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Q9P2J9

- PDP2_HUMAN

UniProt

Q9P2J9 - PDP2_HUMAN

Protein

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Gene

PDP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.By similarity

    Catalytic activityi

    [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi141 – 1411Manganese 1By similarity
    Metal bindingi141 – 1411Manganese 2By similarity
    Metal bindingi142 – 1421Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi412 – 4121Manganese 2By similarity

    GO - Molecular functioni

    1. [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: UniProtKB-EC
    2. magnesium-dependent protein serine/threonine phosphatase activity Source: Ensembl
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. peptidyl-threonine dephosphorylation Source: Ensembl
    3. pyruvate metabolic process Source: Reactome
    4. regulation of acetyl-CoA biosynthetic process from pyruvate Source: Reactome
    5. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12528. Regulation of pyruvate dehydrogenase (PDH) complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (EC:3.1.3.43)
    Short name:
    PDP 2
    Alternative name(s):
    Pyruvate dehydrogenase phosphatase catalytic subunit 2
    Short name:
    PDPC 2
    Gene namesi
    Name:PDP2
    Synonyms:KIAA1348
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:30263. PDP2.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: Reactome

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165450460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6666MitochondrionSequence AnalysisAdd
    BLAST
    Chaini67 – 529463[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialPRO_0000025421Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2J9.
    PaxDbiQ9P2J9.
    PRIDEiQ9P2J9.

    PTM databases

    PhosphoSiteiQ9P2J9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P2J9.
    BgeeiQ9P2J9.
    GenevestigatoriQ9P2J9.

    Organism-specific databases

    HPAiHPA019950.

    Interactioni

    Subunit structurei

    Heterodimer of a catalytic subunit and a FAD protein of unknown function.By similarity

    Protein-protein interaction databases

    BioGridi121604. 2 interactions.
    STRINGi9606.ENSP00000309548.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2J9.
    SMRiQ9P2J9. Positions 79-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000220821.
    HOVERGENiHBG008162.
    InParanoidiQ9P2J9.
    KOiK01102.
    OMAiVHLHVAN.
    PhylomeDBiQ9P2J9.
    TreeFamiTF313505.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 3 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P2J9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTVSYWIL NSTRNSIATL QGGRRLYSRY VSNRNKLKWR LFSRVPPTLN    50
    SSPCGGFTLC KAYRHTSTEE DDFHLQLSPE QINEVLRAGE TTHKILDLES 100
    RVPNSVLRFE SNQLAANSPV EDRRGVASCL QTNGLMFGIF DGHGGHACAQ 150
    AVSERLFYYV AVSLMSHQTL EHMEGAMESM KPLLPILHWL KHPGDSIYKD 200
    VTSVHLDHLR VYWQELLDLH MEMGLSIEEA LMYSFQRLDS DISLEIQAPL 250
    EDEVTRNLSL QVAFSGATAC MAHVDGIHLH VANAGDCRAI LGVQEDNGMW 300
    SCLPLTRDHN AWNQAELSRL KREHPESEDR TIIMEDRLLG VLIPCRAFGD 350
    VQLKWSKELQ RSILERGFNT EALNIYQFTP PHYYTPPYLT AEPEVTYHRL 400
    RPQDKFLVLA SDGLWDMLSN EDVVRLVVGH LAEADWHKTD LAQRPANLGL 450
    MQSLLLQRKA SGLHEADQNA ATRLIRHAIG NNEYGEMEAE RLAAMLTLPE 500
    DLARMYRDDI TVTVVYFNSE SIGAYYKGG 529
    Length:529
    Mass (Da):59,978
    Last modified:January 24, 2001 - v2
    Checksum:i252CAEBCDAF61A5C
    GO

    Sequence cautioni

    The sequence BAA92586.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037769 mRNA. Translation: BAA92586.1. Different initiation.
    AK292539 mRNA. Translation: BAF85228.1.
    CH471092 Genomic DNA. Translation: EAW83048.1.
    BC028030 mRNA. Translation: AAH28030.1.
    CCDSiCCDS10822.1.
    RefSeqiNP_065837.1. NM_020786.2.
    XP_005256121.1. XM_005256064.2.
    XP_005256122.1. XM_005256065.2.
    XP_005256123.1. XM_005256066.2.
    XP_005256124.1. XM_005256067.2.
    XP_005256125.1. XM_005256068.2.
    UniGeneiHs.632214.

    Genome annotation databases

    EnsembliENST00000311765; ENSP00000309548; ENSG00000172840.
    GeneIDi57546.
    KEGGihsa:57546.
    UCSCiuc002eqk.2. human.

    Polymorphism databases

    DMDMi12585321.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037769 mRNA. Translation: BAA92586.1 . Different initiation.
    AK292539 mRNA. Translation: BAF85228.1 .
    CH471092 Genomic DNA. Translation: EAW83048.1 .
    BC028030 mRNA. Translation: AAH28030.1 .
    CCDSi CCDS10822.1.
    RefSeqi NP_065837.1. NM_020786.2.
    XP_005256121.1. XM_005256064.2.
    XP_005256122.1. XM_005256065.2.
    XP_005256123.1. XM_005256066.2.
    XP_005256124.1. XM_005256067.2.
    XP_005256125.1. XM_005256068.2.
    UniGenei Hs.632214.

    3D structure databases

    ProteinModelPortali Q9P2J9.
    SMRi Q9P2J9. Positions 79-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121604. 2 interactions.
    STRINGi 9606.ENSP00000309548.

    PTM databases

    PhosphoSitei Q9P2J9.

    Polymorphism databases

    DMDMi 12585321.

    Proteomic databases

    MaxQBi Q9P2J9.
    PaxDbi Q9P2J9.
    PRIDEi Q9P2J9.

    Protocols and materials databases

    DNASUi 57546.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311765 ; ENSP00000309548 ; ENSG00000172840 .
    GeneIDi 57546.
    KEGGi hsa:57546.
    UCSCi uc002eqk.2. human.

    Organism-specific databases

    CTDi 57546.
    GeneCardsi GC16P066914.
    HGNCi HGNC:30263. PDP2.
    HPAi HPA019950.
    MIMi 615499. gene.
    neXtProti NX_Q9P2J9.
    PharmGKBi PA165450460.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000220821.
    HOVERGENi HBG008162.
    InParanoidi Q9P2J9.
    KOi K01102.
    OMAi VHLHVAN.
    PhylomeDBi Q9P2J9.
    TreeFami TF313505.

    Enzyme and pathway databases

    Reactomei REACT_12528. Regulation of pyruvate dehydrogenase (PDH) complex.

    Miscellaneous databases

    GenomeRNAii 57546.
    NextBioi 64003.
    PROi Q9P2J9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2J9.
    Bgeei Q9P2J9.
    Genevestigatori Q9P2J9.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 3 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPDP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2J9
    Secondary accession number(s): A8K924
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3