Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P2J3

- KLHL9_HUMAN

UniProt

Q9P2J3 - KLHL9_HUMAN

Protein

Kelch-like protein 9

Gene

KLHL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.3 Publications

    Pathwayi

    GO - Biological processi

    1. cytokinesis Source: UniProtKB
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein ubiquitination Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 9
    Gene namesi
    Name:KLHL9
    Synonyms:KIAA1354
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18732. KLHL9.

    Subcellular locationi

    GO - Cellular componenti

    1. Cul3-RING ubiquitin ligase complex Source: UniProtKB
    2. midbody Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38662.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Kelch-like protein 9PRO_0000119110Add
    BLAST

    Proteomic databases

    MaxQBiQ9P2J3.
    PaxDbiQ9P2J3.
    PRIDEiQ9P2J3.

    PTM databases

    PhosphoSiteiQ9P2J3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P2J3.
    BgeeiQ9P2J3.
    CleanExiHS_KLHL9.
    GenevestigatoriQ9P2J3.

    Organism-specific databases

    HPAiHPA046039.

    Interactioni

    Subunit structurei

    Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.2 Publications

    Protein-protein interaction databases

    BioGridi121009. 14 interactions.
    IntActiQ9P2J3. 5 interactions.
    MINTiMINT-1209163.
    STRINGi9606.ENSP00000351933.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P2J3.
    SMRiQ9P2J3. Positions 27-273, 300-592.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 11970BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini154 – 255102BACKAdd
    BLAST
    Repeati300 – 34748Kelch 1Add
    BLAST
    Repeati348 – 39952Kelch 2Add
    BLAST
    Repeati400 – 44647Kelch 3Add
    BLAST
    Repeati448 – 49346Kelch 4Add
    BLAST
    Repeati495 – 54551Kelch 5Add
    BLAST
    Repeati546 – 59550Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG293088.
    HOGENOMiHOG000231583.
    HOVERGENiHBG106526.
    InParanoidiQ9P2J3.
    KOiK10447.
    OMAiDMGVSAH.
    OrthoDBiEOG7VTDMJ.
    PhylomeDBiQ9P2J3.
    TreeFamiTF328485.

    Family and domain databases

    Gene3Di2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 5 hits.
    [Graphical view]
    PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P2J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC    50
    DVTLVPGDGD EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK 100
    VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS 150
    LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLSTGEF LKLPFERLAF 200
    VLSSNSLKHC TELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL 250
    INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL 300
    VTLGGVLRQQ LVVSKELRMY DERAQEWRSL APMDAPRYQH GIAVIGNFLY 350
    VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH 400
    LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI 450
    SGGITHDTFQ NELMCFDPDT DKWMQKAPMT TVRGLHCMCT VGDKLYVIGG 500
    NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV 550
    GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN 600
    PGSPSRESPL SAPSDHS 617
    Length:617
    Mass (Da):69,429
    Last modified:August 16, 2004 - v2
    Checksum:iB74232F28ABF7C82
    GO

    Sequence cautioni

    The sequence BAA92592.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037775 mRNA. Translation: BAA92592.1. Different initiation.
    AL713669 mRNA. Translation: CAD28475.1.
    CCDSiCCDS6503.1.
    RefSeqiNP_061335.1. NM_018847.2.
    UniGeneiHs.701778.
    Hs.710126.
    Hs.744736.

    Genome annotation databases

    EnsembliENST00000359039; ENSP00000351933; ENSG00000198642.
    GeneIDi55958.
    KEGGihsa:55958.
    UCSCiuc003zoy.3. human.

    Polymorphism databases

    DMDMi51338828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037775 mRNA. Translation: BAA92592.1 . Different initiation.
    AL713669 mRNA. Translation: CAD28475.1 .
    CCDSi CCDS6503.1.
    RefSeqi NP_061335.1. NM_018847.2.
    UniGenei Hs.701778.
    Hs.710126.
    Hs.744736.

    3D structure databases

    ProteinModelPortali Q9P2J3.
    SMRi Q9P2J3. Positions 27-273, 300-592.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121009. 14 interactions.
    IntActi Q9P2J3. 5 interactions.
    MINTi MINT-1209163.
    STRINGi 9606.ENSP00000351933.

    PTM databases

    PhosphoSitei Q9P2J3.

    Polymorphism databases

    DMDMi 51338828.

    Proteomic databases

    MaxQBi Q9P2J3.
    PaxDbi Q9P2J3.
    PRIDEi Q9P2J3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359039 ; ENSP00000351933 ; ENSG00000198642 .
    GeneIDi 55958.
    KEGGi hsa:55958.
    UCSCi uc003zoy.3. human.

    Organism-specific databases

    CTDi 55958.
    GeneCardsi GC09M021329.
    HGNCi HGNC:18732. KLHL9.
    HPAi HPA046039.
    MIMi 611201. gene.
    neXtProti NX_Q9P2J3.
    PharmGKBi PA38662.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293088.
    HOGENOMi HOG000231583.
    HOVERGENi HBG106526.
    InParanoidi Q9P2J3.
    KOi K10447.
    OMAi DMGVSAH.
    OrthoDBi EOG7VTDMJ.
    PhylomeDBi Q9P2J3.
    TreeFami TF328485.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 55958.
    NextBioi 61363.
    PROi Q9P2J3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2J3.
    Bgeei Q9P2J3.
    CleanExi HS_KLHL9.
    Genevestigatori Q9P2J3.

    Family and domain databases

    Gene3Di 2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M., He Y.J., Borchers C., Xiong Y.
      Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
    4. "A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells."
      Sumara I., Quadroni M., Frei C., Olma M.H., Sumara G., Ricci R., Peter M.
      Dev. Cell 12:887-900(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AURKB; CUL3 AND KLHL13.
    5. "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."
      Maerki S., Olma M.H., Staubli T., Steigemann P., Gerlich D.W., Quadroni M., Sumara I., Peter M.
      J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiKLHL9_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2J3
    Secondary accession number(s): Q8TCQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3