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Protein

Protein turtle homolog A

Gene

IGSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in dendrite outgrowth and synapse maturation.By similarity

GO - Biological processi

  1. dendrite development Source: Ensembl
  2. homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
  3. regulation of synapse organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein turtle homolog A
Alternative name(s):
Immunoglobulin superfamily member 9A
Short name:
IgSF9A
Gene namesi
Name:IGSF9
Synonyms:IGSF9A, KIAA1355, NRT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18132. IGSF9.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
Note: Enriched at the excitatory synapses in mature neurons.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 734714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei735 – 75521HelicalSequence AnalysisAdd
BLAST
Topological domaini756 – 1179424CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. dendrite Source: Ensembl
  4. inhibitory synapse Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 11791159Protein turtle homolog APRO_0000306107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 108PROSITE-ProRule annotation
Disulfide bondi158 ↔ 206PROSITE-ProRule annotation
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi248 ↔ 301PROSITE-ProRule annotation
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Disulfide bondi440 ↔ 486PROSITE-ProRule annotation
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis
Modified residuei972 – 9721Phosphothreonine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9P2J2.
PaxDbiQ9P2J2.
PRIDEiQ9P2J2.

PTM databases

PhosphoSiteiQ9P2J2.

Expressioni

Developmental stagei

Expressed in a wide variety of tissues at 8 and 14 weeks of gestation.1 Publication

Gene expression databases

BgeeiQ9P2J2.
CleanExiHS_IGSF9.
ExpressionAtlasiQ9P2J2. baseline and differential.
GenevestigatoriQ9P2J2.

Organism-specific databases

HPAiHPA037753.

Interactioni

Subunit structurei

Interacts with MAGI2 and SHANK1.By similarity

Protein-protein interaction databases

BioGridi121606. 1 interaction.
IntActiQ9P2J2. 1 interaction.
STRINGi9606.ENSP00000357073.

Structurei

Secondary structure

1
1179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi628 – 6347Combined sources
Beta strandi636 – 6449Combined sources
Beta strandi655 – 6628Combined sources
Beta strandi668 – 6747Combined sources
Beta strandi680 – 6823Combined sources
Beta strandi696 – 7005Combined sources
Beta strandi703 – 7075Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5JNMR-A624-718[»]
ProteinModelPortaliQ9P2J2.
SMRiQ9P2J2. Positions 33-720.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P2J2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101Ig-like 1Add
BLAST
Domaini136 – 21681Ig-like 2Add
BLAST
Domaini226 – 31893Ig-like 3Add
BLAST
Domaini322 – 41089Ig-like 4Add
BLAST
Domaini418 – 50285Ig-like 5Add
BLAST
Domaini507 – 611105Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini623 – 71896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1177 – 11793PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi823 – 982160Pro-richAdd
BLAST

Domaini

The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.By similarity

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303891.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154716.
HOVERGENiHBG079460.
InParanoidiQ9P2J2.
OMAiNGTLWIR.
OrthoDBiEOG7M98FF.
PhylomeDBiQ9P2J2.
TreeFamiTF326128.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP
60 70 80 90 100
PLHVIEWLRF GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV
110 120 130 140 150
EDQGWYECRV FFLDQHIPED DFANGSWVHL TVNSPPQFQE TPPAVLEVQE
160 170 180 190 200
LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG QGQVQVQNGT LRIRRVERGS
210 220 230 240 250
SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA SQDVSLACHA
260 270 280 290 300
EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT
310 320 330 340 350
CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP
360 370 380 390 400
PLLFVSWTKD GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS
410 420 430 440 450
LGTAGPSPVT RVLLKAPPAF IERPKEEYFQ EVGRELLIPC SAQGDPPPVV
460 470 480 490 500
SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA HGHWECSASN AVARVATSTN
510 520 530 540 550
VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS VWYTPLAKRP
560 570 580 590 600
DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL
610 620 630 640 650
SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP
660 670 680 690 700
KRLDGYVLEG RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA
710 720 730 740 750
GSFVSDPSNT ANVSTSGLEV YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV
760 770 780 790 800
LVSILAGCLL NRRRAARRRR KRLRQDPPLI FSPTGKSAAP SALGSGSPDS
810 820 830 840 850
VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL PLEPICRGPD
860 870 880 890 900
GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI
910 920 930 940 950
EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA
960 970 980 990 1000
APPDYMDTRR CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA
1010 1020 1030 1040 1050
DWTLRERLLP GLLPAAPRGS LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP
1060 1070 1080 1090 1100
APGDTSSWAS GPERWPRREH VVTVSKRRNT SVDENYEWDS EFPGDMELLE
1110 1120 1130 1140 1150
TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA RCAALREEFL
1160 1170
AFRRRRDATR ARLPAYRQPV PHPEQATLL
Length:1,179
Mass (Da):126,580
Last modified:October 2, 2007 - v2
Checksum:i6C2120D439804407
GO
Isoform 2 (identifier: Q9P2J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-337: YPAQVTAMPPETPLPIG → C

Note: No experimental confirmation available.

Show »
Length:1,163
Mass (Da):124,919
Checksum:iD5ADA3C6CA08335B
GO

Sequence cautioni

The sequence BAA92593.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791R → Q in AAH30141 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341G → E.1 Publication
Corresponds to variant rs3747617 [ dbSNP | Ensembl ].
VAR_035256
Natural varianti474 – 4741R → P.
Corresponds to variant rs16842846 [ dbSNP | Ensembl ].
VAR_035257
Natural varianti914 – 9141P → L.
Corresponds to variant rs35574000 [ dbSNP | Ensembl ].
VAR_035258
Natural varianti1026 – 10261S → T.
Corresponds to variant rs34749866 [ dbSNP | Ensembl ].
VAR_035259
Natural varianti1117 – 11171P → T.1 Publication
Corresponds to variant rs1319080 [ dbSNP | Ensembl ].
VAR_035260

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei321 – 33717YPAQV…PLPIG → C in isoform 2. 1 PublicationVSP_047195Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037776 mRNA. Translation: BAA92593.1. Different initiation.
BC030141 mRNA. Translation: AAH30141.1.
CCDSiCCDS1190.1. [Q9P2J2-2]
CCDS44254.1. [Q9P2J2-1]
RefSeqiNP_001128522.1. NM_001135050.1. [Q9P2J2-1]
NP_065840.2. NM_020789.3. [Q9P2J2-2]
UniGeneiHs.591472.

Genome annotation databases

EnsembliENST00000361509; ENSP00000355049; ENSG00000085552. [Q9P2J2-2]
ENST00000368094; ENSP00000357073; ENSG00000085552. [Q9P2J2-1]
GeneIDi57549.
KEGGihsa:57549.
UCSCiuc001fuq.2. human. [Q9P2J2-1]

Polymorphism databases

DMDMi158706515.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037776 mRNA. Translation: BAA92593.1. Different initiation.
BC030141 mRNA. Translation: AAH30141.1.
CCDSiCCDS1190.1. [Q9P2J2-2]
CCDS44254.1. [Q9P2J2-1]
RefSeqiNP_001128522.1. NM_001135050.1. [Q9P2J2-1]
NP_065840.2. NM_020789.3. [Q9P2J2-2]
UniGeneiHs.591472.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5JNMR-A624-718[»]
ProteinModelPortaliQ9P2J2.
SMRiQ9P2J2. Positions 33-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121606. 1 interaction.
IntActiQ9P2J2. 1 interaction.
STRINGi9606.ENSP00000357073.

PTM databases

PhosphoSiteiQ9P2J2.

Polymorphism databases

DMDMi158706515.

Proteomic databases

MaxQBiQ9P2J2.
PaxDbiQ9P2J2.
PRIDEiQ9P2J2.

Protocols and materials databases

DNASUi57549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361509; ENSP00000355049; ENSG00000085552. [Q9P2J2-2]
ENST00000368094; ENSP00000357073; ENSG00000085552. [Q9P2J2-1]
GeneIDi57549.
KEGGihsa:57549.
UCSCiuc001fuq.2. human. [Q9P2J2-1]

Organism-specific databases

CTDi57549.
GeneCardsiGC01M159896.
HGNCiHGNC:18132. IGSF9.
HPAiHPA037753.
MIMi609738. gene.
neXtProtiNX_Q9P2J2.
PharmGKBiPA38508.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303891.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154716.
HOVERGENiHBG079460.
InParanoidiQ9P2J2.
OMAiNGTLWIR.
OrthoDBiEOG7M98FF.
PhylomeDBiQ9P2J2.
TreeFamiTF326128.

Miscellaneous databases

ChiTaRSiIGSF9. human.
EvolutionaryTraceiQ9P2J2.
GenomeRNAii57549.
NextBioi64010.
PROiQ9P2J2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P2J2.
CleanExiHS_IGSF9.
ExpressionAtlasiQ9P2J2. baseline and differential.
GenevestigatoriQ9P2J2.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-34 AND THR-1117.
    Tissue: Neuroblastoma.
  3. "Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system."
    Doudney K., Murdoch J.N., Braybrook C., Paternotte C., Bentley L., Copp A.J., Stanier P.
    Genomics 79:663-670(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-972, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Solution structure of RSGI RUH-008, a FN3 domain in human cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 624-718.

Entry informationi

Entry nameiTUTLA_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.