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Q9P2L0

- WDR35_HUMAN

UniProt

Q9P2L0 - WDR35_HUMAN

Protein

WD repeat-containing protein 35

Gene

WDR35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (29 Mar 2004)
      Previous versions | rss
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    Functioni

    Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.2 Publications

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. intraciliary retrograde transport Source: MGI

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Enzyme and pathway databases

    SignaLinkiQ9P2L0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 35
    Alternative name(s):
    Intraflagellar transport protein 121 homolog
    Gene namesi
    Name:WDR35
    Synonyms:IFT121, KIAA1336
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29250. WDR35.

    Subcellular locationi

    GO - Cellular componenti

    1. axoneme Source: UniProtKB
    2. centrosome Source: UniProtKB
    3. ciliary basal body Source: UniProtKB
    4. intraciliary transport particle A Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely spaced, hypoplastic and fused teeth.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti626 – 6261E → G in CED2. 1 Publication
    VAR_064581
    Natural varianti875 – 8751A → T in CED2. 1 Publication
    VAR_064582
    Short-rib thoracic dysplasia 7 with or without polydactyly (SRTD7) [MIM:614091]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. SRTD7 hallmarks are acromesomelic hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly syndrome through impaired cilia formation. Primary fibroblasts from SRTD7 patients lacking WDR35 fail to produce cilia (PubMed:21473986).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti261 – 2611W → R in SRTD7. 1 Publication
    VAR_065955

    Keywords - Diseasei

    Ciliopathy, Disease mutation, Ectodermal dysplasia

    Organism-specific databases

    MIMi613610. phenotype.
    614091. phenotype.
    Orphaneti1515. Cranioectodermal dysplasia.
    93271. Short rib-polydactyly syndrome, Verma-Naumoff type.
    PharmGKBiPA134928987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11811181WD repeat-containing protein 35PRO_0000051384Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2L0.
    PaxDbiQ9P2L0.
    PRIDEiQ9P2L0.

    PTM databases

    PhosphoSiteiQ9P2L0.

    Expressioni

    Inductioni

    By TNF.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2L0.
    BgeeiQ9P2L0.
    CleanExiHS_WDR35.
    GenevestigatoriQ9P2L0.

    Organism-specific databases

    HPAiHPA044147.

    Interactioni

    Subunit structurei

    Component of the IFT complex A (IFT-A). Interacts with IFT43.2 Publications

    Protein-protein interaction databases

    BioGridi121598. 3 interactions.
    IntActiQ9P2L0. 1 interaction.
    STRINGi9606.ENSP00000314444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2L0.
    SMRiQ9P2L0. Positions 20-186, 295-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati12 – 5140WD 1Add
    BLAST
    Repeati69 – 10840WD 2Add
    BLAST
    Repeati113 – 15240WD 3Add
    BLAST
    Repeati154 – 19340WD 4Add
    BLAST
    Repeati502 – 53938WD 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG263340.
    HOGENOMiHOG000255527.
    HOVERGENiHBG079343.
    InParanoidiQ9P2L0.
    OMAiDENHPQE.
    OrthoDBiEOG7QRQT6.
    PhylomeDBiQ9P2L0.
    TreeFamiTF314076.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    IPR017233. WD_repeat_p35.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037536. WD_repeat_p35. 1 hit.
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2L0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFFYLSKKIS IPNNVKLQCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA     50
    KLRGLAAPSN LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML 100
    YKGSWIEEMI NNRNKSVVRS MSWNADGQKI CIVYEDGAVI VGSVDGNRIW 150
    GKDLKGIQLS HVTWSADSKV LLFGMANGEI HIYDNQGNFM IKMKLSCLVN 200
    VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR HENDQNPVLI 250
    DTGMYVVGIQ WNHMGSVLAV AGFQKAAMQD KDVNIVQFYT PFGEHLGTLK 300
    VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR 350
    PDRPEYCVVF WDTKNNEKYV KYVKGLISIT TCGDFCILAT KADENHPQEE 400
    NEMETFGATF VLVLCNSIGT PLDPKYIDIV PLFVAMTKTH VIAASKEAFY 450
    TWQYRVAKKL TALEINQITR SRKEGRERIY HVDDTPSGSM DGVLDYSKTI 500
    QGTRDPICAI TASDKILIVG RESGTIQRYS LPNVGLIQKY SLNCRAYQLS 550
    LNCNSSRLAI IDISGVLTFF DLDARVTDST GQQVVGELLK LERRDVWDMK 600
    WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE 650
    ILKDPEHPNK DYLINFEIRS LRDSRALIEK VGIKDASQFI EDNPHPRLWR 700
    LLAEAALQKL DLYTAEQAFV RCKDYQGIKF VKRLGKLLSE SMKQAEVVGY 750
    FGRFEEAERT YLEMDRRDLA IGLRLKLGDW FRVLQLLKTG SGDADDSLLE 800
    QANNAIGDYF ADRQKWLNAV QYYVQGRNQE RLAECYYMLE DYEGLENLAI 850
    SLPENHKLLP EIAQMFVRVG MCEQAVTAFL KCSQPKAAVD TCVHLNQWNK 900
    AVELAKNHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA NYFFDAAKLM 950
    FKIADEEAKK GSKPLRVKKL YVLSALLIEQ YHEQMKNAQR GKVKGKSSEA 1000
    TSALAGLLEE EVLSTTDRFT DNAWRGAEAY HFFILAQRQL YEGCVDTALK 1050
    TALHLKDYED IIPPVEIYSL LALCACASRA FGTCSKAFIK LKSLETLSSE 1100
    QKQQYEDLAL EIFTKHTSKD NRKPELDSLM EGGEGKLPTC VATGSPITEY 1150
    QFWMCSVCKH GVLAQEISHY SFCPLCHSPV G 1181
    Length:1,181
    Mass (Da):133,547
    Last modified:March 29, 2004 - v3
    Checksum:i1C0FFAAD0287F129
    GO
    Isoform 2 (identifier: Q9P2L0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         399-409: Missing.

    Show »
    Length:1,170
    Mass (Da):132,308
    Checksum:i24A1BABB959DF302
    GO

    Sequence cautioni

    The sequence BAA92574.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1078 – 10781S → G in AAH36659. (PubMed:15489334)Curated
    Sequence conflicti1171 – 11711S → G in BAG53797. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181Q → R.
    Corresponds to variant rs1060742 [ dbSNP | Ensembl ].
    VAR_053428
    Natural varianti261 – 2611W → R in SRTD7. 1 Publication
    VAR_065955
    Natural varianti626 – 6261E → G in CED2. 1 Publication
    VAR_064581
    Natural varianti875 – 8751A → T in CED2. 1 Publication
    VAR_064582
    Natural varianti878 – 8781A → P.
    Corresponds to variant rs2293669 [ dbSNP | Ensembl ].
    VAR_062102
    Natural varianti878 – 8781A → T.1 Publication
    Corresponds to variant rs2293669 [ dbSNP | Ensembl ].
    VAR_062103
    Natural varianti983 – 9831E → G.1 Publication
    Corresponds to variant rs1191778 [ dbSNP | Ensembl ].
    VAR_053429

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei399 – 40911Missing in isoform 2. 2 PublicationsVSP_009732Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037757 mRNA. Translation: BAA92574.2. Different initiation.
    AK122917 mRNA. Translation: BAG53797.1.
    AC079145 Genomic DNA. Translation: AAX88936.1.
    CH471053 Genomic DNA. Translation: EAX00841.1.
    BC036659 mRNA. Translation: AAH36659.1.
    CCDSiCCDS1695.1. [Q9P2L0-2]
    CCDS33152.1. [Q9P2L0-1]
    RefSeqiNP_001006658.1. NM_001006657.1. [Q9P2L0-1]
    NP_065830.2. NM_020779.3. [Q9P2L0-2]
    UniGeneiHs.205427.

    Genome annotation databases

    EnsembliENST00000281405; ENSP00000281405; ENSG00000118965. [Q9P2L0-2]
    ENST00000345530; ENSP00000314444; ENSG00000118965. [Q9P2L0-1]
    GeneIDi57539.
    KEGGihsa:57539.
    UCSCiuc002rdi.3. human. [Q9P2L0-1]
    uc002rdj.3. human. [Q9P2L0-2]

    Polymorphism databases

    DMDMi48474987.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037757 mRNA. Translation: BAA92574.2 . Different initiation.
    AK122917 mRNA. Translation: BAG53797.1 .
    AC079145 Genomic DNA. Translation: AAX88936.1 .
    CH471053 Genomic DNA. Translation: EAX00841.1 .
    BC036659 mRNA. Translation: AAH36659.1 .
    CCDSi CCDS1695.1. [Q9P2L0-2 ]
    CCDS33152.1. [Q9P2L0-1 ]
    RefSeqi NP_001006658.1. NM_001006657.1. [Q9P2L0-1 ]
    NP_065830.2. NM_020779.3. [Q9P2L0-2 ]
    UniGenei Hs.205427.

    3D structure databases

    ProteinModelPortali Q9P2L0.
    SMRi Q9P2L0. Positions 20-186, 295-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121598. 3 interactions.
    IntActi Q9P2L0. 1 interaction.
    STRINGi 9606.ENSP00000314444.

    PTM databases

    PhosphoSitei Q9P2L0.

    Polymorphism databases

    DMDMi 48474987.

    Proteomic databases

    MaxQBi Q9P2L0.
    PaxDbi Q9P2L0.
    PRIDEi Q9P2L0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281405 ; ENSP00000281405 ; ENSG00000118965 . [Q9P2L0-2 ]
    ENST00000345530 ; ENSP00000314444 ; ENSG00000118965 . [Q9P2L0-1 ]
    GeneIDi 57539.
    KEGGi hsa:57539.
    UCSCi uc002rdi.3. human. [Q9P2L0-1 ]
    uc002rdj.3. human. [Q9P2L0-2 ]

    Organism-specific databases

    CTDi 57539.
    GeneCardsi GC02M020110.
    GeneReviewsi WDR35.
    HGNCi HGNC:29250. WDR35.
    HPAi HPA044147.
    MIMi 613602. gene.
    613610. phenotype.
    614091. phenotype.
    neXtProti NX_Q9P2L0.
    Orphaneti 1515. Cranioectodermal dysplasia.
    93271. Short rib-polydactyly syndrome, Verma-Naumoff type.
    PharmGKBi PA134928987.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263340.
    HOGENOMi HOG000255527.
    HOVERGENi HBG079343.
    InParanoidi Q9P2L0.
    OMAi DENHPQE.
    OrthoDBi EOG7QRQT6.
    PhylomeDBi Q9P2L0.
    TreeFami TF314076.

    Enzyme and pathway databases

    SignaLinki Q9P2L0.

    Miscellaneous databases

    GenomeRNAii 57539.
    NextBioi 63968.
    PROi Q9P2L0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2L0.
    Bgeei Q9P2L0.
    CleanExi HS_WDR35.
    Genevestigatori Q9P2L0.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    IPR017233. WD_repeat_p35.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037536. WD_repeat_p35. 1 hit.
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-983.
      Tissue: Testis.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-878.
      Tissue: Testis.
    7. "SnapShot: Intraflagellar transport."
      Cole D.G., Snell W.J.
      Cell 137:784-784(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IFT43.
    8. "Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis."
      Feng G.G., Li C., Huang L., Tsunekawa K., Sato Y., Fujiwara Y., Komatsu T., Honda T., Fan J.H., Goto H., Koide T., Hasegawa T., Ishikawa N.
      Biochem. Biophys. Res. Commun. 394:153-157(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    9. "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia."
      Mukhopadhyay S., Wen X., Chih B., Nelson C.D., Lane W.S., Scales S.J., Jackson P.K.
      Genes Dev. 24:2180-2193(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE IFT-A COMPLEX.
    10. Cited for: FUNCTION, VARIANT SRTD7 ARG-261.
    11. Cited for: VARIANTS CED2 GLY-626 AND THR-875.

    Entry informationi

    Entry nameiWDR35_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2L0
    Secondary accession number(s): B3KVI5, Q4ZG01, Q8NE11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: March 29, 2004
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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