVLNSKARRD KCGVCGGDNS SCKTVAGTFN TVHYGYNTVV RIPAGATNID 790 800 810 820 830 840 VRQHSFSGET DDDNYLALSS SKGEFLLNGN FVVTMAKREI RIGNAVVEYS GSETAVERIN 850 860 870 880 890 900 STDRIEQELL LQVLSVGKLY NPDVRYSFNI PIEDKPQQFY WNSHGPWQAC SKPCQGERKR 910 920 930 940 950 960 KLVCTRESDQ LTVSDQRCDR LPQPGHITEP CGTDCDLRWH VASRSECSAQ CGLGYRTLDI 970 980 990 1000 1010 1020 YCAKYSRLDG KTEKVDDGFC SSHPKPSNRE KCSGECNTGG WRYSAWTECS KSCDGGTQRR 1030 1040 1050 1060 1070 1080 RAICVNTRND VLDDSKCTHQ EKVTIQRCSE FPCPQWKSGD WSECLVTCGK GHKHRQVWCQ 1090 1100 1110 1120 1130 1140 FGEDRLNDRM CDPETKPTSM QTCQQPECAS WQAGPWGQCS VTCGQGYQLR AVKCIIGTYM 1150 1160 1170 1180 1190 1200 SVVDDNDCNA ATRPTDTQDC ELPSCHPPPA APETRRSTYS APRTQWRFGS WTPCSATCGK 1210 1220 1230 1240 1250 1260 GTRMRYVSCR DENGSVADES ACATLPRPVA KEECSVTPCG QWKALDWSSC SVTCGQGRAT 1270 1280 1290 1300 1310 1320 RQVMCVNYSD HVIDRSECDQ DYIPETDQDC SMSPCPQRTP DSGLAQHPFQ NEDYRPRSAS 1330 1340 1350 1360 1370 1380 PSRTHVLGGN QWRTGPWGAC SSTCAGGSQR RVVVCQDENG YTANDCVERI KPDEQRACES 1390 1400 1410 1420 1430 1440 GPCPQWAYGN WGECTKLCGG GIRTRLVVCQ RSNGERFPDL SCEILDKPPD REQCNTHACP 1450 1460 1470 1480 1490 1500 HDAAWSTGPW SSCSVSCGRG HKQRNVYCMA KDGSHLESDY CKHLAKPHGH RKCRGGRCPK 1510 1520 1530 1540 1550 1560 WKAGAWSQCS VSCGRGVQQR HVGCQIGTHK IARETECNPY TRPESERDCQ GPRCPLYTWR 1570 1580 1590 1600 1610 1620 AEEWQECTKT CGEGSRYRKV VCVDDNKNEV HGARCDVSKR PVDRESCSLQ PCEYVWITGE WSEVPSWEL
	Isoform 3 (Short) [UniParc]. Checksum: 85251C8E59449E0C	FASTA	1,072	120,717
	10 20 30 40 50 60 MQFVSWATLL TLLVRDLAEM GSPDAAAAVR KDRLHPRQVK LLETLSEYEI VSPIRVNALG 70 80 90 100 110 120 EPFPTNVHFK RTRRSINSAT DPWPAFASSS SSSTSSQAHY RLSAFGQQFL FNLTANAGFI 130 140 150 160 170 180 APLFTVTLLG TPGVNQTKFY SEEEAELKHC FYKGYVNTNS EHTAVISLCS GMLGTFRSHD 190 200 210 220 230 240 GDYFIEPLQS MDEQEDEEEQ NKPHIIYRRS APQREPSTGR HACDTSEHKN RHSKDKKKTR 250 260 270 280 290 300 ARKWGERINL AGDVAALNSG LATEAFSAYG NKTDNTREKR THRRTKRFLS YPRFVEVLVV 310 320 330 340 350 360 ADNRMVSYHG ENLQHYILTL MSIVASIYKD PSIGNLINIV IVNLIVIHNE QDGPSISFNA 370 380 390 400 410 420 QTTLKNFCQW QHSKNSPGGI HHDTAVLLTR QDICRAHDKC DTLGLAELGT ICDPYRSCSI 430 440 450 460 470 480 SEDSGLSTAF TIAHELGHVF NMPHDDNNKC KEEGVKSPQH VMAPTLNFYT NPWMWSKCSR 490 500 510 520 530 540 KYITEFLDTG YGECLLNEPE SRPYPLPVQL PGILYNVNKQ CELIFGPGSQ VCPYMMQCRR 550 560 570 580 590 600 LWCNNVNGVH KGCRTQHTPW ADGTECEPGK HCKYGFCVPK EMDVPVTDGS WGSWSPFGTC 610 620 630 640 650 660 SRTCGGGIKT AIRECNRPEP KNGGKYCVGR RMKFKSCNTE PCLKQKRDFR DEQCAHFDGK 670 680 690 700 710 720 HFNINGLLPN VRWVPKYSGI LMKDRCKLFC RVAGNTAYYQ LRDRVIDGTP CGQDTNDICV 730 740 750 760 770 780 QGLCRQAGCD HVLNSKARRD KCGVCGGDNS SCKTVAGTFN TVHYGYNTVV RIPAGATNID 790 800 810 820 830 840 VRQHSFSGET DDDNYLALSS SKGEFLLNGN FVVTMAKREI RIGNAVVEYS GSETAVERIN 850 860 870 880 890 900 STDRIEQELL LQVLSVGKLY NPDVRYSFNI PIEDKPQQFY WNSHGPWQAC SKPCQGERKR 910 920 930 940 950 960 KLVCTRESDQ LTVSDQRCDR LPQPGHITEP CGTDCDLRWH VASRSECSAQ CGLGYRTLDI 970 980 990 1000 1010 1020 YCAKYSRLDG KTEKVDDGFC SSHPKPSNRE KCSGECNTGG WRYSAWTECS KSCDGGTQRR 1030 1040 1050 1060 1070 RAICVNTRND VLDDSKCTHQ EKVTIQRCSE FPCPQWKSGD WSEVRWEGCY FP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ADAMTS 9, a novel member of the ADAM-TS/Metallospondin gene family." Clark M.E., Kelner G.S., Turbeville L.A., Boyer A., Arden K.A., Maki R.A. Genomics 67:343-350(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Fetus.
[2]	"Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1." Somerville R.P., Longpre J.-M., Jungers K.A., Engle J.M., Ross M., Evanko S., Wight T.N., Leduc R., Apte S.S. J. Biol. Chem. 278:9503-9513(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANTS PRO-96 AND GLU-1674.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-1935 (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF261918 mRNA. Translation: AAF89106.1. AF488803 mRNA. Translation: AAO15765.1. AC096888 Genomic DNA. No translation available. AC122178 Genomic DNA. No translation available. BC130578 mRNA. Translation: AAI30579.1. AB037733 mRNA. Translation: BAA92550.1.
IPI	IPI00220986. IPI00329771. IPI00748386.
RefSeq	NP_891550.1. NM_182920.1.
UniGene	Hs.656071.
3D structure databases
ProteinModelPortal	Q9P2N4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2N4. 1 interaction.
STRING	9606.ENSP00000418735.
Protein family/group databases
MEROPS	M12.021.
PTM databases
PhosphoSite	Q9P2N4.
Polymorphism databases
DMDM	212276516.
Proteomic databases
PaxDb	Q9P2N4.
PRIDE	Q9P2N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000498707; ENSP00000418735; ENSG00000163638.
GeneID	56999.
KEGG	hsa:56999.
UCSC	uc003dmg.3. human. uc003dmh.1. human. uc003dmk.1. human.
Organism-specific databases
CTD	56999.
GeneCards	GC03M064476.
HGNC	HGNC:13202. ADAMTS9.
HPA	HPA028567. HPA028577.
MIM	605421. gene.
neXtProt	NX_Q9P2N4.
PharmGKB	PA24553.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG237764.
HOGENOM	HOG000004798.
HOVERGEN	HBG037334.
InParanoid	Q9P2N4.
KO	K08624.
OMA	CQGERKR.
PhylomeDB	Q9P2N4.
Gene expression databases
ArrayExpress	Q9P2N4.
Bgee	Q9P2N4.
CleanEx	HS_ADAMTS9.
Genevestigator	Q9P2N4.
GermOnline	ENSG00000163638. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.10. 2 hits.
InterPro	IPR010294. ADAM_spacer1. IPR024079. MetalloPept_cat_dom. IPR012314. Pept_M12B_GON-ADAMTSs. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF05986. ADAM_spacer1. 1 hit. PF08685. GON. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 13 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY.
SMART	SM00209. TSP1. 15 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 13 hits.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS51046. GON. 1 hit. PS50092. TSP1. 14 hits. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56999.
NextBio	62723.
PMAP-CutDB	Q9P2N4.
SOURCE	Search...

Entry information

Entry name

ATS9_HUMAN

Accession

Primary (citable) accession number: Q9P2N4
Secondary accession number(s): A1L4L0, B9ZVN0, Q9NR29

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 126 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.