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Protein

Kelch-like protein 9

Gene

KLHL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.3 Publications

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 9
Gene namesi
Name:KLHL9
Synonyms:KIAA1354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18732. KLHL9.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: UniProtKB
  • midbody Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

Orphaneti399081. KLHL9-related childhood-onset distal myopathy.
PharmGKBiPA38662.

Polymorphism and mutation databases

BioMutaiKLHL9.
DMDMi51338828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Kelch-like protein 9PRO_0000119110Add
BLAST

Proteomic databases

MaxQBiQ9P2J3.
PaxDbiQ9P2J3.
PRIDEiQ9P2J3.

PTM databases

PhosphoSiteiQ9P2J3.

Expressioni

Gene expression databases

BgeeiQ9P2J3.
CleanExiHS_KLHL9.
ExpressionAtlasiQ9P2J3. baseline and differential.
GenevisibleiQ9P2J3. HS.

Organism-specific databases

HPAiHPA046039.

Interactioni

Subunit structurei

Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.2 Publications

Protein-protein interaction databases

BioGridi121009. 15 interactions.
IntActiQ9P2J3. 5 interactions.
MINTiMINT-1209163.
STRINGi9606.ENSP00000351933.

Structurei

3D structure databases

ProteinModelPortaliQ9P2J3.
SMRiQ9P2J3. Positions 27-273, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 11970BTBPROSITE-ProRule annotationAdd
BLAST
Domaini154 – 255102BACKAdd
BLAST
Repeati300 – 34748Kelch 1Add
BLAST
Repeati348 – 39952Kelch 2Add
BLAST
Repeati400 – 44647Kelch 3Add
BLAST
Repeati448 – 49346Kelch 4Add
BLAST
Repeati495 – 54551Kelch 5Add
BLAST
Repeati546 – 59550Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG293088.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ9P2J3.
KOiK10447.
OMAiCRWLRYE.
OrthoDBiEOG7VTDMJ.
PhylomeDBiQ9P2J3.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P2J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC
60 70 80 90 100
DVTLVPGDGD EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK
110 120 130 140 150
VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS
160 170 180 190 200
LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLSTGEF LKLPFERLAF
210 220 230 240 250
VLSSNSLKHC TELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL
260 270 280 290 300
INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL
310 320 330 340 350
VTLGGVLRQQ LVVSKELRMY DERAQEWRSL APMDAPRYQH GIAVIGNFLY
360 370 380 390 400
VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH
410 420 430 440 450
LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI
460 470 480 490 500
SGGITHDTFQ NELMCFDPDT DKWMQKAPMT TVRGLHCMCT VGDKLYVIGG
510 520 530 540 550
NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV
560 570 580 590 600
GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN
610
PGSPSRESPL SAPSDHS
Length:617
Mass (Da):69,429
Last modified:August 16, 2004 - v2
Checksum:iB74232F28ABF7C82
GO

Sequence cautioni

The sequence BAA92592.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037775 mRNA. Translation: BAA92592.1. Different initiation.
AL713669 mRNA. Translation: CAD28475.1.
CCDSiCCDS6503.1.
RefSeqiNP_061335.1. NM_018847.2.
UniGeneiHs.701778.
Hs.710126.
Hs.744736.

Genome annotation databases

EnsembliENST00000359039; ENSP00000351933; ENSG00000198642.
GeneIDi55958.
KEGGihsa:55958.
UCSCiuc003zoy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037775 mRNA. Translation: BAA92592.1. Different initiation.
AL713669 mRNA. Translation: CAD28475.1.
CCDSiCCDS6503.1.
RefSeqiNP_061335.1. NM_018847.2.
UniGeneiHs.701778.
Hs.710126.
Hs.744736.

3D structure databases

ProteinModelPortaliQ9P2J3.
SMRiQ9P2J3. Positions 27-273, 300-592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121009. 15 interactions.
IntActiQ9P2J3. 5 interactions.
MINTiMINT-1209163.
STRINGi9606.ENSP00000351933.

PTM databases

PhosphoSiteiQ9P2J3.

Polymorphism and mutation databases

BioMutaiKLHL9.
DMDMi51338828.

Proteomic databases

MaxQBiQ9P2J3.
PaxDbiQ9P2J3.
PRIDEiQ9P2J3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359039; ENSP00000351933; ENSG00000198642.
GeneIDi55958.
KEGGihsa:55958.
UCSCiuc003zoy.3. human.

Organism-specific databases

CTDi55958.
GeneCardsiGC09M021329.
HGNCiHGNC:18732. KLHL9.
HPAiHPA046039.
MIMi611201. gene.
neXtProtiNX_Q9P2J3.
Orphaneti399081. KLHL9-related childhood-onset distal myopathy.
PharmGKBiPA38662.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293088.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG106526.
InParanoidiQ9P2J3.
KOiK10447.
OMAiCRWLRYE.
OrthoDBiEOG7VTDMJ.
PhylomeDBiQ9P2J3.
TreeFamiTF328485.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii55958.
NextBioi61363.
PROiQ9P2J3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2J3.
CleanExiHS_KLHL9.
ExpressionAtlasiQ9P2J3. baseline and differential.
GenevisibleiQ9P2J3. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
  4. "A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells."
    Sumara I., Quadroni M., Frei C., Olma M.H., Sumara G., Ricci R., Peter M.
    Dev. Cell 12:887-900(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AURKB; CUL3 AND KLHL13.
  5. "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."
    Maerki S., Olma M.H., Staubli T., Steigemann P., Gerlich D.W., Quadroni M., Sumara I., Peter M.
    J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKLHL9_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J3
Secondary accession number(s): Q8TCQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.