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Q9P2J2 (TUTLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein turtle homolog A
Alternative name(s):
Immunoglobulin superfamily member 9A
Short name=IgSF9A
Gene names
Name:IGSF9
Synonyms:IGSF9A, KIAA1355, NRT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions in dendrite outgrowth and synapse maturation By similarity.

Subunit structure

Interacts with MAGI2 and SHANK1 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity. Note: Enriched at the excitatory synapses in mature neurons By similarity.

Developmental stage

Expressed in a wide variety of tissues at 8 and 14 weeks of gestation. Ref.3

Domain

The PDZ-binding motif mediates interactions with MAGI2 and SHANK1 By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily. Turtle family.

Contains 2 fibronectin type-III domains.

Contains 5 Ig-like (immunoglobulin-like) domains.

Sequence caution

The sequence BAA92593.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P2J2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P2J2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     321-337: YPAQVTAMPPETPLPIG → C
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 11791159Protein turtle homolog A
PRO_0000306107

Regions

Topological domain21 – 734714Extracellular Potential
Transmembrane735 – 75521Helical; Potential
Topological domain756 – 1179424Cytoplasmic Potential
Domain24 – 124101Ig-like 1
Domain136 – 21681Ig-like 2
Domain226 – 31893Ig-like 3
Domain322 – 41089Ig-like 4
Domain418 – 50285Ig-like 5
Domain507 – 611105Fibronectin type-III 1
Domain623 – 71896Fibronectin type-III 2
Motif1177 – 11793PDZ-binding By similarity
Compositional bias823 – 982160Pro-rich

Amino acid modifications

Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 108 By similarity
Disulfide bond158 ↔ 206 By similarity
Disulfide bond248 ↔ 301 By similarity
Disulfide bond344 ↔ 395 By similarity
Disulfide bond440 ↔ 486 By similarity

Natural variations

Alternative sequence321 – 33717YPAQV…PLPIG → C in isoform 2.
VSP_047195
Natural variant341G → E. Ref.2
Corresponds to variant rs3747617 [ dbSNP | Ensembl ].
VAR_035256
Natural variant4741R → P.
Corresponds to variant rs16842846 [ dbSNP | Ensembl ].
VAR_035257
Natural variant9141P → L.
Corresponds to variant rs35574000 [ dbSNP | Ensembl ].
VAR_035258
Natural variant10261S → T.
Corresponds to variant rs34749866 [ dbSNP | Ensembl ].
VAR_035259
Natural variant11171P → T. Ref.2
Corresponds to variant rs1319080 [ dbSNP | Ensembl ].
VAR_035260

Experimental info

Sequence conflict2791R → Q in AAH30141. Ref.2

Secondary structure

............... 1179
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: 6C2120D439804407

FASTA1,179126,580
        10         20         30         40         50         60 
MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP PLHVIEWLRF 

        70         80         90        100        110        120 
GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV EDQGWYECRV FFLDQHIPED 

       130        140        150        160        170        180 
DFANGSWVHL TVNSPPQFQE TPPAVLEVQE LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG 

       190        200        210        220        230        240 
QGQVQVQNGT LRIRRVERGS SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA 

       250        260        270        280        290        300 
SQDVSLACHA EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT 

       310        320        330        340        350        360 
CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP PLLFVSWTKD 

       370        380        390        400        410        420 
GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS LGTAGPSPVT RVLLKAPPAF 

       430        440        450        460        470        480 
IERPKEEYFQ EVGRELLIPC SAQGDPPPVV SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA 

       490        500        510        520        530        540 
HGHWECSASN AVARVATSTN VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS 

       550        560        570        580        590        600 
VWYTPLAKRP DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL 

       610        620        630        640        650        660 
SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP KRLDGYVLEG 

       670        680        690        700        710        720 
RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA GSFVSDPSNT ANVSTSGLEV 

       730        740        750        760        770        780 
YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV LVSILAGCLL NRRRAARRRR KRLRQDPPLI 

       790        800        810        820        830        840 
FSPTGKSAAP SALGSGSPDS VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL 

       850        860        870        880        890        900 
PLEPICRGPD GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI 

       910        920        930        940        950        960 
EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA APPDYMDTRR 

       970        980        990       1000       1010       1020 
CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA DWTLRERLLP GLLPAAPRGS 

      1030       1040       1050       1060       1070       1080 
LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP APGDTSSWAS GPERWPRREH VVTVSKRRNT 

      1090       1100       1110       1120       1130       1140 
SVDENYEWDS EFPGDMELLE TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA 

      1150       1160       1170 
RCAALREEFL AFRRRRDATR ARLPAYRQPV PHPEQATLL 

« Hide

Isoform 2 [UniParc].

Checksum: D5ADA3C6CA08335B
Show »

FASTA1,163124,919

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-34 AND THR-1117.
Tissue: Neuroblastoma.
[3]"Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system."
Doudney K., Murdoch J.N., Braybrook C., Paternotte C., Bentley L., Copp A.J., Stanier P.
Genomics 79:663-670(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[4]"Solution structure of RSGI RUH-008, a FN3 domain in human cDNA."
RIKEN structural genomics initiative (RSGI)
Submitted (MAY-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 624-718.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037776 mRNA. Translation: BAA92593.1. Different initiation.
BC030141 mRNA. Translation: AAH30141.1.
CCDSCCDS1190.1. [Q9P2J2-2]
CCDS44254.1. [Q9P2J2-1]
RefSeqNP_001128522.1. NM_001135050.1. [Q9P2J2-1]
NP_065840.2. NM_020789.3. [Q9P2J2-2]
UniGeneHs.591472.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5JNMR-A624-718[»]
ProteinModelPortalQ9P2J2.
SMRQ9P2J2. Positions 33-592, 626-718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121606. 1 interaction.
IntActQ9P2J2. 1 interaction.
STRING9606.ENSP00000357073.

PTM databases

PhosphoSiteQ9P2J2.

Polymorphism databases

DMDM158706515.

Proteomic databases

MaxQBQ9P2J2.
PaxDbQ9P2J2.
PRIDEQ9P2J2.

Protocols and materials databases

DNASU57549.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361509; ENSP00000355049; ENSG00000085552. [Q9P2J2-2]
ENST00000368094; ENSP00000357073; ENSG00000085552. [Q9P2J2-1]
GeneID57549.
KEGGhsa:57549.
UCSCuc001fuq.2. human. [Q9P2J2-1]

Organism-specific databases

CTD57549.
GeneCardsGC01M159896.
HGNCHGNC:18132. IGSF9.
HPAHPA037753.
MIM609738. gene.
neXtProtNX_Q9P2J2.
PharmGKBPA38508.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303891.
HOGENOMHOG000154716.
HOVERGENHBG079460.
InParanoidQ9P2J2.
OMAERPKEEY.
OrthoDBEOG7M98FF.
PhylomeDBQ9P2J2.
TreeFamTF326128.

Gene expression databases

ArrayExpressQ9P2J2.
BgeeQ9P2J2.
CleanExHS_IGSF9.
GenevestigatorQ9P2J2.

Family and domain databases

Gene3D2.60.40.10. 7 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIGSF9. human.
EvolutionaryTraceQ9P2J2.
GenomeRNAi57549.
NextBio64010.
PROQ9P2J2.
SOURCESearch...

Entry information

Entry nameTUTLA_HUMAN
AccessionPrimary (citable) accession number: Q9P2J2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM