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Protein

Zinc finger protein 624

Gene

ZNF624

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri276 – 29823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri668 – 69023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri696 – 71823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri724 – 74623C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri752 – 77423C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri780 – 80223C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri808 – 83023C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri836 – 85823C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 624
Gene namesi
Name:ZNF624
Synonyms:KIAA1349
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29254. ZNF624.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977006.

Polymorphism and mutation databases

BioMutaiZNF624.
DMDMi239938815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Zinc finger protein 624PRO_0000047695Add
BLAST

Proteomic databases

EPDiQ9P2J8.
PaxDbiQ9P2J8.
PeptideAtlasiQ9P2J8.
PRIDEiQ9P2J8.

PTM databases

iPTMnetiQ9P2J8.
PhosphoSiteiQ9P2J8.

Expressioni

Gene expression databases

BgeeiENSG00000197566.
CleanExiHS_ZNF624.
ExpressionAtlasiQ9P2J8. baseline and differential.
GenevisibleiQ9P2J8. HS.

Organism-specific databases

HPAiHPA023157.
HPA023244.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR593EBI-9116427,EBI-742948

Protein-protein interaction databases

BioGridi121605. 10 interactions.
IntActiQ9P2J8. 4 interactions.
STRINGi9606.ENSP00000310472.

Structurei

3D structure databases

ProteinModelPortaliQ9P2J8.
SMRiQ9P2J8. Positions 54-94, 255-864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 12572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 21 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri276 – 29823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri584 – 60623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri612 – 63423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri640 – 66223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri668 – 69023C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri696 – 71823C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri724 – 74623C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri752 – 77423C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri780 – 80223C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri808 – 83023C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri836 – 85823C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P2J8.
KOiK09228.
OMAiQRGFRFE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P2J8.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2J8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQDSTLSR EGKPEGEIMA AVFFSVGRLS PEVTQPDEDL HLQAEETQLV
60 70 80 90 100
KESVTFKDVA IDFTLEEWRL MDPTQRNLHK DVMLENYRNL VSLGLAVSKP
110 120 130 140 150
DMISHLENGK GPWVTVREIS RIPYPDMEPK PATKKATRTK AISEDLSQEA
160 170 180 190 200
ILEKLTENGL WDSRMEGLWK WNDRILRLQN NQENHLSQRI IPLKKTPTSQ
210 220 230 240 250
RGFRFESILI PEPGIATEEL HSRCQTQEEN FTENLNLITD THLGKIICKE
260 270 280 290 300
MKGSKAIRQT SELTLGKKSN NKEKPYKCST CEKAFHYRSL LIQHQRTHTK
310 320 330 340 350
EKPYECNECG KTFSQPSYLS QHKKIHTGEK PYKCNECGKA FIASSSLMVH
360 370 380 390 400
QRIHTKEKPY QCNVCGKSFS QCARLNQHQR IQTGEKPYKC SECGKAFSDK
410 420 430 440 450
SKLARHQETH NGEKPYKCDD CGKAFRNKSY LSVHQKTHTE EKPYQCNECG
460 470 480 490 500
KSFKNTTIFN VHQRIHTGEK PFRCNECGKA YRSNSSLIVH IRTHTGEKPY
510 520 530 540 550
ECNECGKAFN RIANFTEHQR IHTGEKPYKC NECGKAFINY SCLTVHHRMH
560 570 580 590 600
TGEKPYKCTE CGKAFMRSSS LIIHQRIHTE EKPYLCNECG ESFRIKSHLT
610 620 630 640 650
VHQRIHTGEK PYKCTDCERA FTKMVNLKEH QKIHTGVKPY KCYDCGKSFR
660 670 680 690 700
TKSYLIVHQR THTGEKPYKC NECEKAFTNT SQLTVHQRRH TGEKPYKCNE
710 720 730 740 750
CGKVFTSNSG FNTHQRTHTG EKPFKCNDCG KAFSQMVHVT EHQKIHSGEK
760 770 780 790 800
PYKCDVCGKA FRRGSYLTVH WRTHTGEKPY TCKECGKGCI TLSQLTLHQR
810 820 830 840 850
IHTGERPYKC EECGKAFRTN SDFTVHLRMH TGEKPYKCNE CGKAFRSSSS
860
LTVHQRIHQR ETQLI
Length:865
Mass (Da):99,929
Last modified:June 16, 2009 - v3
Checksum:i12BB2E9410FFF91F
GO
Isoform 2 (identifier: Q9P2J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:739
Mass (Da):85,606
Checksum:iDB5EE1CEEA570A2F
GO

Sequence cautioni

The sequence BAA92587 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti576 – 5761R → C in BAD18548 (PubMed:14702039).Curated
Sequence conflicti747 – 7471S → T in AAI03947 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351K → N.2 Publications
Corresponds to variant rs8065506 [ dbSNP | Ensembl ].
VAR_058001
Natural varianti558 – 5581C → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035592

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 126126Missing in isoform 2. 2 PublicationsVSP_037538Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037770 mRNA. Translation: BAA92587.1. Different initiation.
AK131401 mRNA. Translation: BAD18548.1.
AC092714 Genomic DNA. No translation available.
AC098850 Genomic DNA. No translation available.
BC103943 mRNA. Translation: AAI03944.1.
BC103944 mRNA. Translation: AAI03945.1.
BC103946 mRNA. Translation: AAI03947.1.
CCDSiCCDS11180.1. [Q9P2J8-1]
RefSeqiNP_065838.2. NM_020787.3. [Q9P2J8-1]
XP_006721625.1. XM_006721562.3. [Q9P2J8-1]
UniGeneiHs.128078.

Genome annotation databases

EnsembliENST00000311331; ENSP00000310472; ENSG00000197566. [Q9P2J8-1]
GeneIDi57547.
KEGGihsa:57547.
UCSCiuc010cpi.3. human. [Q9P2J8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037770 mRNA. Translation: BAA92587.1. Different initiation.
AK131401 mRNA. Translation: BAD18548.1.
AC092714 Genomic DNA. No translation available.
AC098850 Genomic DNA. No translation available.
BC103943 mRNA. Translation: AAI03944.1.
BC103944 mRNA. Translation: AAI03945.1.
BC103946 mRNA. Translation: AAI03947.1.
CCDSiCCDS11180.1. [Q9P2J8-1]
RefSeqiNP_065838.2. NM_020787.3. [Q9P2J8-1]
XP_006721625.1. XM_006721562.3. [Q9P2J8-1]
UniGeneiHs.128078.

3D structure databases

ProteinModelPortaliQ9P2J8.
SMRiQ9P2J8. Positions 54-94, 255-864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121605. 10 interactions.
IntActiQ9P2J8. 4 interactions.
STRINGi9606.ENSP00000310472.

PTM databases

iPTMnetiQ9P2J8.
PhosphoSiteiQ9P2J8.

Polymorphism and mutation databases

BioMutaiZNF624.
DMDMi239938815.

Proteomic databases

EPDiQ9P2J8.
PaxDbiQ9P2J8.
PeptideAtlasiQ9P2J8.
PRIDEiQ9P2J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311331; ENSP00000310472; ENSG00000197566. [Q9P2J8-1]
GeneIDi57547.
KEGGihsa:57547.
UCSCiuc010cpi.3. human. [Q9P2J8-1]

Organism-specific databases

CTDi57547.
GeneCardsiZNF624.
HGNCiHGNC:29254. ZNF624.
HPAiHPA023157.
HPA023244.
neXtProtiNX_Q9P2J8.
PharmGKBiPA134977006.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P2J8.
KOiK09228.
OMAiQRGFRFE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P2J8.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57547.
PROiQ9P2J8.

Gene expression databases

BgeeiENSG00000197566.
CleanExiHS_ZNF624.
ExpressionAtlasiQ9P2J8. baseline and differential.
GenevisibleiQ9P2J8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN624_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J8
Secondary accession number(s): Q3SY62, Q3SY63, Q6ZN27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 16, 2009
Last modified: September 7, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.