Q9P2J2 (TUTLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein turtle homolog A

Alternative name(s):
Immunoglobulin superfamily member 9A
Short name=IgSF9A

Gene names

Name:	IGSF9
Synonyms:	IGSF9A, KIAA1355, NRT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions in dendrite outgrowth and synapse maturation By similarity.
Subunit structure	Interacts with MAGI2 and SHANK1 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › synapse By similarity. Note: Enriched at the excitatory synapses in mature neurons By similarity.
Developmental stage	Expressed in a wide variety of tissues at 8 and 14 weeks of gestation. Ref.2
Domain	The PDZ-binding motif mediates interactions with MAGI2 and SHANK1 By similarity.
Sequence similarities	Belongs to the immunoglobulin superfamily. Turtle family. Contains 2 fibronectin type-III domains. Contains 5 Ig-like (immunoglobulin-like) domains.
Sequence caution	The sequence BAA92593.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dendrite development Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW dendrite Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Potential

Chain

21 – 1179

1159

Protein turtle homolog A

PRO_0000306107

Regions

Topological domain

21 – 734

714

Extracellular Potential

Transmembrane

735 – 755

21

Helical; Potential

Topological domain

756 – 1179

424

Cytoplasmic Potential

Domain

24 – 124

101

Ig-like 1

Domain

136 – 216

81

Ig-like 2

Domain

226 – 318

93

Ig-like 3

Domain

322 – 410

89

Ig-like 4

Domain

418 – 502

85

Ig-like 5

Domain

508 – 604

97

Fibronectin type-III 1

Domain

623 – 714

92

Fibronectin type-III 2

Motif

1177 – 1179

3

PDZ-binding By similarity

Compositional bias

823 – 982

160

Pro-rich

Amino acid modifications

Glycosylation

188

1

N-linked (GlcNAc...) Potential

Glycosylation

256

1

N-linked (GlcNAc...) Potential

Glycosylation

513

1

N-linked (GlcNAc...) Potential

Glycosylation

524

1

N-linked (GlcNAc...) Potential

Disulfide bond

41 ↔ 108

By similarity

Disulfide bond

158 ↔ 206

By similarity

Disulfide bond

248 ↔ 301

By similarity

Disulfide bond

344 ↔ 395

By similarity

Disulfide bond

440 ↔ 486

By similarity

Natural variations

Natural variant

34

1

G → E.
Corresponds to variant rs3747617 [ dbSNP | Ensembl ].

VAR_035256

Natural variant

474

1

R → P.
Corresponds to variant rs16842846 [ dbSNP | Ensembl ].

VAR_035257

Natural variant

914

1

P → L.
Corresponds to variant rs35574000 [ dbSNP | Ensembl ].

VAR_035258

Natural variant

1026

1

S → T.
Corresponds to variant rs34749866 [ dbSNP | Ensembl ].

VAR_035259

Natural variant

1117

1

P → T.
Corresponds to variant rs1319080 [ dbSNP | Ensembl ].

VAR_035260

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1179

Helix Strand Turn

Details...

Beta strand

628 – 634

7

Beta strand

636 – 644

9

Beta strand

655 – 662

8

Beta strand

668 – 674

7

Beta strand

680 – 682

3

Beta strand

696 – 700

5

Beta strand

703 – 707

5

Sequences

	Sequence		Length	Mass (Da)
	Q9P2J2 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 6C2120D439804407	FASTA	1,179	126,580
	10 20 30 40 50 60 MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP PLHVIEWLRF 70 80 90 100 110 120 GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV EDQGWYECRV FFLDQHIPED 130 140 150 160 170 180 DFANGSWVHL TVNSPPQFQE TPPAVLEVQE LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG 190 200 210 220 230 240 QGQVQVQNGT LRIRRVERGS SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA 250 260 270 280 290 300 SQDVSLACHA EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT 310 320 330 340 350 360 CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP PLLFVSWTKD 370 380 390 400 410 420 GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS LGTAGPSPVT RVLLKAPPAF 430 440 450 460 470 480 IERPKEEYFQ EVGRELLIPC SAQGDPPPVV SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA 490 500 510 520 530 540 HGHWECSASN AVARVATSTN VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS 550 560 570 580 590 600 VWYTPLAKRP DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL 610 620 630 640 650 660 SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP KRLDGYVLEG 670 680 690 700 710 720 RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA GSFVSDPSNT ANVSTSGLEV 730 740 750 760 770 780 YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV LVSILAGCLL NRRRAARRRR KRLRQDPPLI 790 800 810 820 830 840 FSPTGKSAAP SALGSGSPDS VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL 850 860 870 880 890 900 PLEPICRGPD GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI 910 920 930 940 950 960 EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA APPDYMDTRR 970 980 990 1000 1010 1020 CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA DWTLRERLLP GLLPAAPRGS 1030 1040 1050 1060 1070 1080 LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP APGDTSSWAS GPERWPRREH VVTVSKRRNT 1090 1100 1110 1120 1130 1140 SVDENYEWDS EFPGDMELLE TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA 1150 1160 1170 RCAALREEFL AFRRRRDATR ARLPAYRQPV PHPEQATLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system." Doudney K., Murdoch J.N., Braybrook C., Paternotte C., Bentley L., Copp A.J., Stanier P. Genomics 79:663-670(2002) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[3]	"Solution structure of RSGI RUH-008, a FN3 domain in human cDNA." RIKEN structural genomics initiative (RSGI) Submitted (MAY-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 624-718.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB037776 mRNA. Translation: BAA92593.1. Different initiation.

IPI

IPI00024053.

RefSeq

NP_001128522.1. NM_001135050.1.
NP_065840.2. NM_020789.3.

UniGene

Hs.591472.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V5J	NMR	-	A	624-718	[»]

ProteinModelPortal

Q9P2J2.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9P2J2. 1 interaction.

STRING

9606.ENSP00000357073.

PTM databases

PhosphoSite

Q9P2J2.

Polymorphism databases

DMDM

158706515.

Proteomic databases

PaxDb

Q9P2J2.

PRIDE

Q9P2J2.

Protocols and materials databases

DNASU

57549.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000368094; ENSP00000357073; ENSG00000085552.

GeneID

57549.

KEGG

hsa:57549.

UCSC

uc001fuq.2. human.

Organism-specific databases

CTD

57549.

GeneCards

GC01M159896.

HGNC

HGNC:18132. IGSF9.

HPA

HPA037753.

MIM

609738. gene.

neXtProt

NX_Q9P2J2.

PharmGKB

PA38508.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG303891.

HOGENOM

HOG000154716.

HOVERGEN

HBG079460.

InParanoid

Q9P2J2.

OMA

WAKVGRG.

Gene expression databases

ArrayExpress

Q9P2J2.

Bgee

Q9P2J2.

CleanEx

HS_IGSF9.

Genevestigator

Q9P2J2.

Family and domain databases

Gene3D

2.60.40.10. 7 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]

Pfam

PF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]

SMART

SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

IGSF9. human.

EvolutionaryTrace

Q9P2J2.

GenomeRNAi

57549.

NextBio

64010.

SOURCE

Search...

Entry information

Entry name

TUTLA_HUMAN

Accession

Primary (citable) accession number: Q9P2J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.