Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P2J2

- TUTLA_HUMAN

UniProt

Q9P2J2 - TUTLA_HUMAN

Protein

Protein turtle homolog A

Gene

IGSF9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions in dendrite outgrowth and synapse maturation.By similarity

    GO - Biological processi

    1. dendrite development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein turtle homolog A
    Alternative name(s):
    Immunoglobulin superfamily member 9A
    Short name:
    IgSF9A
    Gene namesi
    Name:IGSF9
    Synonyms:IGSF9A, KIAA1355, NRT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18132. IGSF9.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
    Note: Enriched at the excitatory synapses in mature neurons.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38508.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 11791159Protein turtle homolog APRO_0000306107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 108PROSITE-ProRule annotation
    Disulfide bondi158 ↔ 206PROSITE-ProRule annotation
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi248 ↔ 301PROSITE-ProRule annotation
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
    Disulfide bondi440 ↔ 486PROSITE-ProRule annotation
    Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9P2J2.
    PaxDbiQ9P2J2.
    PRIDEiQ9P2J2.

    PTM databases

    PhosphoSiteiQ9P2J2.

    Expressioni

    Developmental stagei

    Expressed in a wide variety of tissues at 8 and 14 weeks of gestation.1 Publication

    Gene expression databases

    ArrayExpressiQ9P2J2.
    BgeeiQ9P2J2.
    CleanExiHS_IGSF9.
    GenevestigatoriQ9P2J2.

    Organism-specific databases

    HPAiHPA037753.

    Interactioni

    Subunit structurei

    Interacts with MAGI2 and SHANK1.By similarity

    Protein-protein interaction databases

    BioGridi121606. 1 interaction.
    IntActiQ9P2J2. 1 interaction.
    STRINGi9606.ENSP00000357073.

    Structurei

    Secondary structure

    1
    1179
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi628 – 6347
    Beta strandi636 – 6449
    Beta strandi655 – 6628
    Beta strandi668 – 6747
    Beta strandi680 – 6823
    Beta strandi696 – 7005
    Beta strandi703 – 7075

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V5JNMR-A624-718[»]
    ProteinModelPortaliQ9P2J2.
    SMRiQ9P2J2. Positions 33-592, 626-718.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9P2J2.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 734714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini756 – 1179424CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei735 – 75521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 124101Ig-like 1Add
    BLAST
    Domaini136 – 21681Ig-like 2Add
    BLAST
    Domaini226 – 31893Ig-like 3Add
    BLAST
    Domaini322 – 41089Ig-like 4Add
    BLAST
    Domaini418 – 50285Ig-like 5Add
    BLAST
    Domaini507 – 611105Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini623 – 71896Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1177 – 11793PDZ-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi823 – 982160Pro-richAdd
    BLAST

    Domaini

    The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.By similarity

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303891.
    HOGENOMiHOG000154716.
    HOVERGENiHBG079460.
    InParanoidiQ9P2J2.
    OMAiERPKEEY.
    OrthoDBiEOG7M98FF.
    PhylomeDBiQ9P2J2.
    TreeFamiTF326128.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 2 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P2J2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP     50
    PLHVIEWLRF GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV 100
    EDQGWYECRV FFLDQHIPED DFANGSWVHL TVNSPPQFQE TPPAVLEVQE 150
    LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG QGQVQVQNGT LRIRRVERGS 200
    SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA SQDVSLACHA 250
    EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT 300
    CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP 350
    PLLFVSWTKD GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS 400
    LGTAGPSPVT RVLLKAPPAF IERPKEEYFQ EVGRELLIPC SAQGDPPPVV 450
    SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA HGHWECSASN AVARVATSTN 500
    VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS VWYTPLAKRP 550
    DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL 600
    SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP 650
    KRLDGYVLEG RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA 700
    GSFVSDPSNT ANVSTSGLEV YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV 750
    LVSILAGCLL NRRRAARRRR KRLRQDPPLI FSPTGKSAAP SALGSGSPDS 800
    VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL PLEPICRGPD 850
    GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI 900
    EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA 950
    APPDYMDTRR CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA 1000
    DWTLRERLLP GLLPAAPRGS LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP 1050
    APGDTSSWAS GPERWPRREH VVTVSKRRNT SVDENYEWDS EFPGDMELLE 1100
    TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA RCAALREEFL 1150
    AFRRRRDATR ARLPAYRQPV PHPEQATLL 1179
    Length:1,179
    Mass (Da):126,580
    Last modified:October 2, 2007 - v2
    Checksum:i6C2120D439804407
    GO
    Isoform 2 (identifier: Q9P2J2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         321-337: YPAQVTAMPPETPLPIG → C

    Note: No experimental confirmation available.

    Show »
    Length:1,163
    Mass (Da):124,919
    Checksum:iD5ADA3C6CA08335B
    GO

    Sequence cautioni

    The sequence BAA92593.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti279 – 2791R → Q in AAH30141. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341G → E.1 Publication
    Corresponds to variant rs3747617 [ dbSNP | Ensembl ].
    VAR_035256
    Natural varianti474 – 4741R → P.
    Corresponds to variant rs16842846 [ dbSNP | Ensembl ].
    VAR_035257
    Natural varianti914 – 9141P → L.
    Corresponds to variant rs35574000 [ dbSNP | Ensembl ].
    VAR_035258
    Natural varianti1026 – 10261S → T.
    Corresponds to variant rs34749866 [ dbSNP | Ensembl ].
    VAR_035259
    Natural varianti1117 – 11171P → T.1 Publication
    Corresponds to variant rs1319080 [ dbSNP | Ensembl ].
    VAR_035260

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei321 – 33717YPAQV…PLPIG → C in isoform 2. 1 PublicationVSP_047195Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037776 mRNA. Translation: BAA92593.1. Different initiation.
    BC030141 mRNA. Translation: AAH30141.1.
    CCDSiCCDS1190.1. [Q9P2J2-2]
    CCDS44254.1. [Q9P2J2-1]
    RefSeqiNP_001128522.1. NM_001135050.1. [Q9P2J2-1]
    NP_065840.2. NM_020789.3. [Q9P2J2-2]
    UniGeneiHs.591472.

    Genome annotation databases

    EnsembliENST00000361509; ENSP00000355049; ENSG00000085552. [Q9P2J2-2]
    ENST00000368094; ENSP00000357073; ENSG00000085552. [Q9P2J2-1]
    GeneIDi57549.
    KEGGihsa:57549.
    UCSCiuc001fuq.2. human. [Q9P2J2-1]

    Polymorphism databases

    DMDMi158706515.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037776 mRNA. Translation: BAA92593.1 . Different initiation.
    BC030141 mRNA. Translation: AAH30141.1 .
    CCDSi CCDS1190.1. [Q9P2J2-2 ]
    CCDS44254.1. [Q9P2J2-1 ]
    RefSeqi NP_001128522.1. NM_001135050.1. [Q9P2J2-1 ]
    NP_065840.2. NM_020789.3. [Q9P2J2-2 ]
    UniGenei Hs.591472.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V5J NMR - A 624-718 [» ]
    ProteinModelPortali Q9P2J2.
    SMRi Q9P2J2. Positions 33-592, 626-718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121606. 1 interaction.
    IntActi Q9P2J2. 1 interaction.
    STRINGi 9606.ENSP00000357073.

    PTM databases

    PhosphoSitei Q9P2J2.

    Polymorphism databases

    DMDMi 158706515.

    Proteomic databases

    MaxQBi Q9P2J2.
    PaxDbi Q9P2J2.
    PRIDEi Q9P2J2.

    Protocols and materials databases

    DNASUi 57549.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361509 ; ENSP00000355049 ; ENSG00000085552 . [Q9P2J2-2 ]
    ENST00000368094 ; ENSP00000357073 ; ENSG00000085552 . [Q9P2J2-1 ]
    GeneIDi 57549.
    KEGGi hsa:57549.
    UCSCi uc001fuq.2. human. [Q9P2J2-1 ]

    Organism-specific databases

    CTDi 57549.
    GeneCardsi GC01M159896.
    HGNCi HGNC:18132. IGSF9.
    HPAi HPA037753.
    MIMi 609738. gene.
    neXtProti NX_Q9P2J2.
    PharmGKBi PA38508.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303891.
    HOGENOMi HOG000154716.
    HOVERGENi HBG079460.
    InParanoidi Q9P2J2.
    OMAi ERPKEEY.
    OrthoDBi EOG7M98FF.
    PhylomeDBi Q9P2J2.
    TreeFami TF326128.

    Miscellaneous databases

    ChiTaRSi IGSF9. human.
    EvolutionaryTracei Q9P2J2.
    GenomeRNAii 57549.
    NextBioi 64010.
    PROi Q9P2J2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P2J2.
    Bgeei Q9P2J2.
    CleanExi HS_IGSF9.
    Genevestigatori Q9P2J2.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 2 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-34 AND THR-1117.
      Tissue: Neuroblastoma.
    3. "Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system."
      Doudney K., Murdoch J.N., Braybrook C., Paternotte C., Bentley L., Copp A.J., Stanier P.
      Genomics 79:663-670(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    4. "Solution structure of RSGI RUH-008, a FN3 domain in human cDNA."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAY-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 624-718.

    Entry informationi

    Entry nameiTUTLA_HUMAN
    AccessioniPrimary (citable) accession number: Q9P2J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3