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Protein

Zinc finger protein 624

Gene

ZNF624

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 746C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri752 – 774C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri780 – 802C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri808 – 830C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri836 – 858C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32381-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 624
Gene namesi
Name:ZNF624
Synonyms:KIAA1349
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29254. ZNF624.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197566.
PharmGKBiPA134977006.

Polymorphism and mutation databases

BioMutaiZNF624.
DMDMi239938815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476951 – 865Zinc finger protein 624Add BLAST865

Proteomic databases

EPDiQ9P2J8.
MaxQBiQ9P2J8.
PaxDbiQ9P2J8.
PeptideAtlasiQ9P2J8.
PRIDEiQ9P2J8.

PTM databases

iPTMnetiQ9P2J8.
PhosphoSitePlusiQ9P2J8.

Expressioni

Gene expression databases

BgeeiENSG00000197566.
CleanExiHS_ZNF624.
ExpressionAtlasiQ9P2J8. baseline and differential.
GenevisibleiQ9P2J8. HS.

Organism-specific databases

HPAiHPA023157.
HPA023244.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR593EBI-9116427,EBI-742948

Protein-protein interaction databases

BioGridi121605. 10 interactors.
IntActiQ9P2J8. 5 interactors.
STRINGi9606.ENSP00000310472.

Structurei

3D structure databases

ProteinModelPortaliQ9P2J8.
SMRiQ9P2J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 125KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 21 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 746C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri752 – 774C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri780 – 802C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri808 – 830C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri836 – 858C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P2J8.
KOiK09228.
OMAiQRGFRFE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P2J8.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2J8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQDSTLSR EGKPEGEIMA AVFFSVGRLS PEVTQPDEDL HLQAEETQLV
60 70 80 90 100
KESVTFKDVA IDFTLEEWRL MDPTQRNLHK DVMLENYRNL VSLGLAVSKP
110 120 130 140 150
DMISHLENGK GPWVTVREIS RIPYPDMEPK PATKKATRTK AISEDLSQEA
160 170 180 190 200
ILEKLTENGL WDSRMEGLWK WNDRILRLQN NQENHLSQRI IPLKKTPTSQ
210 220 230 240 250
RGFRFESILI PEPGIATEEL HSRCQTQEEN FTENLNLITD THLGKIICKE
260 270 280 290 300
MKGSKAIRQT SELTLGKKSN NKEKPYKCST CEKAFHYRSL LIQHQRTHTK
310 320 330 340 350
EKPYECNECG KTFSQPSYLS QHKKIHTGEK PYKCNECGKA FIASSSLMVH
360 370 380 390 400
QRIHTKEKPY QCNVCGKSFS QCARLNQHQR IQTGEKPYKC SECGKAFSDK
410 420 430 440 450
SKLARHQETH NGEKPYKCDD CGKAFRNKSY LSVHQKTHTE EKPYQCNECG
460 470 480 490 500
KSFKNTTIFN VHQRIHTGEK PFRCNECGKA YRSNSSLIVH IRTHTGEKPY
510 520 530 540 550
ECNECGKAFN RIANFTEHQR IHTGEKPYKC NECGKAFINY SCLTVHHRMH
560 570 580 590 600
TGEKPYKCTE CGKAFMRSSS LIIHQRIHTE EKPYLCNECG ESFRIKSHLT
610 620 630 640 650
VHQRIHTGEK PYKCTDCERA FTKMVNLKEH QKIHTGVKPY KCYDCGKSFR
660 670 680 690 700
TKSYLIVHQR THTGEKPYKC NECEKAFTNT SQLTVHQRRH TGEKPYKCNE
710 720 730 740 750
CGKVFTSNSG FNTHQRTHTG EKPFKCNDCG KAFSQMVHVT EHQKIHSGEK
760 770 780 790 800
PYKCDVCGKA FRRGSYLTVH WRTHTGEKPY TCKECGKGCI TLSQLTLHQR
810 820 830 840 850
IHTGERPYKC EECGKAFRTN SDFTVHLRMH TGEKPYKCNE CGKAFRSSSS
860
LTVHQRIHQR ETQLI
Length:865
Mass (Da):99,929
Last modified:June 16, 2009 - v3
Checksum:i12BB2E9410FFF91F
GO
Isoform 2 (identifier: Q9P2J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:739
Mass (Da):85,606
Checksum:iDB5EE1CEEA570A2F
GO

Sequence cautioni

The sequence BAA92587 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti576R → C in BAD18548 (PubMed:14702039).Curated1
Sequence conflicti747S → T in AAI03947 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058001135K → N.2 PublicationsCorresponds to variant rs8065506dbSNPEnsembl.1
Natural variantiVAR_035592558C → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0375381 – 126Missing in isoform 2. 2 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037770 mRNA. Translation: BAA92587.1. Different initiation.
AK131401 mRNA. Translation: BAD18548.1.
AC092714 Genomic DNA. No translation available.
AC098850 Genomic DNA. No translation available.
BC103943 mRNA. Translation: AAI03944.1.
BC103944 mRNA. Translation: AAI03945.1.
BC103946 mRNA. Translation: AAI03947.1.
CCDSiCCDS11180.1. [Q9P2J8-1]
RefSeqiNP_065838.2. NM_020787.3. [Q9P2J8-1]
XP_006721625.1. XM_006721562.3. [Q9P2J8-1]
UniGeneiHs.128078.

Genome annotation databases

EnsembliENST00000311331; ENSP00000310472; ENSG00000197566. [Q9P2J8-1]
GeneIDi57547.
KEGGihsa:57547.
UCSCiuc010cpi.3. human. [Q9P2J8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037770 mRNA. Translation: BAA92587.1. Different initiation.
AK131401 mRNA. Translation: BAD18548.1.
AC092714 Genomic DNA. No translation available.
AC098850 Genomic DNA. No translation available.
BC103943 mRNA. Translation: AAI03944.1.
BC103944 mRNA. Translation: AAI03945.1.
BC103946 mRNA. Translation: AAI03947.1.
CCDSiCCDS11180.1. [Q9P2J8-1]
RefSeqiNP_065838.2. NM_020787.3. [Q9P2J8-1]
XP_006721625.1. XM_006721562.3. [Q9P2J8-1]
UniGeneiHs.128078.

3D structure databases

ProteinModelPortaliQ9P2J8.
SMRiQ9P2J8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121605. 10 interactors.
IntActiQ9P2J8. 5 interactors.
STRINGi9606.ENSP00000310472.

PTM databases

iPTMnetiQ9P2J8.
PhosphoSitePlusiQ9P2J8.

Polymorphism and mutation databases

BioMutaiZNF624.
DMDMi239938815.

Proteomic databases

EPDiQ9P2J8.
MaxQBiQ9P2J8.
PaxDbiQ9P2J8.
PeptideAtlasiQ9P2J8.
PRIDEiQ9P2J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311331; ENSP00000310472; ENSG00000197566. [Q9P2J8-1]
GeneIDi57547.
KEGGihsa:57547.
UCSCiuc010cpi.3. human. [Q9P2J8-1]

Organism-specific databases

CTDi57547.
GeneCardsiZNF624.
HGNCiHGNC:29254. ZNF624.
HPAiHPA023157.
HPA023244.
neXtProtiNX_Q9P2J8.
OpenTargetsiENSG00000197566.
PharmGKBiPA134977006.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9P2J8.
KOiK09228.
OMAiQRGFRFE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P2J8.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-32381-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57547.
PROiQ9P2J8.

Gene expression databases

BgeeiENSG00000197566.
CleanExiHS_ZNF624.
ExpressionAtlasiQ9P2J8. baseline and differential.
GenevisibleiQ9P2J8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 12 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 21 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN624_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J8
Secondary accession number(s): Q3SY62, Q3SY63, Q6ZN27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.