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Protein

Thioredoxin domain-containing protein 16

Gene

TXNDC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 16
Gene namesi
Name:TXNDC16
Synonyms:KIAA1344
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19965. TXNDC16.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407488.

Polymorphism and mutation databases

BioMutaiTXNDC16.
DMDMi212276524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 825798Thioredoxin domain-containing protein 16PRO_0000257789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9P2K2.
MaxQBiQ9P2K2.
PaxDbiQ9P2K2.
PRIDEiQ9P2K2.

PTM databases

PhosphoSiteiQ9P2K2.

Expressioni

Gene expression databases

BgeeiQ9P2K2.
CleanExiHS_TXNDC16.
ExpressionAtlasiQ9P2K2. baseline and differential.
GenevisibleiQ9P2K2. HS.

Organism-specific databases

HPAiHPA002543.

Interactioni

Protein-protein interaction databases

BioGridi121602. 25 interactions.
IntActiQ9P2K2. 2 interactions.
STRINGi9606.ENSP00000281741.

Structurei

3D structure databases

ProteinModelPortaliQ9P2K2.
SMRiQ9P2K2. Positions 394-660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 495104ThioredoxinAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000006080.
HOGENOMiHOG000090200.
HOVERGENiHBG081835.
InParanoidiQ9P2K2.
OMAiRINCADW.
OrthoDBiEOG754HNZ.
PhylomeDBiQ9P2K2.
TreeFamiTF328825.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGFNVFRV GISFVIMCIF YMPTVNSLPE LSPQKYFSTL QPGKASLAYF
60 70 80 90 100
CQADSPRTSV FLEELNEAVR PLQDYGISVA KVNCVKEEIS RYCGKEKDLM
110 120 130 140 150
KAYLFKGNIL LREFPTDTLF DVNAIVAHVL FALLFSEVKY ITNLEDLQNI
160 170 180 190 200
ENALKGKANI IFSYVRAIGI PEHRAVMEAA FVYGTTYQFV LTTEIALLES
210 220 230 240 250
IGSEDVEYAH LYFFHCKLVL DLTQQCRRTL MEQPLTTLNI HLFIKTMKAP
260 270 280 290 300
LLTEVAEDPQ QVSTVHLQLG LPLVFIVSQQ ATYEADRRTA EWVAWRLLGK
310 320 330 340 350
AGVLLLLRDS LEVNIPQDAN VVFKRAEEGV PVEFLVLHDV DLIISHVENN
360 370 380 390 400
MHIEEIQEDE DNDMEGPDID VQDDEVAETV FRDRKRKLPL ELTVELTEET
410 420 430 440 450
FNATVMASDS IVLFYAGWQA VSMAFLQSYI DVAVKLKGTS TMLLTRINCA
460 470 480 490 500
DWSDVCTKQN VTEFPIIKMY KKGENPVSYA GMLGTEDLLK FIQLNRISYP
510 520 530 540 550
VNITSIQEAE EYLSGELYKD LILYSSVSVL GLFSPTMKTA KEDFSEAGNY
560 570 580 590 600
LKGYVITGIY SEEDVLLLST KYAASLPALL LARHTEGKIE SIPLASTHAQ
610 620 630 640 650
DIVQIITDAL LEMFPEITVE NLPSYFRLQK PLLILFSDGT VNPQYKKAIL
660 670 680 690 700
TLVKQKYLDS FTPCWLNLKN TPVGRGILRA YFDPLPPLPL LVLVNLHSGG
710 720 730 740 750
QVFAFPSDQA IIEENLVLWL KKLEAGLENH ITILPAQEWK PPLPAYDFLS
760 770 780 790 800
MIDAATSQRG TRKVPKCMKE TDVQENDKEQ HEDKSAVRKE PIETLRIKHW
810 820
NRSNWFKEAE KSFRRDKELG CSKVN
Length:825
Mass (Da):93,572
Last modified:November 4, 2008 - v4
Checksum:iB86F6DA47B5098D6
GO

Sequence cautioni

The sequence BAB14101.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801A → G in BAA92582 (PubMed:10718198).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361S → N.
Corresponds to variant rs28759013 [ dbSNP | Ensembl ].
VAR_061899
Natural varianti152 – 1521N → Y.
Corresponds to variant rs28593180 [ dbSNP | Ensembl ].
VAR_061900
Natural varianti486 – 4861E → K.2 Publications
Corresponds to variant rs7155490 [ dbSNP | Ensembl ].
VAR_028919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037765 mRNA. Translation: BAA92582.2.
CH471078 Genomic DNA. Translation: EAW65650.1.
BC137081 mRNA. Translation: AAI37082.1.
BC137082 mRNA. Translation: AAI37083.1.
BC142650 mRNA. Translation: AAI42651.1.
BC150205 mRNA. Translation: AAI50206.1.
BC152428 mRNA. Translation: AAI52429.1.
AK022563 mRNA. Translation: BAB14101.1. Different initiation.
CCDSiCCDS32083.1.
RefSeqiNP_001153519.1. NM_001160047.1.
NP_065835.2. NM_020784.2.
UniGeneiHs.532609.

Genome annotation databases

EnsembliENST00000281741; ENSP00000281741; ENSG00000087301.
GeneIDi57544.
KEGGihsa:57544.
UCSCiuc001wzs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037765 mRNA. Translation: BAA92582.2.
CH471078 Genomic DNA. Translation: EAW65650.1.
BC137081 mRNA. Translation: AAI37082.1.
BC137082 mRNA. Translation: AAI37083.1.
BC142650 mRNA. Translation: AAI42651.1.
BC150205 mRNA. Translation: AAI50206.1.
BC152428 mRNA. Translation: AAI52429.1.
AK022563 mRNA. Translation: BAB14101.1. Different initiation.
CCDSiCCDS32083.1.
RefSeqiNP_001153519.1. NM_001160047.1.
NP_065835.2. NM_020784.2.
UniGeneiHs.532609.

3D structure databases

ProteinModelPortaliQ9P2K2.
SMRiQ9P2K2. Positions 394-660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121602. 25 interactions.
IntActiQ9P2K2. 2 interactions.
STRINGi9606.ENSP00000281741.

PTM databases

PhosphoSiteiQ9P2K2.

Polymorphism and mutation databases

BioMutaiTXNDC16.
DMDMi212276524.

Proteomic databases

EPDiQ9P2K2.
MaxQBiQ9P2K2.
PaxDbiQ9P2K2.
PRIDEiQ9P2K2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281741; ENSP00000281741; ENSG00000087301.
GeneIDi57544.
KEGGihsa:57544.
UCSCiuc001wzs.4. human.

Organism-specific databases

CTDi57544.
GeneCardsiTXNDC16.
H-InvDBHIX0011658.
HGNCiHGNC:19965. TXNDC16.
HPAiHPA002543.
MIMi616179. gene.
neXtProtiNX_Q9P2K2.
PharmGKBiPA162407488.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00390000006080.
HOGENOMiHOG000090200.
HOVERGENiHBG081835.
InParanoidiQ9P2K2.
OMAiRINCADW.
OrthoDBiEOG754HNZ.
PhylomeDBiQ9P2K2.
TreeFamiTF328825.

Miscellaneous databases

ChiTaRSiTXNDC16. human.
GenomeRNAii57544.
NextBioi63992.
PROiQ9P2K2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2K2.
CleanExiHS_TXNDC16.
ExpressionAtlasiQ9P2K2. baseline and differential.
GenevisibleiQ9P2K2. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-486.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-486.
    Tissue: Lung and Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 456-825.

Entry informationi

Entry nameiTXD16_HUMAN
AccessioniPrimary (citable) accession number: Q9P2K2
Secondary accession number(s): A5PKW9
, A7E260, A7MD07, B9EH67, Q9H9W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 4, 2008
Last modified: April 13, 2016
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.