Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin expression factor 2

Gene

MYEF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • myotube differentiation Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin expression factor 2
Short name:
MEF-2
Short name:
MyEF-2
Alternative name(s):
MST156
Gene namesi
Name:MYEF2
Synonyms:KIAA1341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17940. MYEF2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi50804.
OpenTargetsiENSG00000104177.
PharmGKBiPA134877084.

Polymorphism and mutation databases

BioMutaiMYEF2.
DMDMi296439294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816551 – 600Myelin expression factor 2Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei406Omega-N-methylarginineBy similarity1
Modified residuei431PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9P2K5.
MaxQBiQ9P2K5.
PaxDbiQ9P2K5.
PeptideAtlasiQ9P2K5.
PRIDEiQ9P2K5.

PTM databases

iPTMnetiQ9P2K5.
PhosphoSitePlusiQ9P2K5.

Expressioni

Gene expression databases

BgeeiENSG00000104177.
CleanExiHS_MYEF2.
ExpressionAtlasiQ9P2K5. baseline and differential.

Organism-specific databases

HPAiHPA004883.

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
COG8Q96MW53EBI-10318831,EBI-720875
GOLGA2Q083793EBI-10318831,EBI-618309
TEX11Q8IYF33EBI-10318831,EBI-742397
TRAF1Q130773EBI-10318831,EBI-359224

Protein-protein interaction databases

BioGridi119124. 47 interactors.
IntActiQ9P2K5. 27 interactors.
STRINGi9606.ENSP00000316950.

Structurei

3D structure databases

ProteinModelPortaliQ9P2K5.
SMRiQ9P2K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 178RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini233 – 310RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini523 – 599RRM 3PROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi330 – 522Gly-richAdd BLAST193

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IKNU. Eukaryota.
ENOG4110PAX. LUCA.
GeneTreeiENSGT00410000025635.
HOVERGENiHBG054880.
InParanoidiQ9P2K5.
PhylomeDBiQ9P2K5.
TreeFamiTF313406.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN
60 70 80 90 100
GVKMENDESA KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN
110 120 130 140 150
RVFISNIPYD MKWQAIKDLM REKVGEVTYV ELFKDAEGKS RGCGVVEFKD
160 170 180 190 200
EEFVKKALET MNKYDLSGRP LNIKEDPDGE NARRALQRTG GSFPGGHVPD
210 220 230 240 250
MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL DFKVGWKKLK
260 270 280 290 300
EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD
310 320 330 340 350
RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL
360 370 380 390 400
NIGGVMGNLG PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR
410 420 430 440 450
MGELYRGAMT SSMERDFGRG DIGINQGFGD SFGRLGSAMI GGFAGRIGSS
460 470 480 490 500
NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM SSSFDRMGPG IGAILERSID
510 520 530 540 550
MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK EKFSQCGHVM
560 570 580 590 600
FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA
Length:600
Mass (Da):64,122
Last modified:May 18, 2010 - v3
Checksum:iC965138A61B62DC3
GO
Isoform 2 (identifier: Q9P2K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-460: Missing.

Show »
Length:576
Mass (Da):61,929
Checksum:i5A3A9D34B084ABC7
GO
Isoform 3 (identifier: Q9P2K5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.
     437-460: Missing.

Show »
Length:188
Mass (Da):20,266
Checksum:i40BBBBDDA769E353
GO
Isoform 4 (identifier: Q9P2K5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-128: VGEVT → GLWCG
     129-600: Missing.

Show »
Length:128
Mass (Da):14,125
Checksum:i7322C827DC690A50
GO

Sequence cautioni

The sequence AAH14533 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ13703 differs from that shown. Reason: Frameshift at position 344.Curated
The sequence BAA92579 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186L → S in BAB14421 (PubMed:14702039).Curated1
Sequence conflicti364M → G in AAH14533 (PubMed:15489334).Curated1
Sequence conflicti578A → T in AAQ13703 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05220991A → T.4 PublicationsCorresponds to variant rs8023906dbSNPEnsembl.1
Natural variantiVAR_061829426Q → R.4 PublicationsCorresponds to variant rs2470103dbSNPEnsembl.1
Natural variantiVAR_052210465S → G.2 PublicationsCorresponds to variant rs36075490dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0134511 – 388Missing in isoform 3. 1 PublicationAdd BLAST388
Alternative sequenceiVSP_013452124 – 128VGEVT → GLWCG in isoform 4. 1 Publication5
Alternative sequenceiVSP_013453129 – 600Missing in isoform 4. 1 PublicationAdd BLAST472
Alternative sequenceiVSP_013454437 – 460Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037762 mRNA. Translation: BAA92579.1. Different initiation.
AK002075 mRNA. Translation: BAA92070.1.
AK023133 mRNA. Translation: BAB14421.1.
AC066612 Genomic DNA. No translation available.
AC090526 Genomic DNA. No translation available.
BC014533 mRNA. Translation: AAH14533.3. Different initiation.
BC068523 mRNA. Translation: AAH68523.1.
BC152420 mRNA. Translation: AAI52421.1.
BC152451 mRNA. Translation: AAI52452.1.
AF190159 mRNA. Translation: AAQ13703.1. Frameshift.
CCDSiCCDS32230.1. [Q9P2K5-1]
CCDS73722.1. [Q9P2K5-2]
RefSeqiNP_001288139.1. NM_001301210.1.
NP_057216.2. NM_016132.4.
UniGeneiHs.653123.
Hs.6638.

Genome annotation databases

EnsembliENST00000561151; ENSP00000452913; ENSG00000104177. [Q9P2K5-4]
ENST00000561351; ENSP00000453125; ENSG00000104177. [Q9P2K5-4]
GeneIDi50804.
KEGGihsa:50804.
UCSCiuc059iwz.1. human. [Q9P2K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037762 mRNA. Translation: BAA92579.1. Different initiation.
AK002075 mRNA. Translation: BAA92070.1.
AK023133 mRNA. Translation: BAB14421.1.
AC066612 Genomic DNA. No translation available.
AC090526 Genomic DNA. No translation available.
BC014533 mRNA. Translation: AAH14533.3. Different initiation.
BC068523 mRNA. Translation: AAH68523.1.
BC152420 mRNA. Translation: AAI52421.1.
BC152451 mRNA. Translation: AAI52452.1.
AF190159 mRNA. Translation: AAQ13703.1. Frameshift.
CCDSiCCDS32230.1. [Q9P2K5-1]
CCDS73722.1. [Q9P2K5-2]
RefSeqiNP_001288139.1. NM_001301210.1.
NP_057216.2. NM_016132.4.
UniGeneiHs.653123.
Hs.6638.

3D structure databases

ProteinModelPortaliQ9P2K5.
SMRiQ9P2K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119124. 47 interactors.
IntActiQ9P2K5. 27 interactors.
STRINGi9606.ENSP00000316950.

PTM databases

iPTMnetiQ9P2K5.
PhosphoSitePlusiQ9P2K5.

Polymorphism and mutation databases

BioMutaiMYEF2.
DMDMi296439294.

Proteomic databases

EPDiQ9P2K5.
MaxQBiQ9P2K5.
PaxDbiQ9P2K5.
PeptideAtlasiQ9P2K5.
PRIDEiQ9P2K5.

Protocols and materials databases

DNASUi50804.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561151; ENSP00000452913; ENSG00000104177. [Q9P2K5-4]
ENST00000561351; ENSP00000453125; ENSG00000104177. [Q9P2K5-4]
GeneIDi50804.
KEGGihsa:50804.
UCSCiuc059iwz.1. human. [Q9P2K5-1]

Organism-specific databases

CTDi50804.
DisGeNETi50804.
GeneCardsiMYEF2.
HGNCiHGNC:17940. MYEF2.
HPAiHPA004883.
neXtProtiNX_Q9P2K5.
OpenTargetsiENSG00000104177.
PharmGKBiPA134877084.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKNU. Eukaryota.
ENOG4110PAX. LUCA.
GeneTreeiENSGT00410000025635.
HOVERGENiHBG054880.
InParanoidiQ9P2K5.
PhylomeDBiQ9P2K5.
TreeFamiTF313406.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104177-MONOMER.

Miscellaneous databases

GenomeRNAii50804.
PROiQ9P2K5.

Gene expression databases

BgeeiENSG00000104177.
CleanExiHS_MYEF2.
ExpressionAtlasiQ9P2K5. baseline and differential.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYEF2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2K5
Secondary accession number(s): A7MCZ9
, C9J921, C9K0J4, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.