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Q9P2L0

- WDR35_HUMAN

UniProt

Q9P2L0 - WDR35_HUMAN

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Protein

WD repeat-containing protein 35

Gene

WDR35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.2 Publications

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. intraciliary retrograde transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkiQ9P2L0.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 35
Alternative name(s):
Intraflagellar transport protein 121 homolog
Gene namesi
Name:WDR35
Synonyms:IFT121, KIAA1336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29250. WDR35.

Subcellular locationi

GO - Cellular componenti

  1. axoneme Source: UniProtKB
  2. centrosome Source: UniProtKB
  3. ciliary basal body Source: UniProtKB
  4. intraciliary transport particle A Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely spaced, hypoplastic and fused teeth.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti626 – 6261E → G in CED2. 1 Publication
VAR_064581
Natural varianti875 – 8751A → T in CED2. 1 Publication
VAR_064582
Short-rib thoracic dysplasia 7 with or without polydactyly (SRTD7) [MIM:614091]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. SRTD7 hallmarks are acromesomelic hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly syndrome through impaired cilia formation. Primary fibroblasts from SRTD7 patients lacking WDR35 fail to produce cilia (PubMed:21473986).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611W → R in SRTD7. 1 Publication
VAR_065955

Keywords - Diseasei

Ciliopathy, Disease mutation, Ectodermal dysplasia

Organism-specific databases

MIMi613610. phenotype.
614091. phenotype.
Orphaneti1515. Cranioectodermal dysplasia.
93271. Short rib-polydactyly syndrome, Verma-Naumoff type.
PharmGKBiPA134928987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11811181WD repeat-containing protein 35PRO_0000051384Add
BLAST

Proteomic databases

MaxQBiQ9P2L0.
PaxDbiQ9P2L0.
PRIDEiQ9P2L0.

PTM databases

PhosphoSiteiQ9P2L0.

Expressioni

Inductioni

By TNF.1 Publication

Gene expression databases

BgeeiQ9P2L0.
CleanExiHS_WDR35.
ExpressionAtlasiQ9P2L0. baseline and differential.
GenevestigatoriQ9P2L0.

Organism-specific databases

HPAiHPA044147.

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A). Interacts with IFT43.2 Publications

Protein-protein interaction databases

BioGridi121598. 6 interactions.
IntActiQ9P2L0. 1 interaction.
STRINGi9606.ENSP00000314444.

Structurei

3D structure databases

ProteinModelPortaliQ9P2L0.
SMRiQ9P2L0. Positions 20-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 5140WD 1Add
BLAST
Repeati69 – 10840WD 2Add
BLAST
Repeati113 – 15240WD 3Add
BLAST
Repeati154 – 19340WD 4Add
BLAST
Repeati502 – 53938WD 5Add
BLAST

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG263340.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000255527.
HOVERGENiHBG079343.
InParanoidiQ9P2L0.
OMAiDENHPQE.
OrthoDBiEOG7QRQT6.
PhylomeDBiQ9P2L0.
TreeFamiTF314076.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR017233. WD_repeat_p35.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF037536. WD_repeat_p35. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P2L0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFYLSKKIS IPNNVKLQCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA
60 70 80 90 100
KLRGLAAPSN LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML
110 120 130 140 150
YKGSWIEEMI NNRNKSVVRS MSWNADGQKI CIVYEDGAVI VGSVDGNRIW
160 170 180 190 200
GKDLKGIQLS HVTWSADSKV LLFGMANGEI HIYDNQGNFM IKMKLSCLVN
210 220 230 240 250
VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR HENDQNPVLI
260 270 280 290 300
DTGMYVVGIQ WNHMGSVLAV AGFQKAAMQD KDVNIVQFYT PFGEHLGTLK
310 320 330 340 350
VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR
360 370 380 390 400
PDRPEYCVVF WDTKNNEKYV KYVKGLISIT TCGDFCILAT KADENHPQEE
410 420 430 440 450
NEMETFGATF VLVLCNSIGT PLDPKYIDIV PLFVAMTKTH VIAASKEAFY
460 470 480 490 500
TWQYRVAKKL TALEINQITR SRKEGRERIY HVDDTPSGSM DGVLDYSKTI
510 520 530 540 550
QGTRDPICAI TASDKILIVG RESGTIQRYS LPNVGLIQKY SLNCRAYQLS
560 570 580 590 600
LNCNSSRLAI IDISGVLTFF DLDARVTDST GQQVVGELLK LERRDVWDMK
610 620 630 640 650
WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE
660 670 680 690 700
ILKDPEHPNK DYLINFEIRS LRDSRALIEK VGIKDASQFI EDNPHPRLWR
710 720 730 740 750
LLAEAALQKL DLYTAEQAFV RCKDYQGIKF VKRLGKLLSE SMKQAEVVGY
760 770 780 790 800
FGRFEEAERT YLEMDRRDLA IGLRLKLGDW FRVLQLLKTG SGDADDSLLE
810 820 830 840 850
QANNAIGDYF ADRQKWLNAV QYYVQGRNQE RLAECYYMLE DYEGLENLAI
860 870 880 890 900
SLPENHKLLP EIAQMFVRVG MCEQAVTAFL KCSQPKAAVD TCVHLNQWNK
910 920 930 940 950
AVELAKNHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA NYFFDAAKLM
960 970 980 990 1000
FKIADEEAKK GSKPLRVKKL YVLSALLIEQ YHEQMKNAQR GKVKGKSSEA
1010 1020 1030 1040 1050
TSALAGLLEE EVLSTTDRFT DNAWRGAEAY HFFILAQRQL YEGCVDTALK
1060 1070 1080 1090 1100
TALHLKDYED IIPPVEIYSL LALCACASRA FGTCSKAFIK LKSLETLSSE
1110 1120 1130 1140 1150
QKQQYEDLAL EIFTKHTSKD NRKPELDSLM EGGEGKLPTC VATGSPITEY
1160 1170 1180
QFWMCSVCKH GVLAQEISHY SFCPLCHSPV G
Length:1,181
Mass (Da):133,547
Last modified:March 29, 2004 - v3
Checksum:i1C0FFAAD0287F129
GO
Isoform 2 (identifier: Q9P2L0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-409: Missing.

Show »
Length:1,170
Mass (Da):132,308
Checksum:i24A1BABB959DF302
GO

Sequence cautioni

The sequence BAA92574.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1078 – 10781S → G in AAH36659. (PubMed:15489334)Curated
Sequence conflicti1171 – 11711S → G in BAG53797. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181Q → R.
Corresponds to variant rs1060742 [ dbSNP | Ensembl ].
VAR_053428
Natural varianti261 – 2611W → R in SRTD7. 1 Publication
VAR_065955
Natural varianti626 – 6261E → G in CED2. 1 Publication
VAR_064581
Natural varianti875 – 8751A → T in CED2. 1 Publication
VAR_064582
Natural varianti878 – 8781A → P.
Corresponds to variant rs2293669 [ dbSNP | Ensembl ].
VAR_062102
Natural varianti878 – 8781A → T.1 Publication
Corresponds to variant rs2293669 [ dbSNP | Ensembl ].
VAR_062103
Natural varianti983 – 9831E → G.1 Publication
Corresponds to variant rs1191778 [ dbSNP | Ensembl ].
VAR_053429

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei399 – 40911Missing in isoform 2. 2 PublicationsVSP_009732Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037757 mRNA. Translation: BAA92574.2. Different initiation.
AK122917 mRNA. Translation: BAG53797.1.
AC079145 Genomic DNA. Translation: AAX88936.1.
CH471053 Genomic DNA. Translation: EAX00841.1.
BC036659 mRNA. Translation: AAH36659.1.
CCDSiCCDS1695.1. [Q9P2L0-2]
CCDS33152.1. [Q9P2L0-1]
RefSeqiNP_001006658.1. NM_001006657.1. [Q9P2L0-1]
NP_065830.2. NM_020779.3. [Q9P2L0-2]
UniGeneiHs.205427.

Genome annotation databases

EnsembliENST00000281405; ENSP00000281405; ENSG00000118965. [Q9P2L0-2]
ENST00000345530; ENSP00000314444; ENSG00000118965. [Q9P2L0-1]
GeneIDi57539.
KEGGihsa:57539.
UCSCiuc002rdi.3. human. [Q9P2L0-1]
uc002rdj.3. human. [Q9P2L0-2]

Polymorphism databases

DMDMi48474987.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037757 mRNA. Translation: BAA92574.2 . Different initiation.
AK122917 mRNA. Translation: BAG53797.1 .
AC079145 Genomic DNA. Translation: AAX88936.1 .
CH471053 Genomic DNA. Translation: EAX00841.1 .
BC036659 mRNA. Translation: AAH36659.1 .
CCDSi CCDS1695.1. [Q9P2L0-2 ]
CCDS33152.1. [Q9P2L0-1 ]
RefSeqi NP_001006658.1. NM_001006657.1. [Q9P2L0-1 ]
NP_065830.2. NM_020779.3. [Q9P2L0-2 ]
UniGenei Hs.205427.

3D structure databases

ProteinModelPortali Q9P2L0.
SMRi Q9P2L0. Positions 20-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121598. 6 interactions.
IntActi Q9P2L0. 1 interaction.
STRINGi 9606.ENSP00000314444.

PTM databases

PhosphoSitei Q9P2L0.

Polymorphism databases

DMDMi 48474987.

Proteomic databases

MaxQBi Q9P2L0.
PaxDbi Q9P2L0.
PRIDEi Q9P2L0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281405 ; ENSP00000281405 ; ENSG00000118965 . [Q9P2L0-2 ]
ENST00000345530 ; ENSP00000314444 ; ENSG00000118965 . [Q9P2L0-1 ]
GeneIDi 57539.
KEGGi hsa:57539.
UCSCi uc002rdi.3. human. [Q9P2L0-1 ]
uc002rdj.3. human. [Q9P2L0-2 ]

Organism-specific databases

CTDi 57539.
GeneCardsi GC02M020110.
GeneReviewsi WDR35.
HGNCi HGNC:29250. WDR35.
HPAi HPA044147.
MIMi 613602. gene.
613610. phenotype.
614091. phenotype.
neXtProti NX_Q9P2L0.
Orphaneti 1515. Cranioectodermal dysplasia.
93271. Short rib-polydactyly syndrome, Verma-Naumoff type.
PharmGKBi PA134928987.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263340.
GeneTreei ENSGT00610000085970.
HOGENOMi HOG000255527.
HOVERGENi HBG079343.
InParanoidi Q9P2L0.
OMAi DENHPQE.
OrthoDBi EOG7QRQT6.
PhylomeDBi Q9P2L0.
TreeFami TF314076.

Enzyme and pathway databases

SignaLinki Q9P2L0.

Miscellaneous databases

GenomeRNAii 57539.
NextBioi 63968.
PROi Q9P2L0.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2L0.
CleanExi HS_WDR35.
ExpressionAtlasi Q9P2L0. baseline and differential.
Genevestigatori Q9P2L0.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR017233. WD_repeat_p35.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
PIRSFi PIRSF037536. WD_repeat_p35. 1 hit.
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-983.
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-878.
    Tissue: Testis.
  7. "SnapShot: Intraflagellar transport."
    Cole D.G., Snell W.J.
    Cell 137:784-784(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFT43.
  8. "Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis."
    Feng G.G., Li C., Huang L., Tsunekawa K., Sato Y., Fujiwara Y., Komatsu T., Honda T., Fan J.H., Goto H., Koide T., Hasegawa T., Ishikawa N.
    Biochem. Biophys. Res. Commun. 394:153-157(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  9. "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia."
    Mukhopadhyay S., Wen X., Chih B., Nelson C.D., Lane W.S., Scales S.J., Jackson P.K.
    Genes Dev. 24:2180-2193(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE IFT-A COMPLEX.
  10. Cited for: FUNCTION, VARIANT SRTD7 ARG-261.
  11. Cited for: VARIANTS CED2 GLY-626 AND THR-875.

Entry informationi

Entry nameiWDR35_HUMAN
AccessioniPrimary (citable) accession number: Q9P2L0
Secondary accession number(s): B3KVI5, Q4ZG01, Q8NE11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: October 29, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3