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Q9P2K5 (MYEF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin expression factor 2

Short name=MEF-2
Short name=MyEF-2
Alternative name(s):
MST156
Gene names
Name:MYEF2
Synonyms:KIAA1341
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus.

Sequence similarities

Contains 3 RRM (RNA recognition motif) domains.

Sequence caution

The sequence AAH14533.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAQ13703.1 differs from that shown. Reason: Frameshift at position 344.

The sequence BAA92579.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandDNA-binding
RNA-binding
   Molecular functionRepressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmyotube differentiation

Inferred from expression pattern PubMed 8455629. Source: UniProtKB

neuron differentiation

Inferred from expression pattern PubMed 8455629. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay PubMed 8455629. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P2K5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P2K5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     437-460: Missing.
Isoform 3 (identifier: Q9P2K5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.
     437-460: Missing.
Isoform 4 (identifier: Q9P2K5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     124-128: VGEVT → GLWCG
     129-600: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Myelin expression factor 2
PRO_0000081655

Regions

Domain100 – 17879RRM 1
Domain233 – 31078RRM 2
Domain523 – 59977RRM 3
Compositional bias330 – 522193Gly-rich

Amino acid modifications

Modified residue171Phosphoserine Ref.7
Modified residue4311Phosphoserine Ref.7

Natural variations

Alternative sequence1 – 388388Missing in isoform 3.
VSP_013451
Alternative sequence124 – 1285VGEVT → GLWCG in isoform 4.
VSP_013452
Alternative sequence129 – 600472Missing in isoform 4.
VSP_013453
Alternative sequence437 – 46024Missing in isoform 2 and isoform 3.
VSP_013454
Natural variant911A → T. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs8023906 [ dbSNP | Ensembl ].
VAR_052209
Natural variant4261Q → R. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs2470103 [ dbSNP | Ensembl ].
VAR_061829
Natural variant4651S → G. Ref.2 Ref.5
Corresponds to variant rs36075490 [ dbSNP | Ensembl ].
VAR_052210

Experimental info

Sequence conflict1861L → S in BAB14421. Ref.2
Sequence conflict3641M → G in AAH14533. Ref.4
Sequence conflict5781A → T in AAQ13703. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: C965138A61B62DC3

FASTA60064,122
        10         20         30         40         50         60 
MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN GVKMENDESA 

        70         80         90        100        110        120 
KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN RVFISNIPYD MKWQAIKDLM 

       130        140        150        160        170        180 
REKVGEVTYV ELFKDAEGKS RGCGVVEFKD EEFVKKALET MNKYDLSGRP LNIKEDPDGE 

       190        200        210        220        230        240 
NARRALQRTG GSFPGGHVPD MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL 

       250        260        270        280        290        300 
DFKVGWKKLK EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD 

       310        320        330        340        350        360 
RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL NIGGVMGNLG 

       370        380        390        400        410        420 
PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR MGELYRGAMT SSMERDFGRG 

       430        440        450        460        470        480 
DIGINQGFGD SFGRLGSAMI GGFAGRIGSS NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM 

       490        500        510        520        530        540 
SSSFDRMGPG IGAILERSID MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK 

       550        560        570        580        590        600 
EKFSQCGHVM FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA 

« Hide

Isoform 2 [UniParc].

Checksum: 5A3A9D34B084ABC7
Show »

FASTA57661,929
Isoform 3 [UniParc].

Checksum: 40BBBBDDA769E353
Show »

FASTA18820,266
Isoform 4 [UniParc].

Checksum: 7322C827DC690A50
Show »

FASTA12814,125

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-91 AND ARG-426.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS VARIANTS THR-91; ARG-426 AND GLY-465.
Tissue: Placenta and Teratocarcinoma.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-600 (ISOFORM 2), VARIANTS THR-91 AND ARG-426.
Tissue: Bone marrow and Testis.
[5]"Homo sapiens normal aorta mRNA MST156, complete cds."
Hui R.T., Sheng H., Qin B.M., Liu B., Zhao B., Liu Y.Q., Zhang Q., Song L., Liu B.H., Lu H., Wang X.Y.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-582 (ISOFORM 2), VARIANTS THR-91; ARG-426 AND GLY-465.
Tissue: Aorta.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037762 mRNA. Translation: BAA92579.1. Different initiation.
AK002075 mRNA. Translation: BAA92070.1.
AK023133 mRNA. Translation: BAB14421.1.
AC066612 Genomic DNA. No translation available.
AC090526 Genomic DNA. No translation available.
BC014533 mRNA. Translation: AAH14533.3. Different initiation.
BC068523 mRNA. Translation: AAH68523.1.
BC152420 mRNA. Translation: AAI52421.1.
BC152451 mRNA. Translation: AAI52452.1.
AF190159 mRNA. Translation: AAQ13703.1. Frameshift.
CCDSCCDS32230.1. [Q9P2K5-1]
RefSeqNP_057216.2. NM_016132.3.
UniGeneHs.6638.

3D structure databases

ProteinModelPortalQ9P2K5.
SMRQ9P2K5. Positions 102-176, 226-317, 519-600.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119124. 14 interactions.
STRING9606.ENSP00000316950.

PTM databases

PhosphoSiteQ9P2K5.

Polymorphism databases

DMDM296439294.

Proteomic databases

MaxQBQ9P2K5.
PaxDbQ9P2K5.
PRIDEQ9P2K5.

Protocols and materials databases

DNASU50804.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267836; ENSP00000267836; ENSG00000104177. [Q9P2K5-2]
ENST00000324324; ENSP00000316950; ENSG00000104177. [Q9P2K5-1]
ENST00000561151; ENSP00000452913; ENSG00000104177. [Q9P2K5-4]
ENST00000561351; ENSP00000453125; ENSG00000104177. [Q9P2K5-4]
GeneID50804.
KEGGhsa:50804.
UCSCuc001zwg.4. human. [Q9P2K5-3]
uc001zwi.4. human. [Q9P2K5-1]
uc001zwj.4. human. [Q9P2K5-2]

Organism-specific databases

CTD50804.
GeneCardsGC15M048434.
HGNCHGNC:17940. MYEF2.
HPAHPA004883.
neXtProtNX_Q9P2K5.
PharmGKBPA134877084.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0724.
HOVERGENHBG054880.
InParanoidQ9P2K5.
OMAHEEYRSH.
OrthoDBEOG7ZSHSK.
PhylomeDBQ9P2K5.
TreeFamTF313406.

Gene expression databases

BgeeQ9P2K5.
CleanExHS_MYEF2.
GenevestigatorQ9P2K5.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTSM00360. RRM. 3 hits.
[Graphical view]
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi50804.
NextBio53234.
PROQ9P2K5.

Entry information

Entry nameMYEF2_HUMAN
AccessionPrimary (citable) accession number: Q9P2K5
Secondary accession number(s): A7MCZ9 expand/collapse secondary AC list , C9J921, C9K0J4, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM