Q9P2L0 (WDR35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 35

Alternative name(s):
Intraflagellar transport protein 121 homolog

Gene names

Name:	WDR35
Synonyms:	IFT121, KIAA1336

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May promote CASP3 activation and TNF-stimulated apoptosis. Required for ciliogenesis. Ref.8 Ref.9
Subunit structure	Interacts with IFT43. Ref.7
Subcellular location	Cytoplasm › cytoskeleton › centrosome By similarity. Cytoplasm › cytoskeleton › cilium axoneme By similarity. Cytoplasm › cytoskeleton › cilium basal body By similarity.
Induction	By TNF. Ref.8
Involvement in disease	Defects in WDR35 are the cause of cranioectodermal dysplasia type 2 (CED2) [MIM:613610]. A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities included widely spaced, hypoplastic and fused teeth. Ref.10 Defects in WDR35 are the cause of short rib-polydactyly syndrome type 5 (SRPS5) [MIM:614091]. A lethal skeletal dysplasia characterized by markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including heart, intestines, genitalia, kidney, liver, and pancreas. Additional SRPS5 hallmarks are acromesomelic hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys. Note=WDR35 mutations cause short rib-polydactyly syndrome through impaired cilia formation. Primary fibroblasts from SRPS5 patients lacking WDR35 fail to produce cilia (Ref.9). Ref.9
Sequence similarities	Contains 5 WD repeats.
Sequence caution	The sequence BAA92574.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Ciliopathy Disease mutation Ectodermal dysplasia
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cilium assembly Inferred from mutant phenotype Ref.9. Source: UniProtKB
Cellular component	centrosome Inferred from sequence or structural similarity. Source: UniProtKB cilium axoneme Inferred from sequence or structural similarity. Source: UniProtKB microtubule basal body Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P2L0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P2L0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     399-409: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1181	1181	WD repeat-containing protein 35		PRO_0000051384
Regions
	Repeat	12 – 51	40	WD 1
	Repeat	69 – 108	40	WD 2
	Repeat	113 – 152	40	WD 3
	Repeat	154 – 193	40	WD 4
	Repeat	502 – 539	38	WD 5
Natural variations
	Alternative sequence	399 – 409	11	Missing in isoform 2.		VSP_009732
	Natural variant	18	1	Q → R. Corresponds to variant rs1060742 [ dbSNP | Ensembl ].		VAR_053428
	Natural variant	261	1	W → R in SRPS5. Ref.9		VAR_065955
	Natural variant	626	1	E → G in CED2. Ref.10		VAR_064581
	Natural variant	875	1	A → T in CED2. Ref.10		VAR_064582
	Natural variant	878	1	A → P. Corresponds to variant rs2293669 [ dbSNP | Ensembl ].		VAR_062102
	Natural variant	878	1	A → T. Ref.6 Corresponds to variant rs2293669 [ dbSNP | Ensembl ].		VAR_062103
	Natural variant	983	1	E → G. Ref.3 Corresponds to variant rs1191778 [ dbSNP | Ensembl ].		VAR_053429
Experimental info
	Sequence conflict	1078	1	S → G in AAH36659. Ref.6
	Sequence conflict	1171	1	S → G in BAG53797. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 29, 2004. Version 3. Checksum: 1C0FFAAD0287F129	FASTA	1,181	133,547
	10 20 30 40 50 60 MFFYLSKKIS IPNNVKLQCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN 70 80 90 100 110 120 LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML YKGSWIEEMI NNRNKSVVRS 130 140 150 160 170 180 MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLS HVTWSADSKV LLFGMANGEI 190 200 210 220 230 240 HIYDNQGNFM IKMKLSCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR 250 260 270 280 290 300 HENDQNPVLI DTGMYVVGIQ WNHMGSVLAV AGFQKAAMQD KDVNIVQFYT PFGEHLGTLK 310 320 330 340 350 360 VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR PDRPEYCVVF 370 380 390 400 410 420 WDTKNNEKYV KYVKGLISIT TCGDFCILAT KADENHPQEE NEMETFGATF VLVLCNSIGT 430 440 450 460 470 480 PLDPKYIDIV PLFVAMTKTH VIAASKEAFY TWQYRVAKKL TALEINQITR SRKEGRERIY 490 500 510 520 530 540 HVDDTPSGSM DGVLDYSKTI QGTRDPICAI TASDKILIVG RESGTIQRYS LPNVGLIQKY 550 560 570 580 590 600 SLNCRAYQLS LNCNSSRLAI IDISGVLTFF DLDARVTDST GQQVVGELLK LERRDVWDMK 610 620 630 640 650 660 WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE ILKDPEHPNK 670 680 690 700 710 720 DYLINFEIRS LRDSRALIEK VGIKDASQFI EDNPHPRLWR LLAEAALQKL DLYTAEQAFV 730 740 750 760 770 780 RCKDYQGIKF VKRLGKLLSE SMKQAEVVGY FGRFEEAERT YLEMDRRDLA IGLRLKLGDW 790 800 810 820 830 840 FRVLQLLKTG SGDADDSLLE QANNAIGDYF ADRQKWLNAV QYYVQGRNQE RLAECYYMLE 850 860 870 880 890 900 DYEGLENLAI SLPENHKLLP EIAQMFVRVG MCEQAVTAFL KCSQPKAAVD TCVHLNQWNK 910 920 930 940 950 960 AVELAKNHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA NYFFDAAKLM FKIADEEAKK 970 980 990 1000 1010 1020 GSKPLRVKKL YVLSALLIEQ YHEQMKNAQR GKVKGKSSEA TSALAGLLEE EVLSTTDRFT 1030 1040 1050 1060 1070 1080 DNAWRGAEAY HFFILAQRQL YEGCVDTALK TALHLKDYED IIPPVEIYSL LALCACASRA 1090 1100 1110 1120 1130 1140 FGTCSKAFIK LKSLETLSSE QKQQYEDLAL EIFTKHTSKD NRKPELDSLM EGGEGKLPTC 1150 1160 1170 1180 VATGSPITEY QFWMCSVCKH GVLAQEISHY SFCPLCHSPV G
	Isoform 2 [UniParc]. Checksum: 24A1BABB959DF302	FASTA	1,170	132,308
	10 20 30 40 50 60 MFFYLSKKIS IPNNVKLQCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN 70 80 90 100 110 120 LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML YKGSWIEEMI NNRNKSVVRS 130 140 150 160 170 180 MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLS HVTWSADSKV LLFGMANGEI 190 200 210 220 230 240 HIYDNQGNFM IKMKLSCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR 250 260 270 280 290 300 HENDQNPVLI DTGMYVVGIQ WNHMGSVLAV AGFQKAAMQD KDVNIVQFYT PFGEHLGTLK 310 320 330 340 350 360 VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR PDRPEYCVVF 370 380 390 400 410 420 WDTKNNEKYV KYVKGLISIT TCGDFCILAT KADENHPQFV LVLCNSIGTP LDPKYIDIVP 430 440 450 460 470 480 LFVAMTKTHV IAASKEAFYT WQYRVAKKLT ALEINQITRS RKEGRERIYH VDDTPSGSMD 490 500 510 520 530 540 GVLDYSKTIQ GTRDPICAIT ASDKILIVGR ESGTIQRYSL PNVGLIQKYS LNCRAYQLSL 550 560 570 580 590 600 NCNSSRLAII DISGVLTFFD LDARVTDSTG QQVVGELLKL ERRDVWDMKW AKDNPDLFAM 610 620 630 640 650 660 MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI LKDPEHPNKD YLINFEIRSL 670 680 690 700 710 720 RDSRALIEKV GIKDASQFIE DNPHPRLWRL LAEAALQKLD LYTAEQAFVR CKDYQGIKFV 730 740 750 760 770 780 KRLGKLLSES MKQAEVVGYF GRFEEAERTY LEMDRRDLAI GLRLKLGDWF RVLQLLKTGS 790 800 810 820 830 840 GDADDSLLEQ ANNAIGDYFA DRQKWLNAVQ YYVQGRNQER LAECYYMLED YEGLENLAIS 850 860 870 880 890 900 LPENHKLLPE IAQMFVRVGM CEQAVTAFLK CSQPKAAVDT CVHLNQWNKA VELAKNHSMK 910 920 930 940 950 960 EIGSLLARYA SHLLEKNKTL DAIELYRKAN YFFDAAKLMF KIADEEAKKG SKPLRVKKLY 970 980 990 1000 1010 1020 VLSALLIEQY HEQMKNAQRG KVKGKSSEAT SALAGLLEEE VLSTTDRFTD NAWRGAEAYH 1030 1040 1050 1060 1070 1080 FFILAQRQLY EGCVDTALKT ALHLKDYEDI IPPVEIYSLL ALCACASRAF GTCSKAFIKL 1090 1100 1110 1120 1130 1140 KSLETLSSEQ KQQYEDLALE IFTKHTSKDN RKPELDSLME GGEGKLPTCV ATGSPITEYQ 1150 1160 1170 FWMCSVCKHG VLAQEISHYS FCPLCHSPVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-983. Tissue: Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-878. Tissue: Testis.
[7]	"SnapShot: Intraflagellar transport." Cole D.G., Snell W.J. Cell 137:784-784(2009) [PubMed: 19450523] [Abstract] Cited for: INTERACTION WITH IFT43.
[8]	"Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis." Feng G.G., Li C., Huang L., Tsunekawa K., Sato Y., Fujiwara Y., Komatsu T., Honda T., Fan J.H., Goto H., Koide T., Hasegawa T., Ishikawa N. Biochem. Biophys. Res. Commun. 394:153-157(2010) [PubMed: 20193664] [Abstract] Cited for: FUNCTION, INDUCTION.
[9]	"Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis." Mill P., Lockhart P.J., Fitzpatrick E., Mountford H.S., Hall E.A., Reijns M.A., Keighren M., Bahlo M., Bromhead C.J., Budd P., Aftimos S., Delatycki M.B., Savarirayan R., Jackson I.J., Amor D.J. Am. J. Hum. Genet. 88:508-515(2011) [PubMed: 21473986] [Abstract] Cited for: FUNCTION, VARIANT SRPS5 ARG-261.
[10]	"Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome." Gilissen C., Arts H.H., Hoischen A., Spruijt L., Mans D.A., Arts P., van Lier B., Steehouwer M., van Reeuwijk J., Kant S.G., Roepman R., Knoers N.V., Veltman J.A., Brunner H.G. Am. J. Hum. Genet. 87:418-423(2010) [PubMed: 20817137] [Abstract] Cited for: VARIANTS CED2 GLY-626 AND THR-875.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037757 mRNA. Translation: BAA92574.2. Different initiation. AK122917 mRNA. Translation: BAG53797.1. AC079145 Genomic DNA. Translation: AAX88936.1. CH471053 Genomic DNA. Translation: EAX00841.1. BC036659 mRNA. Translation: AAH36659.1.
IPI	IPI00165984. IPI00172480.
RefSeq	NP_001006658.1. NM_001006657.1. NP_065830.2. NM_020779.3.
UniGene	Hs.205427.
3D structure databases
ProteinModelPortal	Q9P2L0.
SMR	Q9P2L0. Positions 14-144, 509-577.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P2L0. 1 interaction.
STRING	Q9P2L0.
PTM databases
PhosphoSite	Q9P2L0.
Polymorphism databases
DMDM	48474987.
Proteomic databases
PRIDE	Q9P2L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345530; ENSP00000314444; ENSG00000118965.
GeneID	57539.
KEGG	hsa:57539.
UCSC	uc002rdi.1. human. uc002rdj.1. human.
Organism-specific databases
CTD	57539.
GeneCards	GC02M020110.
H-InvDB	HIX0200248.
HGNC	HGNC:29250. WDR35.
HPA	HPA044147.
MIM	613602. gene. 613610. phenotype. 614091. phenotype.
neXtProt	NX_Q9P2L0.
Orphanet	1515. Sensenbrenner syndrome. 93271. Short rib-polydactyly syndrome, Verma-Naumoff type.
PharmGKB	PA134928987.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084110.
HOGENOM	HBG358323.
HOVERGEN	HBG079343.
InParanoid	Q9P2L0.
OMA	SRAFGTC.
OrthoDB	EOG43FGW3.
PhylomeDB	Q9P2L0.
Gene expression databases
ArrayExpress	Q9P2L0.
Bgee	Q9P2L0.
CleanEx	HS_WDR35.
Genevestigator	Q9P2L0.
GermOnline	ENSG00000118965. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. IPR017233. WD_repeat_p35. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
PIRSF	PIRSF037536. WD_repeat_p35. 1 hit.
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	63968.
SOURCE	Search...

Entry information

Entry name

WDR35_HUMAN

Accession

Primary (citable) accession number: Q9P2L0
Secondary accession number(s): B3KVI5, Q4ZG01, Q8NE11

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	March 29, 2004
Last modified:	January 25, 2012
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.