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Protein

LRP2-binding protein

Gene

LRP2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as an adapter that regulates LRP2 function.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109771-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LRP2-binding protein
Alternative name(s):
Megalin-binding protein
Short name:
MegBP
Gene namesi
Name:LRP2BP
Synonyms:KIAA1325
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25434. LRP2BP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55805.
OpenTargetsiENSG00000109771.
PharmGKBiPA142671538.

Polymorphism and mutation databases

BioMutaiLRP2BP.
DMDMi166199159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157071 – 347LRP2-binding proteinAdd BLAST347

Proteomic databases

PaxDbiQ9P2M1.
PeptideAtlasiQ9P2M1.
PRIDEiQ9P2M1.

PTM databases

iPTMnetiQ9P2M1.
PhosphoSitePlusiQ9P2M1.

Expressioni

Gene expression databases

BgeeiENSG00000109771.
CleanExiHS_LRP2BP.
ExpressionAtlasiQ9P2M1. baseline and differential.
GenevisibleiQ9P2M1. HS.

Organism-specific databases

HPAiHPA036664.
HPA036665.

Interactioni

Subunit structurei

Interacts with LRP2.1 Publication

Protein-protein interaction databases

BioGridi120916. 2 interactors.
STRINGi9606.ENSP00000332681.

Structurei

3D structure databases

ProteinModelPortaliQ9P2M1.
SMRiQ9P2M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 92TPRAdd BLAST34
Repeati93 – 125Sel1-like 1Add BLAST33
Repeati133 – 168Sel1-like 2Add BLAST36
Repeati173 – 206Sel1-like 3Add BLAST34
Repeati207 – 242Sel1-like 4Add BLAST36
Repeati243 – 277Sel1-like 5Add BLAST35
Repeati297 – 332Sel1-like 6Add BLAST36

Sequence similaritiesi

Contains 6 Sel1-like repeats.Curated
Contains 1 TPR repeat.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000013490.
HOGENOMiHOG000007246.
HOVERGENiHBG108096.
InParanoidiQ9P2M1.
OMAiCLPEFII.
OrthoDBiEOG091G0JNW.
PhylomeDBiQ9P2M1.
TreeFamiTF315257.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL
60 70 80 90 100
KERILKGDTL AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY
110 120 130 140 150
YDGLGTTLDA EKGVDYMKKI LDSPCPKARH LKFAAAYNLG RAYYEGKGVK
160 170 180 190 200
RSNEEAERLW LIAADNGNPK ASVKAQSMLG LYYSTKEPKE LEKAFYWHSE
210 220 230 240 250
ACGNGNLESQ GALGLMYLYG QGIRQDTEAA LQCLREAAER GNVYAQGNLV
260 270 280 290 300
EYYYKMKFFT KCVAFSKRIA DYDEVHDIPM IAQVTDCLPE FIGRGMAMAS
310 320 330 340
FYHARCLQLG LGITRDETTA KHYYSKACRL NPALADELHS LLIRQRI
Length:347
Mass (Da):39,780
Last modified:January 15, 2008 - v2
Checksum:i6BC7C6E758A63F33
GO
Isoform 2 (identifier: Q9P2M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: T → TKS

Note: No experimental confirmation available.
Show »
Length:349
Mass (Da):39,996
Checksum:i18F595FEC1DF3A27
GO

Sequence cautioni

The sequence BAA92563 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03066435T → TKS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037746 mRNA. Translation: BAA92563.1. Different initiation.
AK126913 mRNA. Translation: BAG54395.1.
AL161975 mRNA. Translation: CAB82313.2.
AC106897 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04650.1.
BC150161 mRNA. Translation: AAI50162.1.
BC152444 mRNA. Translation: AAI52445.1.
CCDSiCCDS3840.1. [Q9P2M1-1]
PIRiT47138.
RefSeqiNP_060879.2. NM_018409.3. [Q9P2M1-1]
XP_006714323.1. XM_006714260.3. [Q9P2M1-1]
XP_016863899.1. XM_017008410.1. [Q9P2M1-1]
UniGeneiHs.558513.

Genome annotation databases

EnsembliENST00000328559; ENSP00000332681; ENSG00000109771. [Q9P2M1-1]
ENST00000505916; ENSP00000426203; ENSG00000109771. [Q9P2M1-1]
GeneIDi55805.
KEGGihsa:55805.
UCSCiuc003ixj.3. human. [Q9P2M1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037746 mRNA. Translation: BAA92563.1. Different initiation.
AK126913 mRNA. Translation: BAG54395.1.
AL161975 mRNA. Translation: CAB82313.2.
AC106897 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04650.1.
BC150161 mRNA. Translation: AAI50162.1.
BC152444 mRNA. Translation: AAI52445.1.
CCDSiCCDS3840.1. [Q9P2M1-1]
PIRiT47138.
RefSeqiNP_060879.2. NM_018409.3. [Q9P2M1-1]
XP_006714323.1. XM_006714260.3. [Q9P2M1-1]
XP_016863899.1. XM_017008410.1. [Q9P2M1-1]
UniGeneiHs.558513.

3D structure databases

ProteinModelPortaliQ9P2M1.
SMRiQ9P2M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120916. 2 interactors.
STRINGi9606.ENSP00000332681.

PTM databases

iPTMnetiQ9P2M1.
PhosphoSitePlusiQ9P2M1.

Polymorphism and mutation databases

BioMutaiLRP2BP.
DMDMi166199159.

Proteomic databases

PaxDbiQ9P2M1.
PeptideAtlasiQ9P2M1.
PRIDEiQ9P2M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328559; ENSP00000332681; ENSG00000109771. [Q9P2M1-1]
ENST00000505916; ENSP00000426203; ENSG00000109771. [Q9P2M1-1]
GeneIDi55805.
KEGGihsa:55805.
UCSCiuc003ixj.3. human. [Q9P2M1-1]

Organism-specific databases

CTDi55805.
DisGeNETi55805.
GeneCardsiLRP2BP.
HGNCiHGNC:25434. LRP2BP.
HPAiHPA036664.
HPA036665.
neXtProtiNX_Q9P2M1.
OpenTargetsiENSG00000109771.
PharmGKBiPA142671538.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000013490.
HOGENOMiHOG000007246.
HOVERGENiHBG108096.
InParanoidiQ9P2M1.
OMAiCLPEFII.
OrthoDBiEOG091G0JNW.
PhylomeDBiQ9P2M1.
TreeFamiTF315257.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109771-MONOMER.

Miscellaneous databases

GenomeRNAii55805.
PROiQ9P2M1.

Gene expression databases

BgeeiENSG00000109771.
CleanExiHS_LRP2BP.
ExpressionAtlasiQ9P2M1. baseline and differential.
GenevisibleiQ9P2M1. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR2BP_HUMAN
AccessioniPrimary (citable) accession number: Q9P2M1
Secondary accession number(s): A6NJR7
, A7E219, B3KX83, Q9NSN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.