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Q9P2K5

- MYEF2_HUMAN

UniProt

Q9P2K5 - MYEF2_HUMAN

Protein

Myelin expression factor 2

Gene

MYEF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. myotube differentiation Source: UniProtKB
    2. neuron differentiation Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin expression factor 2
    Short name:
    MEF-2
    Short name:
    MyEF-2
    Alternative name(s):
    MST156
    Gene namesi
    Name:MYEF2
    Synonyms:KIAA1341
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17940. MYEF2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134877084.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Myelin expression factor 2PRO_0000081655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei431 – 4311Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9P2K5.
    PaxDbiQ9P2K5.
    PRIDEiQ9P2K5.

    PTM databases

    PhosphoSiteiQ9P2K5.

    Expressioni

    Gene expression databases

    BgeeiQ9P2K5.
    CleanExiHS_MYEF2.
    GenevestigatoriQ9P2K5.

    Organism-specific databases

    HPAiHPA004883.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi119124. 14 interactions.
    STRINGi9606.ENSP00000316950.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2K5.
    SMRiQ9P2K5. Positions 102-176, 226-317, 519-600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 17879RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini233 – 31078RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 59977RRM 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi330 – 522193Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOVERGENiHBG054880.
    InParanoidiQ9P2K5.
    OMAiHEEYRSH.
    OrthoDBiEOG7ZSHSK.
    PhylomeDBiQ9P2K5.
    TreeFamiTF313406.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2K5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN    50
    GVKMENDESA KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN 100
    RVFISNIPYD MKWQAIKDLM REKVGEVTYV ELFKDAEGKS RGCGVVEFKD 150
    EEFVKKALET MNKYDLSGRP LNIKEDPDGE NARRALQRTG GSFPGGHVPD 200
    MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL DFKVGWKKLK 250
    EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD 300
    RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL 350
    NIGGVMGNLG PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR 400
    MGELYRGAMT SSMERDFGRG DIGINQGFGD SFGRLGSAMI GGFAGRIGSS 450
    NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM SSSFDRMGPG IGAILERSID 500
    MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK EKFSQCGHVM 550
    FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA 600
    Length:600
    Mass (Da):64,122
    Last modified:May 18, 2010 - v3
    Checksum:iC965138A61B62DC3
    GO
    Isoform 2 (identifier: Q9P2K5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         437-460: Missing.

    Show »
    Length:576
    Mass (Da):61,929
    Checksum:i5A3A9D34B084ABC7
    GO
    Isoform 3 (identifier: Q9P2K5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-388: Missing.
         437-460: Missing.

    Show »
    Length:188
    Mass (Da):20,266
    Checksum:i40BBBBDDA769E353
    GO
    Isoform 4 (identifier: Q9P2K5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-128: VGEVT → GLWCG
         129-600: Missing.

    Show »
    Length:128
    Mass (Da):14,125
    Checksum:i7322C827DC690A50
    GO

    Sequence cautioni

    The sequence AAQ13703.1 differs from that shown. Reason: Frameshift at position 344.
    The sequence AAH14533.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA92579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti186 – 1861L → S in BAB14421. (PubMed:14702039)Curated
    Sequence conflicti364 – 3641M → G in AAH14533. (PubMed:15489334)Curated
    Sequence conflicti578 – 5781A → T in AAQ13703. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911A → T.4 Publications
    Corresponds to variant rs8023906 [ dbSNP | Ensembl ].
    VAR_052209
    Natural varianti426 – 4261Q → R.4 Publications
    Corresponds to variant rs2470103 [ dbSNP | Ensembl ].
    VAR_061829
    Natural varianti465 – 4651S → G.2 Publications
    Corresponds to variant rs36075490 [ dbSNP | Ensembl ].
    VAR_052210

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 388388Missing in isoform 3. 1 PublicationVSP_013451Add
    BLAST
    Alternative sequencei124 – 1285VGEVT → GLWCG in isoform 4. 1 PublicationVSP_013452
    Alternative sequencei129 – 600472Missing in isoform 4. 1 PublicationVSP_013453Add
    BLAST
    Alternative sequencei437 – 46024Missing in isoform 2 and isoform 3. 3 PublicationsVSP_013454Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037762 mRNA. Translation: BAA92579.1. Different initiation.
    AK002075 mRNA. Translation: BAA92070.1.
    AK023133 mRNA. Translation: BAB14421.1.
    AC066612 Genomic DNA. No translation available.
    AC090526 Genomic DNA. No translation available.
    BC014533 mRNA. Translation: AAH14533.3. Different initiation.
    BC068523 mRNA. Translation: AAH68523.1.
    BC152420 mRNA. Translation: AAI52421.1.
    BC152451 mRNA. Translation: AAI52452.1.
    AF190159 mRNA. Translation: AAQ13703.1. Frameshift.
    CCDSiCCDS32230.1. [Q9P2K5-1]
    RefSeqiNP_057216.2. NM_016132.3.
    UniGeneiHs.6638.

    Genome annotation databases

    EnsembliENST00000267836; ENSP00000267836; ENSG00000104177. [Q9P2K5-2]
    ENST00000324324; ENSP00000316950; ENSG00000104177. [Q9P2K5-1]
    ENST00000561151; ENSP00000452913; ENSG00000104177. [Q9P2K5-4]
    ENST00000561351; ENSP00000453125; ENSG00000104177. [Q9P2K5-4]
    GeneIDi50804.
    KEGGihsa:50804.
    UCSCiuc001zwg.4. human. [Q9P2K5-3]
    uc001zwi.4. human. [Q9P2K5-1]
    uc001zwj.4. human. [Q9P2K5-2]

    Polymorphism databases

    DMDMi296439294.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037762 mRNA. Translation: BAA92579.1 . Different initiation.
    AK002075 mRNA. Translation: BAA92070.1 .
    AK023133 mRNA. Translation: BAB14421.1 .
    AC066612 Genomic DNA. No translation available.
    AC090526 Genomic DNA. No translation available.
    BC014533 mRNA. Translation: AAH14533.3 . Different initiation.
    BC068523 mRNA. Translation: AAH68523.1 .
    BC152420 mRNA. Translation: AAI52421.1 .
    BC152451 mRNA. Translation: AAI52452.1 .
    AF190159 mRNA. Translation: AAQ13703.1 . Frameshift.
    CCDSi CCDS32230.1. [Q9P2K5-1 ]
    RefSeqi NP_057216.2. NM_016132.3.
    UniGenei Hs.6638.

    3D structure databases

    ProteinModelPortali Q9P2K5.
    SMRi Q9P2K5. Positions 102-176, 226-317, 519-600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119124. 14 interactions.
    STRINGi 9606.ENSP00000316950.

    PTM databases

    PhosphoSitei Q9P2K5.

    Polymorphism databases

    DMDMi 296439294.

    Proteomic databases

    MaxQBi Q9P2K5.
    PaxDbi Q9P2K5.
    PRIDEi Q9P2K5.

    Protocols and materials databases

    DNASUi 50804.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267836 ; ENSP00000267836 ; ENSG00000104177 . [Q9P2K5-2 ]
    ENST00000324324 ; ENSP00000316950 ; ENSG00000104177 . [Q9P2K5-1 ]
    ENST00000561151 ; ENSP00000452913 ; ENSG00000104177 . [Q9P2K5-4 ]
    ENST00000561351 ; ENSP00000453125 ; ENSG00000104177 . [Q9P2K5-4 ]
    GeneIDi 50804.
    KEGGi hsa:50804.
    UCSCi uc001zwg.4. human. [Q9P2K5-3 ]
    uc001zwi.4. human. [Q9P2K5-1 ]
    uc001zwj.4. human. [Q9P2K5-2 ]

    Organism-specific databases

    CTDi 50804.
    GeneCardsi GC15M048434.
    HGNCi HGNC:17940. MYEF2.
    HPAi HPA004883.
    neXtProti NX_Q9P2K5.
    PharmGKBi PA134877084.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOVERGENi HBG054880.
    InParanoidi Q9P2K5.
    OMAi HEEYRSH.
    OrthoDBi EOG7ZSHSK.
    PhylomeDBi Q9P2K5.
    TreeFami TF313406.

    Miscellaneous databases

    GenomeRNAii 50804.
    NextBioi 53234.
    PROi Q9P2K5.

    Gene expression databases

    Bgeei Q9P2K5.
    CleanExi HS_MYEF2.
    Genevestigatori Q9P2K5.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-91 AND ARG-426.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS VARIANTS THR-91; ARG-426 AND GLY-465.
      Tissue: Placenta and Teratocarcinoma.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-600 (ISOFORM 2), VARIANTS THR-91 AND ARG-426.
      Tissue: Bone marrow and Testis.
    5. "Homo sapiens normal aorta mRNA MST156, complete cds."
      Hui R.T., Sheng H., Qin B.M., Liu B., Zhao B., Liu Y.Q., Zhang Q., Song L., Liu B.H., Lu H., Wang X.Y.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-582 (ISOFORM 2), VARIANTS THR-91; ARG-426 AND GLY-465.
      Tissue: Aorta.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYEF2_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2K5
    Secondary accession number(s): A7MCZ9
    , C9J921, C9K0J4, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3