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Q9P2J9

- PDP2_HUMAN

UniProt

Q9P2J9 - PDP2_HUMAN

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Protein

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Gene

PDP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.By similarity

Catalytic activityi

[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Manganese 1By similarity
Metal bindingi141 – 1411Manganese 2By similarity
Metal bindingi142 – 1421Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi412 – 4121Manganese 2By similarity

GO - Molecular functioni

  1. [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: UniProtKB-EC
  2. magnesium-dependent protein serine/threonine phosphatase activity Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. peptidyl-threonine dephosphorylation Source: Ensembl
  3. pyruvate metabolic process Source: Reactome
  4. regulation of acetyl-CoA biosynthetic process from pyruvate Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12528. Regulation of pyruvate dehydrogenase (PDH) complex.

Names & Taxonomyi

Protein namesi
Recommended name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (EC:3.1.3.43)
Short name:
PDP 2
Alternative name(s):
Pyruvate dehydrogenase phosphatase catalytic subunit 2
Short name:
PDPC 2
Gene namesi
Name:PDP2
Synonyms:KIAA1348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:30263. PDP2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165450460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6666MitochondrionSequence AnalysisAdd
BLAST
Chaini67 – 529463[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialPRO_0000025421Add
BLAST

Proteomic databases

MaxQBiQ9P2J9.
PaxDbiQ9P2J9.
PRIDEiQ9P2J9.

PTM databases

PhosphoSiteiQ9P2J9.

Expressioni

Gene expression databases

BgeeiQ9P2J9.
ExpressionAtlasiQ9P2J9. baseline and differential.
GenevestigatoriQ9P2J9.

Organism-specific databases

HPAiHPA019950.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a FAD protein of unknown function.By similarity

Protein-protein interaction databases

BioGridi121604. 2 interactions.
STRINGi9606.ENSP00000309548.

Structurei

3D structure databases

ProteinModelPortaliQ9P2J9.
SMRiQ9P2J9. Positions 79-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00390000006874.
HOGENOMiHOG000220821.
HOVERGENiHBG008162.
InParanoidiQ9P2J9.
KOiK01102.
OMAiVHLHVAN.
PhylomeDBiQ9P2J9.
TreeFamiTF313505.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2J9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTVSYWIL NSTRNSIATL QGGRRLYSRY VSNRNKLKWR LFSRVPPTLN
60 70 80 90 100
SSPCGGFTLC KAYRHTSTEE DDFHLQLSPE QINEVLRAGE TTHKILDLES
110 120 130 140 150
RVPNSVLRFE SNQLAANSPV EDRRGVASCL QTNGLMFGIF DGHGGHACAQ
160 170 180 190 200
AVSERLFYYV AVSLMSHQTL EHMEGAMESM KPLLPILHWL KHPGDSIYKD
210 220 230 240 250
VTSVHLDHLR VYWQELLDLH MEMGLSIEEA LMYSFQRLDS DISLEIQAPL
260 270 280 290 300
EDEVTRNLSL QVAFSGATAC MAHVDGIHLH VANAGDCRAI LGVQEDNGMW
310 320 330 340 350
SCLPLTRDHN AWNQAELSRL KREHPESEDR TIIMEDRLLG VLIPCRAFGD
360 370 380 390 400
VQLKWSKELQ RSILERGFNT EALNIYQFTP PHYYTPPYLT AEPEVTYHRL
410 420 430 440 450
RPQDKFLVLA SDGLWDMLSN EDVVRLVVGH LAEADWHKTD LAQRPANLGL
460 470 480 490 500
MQSLLLQRKA SGLHEADQNA ATRLIRHAIG NNEYGEMEAE RLAAMLTLPE
510 520
DLARMYRDDI TVTVVYFNSE SIGAYYKGG
Length:529
Mass (Da):59,978
Last modified:January 24, 2001 - v2
Checksum:i252CAEBCDAF61A5C
GO

Sequence cautioni

The sequence BAA92586.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037769 mRNA. Translation: BAA92586.1. Different initiation.
AK292539 mRNA. Translation: BAF85228.1.
CH471092 Genomic DNA. Translation: EAW83048.1.
BC028030 mRNA. Translation: AAH28030.1.
CCDSiCCDS10822.1.
RefSeqiNP_065837.1. NM_020786.2.
XP_005256121.1. XM_005256064.2.
XP_005256122.1. XM_005256065.2.
XP_005256123.1. XM_005256066.2.
XP_005256124.1. XM_005256067.2.
XP_005256125.1. XM_005256068.2.
UniGeneiHs.632214.

Genome annotation databases

EnsembliENST00000311765; ENSP00000309548; ENSG00000172840.
GeneIDi57546.
KEGGihsa:57546.
UCSCiuc002eqk.2. human.

Polymorphism databases

DMDMi12585321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037769 mRNA. Translation: BAA92586.1 . Different initiation.
AK292539 mRNA. Translation: BAF85228.1 .
CH471092 Genomic DNA. Translation: EAW83048.1 .
BC028030 mRNA. Translation: AAH28030.1 .
CCDSi CCDS10822.1.
RefSeqi NP_065837.1. NM_020786.2.
XP_005256121.1. XM_005256064.2.
XP_005256122.1. XM_005256065.2.
XP_005256123.1. XM_005256066.2.
XP_005256124.1. XM_005256067.2.
XP_005256125.1. XM_005256068.2.
UniGenei Hs.632214.

3D structure databases

ProteinModelPortali Q9P2J9.
SMRi Q9P2J9. Positions 79-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121604. 2 interactions.
STRINGi 9606.ENSP00000309548.

PTM databases

PhosphoSitei Q9P2J9.

Polymorphism databases

DMDMi 12585321.

Proteomic databases

MaxQBi Q9P2J9.
PaxDbi Q9P2J9.
PRIDEi Q9P2J9.

Protocols and materials databases

DNASUi 57546.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311765 ; ENSP00000309548 ; ENSG00000172840 .
GeneIDi 57546.
KEGGi hsa:57546.
UCSCi uc002eqk.2. human.

Organism-specific databases

CTDi 57546.
GeneCardsi GC16P066914.
HGNCi HGNC:30263. PDP2.
HPAi HPA019950.
MIMi 615499. gene.
neXtProti NX_Q9P2J9.
PharmGKBi PA165450460.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00390000006874.
HOGENOMi HOG000220821.
HOVERGENi HBG008162.
InParanoidi Q9P2J9.
KOi K01102.
OMAi VHLHVAN.
PhylomeDBi Q9P2J9.
TreeFami TF313505.

Enzyme and pathway databases

Reactomei REACT_12528. Regulation of pyruvate dehydrogenase (PDH) complex.

Miscellaneous databases

GenomeRNAii 57546.
NextBioi 64003.
PROi Q9P2J9.
SOURCEi Search...

Gene expression databases

Bgeei Q9P2J9.
ExpressionAtlasi Q9P2J9. baseline and differential.
Genevestigatori Q9P2J9.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 3 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPDP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J9
Secondary accession number(s): A8K924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3